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Apigenin CAS 520-36-5

Molecular Formula: C15H10O5

Formula Weight: 270.24

ZSpharmac: Apigenin Cosmetic Raw Material Supplier

Product Name: Apigenin
CAS No: 520-36-5
Purity: 99%

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Basic Info

Product Name:Apigenin
Other Names:Apigenin Supplement
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:Yellow Powder
EINECS No.:208-292-3
Provide:Apigenin MSDS;
Apigenin COA

What is Apigenin?

Apigenin is a naturally occurring flavonoid compound that exists in a selection of plants in the form of plant yellow pigments. It is primarily derived from the Umbelliferae plant Apigenin, and various other plants such as chamomile, lemon balm, perilla, and horsewhip. It is also located in yards and yarrow.
Chamomile is native to Britain and grown in Germany, France and Morocco. Roman chamomile and German chamomile have numerous features alike: regarding 30 cm tall, yellow center, white flowers, and a little unshaven fallen leaves. Chamomile has the impact helpful rest, relieving clients’ inflammation and discomfort signs, and eliminating sleeping disorders brought on by aberrant skin irritation. It is also cultivated in large amounts in China for usage as medicine and tea. Apigenin is consisted of in the components of natural teas offered daily, generally from the dried out blossoms of Matricaria chamomile.

Apigenin Property

Melting point >300 °C (lit.)
Boiling point 333.35°C (rough estimate)
density 1.2319 (rough estimate)
refractive index 1.6000 (estimate)
storage temp. 2-8°C
solubility DMSO: 27 mg/mL
form powder
color yellow


Apigenin Efficacy and Role

Apigenin is also an extremely powerful anti-cancer material. It is very careful for cancer cells and can induce cancer cells cell apoptosis with high selectivity without damaging regular cells. It similarly has a really high security and safety and security limit, and active (anti-cancer) dosages can be gotten by eating a diet plan abundant in vegetables and fruits. Apigenin beneficially affects most sort of cancer.

Apigenin puts in neuroprotective results versus excitotoxicity and prevents calcium build-up in neural mitochondria. Apigenin and the two glucopyranosides of apigenin can put in antidiabetic impacts in the body. Apigenin exerts its anti-inflammatory effect with the impact of lipopolysaccharide by avoiding NO synthase and COX2 enzyme in macrophages.

Apigenin in addition protects against the production of interleukin-4. Apigenin similarly inhibits TNFα altitude by impeding NF-kb transcription and potentially TNFα-induced upregulation of add-on particle 1. Apigenin is among the widely known bioflavonoid compounds that has high selectivity in causing careful apoptosis of cancer cells in vivo.

Like other bioflavonoids, apigenin can minimize oxidative tension, cause cell cycle inhibition, rise liver detoxing enzymes, and act as an anti-inflammatory somewhat.

Experimental animal investigates have actually revealed that apigenin is antimutagenic against exogenous toxic substances and microbial responses, and plays a straight duty in steel chelation, free extreme scavenging, and induction of phase II cleansing enzymes such as glutathione, It is likewise an avoidance of ornithine decarboxylase and may advertise the development of particular lumps. The presence of apigenin in the body in addition appears to have an extreme safety impact against cancer cells triggering disrespects.

Apigenin Application

Apigenin is commonly used in cosmetics: Apigenin’s absorption of ultraviolet rays is focused in the B area (wavelength in between 280 ~ 320nm), which is a solid absorption and can be taken advantage of in sunscreen cosmetics;

In location A (wavelength in between 320 and 400nm), the absorption is smaller sized, so low-concentration apigenin can be made use of as a skin dimming agent and included in tanning oil;

It can be utilized as a pigment stabilizer in cosmetics, with a suggested dose of 1%; apigenin can be utilized in creams;
It can be aggravated with vitamin B1, vitamin B6, vitamin B12, vitamin C, and so on; it can furthermore be compounded with plant important oils such as chamomile oil, calendula oil, almond oil, and more;.

High focus of apigenin can prevent the job of melanocytes and can be contributed to cosmetics such as sun block, face lotion, relevance, lotion, and face mask; it can be taken advantage of in shampoo and conditioner.

Apigenin Preparation

1. Extraction approach
The treatments involved in the existing apigenin prep work techniques are reasonably complex, and the purity of the apigenin gotten is low, leading to excessive intake and waste of resources. On top of that, in the application process of existing apigenin, as a result of the low pureness of existing apigenin, the treatment and healthcare effects of the pills or other healthcare items generated are not excellent. CN200810127091 offers a preparation approach of apigenin with higher pureness, and an apigenin soft capsule with the functions of managing blood pressure, regulating blood lipids, anti-oxidation, enhancing resistance and postponing aging. In order to achieve the above things, today creation offers a prep work approach of apigenin, which includes the complying with steps:

a. After evaluating and pulverizing the celery seeds, put them in a container with 70% alcohol material, stir and let stand;

b. After the powdered celery seeds are combined with alcohol, they transform from powder to granular;

c. Remove the granular mix in the container three times, with the moment period of each removal being two hours;

d. The drawn out particulate matter is filtered through the service, and subjected to decompression and focus to generate powdered refined apigenin.

The creation has the complying with benefits: the invention provides a technique for preparing apigenin. After evaluating and squashing celery seeds, they are positioned in an alcohol container with a web content of 70%, mixed, and delegated stand; powdered celery seeds and After the alcohol is integrated, it transforms from powder to granular; essence the granular blend in the container three times, with a period of 2 hours in between each removal; the extracted granules are infiltrated the option, and based on decompression and concentration., thereby producing powdered polished apigenin, the purity of which after extraction is 98%. The application of this approach is to prepare powdered apigenin and oily deep-sea fish oil, and put them into pills. The weight of each pill after the proportion of basic materials is 500mg, apigenin is 150-200mg, and deep-sea fish oil is 300-350mg. The present creation has the functions of managing blood pressure, managing blood lipids, resisting oxidation, improving resistance, delaying aging, and so on, and long-term usage is beneficial to health and wellness; in addition, celery seeds are utilized as the primary raw material, and given that the raw products are very easy to get and economical, it additionally boosts the pureness of the item. At the same time, it also avoids the waste of raw materials and lowers processing expenses.

2. Semi-synthetic approach
The semi-synthetic technique of apigenin is defined by utilizing naringenin as raw material in an alkaline environment, responding with iodine at a temperature of 50 to 130 ° C in the solvent 1,4-dioxane, and performing oxidative dehydrogenation. An unrefined apigenin is generated. Liquify the crude product with an alkali solution, include alcohol, readjust the pH worth to 4 to 7, precipitate crystals, filter with suction, and rehydrate with dimethyl sulfoxide/water system or dimethylformamide/water system or alcohol/water system. Crystallize, let stand, and filter to get polished apigenin; or detoxify by refluxing with acetone to obtain refined apigenin.

This approach makes use of biologically energetic all-natural removes as beginning materials to respond to get apigenin. Compared to the plant removal technique and the reaction utilizing pyridine as a solvent to get apigenin, this approach has affordable, moderate reaction conditions, and is eco-friendly. The product purity and yield are both high; the solvent system utilized in the acid hydrolysis process and the raw materials are easy to use. It is readily available and economical, the response conditions are very easy to control, secure, pollution-free and has high yield. From the perspective of the entire synthesis procedure, a lot of solvents can be recovered and reused, greatly minimizing the synthesis price; the whole synthesis procedure has inexpensive and easy-to-obtain resources, easy operation, stable response problems, very easy control, and simple splitting up and filtration of the product. The pureness of apigenin produced can get to more than 97%.

About Products:
If you need the cosmetic raw material Apigenin, please contact our service staff directly, we will provide you with high-quality products at the best price.
Our company, as an experienced Apigenin manufacturer and supplier, ZSpharmac will provide Apigenin raw materials to customers around the world for a long time.
Over the years, the company has adhered to the spirit of “integrity management, strict quality control, and customer first” and has won unanimous praise from customers at home and abroad.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

Help China Chemicals to benefit the happiness of human life
Become the most trusted chemical supplier in the world
Striver – oriented, enrich employees, customer first, deep service, seek development
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Cosmetic raw materials
  • Products/Service:Cosmetic raw materials (flavors and fragrances,antioxidant products, moisturizing and hydrating, whitening agents, cosmetic additives)
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.


After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.


Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

Get Apigenin Quotation