Aucubin CAS 479-98-1

Molecular Formula: C15H22O9

Formula Weight: 346.33

ZSpharmac: Aucubin Raw Material Supplier

Product Name: Aucubin

CAS No: 479-98-1

Purity: 99%

Navigation Bar

Basic Info

Product Name:	Aucubin
Other Names:	B-D-GLUCOPYRANOSIDE
CAS:	479-98-1
Place of Origin:	Shandong, China
Brand Name:	ZSpharmac
Type:	Cosmetic Raw Materials
Appearance:	White Neat
EINECS No.:	207-540-8
Storage:	2-8°C
Provide:	Aucubin MSDS； Aucubin COA

What is Aucubin?

Aucubin, likewise known as aucubin, chemically called β-D-glucopyranoside, has a bitter taste, is conveniently soluble in water, ethanol, methanol, and is insoluble in chloroform, ether, oil ether and various other solvents. This item is an iridoid substance that widely exists in several plant types in nature. It has biological activities such as getting rid of dampness and warmth, advertising urination, analgesic, reducing high blood pressure, shielding the liver, anti-inflammatory, and anti-tumor. It can advertise stem cell regrowth and dramatically hinder the replication of hepatitis B virus DNA. Its aglycone and efficient polymer are prescription antibiotics. Because the exploration of aucubin in all-natural plant types, it has actually been together discovered in plant types such as Garryaceae, Scrophulariaceae, Globulariaceae, and Eucommiaceae. This substance is discovered in high quantities in plantain and eucommia. The primary resource of aucubin is removed from all-natural plants, and some people make use of tissue culture approaches to extract aucubin from the callus of Eucommia ulmoides.

Aucubin Property

Melting point	181°
alpha	D21 -163.1° (c = 1.6)
Boiling point	669.0±55.0 °C(Predicted)
density	1.61±0.1 g/cm3(Predicted)
storage temp.	2-8°C
solubility	DMF: 30 mg/ml; DMSO: 30 mg/ml; PBS (pH 7.2): 10 mg/ml
pka	12.80±0.70(Predicted)
form	neat
color	White

Aucubin Application

1. Drug and Health Care Industry
A considerable variety of Chinese patent medicines included in the “Drug Standards” of the Ministry of Health that have heat-clearing, diuretic, antihypertensive, and hepatoprotective residential properties contain aucubin as the cornerstone. For instance, Eucommia ulmoides tablets have different medicinal impacts such as antihypertensive, diuretic, antibacterial, antiviral, and anti-aging. Its main element is aucubin. At present, Aucubin has actually been utilized as one of the vital indications of quality control in the production of drugs such as Substance Lychee Turf Granules. Auucin is also extensively utilized in the health care industry Eucommia health and wellness tea with Eucommia leaves as the primary component has the functions of eliminating warm and detoxification, lowering high blood pressure and cellulite, and slimming down and strengthening the body.
2. Daily Chemical Sector
With the enhancement of consumer recognition and the renovation of consumption degrees, hair treatment items have ended up being necessities for people’s everyday usage from high-end items. Given that Chinese organic medications usually have double features of nourishment and curative effect, and their results are light, they are very appropriate for usage as cosmetic ingredients. Aucubin, which is widely located in Chinese natural medicine, can respond with amino acids to create tinted items, and can additionally be broken down by weaken acids and enzymes. Relying on its dosage, it can create brown-black to black dendritic polymer speeds up. This precipitate belongs to hair fiber adhesion. Solid, natural color, non-irritating to skin, permanent hair color.
3. Feed Market
Japanese scholars have actually researched over the last few years and believe that Eucommia ulmoides is a rich feed additive. Eucommia ulmoides fallen leave powder can enhance their resistance and minimize the incident of illness when incorporated right into livestock, fowl and fish feeds. This is since adding materials having Aucubin to feed can inhibit the growth of Gram-negative and positive microorganisms and decrease the loss of nutrients.

Aucubin Biological Activity

Aucubin has a wide variety of organic activities, and contemporary scientific study on its organic tasks has permeated right into lots of areas such as food, health care, medication, and daily chemicals.

1. Anti-inflammatory and anti-viral effects
Aucubin has evident hepatoprotective results and can considerably prevent the duplication of hepatitis B virus DNA. Research studies have actually shown that aucubin can considerably prevent the rise in ALT and AST in lotion caused by liver injury triggered by CCl4, and can avoid the decline in liver RNA synthesis degrees brought on by α-amanitin. Neither aucubin neither β-glucosidase revealed anti-hepatitis B infection activity when utilized alone, however when both were pre-incubated, they showed strong anti-hepatitis B infection task. It does not have antiviral results by itself, yet it will create obvious antiviral results when pre-incubated with glucosidase.

2. Antioxidant and anti-aging impacts
Free radicals are toxic compounds that are continually generated by the body during its metabolic process and damage itself. Free radicals in the human body are primarily oxygen totally free radicals, which can peroxidize unsaturated fats on cell membranes, ruin the organic membrane framework, and form lipofuscin, which is just one of the primary attributes of aging. Li Farong et al. studied Aucubin’s scavenging effect on complimentary radicals produced in chemical systems and its safety effect on oxidative damages in tissue homogenates, mitochondria, and microsomes. Collagen is a high molecular protein whose filamentous collagen fibers make skin solid and elastic. As age rises, the body’s collagen will slowly shed, and the skin will progressively lose flexibility and come to be thinner and older, creating spots, wrinkles and a collection of aging phenomena. Study has actually located that both water remove and methanol essence of Eucommia ulmoides leaves can promote collagen synthesis and accomplish anti-aging objectives. The essence of the experimental group with the best impact contains a huge quantity of aucubin.

3. Various other biological activities
Aucubin has evident antihypertensive impact, resilient antihypertensive effect without any damaging reactions, and has a two-way regulation feature on blood pressure, which is unrivaled by chemical antihypertensive drugs. Eucommia fallen leave extract powder has anti-fatigue impacts, and it contains aucubin. Auucrin can promote the parasympathetic facility, increase the transfer and removal of uric acid, and has no “tachyphylaxis” phenomenon; it can additionally annoy uterine tightenings triggered by acetylcholine artificial insemination; it also has anti-tumor activity.

Aucubin Extraction and Isolation

1. Cold soak extraction method: Because Aucubin is quickly soluble in methanol, 30% methanol option is utilized for extraction. When left at space temperature, the shade of the remedy adjustments. The greater the area temperature level, the much faster the adjustment. Nevertheless, when the example is put in the fridge overnight throughout extraction, the color of the example remedy does not change, and there is no change when it is put again. Therefore, chilly removal with 30% methanol remedy guarantees that the sample solution is steady. This technique is basic and affordable, but takes a long time to remove.

2. Alcohol removal of lead salt rainfall technique: Remove with ethanol, concentrate the remove to prepare an extract, add water to dissolve, then add lead salt to precipitate, filter the precipitate, pass the filtrate right into H2S to remove lead, and concentrate under decreased pressure. Liquify the deposit with acetone, focus the acetone option to acquire unrefined aucubin, and lastly recrystallize to obtain the pure item. Due to the fact that the lead rainfall method has certain selectivity for aucubin, this approach can obtain reasonably pure Aucubin. However, because of making use of poisonous heavy metal lead, it might trigger certain pollution to aucubin items.

3. Ultrasonic extraction approach: Ultrasonic wave is a consistent round mechanical wave that creates solid shock waves and micro jets inside the fluid through an one-of-a-kind kind of activity – cavitation, which can break the cell wall surface and permit intracellular parts to penetrate right into the solution., thus accomplishing the purpose of splitting up. The ultrasonic removal method is straightforward and quick to run, has the advantages of conserving time, and does not require home heating. It can be made use of to remove some substances that are conveniently ruined and decayed by warmth. It has low overall price, much less air pollution, and the essence is very easy to divide. It can attain better results than standard removal techniques. More excellent outcomes. On top of that, this approach is easy and suitable for commercial production, but it is currently restricted to lab range.

4. Macroporous resin adsorption method: Macroporous adsorption resin is a polymer adsorbent that does not contain exchange groups and has a macroporous structure. It is also a lipophilic substance. It has the advantages of good selectivity, high mechanical stamina, convenient regeneration handling, rapid adsorption speed, simple procedure, steady product quality, and reduced production price, so it is specifically suitable for dividing and cleansing water-soluble substances. However, this method takes a very long time and is tough to clean up the adsorption material. The adsorption materials presently utilized to cleanse Aucubin primarily include S-8 material and D4020 material. Among them, S-8 resin has great selectivity and huge adsorption capability. It can be entirely eluted with 60% ethanol aqueous option.

About Products:
If you need Aucubin, a cosmetic raw material, please contact our service staff directly, and we will provide you with high-quality products at the best price.
Our company, as an experienced Aucubin manufacturer and supplier, ZSpharmac will provide Aucubin raw materials to customers around the world for a long time.
Over the years, the company has adhered to the spirit of “integrity management, strict quality control, and customer first” and has won unanimous praise from customers at home and abroad.

Company Profile and Corporate Culture

Company Profile：

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture：

OUR MISSION
Help China Chemicals to benefit the happiness of human life
OUR VISSION
Become the most trusted chemical supplier in the world
OUR BUSINESS PHILOSOPHY
Striver – oriented, enrich employees, customer first, deep service, seek development
OUR VALUES
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info

Business Type: Manufacturer
Product Range: Cosmetic raw materials
Products/Service:Cosmetic raw materials (flavors and fragrances,antioxidant products, moisturizing and hydrating, whitening agents, cosmetic additives)
Total Employees: 51~100
Capital (Million US $): 10000000RMB
Year Established: 2016

Production Capacity

No. of Production Lines : 8
No. of QC Staff : 5 -10 People
OEM Services Provided : yes
Factory Size (Sq.meters) : 3,000-5,000 square meters
Certificate: ISO9001 , CE , GMP , API , MSDS
Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.

Service

Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.

After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.

FAQ

Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.

HOW TO CONFIRM THE PRODUCT QUALITY BEFORE PLACING ORDERS?

You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

Is there a discount?

Different quantity has different discount.

Shipping

1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.