Zhishang Chemical

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Zhishang Chemical

Aucubin CAS 479-98-1

Molecular Formula: C15H22O9

Formula Weight: 346.33

ZSpharmac: Aucubin Supplier

Product Name: Aucubin
CAS No: 479-98-1
Purity: 99%

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Basic Info

Product Name:Aucubin
Other Names:Aucubin Structure
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:White Powder
EINECS No.:207-540-8
Provide:Aucubin MSDS;
Aucubin COA

What is Aucubin?

Aucubin (Aucubin), also referred to as reefs wood glucoside, chemical name β-D-glucopyranoside, bitter, soluble in water, ethanol, methanol, insoluble in chloroform, ether, oil ether and also other solvents. This item is an iridoid compound that widely exists in lots of plant species in nature. It has biological tasks such as getting rid of dampness and warm, diuresis, discomfort relief, decreasing blood pressure, safeguarding liver and liver, anti-inflammation, and also anti-tumor. It can advertise the regrowth of stem cells and obviously inhibit the replication of liver disease B virus DNA. Its aglycone and reliable multimer are an antibiotic. Considering that the discovery of aucubin in natural plant varieties, it has been located in plant species such as Garryaceae, Scrophulariaceae, Globulariaceae, and Eucommiaceae. This compound, among which the material of plantain and Eucommia is extremely high. The primary resource of aucubin is extracted from all-natural plants, and also some individuals use the method of tissue society to essence aucubin from the callus of Eucommia ulmoides.

Aucubin Property

Melting point 181°
alpha D21 -163.1° (c = 1.6)
Boiling point 669.0±55.0 °C(Predicted)
density 1.61±0.1 g/cm3(Predicted)
storage temp. 2-8°C
form neat


Application of Aucubin

1. Medication as well as medical care industry
A considerable part of the Chinese patent medicines detailed in the “Drug Requirements” of the Ministry of Health with the functions of removing heat, diuresis, lowering high blood pressure and also securing the liver contain aucubin as the cornerstone. As an example, Eucommia Sound Tablets have various pharmacological results such as high blood pressure lowering, diuresis, antibacterial, antiviral, as well as antiaging, as well as its main component is aucubin. Today, aucubin has actually been used as one of the crucial indications of quality assurance in the manufacturing of compound lychee grass granules as well as various other drugs. Aucubin is also widely made use of in the health care sector Eucommia ulmoides health tea with Eucommia leaves as the main part has the functions of removing heat as well as detoxification, decreasing blood pressure and also decreasing cellulite, slimming down as well as strengthening the body.
2. Daily chemical sector
With the enhancement of intake understanding and the enhancement of intake level, hairdressing items have ended up being necessities of individuals’s everyday intake from deluxe products. Since Chinese natural medicine usually has dual features of nourishment and also medicinal impact, and also the effect is moderate, it is extremely suitable as an aesthetic additive. Aucubin, which commonly exists in Chinese natural medicine, can respond with amino acids to create tinted items, as well as can likewise be decayed by dilute acids and enzymes. Relying on its dose, it can create brown-black to black dendritic polymer speeds up. Strong fiber attachment, natural color, non-irritating to the skin, is an irreversible hair color.
3. Feed market.
In the last few years, Japanese scholars think that Eucommia ulmoides is an abundant feed additive. Eucommia ulmoides leaf powder combined with animals, poultry as well as fish feed can enhance their immunity as well as lower the occurrence of illness. This is due to the fact that the enhancement important including aucubin in the feed can hinder the growth of Gram-negative as well as favorable microorganisms as well as lower the loss of nutrients. The overview, removal and splitting up, organic activity, etc. of aucubin.

Biological Activity of Aucubin

1. Anti-inflammatory as well as anti-viral impacts
Aucubin has apparent hepatoprotective effect and can substantially hinder the replication of liver disease B virus DNA. Researches have actually revealed that aucubin can considerably inhibit the increase of ALT as well as AST in serum triggered by liver injury caused by CCl4, as well as can prevent the reduction of liver RNA synthesis level brought on by α-amanitin. Neither aucubinin nor β-glucosidase revealed anti-HBV activity when made use of alone, yet when both were pre-incubated, they showed solid anti-HBV activity. It does not have antiviral result by itself, however when it is pre-incubated with glucosidase, it will certainly create evident antiviral impact.
2. Antioxidant as well as anti-aging effects
Free radicals are harmful materials that are frequently generated during the body’s metabolism as well as damages itself. Free radicals in the human body are mainly oxygen complimentary radicals, which can peroxidize unsaturated fatty acids on cell membranes, damage biomembrane structures, and type lipofuscin, which is among the main qualities of aging. Li Farong et al. studied the scavenging result of aucubin on free radicals produced in the chemical system and its protective impact on tissue homogenate, mitochondria, and microsomal oxidative damage. Collagen is a high-molecular protein, and its filamentous collagen fibers make the skin company and elastic. With the boost of age, the body’s collagen will slowly lose, the skin will progressively shed its flexibility and also end up being thinner and aging, as well as a collection of aging phenomena such as areas and wrinkles will certainly show up. The research found that both Eucommia fallen leave water essence and methanol remove can advertise collagen synthesis as well as achieve the purpose of anti-aging, and also the remove of the speculative group with the very best effect contains a large amount of aucubin.
3. Other biological activities
Aucubin has noticeable antihypertensive impact, lasting antihypertensive with no adverse response, as well as has two-way law function on high blood pressure, which is unparalleled by chemical antihypertensive medications. Eucommia fallen leave extract powder has anti-fatigue results, and also it includes aucubin. Aucubin can stimulate the parasympathetic facility, increase the transfer and also elimination of uric acid, as well as there is no “tachytolerance” sensation; it can additionally annoy the uterine contraction caused by acetylcholine in vitro; it likewise has antitumor activity.

Extraction and Separation of Aucubin

1. Cold saturating extraction approach: Given that aucubin is quickly soluble in methanol, it is extracted with 30% methanol remedy. When put at space temperature, the color of the remedy adjustments, and the higher the room temperature, the faster the adjustment. However, when the example is put in the fridge over night during removal, the shade of the sample option remains unmodified, and there is no change when it is placed once again. Therefore, the example service was steady when extracted by chilly immersion in 30% methanol solution. The process of this approach is basic and affordable, however the removal time is much longer.
2. Alcohol extraction of lead salt precipitation technique: essence with ethanol, concentrate the essence to prepare extract, include water to liquify, after that add lead salt to precipitate, filter the precipitate, pass the filtrate right into H2S to remove lead, and also concentrate under reduced pressure. The deposit was dissolved in acetone, and the acetone remedy was focused to acquire the crude aucubin, which was ultimately recrystallized to acquire the pure item. Due to the fact that the lead precipitation method has a specific selectivity to aucubin, this method can acquire fairly pure aucubin, however as a result of making use of hazardous heavy metal lead, it might create specific contamination to aucubin products.
3. Ultrasonic extraction approach: Ultrasonic wave is a consistent spherical mechanical wave, which generates strong shock waves as well as micro jets inside the fluid with an unique type of activity – cavitation, which can break the cell wall and also permit intracellular components to pass through right into the service, so regarding accomplish the function of splitting up. Ultrasonic extraction approach is simple and quick to run, has the advantages of saving time and also no demand for home heating, as well as can be utilized to remove some substances that are conveniently damaged and decayed by heating, as well as has reduced overall price, much less contamination, and the extract is very easy to divide, which can reach a greater level than conventional extraction techniques. better outcomes. On top of that, the approach is straightforward as well as ideal for commercial manufacturing, yet it is just restricted to lab scale.
4. Macroporous material adsorption technique: macroporous adsorption material is a polymer adsorbent without exchange groups as well as has a macroporous framework, as well as it is also a lipophilic substance. It has the advantages of great selectivity, high mechanical stamina, practical regrowth treatment, rapid adsorption speed, simple procedure, stable product high quality and also reduced manufacturing cost, so it is especially ideal for the separation and also filtration of water-soluble compounds. Yet this method takes a long time and it is challenging to cleanse the adsorption resin. Currently, the adsorption materials utilized to cleanse aucubin generally include S-8 material and D4020 material, among which S-8 resin has excellent selectivity and also big adsorption ability, and also it can be totally cleansed by 60% ethanol aqueous option. elute.

About That Product:
If you need Aucubin, this cosmetic raw material, please contact our service staff directly, we will provide you with high-quality products at the best price.
As an experienced Aucubin manufacturer and supplier, ZSpharmac will provide Aucubin raw materials to customers all over the world for a long time.
Over the years, the company has been adhering to the spirit of “integrity management, strict quality control, customer first”, and has won unanimous praise from domestic and foreign customers.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

Help China Chemicals to benefit the happiness of human life
Become the most trusted chemical supplier in the world
Striver – oriented, enrich employees, customer first, deep service, seek development
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Cosmetic raw materials
  • Products/Service:Cosmetic raw materials (flavors and fragrances,antioxidant products, moisturizing and hydrating, whitening agents, cosmetic additives)
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.


After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.


Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

Get Aucubin Quotation