There are several sort of ultraviolet absorbers, amongst which benzophenone ultraviolet absorbers are commonly made use of, and this sort of absorbers has excellent sensible research study worth. Avobenzone Safe is a benzophenone UV absorber, and it is additionally a very vital organic synthesis intermediate.
Avobezone (Avobezone) is a synthetic ultraviolet absorber, an excellent UV-A (> 320nm) type ultraviolet absorber, which can block the full-band (320-400nm) UVA, and also is an efficient broad-spectrum Oil-soluble UVA filter, intensified with other UVB sun blocks, can supply full UVA as well as UVB security for the prevention of photoinduced skin cancer.
The research located that Avobenzone Safe can dramatically interfere with the communication in between both healthy proteins PHB and c-Raf1, and also confirmed for the very first time that Avobenzone can dramatically hinder the transition of colon cancer cells via molecular biology experiments and cytology experiments, expanding the capacity of Avobenzone Safe. The range of application of vobenzone enhances its application value. Compared to typical chemotherapeutic medicines, avobenzone has high lump uniqueness, much less adverse effects and also clearer countermeasures for negative effects.
Compared with existing tumor-targeted medicines, Avobenzone Safe does not target a solitary genetics or healthy protein, however targets the communication of 2 proteins, and will certainly not trigger continuous medication pressure on a specific molecule or solitary protein in cancer cells to cause its Anomalies have actually considerably reduced the introduction of clinical drug resistance.
Features of Avobenzone Safe
An oil-soluble sun block. Categorized as a “chemical” sun block since it functions by soaking up a wide wavelength of UV rays, transforming them right into much less unsafe infrared radiation (heat energy). It is marketed as a “broad-spectrum” sunscreen because it withstands the complete range of UVA rays. It is one of the few sun blocks with a large range of UV defense, so it is extensively utilized in sun block items. It is used in cosmetics to additionally prevent other components from wearing away in the sunlight.
The test results show that Avobenzone Safe (Avobenzone) often tends to decay significantly with boosting sunlight direct exposure time, therefore deteriorating its sunlight defense ability. Because of this, many sunscreens including this component include photostabilizers such as octocrylene. Numerous companies have developed modern technologies to help stabilize this ingredient (eg Helioplex ™, Energetic Photo Obstacle Complicated ™), nevertheless, the complete dangers of long-term use of avobenzone have actually not been established.
Avobenzone Safe Preparation
Method 1
Method 2
Method 3
Method 1
Use highly active p-tert-butylbenzoyl chloride instead of methyl p-tert-butylbenzoate, choose sodium amide as the base, and the molar ratio of p-methoxyacetophenone to p-tert-butylbenzoyl chloride is 0.85 , condensation reaction at 90 ℃ for 5 h to generate avobenzone, the yield can reach 81.5%. The method has short route, short reaction time, low cost and high yield, and is an ideal process for realizing industrialized production.
The specific steps are as follows: 7.50 g (0.05 mol) of p-methoxyacetophenone was dissolved in 100 mL of anhydrous toluene in a 250 mL three-neck flask under nitrogen protection, and then 2.15 g (0.055 mol) of sodium amide was added. Heat and keep the temperature at 40°C, add 12.20 g (0.0575 mol) of p-tert-butylbenzoyl chloride dropwise within 30 minutes, raise the temperature to 90°C, react at constant temperature for 5 hours, a lot of solids are formed, cool to room temperature.
Add 50% acetic acid under constant stirring to make the whole system slightly acidic (pH = 5~6), then add saturated NaHCO3 to wash until neutral. The reaction solution was separated, and the organic layer was dried with anhydrous MgSO4, filtered, and pressure-evaporated to remove toluene, and cooled to obtain 14.5 g of a reddish-brown crude product, which was recrystallized in 40 mL of absolute ethanol to obtain 12.61 g of white crystals, with a yield of 81.5%, m.p. 81~82℃
Method 2
A method for preparing Avobenzone Safe, the method may further comprise the steps:
Step 1), adding p-tert-butylbenzaldehyde, a basic catalyst and the first solvent in the condensation reactor, optionally raising the temperature, adding p-methoxyacetophenone to the system, and carrying out the condensation reaction;
Step 2), adjust the pH value of the system obtained in step 1, optionally cool, filter, wash and filter the filter cake obtained to obtain the condensate 3-((4-tert-butyl)phenyl)-1-(4 -Methoxyphenyl)-2-propen-1-one;
Step 3), put the condensate, the second solvent and the catalyst prepared in step 2 into the oxidation reaction kettle, add an oxidizing agent to the system, and carry out the oxidation reaction;
Step 4), adding sodium sulfite solution to the system prepared in step 3, washing, and removing the second solvent to obtain a crude product, which is optionally purified to obtain Avobenzone Safe.
Method 3
a synthetic method of Avobenzone Safe, comprising the following steps:
1), the alkylation reaction takes toluene and chloro-tert-butane as raw materials, uses aluminum trichloride as a catalyst, the reaction temperature is 23.5° C., and the reaction time is 85 minutes to obtain p-tert-butyltoluene; preferably, chloro-tert-butyltoluene The molar ratio of butane to toluene is 1:1.6;
2), potassium permanganate is used as an oxidizing agent in the oxidation reaction, and the p-tert-butyltoluene obtained in step 1) is oxidized into p-tert-butylbenzoic acid; the reaction temperature is 85°C, and the reaction time is 8.5h, and p-tert-butyl The molar ratio of methyl toluene to potassium permanganate is 1:3, and the potassium permanganate oxidant is added in 5 to 8 times. Preferably, the potassium permanganate oxidant of 3 molar parts is put into the reaction system in 6 times, 0.9 molar parts are dropped into for the first time, 0.6 molar parts are dropped into for the 2nd time, 0.5 molar parts are dropped into for the third time and the 4th time, 0.3 mole parts were added for the last time, and 0.2 mole parts were added for the last time, the final yield reached 83.1%, and the purity was 98.6%.
3), in the esterification reaction, p-tert-butylbenzoic acid and methanol are used as raw materials, and the reaction is carried out in two stages; the molar ratio of p-tert-butylbenzoic acid and methanol in the first stage is 1:3.5, and the reaction time is 3h. After the end of distillation, water and methanol are separated; in the second stage, 3.5 mole parts of methanol are added, and the reaction time is 5h; after the reaction is distilled, water and methanol are separated; The molar ratio of benzoic acid to methanol was 1:7, and the reaction was refluxed for 8h.
4) The acylation reaction uses phenetole and acetic anhydride as raw materials, phosphotungstic acid as a catalyst, the molar ratio of anisole and acetic anhydride is 1:1.5, the reaction time is 4 hours, and the reaction temperature is 115°C;
5) In the condensation reaction, methyl p-tert-butylbenzoate and p-methoxyacetophenone are used as raw materials, sodium amide is used as a catalyst, xylene is a solvent, p-methoxyacetophenone and p-tert-butylbenzene The molar ratio of methyl formate was 1:1.4, the reaction temperature was 100°C, and the reaction time was 5 hours, and finally Avobenzone Safe was obtained. The preferred reaction temperature is 95°C, and the molar ratio of p-methoxyacetophenone to methyl p-tert-butylbenzoate is 1:1.4.
About Products: If you need Avobenzone Safe, the cosmetic raw material, please contact our service staff directly, we will provide you with high-quality products at the best price. As an experienced Avobenzone Safe manufacturer and supplier, ZSpharmac will provide Avobenzone Safe raw materials to customers all over the world for a long time. Over the years, the company has been adhering to the spirit of “integrity management, strict quality control, customer first”, and has won unanimous praise from domestic and foreign customers.
Company Profile and Corporate Culture
Company Profile：
ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .
The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .
The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.
Corporate Culture：
OUR MISSION Help China Chemicals to benefit the happiness of human life OUR VISSION Become the most trusted chemical supplier in the world OUR BUSINESS PHILOSOPHY Striver – oriented, enrich employees, customer first, deep service, seek development OUR VALUES Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight
About Us
The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.
“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.
Company Info
Business Type: Manufacturer
Product Range: Cosmetic raw materials
Products/Service:Cosmetic raw materials (flavors and fragrances,antioxidant products, moisturizing and hydrating, whitening agents, cosmetic additives)
Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.
Service
Pre-Sales Service
* Prompt reply and 24 hours online, professional team to provide best price and high quality product.
* Sample testing support.
* Every batch of products will be tested to ensureits quality.
*The packing also can be according the customers` requirment.
*Any inquiries will be replied within 24 hours.
*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.
After-Sales Service
*The fact of logistics information monitoring.
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*Product has any problem can return.
FAQ
Do you accept sample order?
We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.
HOW TO CONFIRM THE PRODUCT QUALITY BEFORE PLACING ORDERS?
You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.
What’s your MOQ?
Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.
Do you supply product report?
Yes. We’ll give you product analysis report before shipping.
Is there a discount?
Different quantity has different discount.
Shipping
1. ≤50kg, Express delivery recommended, usually called as DDU service;
2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;
3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;
4. For high value products, please select air shipping and express delivery for safe.
