Arctium Lappa Root Extract

Burdock root bark ethanol extract, water extract and burdock root meat ethanol extract, water extract have antibacterial effects on Escherichia coli, Staphylococcus aureus, Bacillus subtilis, Aspergillus niger and yeast; 80% of burdock root Ethanol extract has a good inhibitory effect on Vibrio parahaemolyticus. The burdock inulin extracted from burdock root can inhibit Escherichia coli and promote the growth of lactic acid bacteria; the polyphenols chlorogenic acid can inhibit Escherichia coli, Shigella, Staphylococcus aureus, Bacillus subtilis, Garcinia cambogia For the growth of cocci and Legionella, the minimum inhibitory concentration (MIC) is 20-80 μg/ml; chlorogenic acid can increase the permeability of bacterial cell membranes, resulting in the disappearance of barrier function, and even a slight overflow of nucleotides, depleting cells Internal potential, the release of macromolecules in the cytoplasm, leading to apoptosis, thus playing an antibacterial effect. In terms of antiviral activity, arctigenin can directly inhibit or inactivate influenza virus, and has a strong anti-type 1 influenza virus effect in vitro. In vitro, chlorogenic acid can significantly inhibit the activity of adenovirus types 7 and 11, coxsackie B group type 3, and syncytial virus, but its antiviral mechanism is still unclear.

The ethanol extract and water extract of burdock root bark and the ethanol extract and water extract of burdock root meat all have certain antioxidant activities. Among them, Arctium Lappa Root Extract can significantly inhibit the auto-oxidative inhibition rate of pyrogallol and protect the aging of human erythrocyte membrane. The water extract of burdock root has strong scavenging ability to O2-, HO· and ROO·, the order is: ROO·＞HO·＞O2-, and the ability of the water extract of burdock root to remove O2- and HO· increases with the It is enhanced with the increase of mass concentration; Arctium Lappa Root Extract is stronger than Arctium Lappa Root Extract in scavenging free radicals. Water-soluble dietary fiber, chlorogenic acid and lignin in burdock root also have strong antioxidant activity. In terms of anti-aging effect, the results of a Drosophila survival experiment on burdock root extract using Drosophila as an animal model showed that burdock root has the effect of delaying aging, the most obvious with a mass fraction of 1%. Burdock root extract can significantly increase the reserve of hepatic glycogen in mice, prolong the time of mice swimming under load, and improve the blood lactate clearance ability. Burdock oligofructose can significantly improve exercise endurance and hypoxia tolerance time in mice, reduce the content of blood lactic acid (LAC) and blood urea nitrogen (BUN) after exercise, increase the content of muscle and liver glycogen, and has a good anti-fatigue effect . Arctium aglycone enhances mitochondrial regeneration and fatty acid oxidation, thereby enhancing endurance in mice.

Studies have shown that Arctium Lappa Root Extract can protect carbon tetrachloride or acetaminophen-induced liver damage in mice and liver damage caused by alcoholism, and reduce alanine aminotransferase (ALT) in liver tissue in a dose-dependent manner The level of aspartate aminotransferase (AST) and aspartate aminotransferase (AST) can also be seen pathologically to reduce the degree of liver damage. The chloroform extract of burdock root can protect animals from gastric mucosal damage by reducing gastric acid secretion, and the active ingredient chlorogenic acid (50mg/kg) can protect mice from lipopolysaccharide (LPS)-induced acute lung injury (ALI).

Arctium Lappa Root Extract can significantly reduce serum total cholesterol (CHOL), TG and low-density lipoprotein (LDL) levels in hyperlipidemia rats, increase high-density lipoprotein (HDL) levels, alleviate liver fat lesions, and reduce mice The body mass and the fat mass around the genitals have good hypolipidemic and weight loss effects.

Subcutaneous injection of crude burdock root extract can significantly reduce carrageenan-induced airway edema in rats, and can also significantly inhibit carrageenan-induced foot swelling.

The extracts of various parts of burdock root (petroleum ether, chloroform) have different degrees of cytotoxicity on mouse hepatoma cells (HepA) and mouse sarcoma cell line (S180), and there is a certain dose-effect relationship. Its n-butanol extract and water extract can reduce the mutagenesis effect of doxorubicin on TA98 strain and protect the injury of mouse bone marrow cells caused by doxorubicin. In vitro experiments showed that the inhibitory rates of Arctium Lappa Root Extract on Chinese hamster ovary (CHO) tumor cells were (21.29±1.25)% and (38.68±1.83)% at the mass concentration of 5 and 10 mg/ml, respectively, and the mass concentration was 20 mg. The inhibition rate was up to (70.11±2.41)% at /ml. Burdock oligosaccharide can promote the activity of macrophage acid phosphatase, enhance the macrophage phagocytosis function and the ability to produce nitric oxide (NO) in tumor-bearing mice.

Arctium Lappa Root Extract aspartic acid and arginine have the effect of invigorating the brain; burdock inulin has the effect of treating coronary heart disease and diabetes; chlorogenic acid can also resist HIV and allergies.