1. Extraction approach
The treatments involved in the existing apigenin prep work techniques are reasonably complex, and the purity of the apigenin gotten is low, leading to excessive intake and waste of resources. On top of that, in the application process of existing apigenin, as a result of the low pureness of existing apigenin, the treatment and healthcare effects of the pills or other healthcare items generated are not excellent. CN200810127091 offers a preparation approach of apigenin with higher pureness, and an apigenin soft capsule with the functions of managing blood pressure, regulating blood lipids, anti-oxidation, enhancing resistance and postponing aging. In order to achieve the above things, today creation offers a prep work approach of apigenin, which includes the complying with steps:
a. After evaluating and pulverizing the celery seeds, put them in a container with 70% alcohol material, stir and let stand;
b. After the powdered celery seeds are combined with alcohol, they transform from powder to granular;
c. Remove the granular mix in the container three times, with the moment period of each removal being two hours;
d. The drawn out particulate matter is filtered through the service, and subjected to decompression and focus to generate powdered refined apigenin.
The creation has the complying with benefits: the invention provides a technique for preparing apigenin. After evaluating and squashing celery seeds, they are positioned in an alcohol container with a web content of 70%, mixed, and delegated stand; powdered celery seeds and After the alcohol is integrated, it transforms from powder to granular; essence the granular blend in the container three times, with a period of 2 hours in between each removal; the extracted granules are infiltrated the option, and based on decompression and concentration., thereby producing powdered polished apigenin, the purity of which after extraction is 98%. The application of this approach is to prepare powdered apigenin and oily deep-sea fish oil, and put them into pills. The weight of each pill after the proportion of basic materials is 500mg, apigenin is 150-200mg, and deep-sea fish oil is 300-350mg. The present creation has the functions of managing blood pressure, managing blood lipids, resisting oxidation, improving resistance, delaying aging, and so on, and long-term usage is beneficial to health and wellness; in addition, celery seeds are utilized as the primary raw material, and given that the raw products are very easy to get and economical, it additionally boosts the pureness of the item. At the same time, it also avoids the waste of raw materials and lowers processing expenses.
2. Semi-synthetic approach
The semi-synthetic technique of apigenin is defined by utilizing naringenin as raw material in an alkaline environment, responding with iodine at a temperature of 50 to 130 ° C in the solvent 1,4-dioxane, and performing oxidative dehydrogenation. An unrefined apigenin is generated. Liquify the crude product with an alkali solution, include alcohol, readjust the pH worth to 4 to 7, precipitate crystals, filter with suction, and rehydrate with dimethyl sulfoxide/water system or dimethylformamide/water system or alcohol/water system. Crystallize, let stand, and filter to get polished apigenin; or detoxify by refluxing with acetone to obtain refined apigenin.
This approach makes use of biologically energetic all-natural removes as beginning materials to respond to get apigenin. Compared to the plant removal technique and the reaction utilizing pyridine as a solvent to get apigenin, this approach has affordable, moderate reaction conditions, and is eco-friendly. The product purity and yield are both high; the solvent system utilized in the acid hydrolysis process and the raw materials are easy to use. It is readily available and economical, the response conditions are very easy to control, secure, pollution-free and has high yield. From the perspective of the entire synthesis procedure, a lot of solvents can be recovered and reused, greatly minimizing the synthesis price; the whole synthesis procedure has inexpensive and easy-to-obtain resources, easy operation, stable response problems, very easy control, and simple splitting up and filtration of the product. The pureness of apigenin produced can get to more than 97%.
