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Zhishang Chemical

Azithromycin Bnf CAS 83905-01-5

Molecular Formula: C38H72N2O12

Formula Weight: 748.98

ZSpharmac: Azithromycin Bnf Supplement

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Product Name: Azithromycin Bnf
CAS No: 83905-01-5
Purity: 99%

Basic Info

Product Name:Azithromycin Bnf
Other Names:Azithromycin
CAS:83905-01-5
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Pharmaceutical Raw Materials
Appearance:White Solid
EINECS No.:617-500-5
Storage:Sealed in Dry,2-8°C
Provide:Azithromycin Bnf MSDS;
Azithromycin Bnf COA

What is Azithromycin Bnf?

Azithromycin Bnf is an extensively made use of antibiotic medication with the advantages of broad anti-bacterial range, less irritability to the stomach system, as well as quick oral absorption. It is made use of by grownups and youngsters alike. Azithromycin has less side effects than cephalosporin anti-biotics. It is currently the most frequently made use of antibiotic medicine for the treatment of microbial infection-related conditions in medical facilities in my nation. This medication is a second-generation semi-synthetic by-product of macrolides. Unlike erythromycin, it inserts a methyl-substituted nitrogen at the 9a setting of the erythromycin lactone ring, causing a 15-membered macrolide.

The mechanism of activity of Azithromycin Bnf resembles that of erythromycin. It binds to the 50S subunit of the ribosome of delicate microorganisms as well as prevents RNA-dependent healthy protein synthesis to put in an anti-bacterial result, retaining the antibacterial range of typical erythromycin. The task against chlamydia resembles that of erythromycin. Compared to erythromycin, the antibacterial activity against Gram-negative microorganisms has actually been considerably boosted. The antibacterial activity versus influenza bacillus and also Neisseria gonorrhoeae is greater than 4 times stronger than that of erythromycin, as well as the anti-bacterial activity versus Legionella has to do with 2 times more powerful. The antibacterial task against Enterobacteriaceae was also significantly more powerful than that of erythromycin. The MIC for the majority of Gram-negative bacteria is less than 1 μg/ ml. Staphylococcus aureus and also Streptococcus pyogenes are cross-resistant to this product as well as erythromycin. It additionally has a great killing result on Toxoplasma and also Treponema pallidum. Azithromycin Bnf is mainly made use of for respiratory tract infections, urogenital tract infections, skin as well as soft cells infections as well as venereal diseases caused by sensitive microbes.

Azithromycin Bnf Properties:

Melting point 113-115°C
alpha D20 -37° (c = 1 in CHCl3)
Boiling point 822.1±65.0 °C(Predicted)
density 1.18±0.1 g/cm3(Predicted)
storage temp. Sealed in dry,2-8°C
solubility Practically insoluble in water, freely soluble in anhydrous ethanol and in methylene chloride.
form neat

 

Azithromycin Bnf Uses

  1. Azithromycin Bnf macrolide antibiotic, 15-membered nitrogen-containing heterocycle, with similar anti-bacterial system to erythromycin, yet wider antibacterial spectrum. It has stronger antibacterial task versus gram-positive microorganisms as well as stronger antibacterial task versus gram-negative microorganisms such as Haemophilus influenzae, Salmonella, Escherichia coli, Shigella, and so on. It is secure to acid and also has excellent tolerance.
  2. Azithromycin Bnf is an antibiotic drug used for various infections triggered by delicate bacteria, such as respiratory system infections, skin and also soft tissue infections.
  3. Azithromycin Bnf is utilized for respiratory system infections, urinary system infections, skin as well as soft cells infections and venereal diseases.

Azithromycin Bnf Purification

First, take 200 kg of crude Azithromycin Bnf (preserve the chromatogram) and dissolve it in 600 liters of dichloromethane. Follow the steps below:

The first step: separation of easily water-soluble impurities
1. Add 40 liters of pure water, add 5 liters of 10% hydrochloric acid aqueous solution dropwise at 0-5 °C, stir for 1 hour, let stand for 1 hour, separate the upper water phase to the water phase tank, add 10 liters of pure water to the reactor to rinse Clean into the water phase tank.

2. Return the dichloromethane phase from the oil phase tank to the reaction kettle, add 40 liters of pure water, dropwise add 5 liters of 10% hydrochloric acid aqueous solution at 0-5 °C, stir for 1 hour, leave standstill for 1 hour, and separate the upper water phase to Water phase tank, add 10 liters of pure water to the reaction kettle and rinse it to the water phase tank.

3. Return the dichloromethane phase from the oil phase tank to the reaction kettle, add 40 liters of pure water, dropwise add 5 liters of 10% hydrochloric acid aqueous solution at 0-5 °C, stir for 1 hour, leave standstill for 1 hour, and separate the upper water phase to Water phase tank, add 10 liters of pure water to the reaction kettle and rinse it to the water phase tank.

④, the methylene chloride layer is washed once with 40 liters of pure water, and the separated water phase is merged into the water phase tank, which is the water phase containing easily water-soluble impurities.

The second step: separation of the dichloromethane phase containing oil-soluble impurities
①, return the dichloromethane phase from the oil phase tank to the reaction kettle, add 10 liters of dichloromethane rinsing oil phase tank to the reaction kettle, add 240 liters of pure water to the dichloromethane phase, add dropwise at 0-5 °C 117 kg of 10% hydrochloric acid aqueous solution, sampled to detect the dichloromethane phase containing 5.8% (weight ratio). Stir for 1 hour, let stand for 1 hour, and separate the lower layer of dichloromethane to the oil phase tank.

2. Add 40 liters of dichloromethane to the water phase, add 2.6 kg of 20% aqueous sodium hydroxide solution dropwise below 10°C, stir for 1 hour, let stand for 1 hour, and separate the dichloromethane phase to the oil phase tank.

3. The water layer was stirred with 40 liters of dichloromethane for 1 hour, and allowed to stand for 1 hour. The separated dichloromethane phase was merged into the oil phase tank, which was the dichloromethane phase containing oil-soluble impurities. The aqueous phase was sampled and chromatographed to make it qualified.

The third step: extraction and crystallization:
①. The water layer in the reaction kettle is heated to 30 degrees Celsius, and the vacuum (-0.8MP) is pulled for 1 hour to remove clean methylene chloride, then 240 liters of acetone are added, and activated carbon is added and stirred for 2 hours. Add 20% aqueous sodium hydroxide solution dropwise at 45°C, stop adding alkali when crystals are precipitated, add 0.1 kg of seed crystals, and stir for 0.5 hours.

2. Continue to add 20% aqueous sodium hydroxide solution dropwise until the pH value is 9.5, continue to add 120 kg of purified water dropwise, and maintain stirring for 1 hour.

③. Cool down to 20°C, keep stirring for 1 hour, and centrifuge. Dry at 60°C and weigh.

Azithromycin Bnf Combination Study

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Additive , Chemical Auxiliary & Catalyst , Organic Chemicals
  • Products/Service: Organic Intermediate,Inorganic Chemistry, APIs, Dyestuffs And Pigments, Fragrance And Spices, Food Additives
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.

Service

Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.

 

After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.

FAQ

Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.

 

HOW TO CONFIRM THE PRODUCT QUALITY BEFORE PLACING ORDERS?

You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.

Shipping

1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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