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Aspartame Powder CAS 22839-47-0

Molecular Formula: C14H18N2O5

Formula Weight: 294.31

ZSpharmac: Aspartame Powder Supplier

Product Name: Aspartame Powder
CAS No: 22839-47-0
Purity: 99%

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Basic Info

Product Name:Aspartame Powder
Other Names:Aspartame
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:White Powder
EINECS No.:245-261-3
Provide:Aspartame Powder MSDS;
Aspartame Powder COA

What is Aspartame Powder?

Aspartame Powder is a sweetening agent that belongs to amino acid dipeptide derivatives, discovered by chemists in 1965 when creating ulcer medication. It has low dosage, high sweet taste (150-200 times the sweet taste of sucrose), taste, can enhance the taste of citrus and also other fruits, minimize calories, does not create cavities, and is extra poisonous than saccharin as well as other artificial sugar It has low advantages and is commonly utilized in beverages, diabetic foods and also some weight-loss natural food. The formula of soda pop we drink in our daily life when included this item.

The main damage items of Aspartame Powder in the process of metabolic procedure in the body are phenylalanine, methanol as well as additionally aspartic acid, which do not go into the blood circulation, do not accumulate in the body, as well as are safe to healthy and balanced and also well balanced people. However, as a result of the metabolic flaw in clients with phenylketonuria (PKU), excessive phenylalanine in the body can impact their growth, so aspartame-added foods should be banned for people with this disease.

Aspartame Powder Property

Melting point 242-248 °C
alpha 15.5 º (c=4, 15N formic acid)
Boiling point 436.08°C (rough estimate)
density 1.2051 (rough estimate)
refractive index 14.5 ° (C=4, 15mol/L Formic Acid)
storage temp. 2-8°C
solubility Sparingly soluble or slightly soluble in water and in ethanol (96 per cent), practically insoluble in hexane and in methylene chloride.
pkapKa 3.19±0.01 (H2O t=25.0 I=0.100(NaCl))(Approximate);7.87±0.02(H2O t=25.0 I=0.100(NaCl))(Approximate)
form Powder
color White
PHpH(8g/l, 25℃) : 4.5~6.0
Odorodorless with a sweet taste
Water Solubility Soluble in formic acid, dimethyl sulfoxide. Sparingly soluble in water and ethanol.


Aspartame Powder Uses

  1. Aspartame Powder is a synthetic low-calorie sugar, often incorporated with sucrose or other sugar. It can be made use of in all sort of food, and also it can be made use of in suitable quantity according to the production demands. The basic dose is 0.5 g/kg.
  2. Aspartame Powder can be utilized in all sort of food according to my nation’s GB2760-90 policies, and also the maximum use relies on normal manufacturing requirements. According to the policies of FAO/WHO (1984 ), it can be made use of for sweet food, dosage 0.3%, periodontal 1.0%, beverage 0.1%, morning meal cereal 0.5%, as well as reduced sugar preparation for diabetes mellitus, hypertension, obesity, cardio individuals Course, low-calorie organic food, the dosage depends upon the requirement. Can additionally be used as a flavor enhancer.
  3. Aspartame Powder is a dipeptide manufactured from L-aspartic acid and L-phenylalanine (essential nutrients for the body), which can be entirely taken in and metabolized by the body. It is safe, harmless, safe as well as reliable, as well as has a pure, awesome and also rejuvenating taste. It is similar to sucrose, however its sweetness is 200 times that of sucrose, and its calories are only 1/200 of that of sucrose. Normal intake does not create dental caries, does not influence blood sugar level, and does not cause excessive weight, hypertension, and coronary heart disease. It has been determined as A (1) sugar by the Globe Health Organization (THAT) as well as the Food as well as Agriculture Organization of the United Nations (FAO), as well as has actually been accepted for use in greater than 130 nations and regions worldwide. It is commonly contributed to numerous foods, non-staple foods as well as different soft as well as hard drinks, as well as more than 4,000 varieties of aspartame have actually been made use of. It can be made use of as an artificial additive and a healthy sugar with high sweetness. Packing: 25 kg fiber cardboard drum, lined with plastic bags.

Aspartame Powder Safety Limit Standard

After Aspartame Powder is digested by the human body, it decomposes to produce aspartic acid, phenylalanine and methanol, and continues to metabolize to obtain formaldehyde, formic acid and a diketopiperazine substance. Methanol is a toxic substance that is easily absorbed but difficult to excrete from the body. Therefore, the US Environmental Protection Agency recommends no more than 7.8 mg of methanol per day. Improper storage or heating of products containing aspartame to 30°C or above will lead to the production of more methanol, which is harmful to the human body.

In 1980 and 1993, JECFA evaluated the safety of Aspartame Powder respectively, and set its acceptable daily intake (ADI) as 0-40 mg/kg. In 1981, the US FDA approved the use of aspartame, setting the ADI at 0-50 mg/kg. my country’s Food Additive Edible Standard stipulates that aspartame “can be used in various foods as needed”, and also requires that foods added with aspartame should be marked with “aspartame (containing phenylalanine)”. Patients with phenylketonuria should pay more attention to the relevant information on food labels.

Aspartame Powder Production Method

The preparation of Aspartame Powder typically has two sort of chemical synthesis as well as enzymatic synthesis
enzymatic synthesis.
Tao Guoliang, Department of Chemistry, Wuhan University and also others offered the following artificial course:
Preparation of I Add 0.5 mmol benzyloxycarbonyl aspartate, 1.5 mmol phenylalanine methyl ester hydrochloride and also 2.5 mL water into a 25mL Erlenmeyer flask, change the pH worth to 6 with ammonia water, include 7mg thermophilic For protease, mix the response at 40 ° C for 6h. It was filteringed system, washed with pure water, and also dried to acquire 0.29 g of white solid (I), with a yield of 95.6% and a melting point of 116-118 ° C. Elemental analysis results: C62.96%, H6.09%. N6.65%.
( 2) Preparation of II Add 0.5 g of example I and 20 mL of 3 mol/L hydrochloric acid right into a 25 mL Erlenmeyer flask, as well as stir and react at 45 ° C. for 0.5 h. Purification, washing with distilled water, as well as drying provided 0.32 g of item II with a yield of 92% and a melting point of 129-131 ° C. Elemental analysis results: C61.45%, H5.42%, N6.82%.
Preparation of III Include 0.2 g of palladium-carbon (10%) stimulant, 20mL of glacial acetic acid, and also 5mL of water into a 100mL three-necked flask, as well as activate it by hydrogenation for 1.5 h. Add 20mL of antarctic acetic acid liquified in 0.6 g II, as well as mix as well as hydrogenate at 30 ° C for 6h. After the response was completed, filter as well as clean the catalyst three times with glacial acetic acid; focus the filtrate and launderings to dryness under lowered stress, include 15 mL of benzene, and remain to focus under minimized pressure to dry skin to obtain a white solid, which was dried out to obtain 0.38 g of item III, with a return of 92.3%, melting point 245 ° C. Elemental analysis results: C55.63%, H6.23%, N8.96%.

chemical synthesis
Using aspartic acid and phenylalanine as raw materials, it is manufactured with the steps of amino defense, interior anhydride, condensation, hydrolysis, and also neutralization. Different shielding teams and methyl esterification sequences can have various artificial techniques. Such as adopting formyl as the process route of protecting group and also methyl esterification after, its
Put 27mL of 95% methanol and 0.2 g of magnesium oxide into a 250mL flask. After the magnesium oxide is liquified, include 100mL of 98% acetic anhydride. Currently, the temperature progressively rises to 40 ° C. Include 67g of L-aspartic acid, raise the temperature to 50 ° C, mix and also keep it warm for 2.5 h, include 15mL of 98% acetic anhydride, continue to maintain cozy for 2.5 h, add 16mL of isopropanol, remain to respond for 1.5 h, trendy to space temperature after the response.
Add the above-mentioned interior anhydride right into a 1000mL flask, after that add 207mL ethyl acetate as well as 66Gl-phenylalanine, mix at 25 ~ 30 ° C for 1.5 h, then include 126mL of antarctic acetic acid, proceed the reaction for 4.5 h, get rid of the vacuum cleaner after the reaction Solvent, until the temperature level of the response system is 65 ° C. After that 45mL of 35% hydrochloric acid was added, the temperature level was elevated to 60 ° C, as well as the response was refluxed for 2h. After hydrolysis, carry out climatic distillation up until the purification temperature reaches 63 ° C( response system temperature 73 ° C), include 180mL of methanol, and also proceed climatic purification up until the system temperature level is 85 ° C. After cooling down to 25 ° C, the light ends were eliminated in vacuo. Add 54mL of 35% hydrochloric acid, 9mL of methanol and 43mL of water to the above hydrolysis response remedy, and also perform esterification response at 20 ~ 30 ° C for 7 days. Then suction filter and also wash with water to separate α-APM hydrochloride. Liquify it in 600mL of distilled water, as well as neutralize it to Ph= 4.5 with 5% -10% NaOH remedy at 40 ° C. Cool to listed below 5 ° C, suction filter and also wash to acquire the unrefined α-APM, and after that liquify it in a mixture of 500 mL methanol as well as water (volume ratio 1:2). After cooling down and also formation, suction filtering as well as washing, as well as vacuum cleaner drying, the yield is 45% (based upon L-phenylalanine).
Japanese scholars propose an unprotected route:
Dissolve 90g of phenylalanine methyl ester hydrochloride in 450mL of water, neutralize with 24g of sodium carbonate, and then remove with two 350mL dichlorethylene to obtain phenylalanine methyl ester. Add 9g of acetic acid as well as 8mL of methanol to the remove, after that include 15.2 g of aspartic anhydride hydrochloride at -20 ° C, keep mixing for 30min, then add 350mL of warm water at 70 ~ 80 ° C as well as sodium carbonate (5.7 g) solution 300mL. After drawing out the staying phenylalanine methyl ester twice with 150 mL of dichloroethylene, the pH value of the aqueous layer was adjusted to 4.8 with dilute hydrochloric acid. This liquid service was gauged by paper electrophoresis to have 18.2 g (60% molar return) of α-APM and also 6.1 g (20% molar return) of β-APM. This liquid remedy was focused in vacuo to 100mL, as well as added. 30mL of 36% hydrochloric acid, put in the fridge over night. 21.3 g of α-APM · HCl crystals were precipitated (yield 58%), as well as the crystals were filtered off and also dissolved in 200 mL of water. The remedy was mixed at 50 ° C, and the pH worth was adapted to 4.8 with 5% sodium carbonate service, after that placed in the refrigerator overnight, precipitated as well as filtered to obtain 13.0 g of α-APM crystals (return 43%). The crystals were dissolved in 500 mL of water, travelled through a Dowex 1 × 4 (acetate form) column (1 × 20 centimeters) at 45 ° C., as well as washed with 20 mL of water. The effluent was focused in vacuo with the cleaning liquid, as well as 11.2 g of α-APM crystals were sped up. Return 37%, melting point 235 ~ 236 ° C(decomposition), specific rotation αD22 +32.0 ° (C=1, in acetic acid). Elemental evaluation results: C55.30%, H6.19%, N9.36%.

About Products:
If you need Aspartame Powder, the cosmetic raw material, please contact our service staff directly, and we will provide you with high-quality products at the best price.
As an experienced Aspartame Powder manufacturer and supplier, ZSpharmac will provide Aspartame Powder raw materials to customers all over the world for a long time.
Over the years, the company has been adhering to the spirit of “integrity management, strict quality control, customer first”, and has won unanimous praise from domestic and foreign customers.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

Help China Chemicals to benefit the happiness of human life
Become the most trusted chemical supplier in the world
Striver – oriented, enrich employees, customer first, deep service, seek development
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Cosmetic raw materials
  • Products/Service:Cosmetic raw materials (flavors and fragrances,antioxidant products, moisturizing and hydrating, whitening agents, cosmetic additives)
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.


After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.


Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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