The scientific effectiveness and also security of Xiaoer Soy Qiao Qingre Granules incorporated with azithromycin in the treatment of children with Mycoplasma pneumoniae pneumonia were systematically assessed. Approaches: Computer system browsed Chinese Academic Journals Full-text Data Source (CNKI), VIP Chinese Journals Full-text Data Source (VIP), Wanfang Data, China Biomedical Literary Works Database (CBM), Cochrane Library, PubMed and Web of Science in Chinese as well as English The data source was accumulated from the randomized controlled tests (RCTs) of Xiaoer Chiqiao Qingre Granules incorporated with Azithromycin Bnfin the treatment of youngsters with Mycoplasma pneumoniae pneumonia. Outcomes: A total of 9 RCTs including 1 072 kids were consisted of. The results of Meta-analysis showed that: Xiaoer Chiqiao Qingre Granules combined with azithromycin group could improve the complete effective price [RR= 1.16, 95% CI( 1.05, 1.27), P= 0.003] and shorten the cough loss time [MD= -2.54, 95% CI( -3.44, -1.46), P< 0.000 01], shortening the loss time of pulmonary rales [MD= -2.55, 95% CI( -4.39, -0.70), P= 0.007], antipyretic time [MD= -2.08, 95% CI (-2.84, -1.31), P< 0.000 01], reduced interleukin-6 degree [MD= -7.88, 95% CI (-12.33, -3.43), P= 0.000 5], lower the unfavorable reaction rate [RR= 0.44, 95% CI (0.28, 0.68), P= 0.000 2], as well as the distinction was statistically substantial. VERDICT: The efficiency of Xiaoer Chiqiao Qingre Granules combined with Azithromycin Bnf in the therapy of kids with Mycoplasma pneumoniae pneumonia is far better than that of azithromycin alone, as well as it is much safer.