Zhishang Chemical

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Zhishang Chemical

Argireline Cena CAS 616204-22-9

Molecular Formula: C34H60N14O12S

Formula Weight: 889

ZSpharmac: Argireline Cena Supplement

Product Name: Argireline Cena
CAS No: 616204-22-9
Purity: 99%

Basic Info

Product Name:Argireline Cena
Other Names:Argireline
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:White Lyophilized Solid
EINECS No.:1592732-453-0
Provide:Argireline Cena MSDS;
Argireline Cena COA

What is Argireline Cena?

Argireline Cena, likewise called botulinum toxin, is an oligopeptide that resembles the N-terminal 6 amino acids of SNAP-25 healthy protein. Aguirellin is one of the commonly utilized basic materials for premium cosmetics. Its major result is to reduce creases caused by the tightening of facial expression muscles, as well as it has a perfect impact on getting rid of creases around the temple or eyes. Plus, it enhances collagen manufacturing, which assists reconstruct skin tissue.

Argireline Cena is a much safer, more affordable, and milder option to botulinum contaminant. Argireline Cena takes part in the competitors for the site of SNAP-25 in the blend blister complex, consequently impacting the formation of the vesicle blend complex, causing the ineffective launch of neurotransmitters from vesicles, compromising muscle contraction, which subsequently can loosen up muscle mass and alleviate fine lines. It can make the skin show up clear as well as remarkable, as well as can additionally promote cell regeneration to recover gentleness as well as flexibility of the skin, so it is commonly used in the preparation of cosmetics and also health care products.

In recent years, with the enhancement of people’s awareness of health care, the market for cosmetics and health care products has become wider and wider, and the market demand for Argireline Cena is also increasing. At present, the preparation method of akirelin is mainly fragment synthesis. For example, two tripeptide fragments are first synthesized by different preparation methods: NH2-Gln(Trt)-Arg(pbf)-Arg(pdf)- NH-resin peptide resin, Fmoc-Glu(tbu)-Gln(tbu)-Met-COOH was prepared by liquid-phase synthesis, and then the two were coupled, deprotected, acylated, and cracked. The preparation method has cumbersome steps and low yield, and because of the short peptide chain of akirelin, the fragment synthesis method will inevitably lead to a large amount of waste of fragments, all of which lead to high cost of akirelin, which is not conducive to its popularization and application. use.

Argireline Cena Properties:

density 1.54
storage temp. -20°C
form lyophilized solid
color white


Argireline Cena Application

Argireline Cena can be widely used in cosmetics. Examples of its application are as follows;

1. Prepare a kind of anti-allergic traditional Chinese medicine type cream, including 10-40 parts of safflower comfrey, 32-68 parts of Antrodia camphorata extract, 25-43 parts of soybean lecithin, 10-40 parts of arbutin by mass parts, 21-50 parts of urea, 15-54 parts of Prunella, 15-50 parts of polyethanol-7-stearate, 50-90 parts of propylene glycol, 18-55 parts of triethanolamine, 30-63 parts of lactic acid, monostearic acid 22-46 parts of glycerides, 10-50 parts of Scutellaria baicalensis, 20-60 parts of Acrelin, 20-50 parts of liquid wax, and 80-160 parts of deionized water. The cream can reduce skin epidermal pigmentation and prevent skin allergies.

2. Prepare a whitening and anti-aging cream, including 10-40 parts of licorice glycyrrhizin, 12-58 parts of licorice, 15-43 parts of benzylmethylamine, 20-50 parts of arbutin, 15 parts of reed root in parts by mass -50 parts, 15-54 parts Prunella, 15-50 parts alum, 23-70 parts almonds, 28-55 parts triethanolamine, 20-63 parts lactic acid, 10-46 parts ephedra, 20 parts Houttuynia cordata 60 parts, 10-60 parts of Acrelin, 10-50 parts of liquid wax, 80-160 parts of deionized water. As a result, it can reduce the pigmentation of the skin epidermis, has a good removal effect on freckles, melasma and Reye’s melanosis, can effectively reduce the formation of melanin, and can dilute the pigmentation and other effects of the formed melanin.

3. Prepare a kind of whitening and acne-removing lotion, including 20-40 parts of ginseng, 12-68 parts of Angelica dahurica, 25-43 parts of light tempeh, 15-50 parts of Yu Liren, 11-50 parts of urea, 25-50 parts of urea by mass parts. 54 parts, 25-50 parts of dimethyl alum, 20-90 parts of propylene glycol, 18-55 parts of triethanolamine, 25-63 parts of hawthorn slices, 22-46 parts of glycerol monostearate, 15-50 parts of chrysanthemum, Kerelin 20-60 parts, liquid wax 10-50 parts, deionized water 80-160 parts. As a result, it can reduce the pigmentation of the skin epidermis, has a good removal effect on freckles, melasma and Reye’s melanosis, can effectively reduce the formation of melanin, and can dilute the pigmentation and other effects of the formed melanin.

4. Prepare a melanin removing cream, including 21-60 parts of Nepeta seven, 22-78 parts of honeysuckle, 15-63 parts of Schisandra chinensis, 10-60 parts of Scrophulariaceae, 11-50 parts of rush, and Prunella in parts by mass. 10-54 parts, Forsythia 25-50 parts, Propylene glycol 20-60 parts, Triethanolamine 10-65 parts, Lactic acid 30-63 parts, Glyceryl monostearate 22-46 parts, Decyl alcohol 10-50 parts, Kerelin 10-60 parts, Chuanxiong 20-50 parts, deionized water 150-260 parts. As a result, the formation of melanin can be effectively reduced, and the formed melanin can be used to lighten pigmentation and other effects.

Argireline Cena Preparation

A preparation method of Argireline Cena, comprising the following steps:

Step 1: take the resin, activate it, and get the amino resin;

Step 2: Take the amino resin obtained in Step 1, and step by step coupling guanidine-protected L-arginine, guanidine-protected L-arginine, and side-chain amino-protected L-glutamine to obtain tripeptide resin ;

Step 3: Take the tripeptide resin obtained in step 2, and then stepwise couple L-methionine, L-glutamic acid protected by the carboxyl group of the side chain, and N-acetyl-L-glutamic acid protected by the carboxyl group of the side chain to obtain Hexapeptide resin;

Step 4: crack the hexapeptide resin obtained in step 3 to obtain the first product;

Step 5: Take the first product obtained in step 4, purify, and get it.

Argireline Cena Efficacy And Role

It inhibits the release of the neurotransmitter acetylcholine, weakens muscle contractions, thereby reducing wrinkles, increases elastin activity, improves skin sagging, and makes skin smooth and firm.

In layman’s terms, the nerves say hi to the muscles! The skin has no choice but to follow the muscles, and the excessive contraction of the skin produces wrinkles. And acetyl hexapeptide-8 can block the nerves giving orders to the muscles, the muscles are stable, and the skin will not form wrinkles.

Difference Between Botox and Botox

Botulinum toxin is a biotoxin-like muscle relaxant that inhibits the release of acetylcholine (Ach) by destroying the neuromuscular junction (NMJ) body-associated protein (SNAP-25) in the skin, blocking neuromuscular conduction, resulting in muscle Relaxation paralysis, inhibits muscle contraction to achieve the effect of wrinkle reduction.

However, this botulinum toxin, which destroys the mechanism of the neuromuscular junction protein, is improperly controlled in the form of injection, which can cause excessive muscle paralysis, lead to poisoning infection, and may lead to facial paralysis in severe cases, which has certain safety risks.

Argireline Cena is a high-quality wrinkle-removing ingredient with anti-wrinkle and anti-aging effects comparable to botulinum toxin, while avoiding the disadvantages of botulinum toxin injection, high price and a series of side effects. “Botox-like” reputation.

Clinically proven: wrinkle reduction around the eyes is up to 17% after 15 days of use and 27% after 30 days of use, demonstrating its amazing effect in anti-wrinkle activity. And because it has no other side effects, it is safer than botulinum toxin and more suitable for long-term use, so it has become the core ingredient used in top cosmetics on the market.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

Help China Chemicals to benefit the happiness of human life
Become the most trusted chemical supplier in the world
Striver – oriented, enrich employees, customer first, deep service, seek development
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Additive , Chemical Auxiliary & Catalyst , Organic Chemicals
  • Products/Service: Organic Intermediate,Inorganic Chemistry, APIs, Dyestuffs And Pigments, Fragrance And Spices, Food Additives
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.


After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.


Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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