Azelaic Acid Deutsch CAS 123-99-9

Chen Song et al. used potassium permanganate as the oxidant, tetrabutylammonium bromide as the catalyst, the reaction temperature was 50 °C, and the yield of azelaic acid was 57%; Zhao Ma used ricinoleic acid as the raw material, and potassium permanganate as the oxidant , the molar ratio of potassium permanganate to ricinoleic acid was 3.5:1, the reaction temperature was 60-70 ℃, the reaction time was 0.35 h, and the yield of Azelaic Acid Deutsch was 95%; Catalyst, using emulsifier and phase transfer catalyst at the same time, microwave ultrasonic, the reaction temperature is 50 ℃, the reaction time is 1.5 h, and the yield of azelaic acid is 60%;

Yang Yang et al. used potassium permanganate as the oxidant and benzyl triethylammonium chloride as the phase transfer catalyst, and the yield of azelaic acid was 58.1%; He Conglin et al. used industrial oleic acid as the raw material and potassium permanganate as the oxidant , the reaction temperature is 50 ℃, the pH value is 2.5, and the yield of Azelaic Acid Deutsch is 55%; Catalyst, azelaic acid was prepared with a yield of 52%; Shao Huayue et al. used castor oil as raw material and potassium permanganate as oxidant to prepare Azelaic Acid Deutsch with a yield of 90%; Wu Haiyong et al. As raw material, potassium permanganate as oxidant, tetrabutylammonium bromide as phase transfer catalyst, azelaic acid was prepared under ultrasonic, and the yield was 5%.

Wang Shuqian of Qingdao University of Science and Technology used cottonseed oil as raw material, glacial acetic acid and water mixture as solvent, and ozone as oxidant. Oleic acid was used as the raw material, and the capacitor-grade Azelaic Acid Deutsch was obtained through ozone oxidation, with a yield of 46%; Chen Yan et al. used acetic acid as a solvent, ozone as an oxidant, and prepared azelaic acid under the action of microwave, with a yield of 69.7%; Sun Zicai et al. used a mixed system of oleic acid, water, nonanoic acid and acetic acid to stir vigorously at 0~15 °C, then introduced ozone until the reaction was complete, gradually heated up to 85~100 °C under an oxygen atmosphere, and added Mn(Ac) to the system. 2 and CoCl2 were used as catalysts or microwave heating catalysts for 2~3 h, and the yield of azelaic acid was 70%;

Sun Zicai and others also used ozone as the oxidant to investigate the effect of different catalysts on the yield of Azelaic Acid Deutsch in the mixed system of oleic acid, water, nonanoic acid and acetic acid. When MoO3 or PbO2 was used as the catalyst, the yield of azelaic acid was 75%. ; Li Zhiwei et al used linoleic acid as raw material, ozone as oxidant, acetic acid as solvent, the reaction temperature was 90~95 °C, the reaction time was 2~2.5 h, and the yield of azelaic acid was 46%; Li Yingchun et al. used oleic acid as raw material , ozone was used as oxidant, copper acetate was used as catalyst, the reaction temperature was 90~95℃, and the reaction time was 2.5 h. The yield of Azelaic Acid Deutsch was 47.1%. MoO3 was used as catalyst, ozone was used as oxidant, the ozonation temperature was 20~25℃, and the oxidative cracking temperature was 90℃. The total yield of Azelaic Acid Deutsch was 72.42%.

Sheng Fengjun et al. used WO3/mesoporous SiO2 as the catalyst, tert-butanol as the solvent, hydrogen peroxide and oxygen as the oxidant, and reacted at 50-80 °C for 36 h, and the yield of azelaic acid was 22.6%.

Shi Chunwei of Liaoning University of Petrochemical Technology used Ce-SBA-15 as catalyst, 30% hydrogen peroxide and ozone as oxidant, reacted at 70℃ for 1 h, and reacted at 95~105℃ for 8 h, the total yield of Azelaic Acid Deutsch was 86%; Shi Chunwei et al. used SO42-/TiO2 solid acid as catalyst, 30% hydrogen peroxide and ozone as oxidants, reacted at 70 °C for 1 h, and reacted at 95~105 °C for 8 h. The primary yield of azelaic acid was 52%. The secondary yield was 25%; Shi Chunwei et al. used oleic acid as the raw material, phosphotungstic acid as the catalyst, cetyltrimethylammonium bromide as the phase transfer catalyst, 30% hydrogen peroxide and ozone as the oxidant, and the reaction temperature was 70 ℃ , the reaction time was 8 h, and the yield of Azelaic Acid Deutsch was 71%; Sun Yuanxue et al. used oleic acid as raw material, hydrogen peroxide and ozone as oxidants, and reacted at 70 ℃ for 4 h, and the yield of Azelaic Acid Deutsch was 51%.

Gao Junjun et al. used oleic acid as raw material, first used 50% hydrogen peroxide as oxidant, isopropanol as co-catalyst, and tungstic acid as catalyst to synthesize the intermediate product 9,10-dihydroxystearic acid, and after removing the solvent, added homemade Peracetic acid, reacted under microwave for 2 h, the yield of Azelaic Acid Deutsch was 74.6%; Ayxiamuguli Nueraimat et al. used ionic liquid (BMIM) PF6 as solvent, tungsten Acid as catalyst, 50% hydrogen peroxide and 25% peracetic acid as oxidant, react at 60-90 ℃ for 4 h, the total yield of Azelaic Acid Deutsch is 39%.

Song Heyuan of Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences used 50% hydrogen peroxide as the oxidant, phosphotungstic acid as the catalyst, and trioctylmethylammonium chloride as the phase transfer catalyst. The reaction temperature was 95-100 °C, the reaction time was 8 h, and the oil The acid conversion rate was 100%, and the Azelaic Acid Deutsch selectivity was 91.5%; Li Pinghui et al. used 30% hydrogen peroxide as the oxidant, phosphotungstic acid as the catalyst, and used a phase transfer catalyst at a reaction temperature of 95~105 ℃. Diacid in 68.4% yield. Azelaic Acid Deutsch and its derivatives are important fine chemical intermediates with broad development prospects.

In recent years, on the basis of technology introduction and digestion and absorption, my country has carried out a lot of research on the selection of Azelaic Acid Deutsch oxidant for the preparation of oleic acid. The oleic acid oxidation method using potassium permanganate as the oxidant, although the yield is high, needs to add a large amount of phase transfer agent and emulsifier, consumes a large amount of sulfuric acid and potassium permanganate, not only high cost but also serious pollution.

Oleic acid ozone oxidation is currently the only industrial production method in China, developed by Emery in the United States. Although this method has the advantages of mild reaction conditions and no pollution, the reaction yield is not too high, the production scale is also limited by ozone, and the selection of catalysts and the separation and purification of products need to be further improved. As a cheap, clean and environmentally friendly green oxidant, hydrogen peroxide has attracted extensive attention of researchers and has achieved rapid development. The development of a process for preparing Azelaic Acid Deutsch by hydrogen peroxide oxidation with oleic acid as raw material has the advantages of low production cost, high product yield, cleanness and environmental protection, etc., which can not only fill the shortage of domestic azelaic acid production capacity, but also help the preparation of azelaic acid from oleic acid in my country. The development of independent research and development technology will play a huge role in promoting.