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Azelaic Acid Deutsch CAS 123-99-9

Molecular Formula: C9H16O4

Formula Weight: 188.22

ZSpharmac: Azelaic Acid Deutsch Supplement

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Product Name: Azelaic Acid Deutsch
CAS No: 123-99-9
Purity: 99%

Basic Info

Product Name:Azelaic Acid Deutsch
Other Names:Azelaic acid
CAS:123-99-9
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:White to Slightly Yellow Slightly Crystalline Powder or Flakes
EINECS No.:204-669-1
Storage:Store Below +30°C.
Provide:Azelaic Acid Deutsch MSDS;
Azelaic Acid Deutsch COA

What is Azelaic Acid Deutsch?

Azelaic Acid Deutsch, additionally known as azalea acid, exists in rhododendron, pyrethrum as well as cocoa butter, and is currently prepared by oxidizing oleic acid with nitric acid. Azelaic acid is a yellowish powder, conveniently soluble in hot water, alcohol and warm benzene, and a little soluble in water.

Azelaic Acid Deutsch has anti-bacterial homes, can be made use of as a chemical for food and also cosmetics, and can additionally be used in oral health products to avoid cavities; Azelaic Acid Deutsch has significant infiltration in the skin surface, as well as the penetration performance is several times that of dimethyl sulfoxide. In the emulsion system generally made use of in cosmetics, the efficiency of Azelaic Acid Deutsch to lug energetic components right into the skin is greater than that of dimethyl sulfoxide, and also 43% to 64% of the drug can permeate into the skin, so it can be made use of as the penetration of emulsions as well as ointments. It is used to treat more serious skin disease such as acne and also skin problems. Azelaic Acid Deutsch and also its zinc salt can balance male hormonal agents, and when combined with vitamin B6 in external hair water, it can stop androgen alopecia triggered by solid endocrine in guys, as well as can stimulate hair development at the same time. The dosage is 0.001% to 1.000%. Rhododendron has reduced poisoning and also can be used with a range of energetic materials to raise its feature.

Azelaic Acid Deutsch is an excellent stabilizer for solution systems, and also its salts have self-emulsifying functions. Including it to soaps can protect against the surface of the soap from breaking. Azelaic Acid Deutsch, as a crucial chemical intermediate, is generally made use of for the manufacturing of dioctyl azelaic acid plasticizer, and additionally as a resources for the production of fragrances, lubing oils as well as polyamide resins. In addition, azelaic acid likewise has particular applications in capacitor electrolyte additives and treatment of skin diseases. Over the last few years, with the fast development of azelaic acid downstream materials and the pharmaceutical market, the need for azelaic acid in the Chinese market has boosted dramatically, while the residential manufacturing capability of azelaic acid is seriously not enough. Consequently, it is of excellent social and financial benefit to accelerate the research as well as enhancement of the preparation modern technology of Azelaic Acid Deutsch and boost its reaction return.

Azelaic Acid Deutsch Properties:

Melting point 98 °C
Boiling point 286 °C100 mm Hg(lit.)
density 1,029 g/cm3
vapor density 6.5 (vs air)
vapor pressure <1 mm Hg ( 20 °C)
refractive index 1.4303
Fp 215 °C
storage temp. Store below +30°C.
solubility 2.4g/l
pka4.53, 5.33(at 25℃)
form Slightly Crystalline Powder or Flakes
color White to slightly yellow
PH3.5 (1g/l, H2O)
Water Solubility 2.4 g/L (20 ºC)

 

Azelaic Acid Deutsch Uses

  1. The Majority Of Azelaic Acid Deutsch is used in the manufacturing of dioctyl azelaate (DOZ) plasticizer, and also various other uses are as basic materials for scents, lubricating oils, oils, and polyamide materials. DOZ is utilized as a cold-resistant plasticizer for cords, movies, artificial leather, and so on, with reduced volatility as well as good aging resistance. DOZ can also be utilized as a conditioner for synthetic rubber. Azelaic Acid Deutsch made use of in the manufacturing of DOZ in Japan accounts for about 70% of the total usage of azelaic acid. Azelaic Acid Deutsch can be dehydrated via ammonia to produce azelaic acid.
  2. Azelaic Acid Deutsch is made use of as a raw material for the production of plasticizer dioctyl azelaate as well as fragrances, lubricating oils, oils, as well as polyamide resins.
  3. Azelaic Acid Deutsch is utilized as a reagent as well as additionally in natural synthesis.
  4. Azelaic Acid Deutsch is extensively used in medicine as well as cosmetics.

Azelaic Acid Deutsch Preparation

Using unsaturated fatty acid or its derivatives as raw materials, the preparation of pelargonic acid and Azelaic Acid Deutsch by ozone oxidation is the earliest industrialized production method. Commonly used unsaturated fatty acids are oleic acid, linoleic acid, red oil, castor oil, etc., of which oleic acid is the most common. Oleic acid is used as raw material to oxidize azelaic acid. According to the different oxidants, it is mainly divided into potassium permanganate oxidation method, ozone oxidation method and hydrogen peroxide oxidation method.

Chen Song et al. used potassium permanganate as the oxidant, tetrabutylammonium bromide as the catalyst, the reaction temperature was 50 °C, and the yield of azelaic acid was 57%; Zhao Ma used ricinoleic acid as the raw material, and potassium permanganate as the oxidant , the molar ratio of potassium permanganate to ricinoleic acid was 3.5:1, the reaction temperature was 60-70 ℃, the reaction time was 0.35 h, and the yield of Azelaic Acid Deutsch was 95%; Catalyst, using emulsifier and phase transfer catalyst at the same time, microwave ultrasonic, the reaction temperature is 50 ℃, the reaction time is 1.5 h, and the yield of azelaic acid is 60%;

Yang Yang et al. used potassium permanganate as the oxidant and benzyl triethylammonium chloride as the phase transfer catalyst, and the yield of azelaic acid was 58.1%; He Conglin et al. used industrial oleic acid as the raw material and potassium permanganate as the oxidant , the reaction temperature is 50 ℃, the pH value is 2.5, and the yield of Azelaic Acid Deutsch is 55%; Catalyst, azelaic acid was prepared with a yield of 52%; Shao Huayue et al. used castor oil as raw material and potassium permanganate as oxidant to prepare Azelaic Acid Deutsch with a yield of 90%; Wu Haiyong et al. As raw material, potassium permanganate as oxidant, tetrabutylammonium bromide as phase transfer catalyst, azelaic acid was prepared under ultrasonic, and the yield was 5%.

Wang Shuqian of Qingdao University of Science and Technology used cottonseed oil as raw material, glacial acetic acid and water mixture as solvent, and ozone as oxidant. Oleic acid was used as the raw material, and the capacitor-grade Azelaic Acid Deutsch was obtained through ozone oxidation, with a yield of 46%; Chen Yan et al. used acetic acid as a solvent, ozone as an oxidant, and prepared azelaic acid under the action of microwave, with a yield of 69.7%; Sun Zicai et al. used a mixed system of oleic acid, water, nonanoic acid and acetic acid to stir vigorously at 0~15 °C, then introduced ozone until the reaction was complete, gradually heated up to 85~100 °C under an oxygen atmosphere, and added Mn(Ac) to the system. 2 and CoCl2 were used as catalysts or microwave heating catalysts for 2~3 h, and the yield of azelaic acid was 70%;

Sun Zicai and others also used ozone as the oxidant to investigate the effect of different catalysts on the yield of Azelaic Acid Deutsch in the mixed system of oleic acid, water, nonanoic acid and acetic acid. When MoO3 or PbO2 was used as the catalyst, the yield of azelaic acid was 75%. ; Li Zhiwei et al used linoleic acid as raw material, ozone as oxidant, acetic acid as solvent, the reaction temperature was 90~95 °C, the reaction time was 2~2.5 h, and the yield of azelaic acid was 46%; Li Yingchun et al. used oleic acid as raw material , ozone was used as oxidant, copper acetate was used as catalyst, the reaction temperature was 90~95℃, and the reaction time was 2.5 h. The yield of Azelaic Acid Deutsch was 47.1%. MoO3 was used as catalyst, ozone was used as oxidant, the ozonation temperature was 20~25℃, and the oxidative cracking temperature was 90℃. The total yield of Azelaic Acid Deutsch was 72.42%.

Sheng Fengjun et al. used WO3/mesoporous SiO2 as the catalyst, tert-butanol as the solvent, hydrogen peroxide and oxygen as the oxidant, and reacted at 50-80 °C for 36 h, and the yield of azelaic acid was 22.6%.

Shi Chunwei of Liaoning University of Petrochemical Technology used Ce-SBA-15 as catalyst, 30% hydrogen peroxide and ozone as oxidant, reacted at 70℃ for 1 h, and reacted at 95~105℃ for 8 h, the total yield of Azelaic Acid Deutsch was 86%; Shi Chunwei et al. used SO42-/TiO2 solid acid as catalyst, 30% hydrogen peroxide and ozone as oxidants, reacted at 70 °C for 1 h, and reacted at 95~105 °C for 8 h. The primary yield of azelaic acid was 52%. The secondary yield was 25%; Shi Chunwei et al. used oleic acid as the raw material, phosphotungstic acid as the catalyst, cetyltrimethylammonium bromide as the phase transfer catalyst, 30% hydrogen peroxide and ozone as the oxidant, and the reaction temperature was 70 ℃ , the reaction time was 8 h, and the yield of Azelaic Acid Deutsch was 71%; Sun Yuanxue et al. used oleic acid as raw material, hydrogen peroxide and ozone as oxidants, and reacted at 70 ℃ for 4 h, and the yield of Azelaic Acid Deutsch was 51%.

Gao Junjun et al. used oleic acid as raw material, first used 50% hydrogen peroxide as oxidant, isopropanol as co-catalyst, and tungstic acid as catalyst to synthesize the intermediate product 9,10-dihydroxystearic acid, and after removing the solvent, added homemade Peracetic acid, reacted under microwave for 2 h, the yield of Azelaic Acid Deutsch was 74.6%; Ayxiamuguli Nueraimat et al. used ionic liquid (BMIM) PF6 as solvent, tungsten Acid as catalyst, 50% hydrogen peroxide and 25% peracetic acid as oxidant, react at 60-90 ℃ for 4 h, the total yield of Azelaic Acid Deutsch is 39%.

Song Heyuan of Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences used 50% hydrogen peroxide as the oxidant, phosphotungstic acid as the catalyst, and trioctylmethylammonium chloride as the phase transfer catalyst. The reaction temperature was 95-100 °C, the reaction time was 8 h, and the oil The acid conversion rate was 100%, and the Azelaic Acid Deutsch selectivity was 91.5%; Li Pinghui et al. used 30% hydrogen peroxide as the oxidant, phosphotungstic acid as the catalyst, and used a phase transfer catalyst at a reaction temperature of 95~105 ℃. Diacid in 68.4% yield. Azelaic Acid Deutsch and its derivatives are important fine chemical intermediates with broad development prospects.

In recent years, on the basis of technology introduction and digestion and absorption, my country has carried out a lot of research on the selection of Azelaic Acid Deutsch oxidant for the preparation of oleic acid. The oleic acid oxidation method using potassium permanganate as the oxidant, although the yield is high, needs to add a large amount of phase transfer agent and emulsifier, consumes a large amount of sulfuric acid and potassium permanganate, not only high cost but also serious pollution.

Oleic acid ozone oxidation is currently the only industrial production method in China, developed by Emery in the United States. Although this method has the advantages of mild reaction conditions and no pollution, the reaction yield is not too high, the production scale is also limited by ozone, and the selection of catalysts and the separation and purification of products need to be further improved. As a cheap, clean and environmentally friendly green oxidant, hydrogen peroxide has attracted extensive attention of researchers and has achieved rapid development. The development of a process for preparing Azelaic Acid Deutsch by hydrogen peroxide oxidation with oleic acid as raw material has the advantages of low production cost, high product yield, cleanness and environmental protection, etc., which can not only fill the shortage of domestic azelaic acid production capacity, but also help the preparation of azelaic acid from oleic acid in my country. The development of independent research and development technology will play a huge role in promoting.

Clinical application of Azelaic Acid Deutsch

1. Treatment of acne According to reports, 309 cases of mild to moderate inflammatory acne patients, a multi-center randomized single-blind trial, one group was given azelaic acid cream, applied twice a day, and the other group was given 5% benzoyl peroxide Gel was used as a control, and the course of treatment was 6 months. Results: In the azelaic acid cream group, the inflammatory damage was reduced by 84% compared with that before treatment, and the control group was reduced by 83%. The former had an average effective rate of 66%, while the latter was 70%, and there was no statistical significance between the two groups. Another 306 cases of mild to moderate inflammatory acne patients were randomized and double-blind. The azelaic acid cream group was applied twice a day, and the other group was given 2% erythromycin cream as a control, and the course of treatment was 5 months. Results: In the azelaic acid cream group, the inflammatory damage was reduced by 79% compared with that before treatment, and the control group was reduced by 68%. The average effective rate of the former is 71%, and the latter is 67%, indicating that the efficacy of azelaic acid cream is similar to that of erythromycin cream. According to another report, 289 cases of acne vulgaris (acne) patients were observed by random single-blind multi-center, and 0.05% retinoic acid cream was used as control. Results: The acne number in the azelaic acid group was reduced by 79% compared with that before treatment, and the control group was reduced by 82% compared with that before treatment. The average effective rate of the two groups was 65% for the former and 69% for the latter. Hjorth reported that 261 cases of severe inflammatory acne patients were treated with random double-blind multi-center treatment observation, and the control group was treated with oral tetracycline 0.5-1.0g for 6 months. Results: The inflammatory damage in the azelaic acid group was reduced by 79% compared with that before treatment, the control group was reduced by 79% compared with that before treatment, the number of cystic nodules in the azelaic acid group was reduced by 86% compared with that before treatment, and the tetracycline group was reduced by 83%. The efficiency of the former was 65%, and the latter was 69%. After statistics, the difference between the two groups was not significant.

2. In the treatment of rosacea, 146 patients with papulopustular rosacea were reported, with an average age of 49 years and a course of disease of 5.5 years. A multicenter randomized double-blind trial was used. Among them, 77 patients received azelaic acid cream, and 39 patients in the other group were treated with azelaic acid cream. Placebo control, topical application 2 times a day, 3-month course of treatment. Results: About 73% of the patients in the azelaic acid cream group had improved inflammation, but only 50.6% in the control group; the erythema severity score was reduced by an average of 47.9% in the azelaic acid group and 37.9% in the control group. Comparison, the difference is significant, but the improvement of vascular dilatation is not obvious in the two groups.

3. In the treatment of chloasma, 66 cases of facial chloasma have been reported. One group was given 1.5% azelaic acid, twice a day, and the other group of 28 cases was given 2% hydroquinone cream as a control, and the course of treatment was 3 months each. . Results: In the treatment group, 12 cases were cured, 18 cases were markedly effective, 5 cases were effective, 3 cases were ineffective, and the total effective rate was 92.1%; The difference between the two groups was extremely significant (P<0.01). No allergies and other adverse reactions were found during the treatment. Another report of 50 cases of chloasma was topical application of azelaic acid, 2 times a day, for 1 to 7 months. Results: 1 case was cured, 30 cases were markedly effective, 17 cases were effective, 2 cases were ineffective, and the effective rate was 62%.

4. Treatment of hyperpigmentation of the skin. Local application of azelaic acid cream for a long time can treat (relieve or lighten) skin melasma, senile plaques, small malignant moles, melanoma, etc. Oral administration of azelaic acid 10-15g·d-1 and topical application of azelaic acid cream can make epithelial melanoma disappear.

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Additive , Chemical Auxiliary & Catalyst , Organic Chemicals
  • Products/Service: Organic Intermediate,Inorganic Chemistry, APIs, Dyestuffs And Pigments, Fragrance And Spices, Food Additives
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.

Service

Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.

 

After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.

FAQ

Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.

 

HOW TO CONFIRM THE PRODUCT QUALITY BEFORE PLACING ORDERS?

You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.

Shipping

1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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