Zhishang Chemical

Welcome to Zhishang Chemical      +86-176 5311 3209     Simon@sdzschem.com

Zhishang Chemical
Search
Close this search box.

Asiatic Acid CAS 464-92-6

Molecular Formula: C30H48O5

Formula Weight: 488.7

ZSpharmac: Asiatic Acid Supplier

Facebook
Twitter
LinkedIn
Pinterest
WhatsApp
Email
Product Name: Asiatic Acid
CAS No: 464-92-6
Purity: 99%

Navigation Bar

Basic Info

Product Name:Asiatic Acid
Other Names:Madecassoside
CAS:464-92-6
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:White Powder
EINECS No.:482-720-9
Storage:2-8°C
Provide:Asiatic Acid MSDS;
Asiatic Acid COA

What is Asiatic Acid?

Asiatic acid (Asiatic acid, AA), also known as Asiatic acid, is one of the main components of the triterpene extract of the natural plant Centella asiatica (L.) Urban. It has an ursane-type skeleton structure, and its The structure is shown in Figure 1.

464-92-6.jpg

Asiatic Acid Property

Melting point 325-330 °C(lit.)
Boiling point 609.4±55.0 °C(Predicted)
density 1.18±0.1 g/cm3(Predicted)
RTECS YU9580000
storage temp. 2-8°C
solubility methanol: soluble1mg/mL, clear, colorless
form powder
pka4.66±0.70(Predicted)
color white
Water Solubility Soluble in dimethyl sulfoxide, ethanol and dimethylformamide. Sparingly soluble in water

 

Efficacy and Role of Asiatic Acid

The result on skin care
Given that Chasseaud et al. determined that Asiatic acid itself has the result of treating skin injuries in 1971, Centella Asiatica extract (mostly consisting of Asiatic acid as well as Asiatica saponin) has been utilized to treat skin injuries and also persistent ulcers. Treatment of skin deformities triggered by consumption and also leprosy. Typically the skin is conveniently exposed directly to ultraviolet rays (UVA), as well as is one of the most delicate body organ to UVA. Premature aging of the skin takes place after UVA damage, that is, photoaging. The signal transduction pathway mediated by UVA ultimately causes photoaging, both most important reasons of which are the excessive manufacturing of oxygen free radicals and the look of matrix metalloproteinases (matrix metalloproteinases, MMPs).

HaCaT keratinocytes were irradiated with ultraviolet rays, which generated oxidative stress and anxiety, improved MMP-2 expression, and also triggered modifications in UVA-mediated signaling paths. Asiatic acid can considerably inhibit the generation of oxygen cost-free radical items and lipid peroxidation caused by ultraviolet rays. Treatment with 5 micromolar asiatic acid can decrease the expression degree of MMP-2 caused by UVA, and lower the task of MMP-2 healthy protein. On top of that, UVA had the ability to increase p53 expression in HaCaT cells, which is characteristic of UVA-induced DNA damage and cell death. Asiatic acid pretreatment can likewise dramatically inhibit this process. For that reason, asiatic acid can successfully inhibit skin damage caused by UVA and also stop UVA-induced photoaging. By comparing the results of asiatic acid, asiaticoside, and also hydroxyasiatic acid on wound recovery in rats, it was discovered that asiatic acid is one of the most effective part for advertising injury healing.

Antibacterial impact
Research studies have located that asiatic acid has excellent repressive effects on Yeast albicans, Candida krusei, Cryptococcus neoformans, Escherichia coli, Sporothrix schenckii, Bacillus subtilis, Staphylococcus aureus, Shigella as well as various other microbes effect

Antidepressant impact
In order to improve the bioavailability of medicines, Li Tiejun et al. manufactured salt by-products such as salt asiatic acid and also ammonium, as well as found that asiatic acid, salt asiatic acid and also hydroxyl product Noticic acid at a dose of 30 mg/kg can significantly shorten the stability time of tail suspension and also forced swimming in mice. On top of that, in the experiment of annoying the ptosis of computer mouse eyelids caused by reserpine, they also located that asiatic acid sodium salt, asiatic acid and hydroxyasiatic acid had evident antagonism at a dose of 60 mg/kg, and the impact was substantially better than that of asiatic acid. Doxepin is provided as a tricyclic drug, so it can be judged that asiatic acid and also its derivatives have solid antidepressant task.

Hypoglycemic result
Asiatic acid can substantially boost the sugar excretion of alloxan-induced diabetic computer mice. The specific effect is not yet clear, and also it may achieve the impact of reducing blood sugar by hindering the task of glycogen phosphorylase. Asiatic acid can withstand streptozotocin-induced decline in myocardial mitochondrial membrane layer possibility, superoxide dismutase (TURF), ATPase, catalase (PET CAT) task, and also contribute in diabetic issues. to a particular degree of relief.

Anti-inflammatory effect.
It is reported that asiatic acid can significantly hinder the rise of interleukin-8 (IL-8) secretion triggered by lump death aspect (TNF-α), and has evident anti-inflammatory impact. Asiatic acid can dramatically prevent the inflammatory feedback of RAW264.7 cells induced by LPS, and its mechanism is to contribute by reducing the quantity of NO as well as the secretion of TNF-α. Due to its excellent anti-inflammatory impact, asiatic acid has been utilized scientifically in the treatment of medical illness and in the field of appeal treatment, such as skin injuries, chronic ulcers, delayed injury healing, surgical injuries and cellulitis, and shampooing, etc. Security against liver damage
Asiatic acid can hinder the activation and also transformation of rat hepatic stellate cells (HSC-T6), lower the expression of alpha actin (alpha-SMA), as well as consequently inhibit liver fibrosis. The hepatoprotective system of asiatic acid is to shield liver cell mitochondria and scavenge superoxide anion as well as hydroxyl cost-free radicals. Research studies have actually shown that asiatic acid can inhibit the activation and also transformation of rat hepatic stellate cells caused by TGF-β. Asiatic acid up-regulates the unfavorable comments signal of Smad7 mRNA, and avoids TGF-β-induced kind collagen synthesis in rat hepatic stellate cells with Smad7, thereby accomplishing the effect of preventing liver fibrosis. Asiatic acid is a medicine that can substantially resist liver fibrosis. Its analogs have a strong safety result on hepatotoxicity generated by galactosamine as well as carbon tetrachloride. Because the present wide study prospects of triterpenoids, and asiatic acid is stronger than oleanolic acid (OA) as well as ursolic acid (UA) in scavenging totally free radicals and also shielding mitochondria, Asiatic acid has the potential to be developed The possibility of ending up being a brand-new liver-protecting medication.

About Products:
If you need Asiatic Acid as a cosmetic raw material, please contact our service staff directly, and we will provide you with high-quality products at the best price.
As an experienced Asiatic Acid manufacturer and supplier, ZSpharmac will provide Asiatic Acid raw materials to customers all over the world for a long time.
Over the years, the company has been adhering to the spirit of “integrity management, strict quality control, customer first”, and has won unanimous praise from domestic and foreign customers.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

OUR MISSION
Help China Chemicals to benefit the happiness of human life
OUR VISSION
Become the most trusted chemical supplier in the world
OUR BUSINESS PHILOSOPHY
Striver – oriented, enrich employees, customer first, deep service, seek development
OUR VALUES
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Cosmetic raw materials
  • Products/Service:Cosmetic raw materials (flavors and fragrances,antioxidant products, moisturizing and hydrating, whitening agents, cosmetic additives)
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.

Service

Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.

 

After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.

FAQ

Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.

 

HOW TO CONFIRM THE PRODUCT QUALITY BEFORE PLACING ORDERS?

You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.

Shipping

1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

Get Asiatic Acid Quotation