(1) Human respiratory organs will immediately produce allergic reactions to inhalation of low molecular weight industrial intermediates (such as ethylenediamine, chloramine, hexamethylenetetramine, monovinylamine, ammonium thioglycolate, penicillin and sulfonamides), Causes breathing difficulties and asthma.
(2) Occupational allergic contact dermatitis was investigated by patch testing of 13 young female beauticians, all of whom suffered from allergic contact dermatitis of the hands, onset within 1 month to 1 year after starting work . …products and allergens with a clear positive reaction included 6 of 12 subjects with hair dye stock solution, 7 of 13 with cold perm stock, 1 of 13 with shampoo, 1 of 13 with shampoo, Twelve people used p-phenylenediamine, p-toluenediamine p-7/9, ammonium thioglycolate three-seventh, p-aminophenol and o-aminophenol one-quarter, quinoline-SS accounted for seven nickel sulfate, cobalt sulfate, thimerosal and procaine hydrochloride each account for one-twelfth. Of the 5 patients who continued their career as a beautician, 1 remained free of hand dermatitis while wearing gloves, and dyed or shampooed their hair, although the other four found that wearing gloves did not improve their Hand dermatitis. 62% of beauticians had a personal history of allergies and 56% had a family history of allergies. The authors recommend that people with a personal or family history of atopic disease, especially atopic dermatitis, should be counseled against becoming a cosmetologist.
(3) 14 asthma patients (13-60 years old) inhaled mist of the following dilutions of ammonium thioglycolate: 1:10, 1:100, 1:10,000 and 1:100,000. Following exposure, 13 patients developed the following signs and symptoms: wheezing, uncontrollable paroxysmal cough, throat irritation, nasal passage obstruction, or nasal drip. Pharyngeal irritation lasts 0.5-2 hours, depending on the patient’s sensitivity. Eight control patients (non-asthmatic and non-atopic) had no positive response to the test substance.
(4) Ammonium thioglycolate (6.0%) was classified as a skin irritant and sensitizer after a single application (via an elastic patch) to patients during induction and challenge. Mild to moderate skin irritation was observed when 18.0% ammonium thioglycolate was repeatedly applied to two groups of normal subjects (different experimental procedures). Allergic contact dermatitis may be observed in 1 subject in one of the two groups. Repeated application of 14.4% ammonium thioglycolate did not cause clinically meaningful irritation or induce any evidence of allergic contact dermatitis in normal human subjects. In other repetitive damage patch tests, a cold wave product containing 9.0% ammonium thioglycolate and a perm solution containing 12.0% ammonium thioglycolate (diluted to 0.12% ammonium thioglycolate) did not cause skin irritation in normal subjects irritation or allergy. However, in a similar test, mild to intense erythema (induction and irritation) was observed in normal subject patches tested with a perm solution containing 7.1% ammonium thioglycollate. Cold wave products containing 17.5% ammonium thioglycolate (diluted to 4.4% ammonium thioglycolate) were classified as either cumulative irritants or low-grade sensitizers in repetitive lesion patch testing involving normal subjects.