Zhishang Chemical

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Zhishang Chemical

Asiatic Acid CAS 464-92-6

Molecular Formula: C30H48O5

Formula Weight: 488.7

ZSpharmac: Asiatic Acid Supplier

Product Name: Asiatic Acid
CAS No: 464-92-6
Purity: 99%

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Basic Info

Product Name:Asiatic Acid
Other Names:Madecassoside
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:White Powder
EINECS No.:482-720-9
Provide:Asiatic Acid MSDS;
Asiatic Acid COA

What is Asiatic Acid?

Asiatic Acid, also known as asiatic acid, is one of the main components of the triterpenoid extract of the natural plant Centella asiatica (L.) Urban, with a ursane-type skeleton structure.

Asiatic Acid Property

Melting point 325-330 °C(lit.)
Boiling point 609.4±55.0 °C(Predicted)
density 1.18±0.1 g/cm3(Predicted)
RTECS YU9580000
storage temp. 2-8°C
solubility methanol: soluble1mg/mL, clear, colorless
form powder
color white
Water Solubility Soluble in dimethyl sulfoxide, ethanol and dimethylformamide. Sparingly soluble in water


Asiatic Acid Uses

  1. Asiatic Acid has anti-depressant, anti-stomach ulcer, anti-tumor, and memory-enhancing effects.
  2. Asiatic Acid is used for content determination/identification/pharmacological experiments, etc. Pharmacological results: This product has the functions of enhancing clinical depression, anti-cancer, preventing and treating coronary infarction, analytical thrombosis, cerebral infarction, improving memory, and also skin whitening.
  3. Asiatic Acid has anti-irritant residential or commercial properties; skin repair work, inhibits collagen synthesis; boosts keratinization; promotes skin cells, and so on.

Efficacy and Function of Asiatic Acid

The Effect of Asiatic Acid on Myocardial Ischemia in Vitro and in Vivo

Myocardial ischemia-reperfusion injury (MIRI) is the main root cause of cardiac arrest in clients with coronary heart disease. Extreme buildup of responsive oxygen species (ROS) throughout MIRI results in overactivation of the autophagic reaction, thereby aggravating cardiomyocyte damages. Asiatic acid (AA) is a triterpenoid substance drawn out from Centella asiatica with different pharmacological effects such as liver protection, nerve protection, and anti-oxidation. However, the partnership of AA to autophagy in MIRI is not totally understood. In this research study, the favorable function of AA in MIRI injury was identified by establishing a MIRI computer mouse model. showed that pretreatment with AA boosted heart function as well as lowered cardiomyocyte autophagy in MIRI mice. To examine the safety effects of AA and the hidden systems in MIRI, a cardiomyocyte sugar deprivation/reperfusion (OGD) model was developed. Administration of AA decreased the degrees of ROS and also malondialdehyde, as well as increased the level of superoxide dismutase activity in OGD-treated cells. Making use of western blotting, it has been shown that therapy with AA reduces p38 phosphorylation and enhances Bcl-2 expression in OGD-treated cells. Furthermore, the expression of autophagy pens, consisting of beclin-1 and microtubule-associated healthy protein 1A/1B light chain 3B II/I proportion, was additionally lowered in AA-treated cells compared to OGD-treated cells. These results recommend that AA pretreatment protects cardiomyocytes from ROS-mediated autophagy via the p38 mitogen-activated protein kinase/Bcl -2/ beclin-1 signaling path in MIRI.

About Products:
If you need Asiatic Acid, a cosmetic raw material, please contact our service staff directly, we will provide you with high-quality products at the best price.
As an experienced Asiatic Acid manufacturer and supplier, our company ZSpharmac will provide Asiatic Acid raw materials to customers all over the world for a long time.
Over the years, the company has been adhering to the spirit of “integrity management, strict quality control, and customer first”, and has won unanimous praise from domestic and foreign customers.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

Help China Chemicals to benefit the happiness of human life
Become the most trusted chemical supplier in the world
Striver – oriented, enrich employees, customer first, deep service, seek development
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Cosmetic raw materials
  • Products/Service:Cosmetic raw materials (flavors and fragrances,antioxidant products, moisturizing and hydrating, whitening agents, cosmetic additives)
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.


After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.


Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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