Song Heyuan of Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences used 50% hydrogen peroxide as the oxidant, phosphotungstic acid as the catalyst, and trioctylmethylammonium chloride as the phase transfer catalyst. The reaction temperature was 95-100 °C, the reaction time was 8 h, and the oil The acid conversion rate was 100%, and the Azelaic Acid Deutsch selectivity was 91.5%; Li Pinghui et al. used 30% hydrogen peroxide as the oxidant, phosphotungstic acid as the catalyst, and used a phase transfer catalyst at a reaction temperature of 95~105 ℃. Diacid in 68.4% yield. Azelaic Acid Deutsch and its derivatives are important fine chemical intermediates with broad development prospects.
In recent years, on the basis of technology introduction and digestion and absorption, my country has carried out a lot of research on the selection of Azelaic Acid Deutsch oxidant for the preparation of oleic acid. The oleic acid oxidation method using potassium permanganate as the oxidant, although the yield is high, needs to add a large amount of phase transfer agent and emulsifier, consumes a large amount of sulfuric acid and potassium permanganate, not only high cost but also serious pollution.
Oleic acid ozone oxidation is currently the only industrial production method in China, developed by Emery in the United States. Although this method has the advantages of mild reaction conditions and no pollution, the reaction yield is not too high, the production scale is also limited by ozone, and the selection of catalysts and the separation and purification of products need to be further improved. As a cheap, clean and environmentally friendly green oxidant, hydrogen peroxide has attracted extensive attention of researchers and has achieved rapid development. The development of a process for preparing Azelaic Acid Deutsch by hydrogen peroxide oxidation with oleic acid as raw material has the advantages of low production cost, high product yield, cleanness and environmental protection, etc., which can not only fill the shortage of domestic azelaic acid production capacity, but also help the preparation of azelaic acid from oleic acid in my country. The development of independent research and development technology will play a huge role in promoting.