Zhishang Chemical

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Zhishang Chemical

Apa Itu Methylparaben CAS 99-76-3

Molecular Formula: C8H8O3

Formula Weight: 152.15

ZSpharmac: Apa Itu Methylparaben Supplement

Product Name: Apa Itu Methylparaben
CAS No: 99-76-3
Purity: 99%

Basic Info

Product Name:Apa Itu Methylparaben
Other Names:Methylparaben
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:White to Almost White Crystalline Powder
EINECS No.:202-785-7
Storage:Room Temp
Provide:Apa Itu Methylparaben MSDS;
Apa Itu Methylparaben COA

What is Apa Itu Methylparaben?

Apa Itu Methylparaben, additionally referred to as parahydroxybenzoin ester, paraben (NipaEster.Paraben).Apa Itu Methylparaben, ethyl, propyl, isopropyl, butyl, isobutyl, etc are made use of as fungicides and chemicals. Representative is Apa Itu Methylparaben (paraben A. Nipagin A. Ethylparaben. Ethylparasept). This product is anemic penalty crystal or white crystalline powder, with unique fragrance, somewhat bitter preference, shedding numb. Melting point: 116 ~ 118 ℃, Boiling point: 297 ~ 298 ℃ (decay).LD505g/kg (mice, oral), no uncommon blood photo and pathological adjustments of interior organs were found in the subacute poisoning examination. Concentration below 5% is not annoying to human skin. ADI is 0 to 10 mg/kg. Among the Apa Itu Methylparaben, butyl ester has the most affordable poisoning and also the greatest disinfectant and antiseptic result, but has bad water solubility as well as is typically utilized in mix with various other esters.

Apa Itu Methylparaben Properties:

Melting point 125-128 °C (lit.)
Boiling point 298.6 °C
density 1,46g/cm
vapor pressure 0.000005 hPa (20 °C)
refractive index 1.4447 (estimate)
Fp 280°C
storage temp. room temp
solubility ethanol: soluble0.1M, clear, colorless
pkapKa 8.15(H2O,t =20.0) (Uncertain)
form Crystalline Powder
color White to almost white
PH5.8 (H2O, 20°C) (saturated solution)
Water Solubility Slightly soluble in water.


Apa Itu Methylparaben Uses

  1. Apa Itu Methylparaben is mainly utilized as an antiseptic chemical in organic synthesis, food, cosmetics, medicine, as well as additionally as a feed preservative.
  2. Apa Itu Methylparaben is used as a preservative and additionally in medication as well as natural synthesis.
  3. Apa Itu Methylparaben is utilized as antifungal representative in food, cosmetics and medication.
  4. Apa Itu Methylparaben is made use of in the pharmaceutical sector as a preservative and also bactericide for pharmaceuticals, and also is additionally made use of in natural synthesis and also as a preservative additive for food, spices, films, and so on. Similar products, ethyl parahydroxybenzoate (B paraben) and also propyl parahydroxybenzoate (C paraben) generated by comparable manufacturing approaches, are likewise anti-bacterials and bactericides. This product is annoying to the skin.
  5. Apa Itu Methylparaben is used in antiseptic fungicides. Insect cell society qualities are used to examine the biosynthesis of steroid hormonal agents such as testerone.

Safety of Apa Itu Methylparaben

Many countries and regions in the world allow sodium parabens to be used in food, and consider them generally safe, and their maximum addition amount converted into Apa Itu Methylparaben(the same below) can reach 0.1%, when When several esters and sodium are used in combination, the total amount should not exceed 0.1%. Heptyl p-hydroxybenzoate is generally selectively used in some foods. In beer, the maximum dosage is 12mg/kg, and in some carbon dioxide-free soft drinks and fruit alcoholic beverages, the maximum dosage can reach 20mg /kg. Developed countries such as the United States, the United Kingdom, and Japan allow sodium parabens to be used in food and are considered safe.
Toxicity comparison of Apa Itu Methylparaben (sodium), benzoic acid (sodium) and sorbic acid (potassium), it can be seen that these three preservatives have the highest apparent safety of potassium sorbate, potassium sorbate 3 p-hydroxy Sodium Benzoate 3 Sodium Benzoate. However, in actual use, the amount of sodium Apa Itu Methylparaben
added is much less than that of sodium benzoate and potassium sorbate. Eating the same and the same amount of food, the amount of sodium paraben ingested in the human body is also Much lower than sodium benzoate and potassium sorbate. Therefore, the actual use of safety sodium paraben is the best, sodium paraben 3 potassium sorbate 3 sodium benzoate. In fact, sodium benzoate is restricted as a food additive in many countries, and my country also stipulates that sodium benzoate is not allowed in grade A green food. Due to the small amount of sodium paraben added, the use cost of sodium paraben is much lower than that of potassium sorbate, and it is close to sodium benzoate. Therefore, sodium Apa Itu Methylparaben is a kind of low-toxicity, high-efficiency, broad-spectrum food preservative worthy of development, and it is the best product to gradually replace sodium benzoate in line with international standards.

Antibacterial activity of Apa Itu Methylparaben

Apa Itu Methylparaben have been used as food and pharmaceutical preservatives since the 1930s. Due to poor water solubility, the application of Apa Itu Methylparaben in the food industry is limited. Utilizing the acidity of the para-phenolic group of Apa Itu Methylparaben, the produced sodium parabens is easily soluble in water, which is convenient for popularization and application in the food industry. It is worth pointing out that it has the same effect as sodium benzoate and potassium sorbate. , The production of sodium paraben is to improve the water solubility, and the antibacterial effect is still molecular paraben. On a dry basis, 1g sodium Apa Itu Methylparaben, sodium ethylparaben, sodium propylparaben and sodium butylparaben are equivalent to 0.873g methylparaben, 0.883 g ethyl paraben, 0.891 g propyl paraben, and 0.898 g butyl paraben.

The mechanism of action of sodium paraben is to destroy the cell membrane of microorganisms, denature the proteins in the cells, and inhibit the activity of the respiratory enzymes and electron transfer enzymes of the cells. The antibacterial activity of sodium paraben mainly works in the molecular state. Because the carboxyl group in the molecule has been esterified and is no longer ionized, the ionization constant of the para-phenol group is very small. The bacteriostatic effect has good effect in a wide pH range. The antibacterial mechanism of sodium benzoate and potassium sorbate lies in the inhibition of various enzymes in microbial cells. Only molecular benzoic acid and sorbic acid can penetrate the cell wall and enter the cells of microorganisms to exert antibacterial activity. Strictly speaking, these three types of preservatives are organic weak acids, which can be ionized in aqueous solution, and exist in molecular state and ionic state in solution.

Apa Itu Methylparaben Use Limit

FAO/WHO (1984 ); jam, jelly, 1000mg/kg (solitary or integrated with benzoates, sorbic acid as well as potassium sorbate). EEC (1990, mg/kg): Approved for pigment solutions, flavorful syrups, coffee essences, icy beverages, fruit juices, dextrose and also soft drinks, pickled fish, salads, sauces, snack foods, focused soups, and so on. GMP is limited; Beer 70; Snack Grain and also Soup Concentrate 175, the rest is the same as “07018 Propylparaben“. HACSG is detailed on the restricted checklist. FDA, § 184.1490 (2000 ): 0.1%.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

Help China Chemicals to benefit the happiness of human life
Become the most trusted chemical supplier in the world
Striver – oriented, enrich employees, customer first, deep service, seek development
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Additive , Chemical Auxiliary & Catalyst , Organic Chemicals
  • Products/Service: Organic Intermediate,Inorganic Chemistry, APIs, Dyestuffs And Pigments, Fragrance And Spices, Food Additives
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.


After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.


Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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