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Ammonium Glycyrrhizinate CAS 53956-04-0

Molecular Formula: C42H65NO16

Formula Weight: 839.97

ZSpharmac: Ammonium Glycyrrhizinate Supplier

Product Name: Ammonium Glycyrrhizinate
CAS No: 53956-04-0
Purity: 99%

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Basic Info

Product Name:Ammonium Glycyrrhizinate
Other Names:Glycyrrhizic Acid Ammonium Salt
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:Yellow to Yellow-Green Powder or Crystals
EINECS No.:258-887-7
Provide:Ammonium Glycyrrhizinate MSDS;
Ammonium Glycyrrhizinate COA

What is Ammonium Glycyrrhizinate?

Ammonium glycyrrhizinate has a strong wonderful preference as well as additionally the pleasant taste has to do with 200 times that of sucrose. It can normally be utilized as a sweetener in artificial additive for tinned meat, flavorings, sweets, biscuits, managed fruits along with drinks. Monoammonium glycyrrhizinate has a strong fondness for liver sterol metabolizing enzymes, as a result restraining the inactivation of cortisol as well as aldosterone. After usage, it reveals apparent corticosteroid-like results, such as anti-inflammatory effect, anti-allergy in addition to security film structure.; No obvious corticosteroid-like unfavorable impacts.

Ammonium Glycyrrhizinate Property

Melting point 

>200°C (dec.)

Boiling point 

768.56°C (rough estimate)


1.1846 (rough estimate)

refractive index 

49 ° (C=1.5, EtOH)

storage temp. 



Slightly soluble in water, very slightly soluble in anhydrous ethanol, practically insoluble in acetone. It dissolves in dilute solutions of acids and of alkali hydroxides.


Powder or Crystals


Yellow to yellow-green



The Role and Efficacy of Ammonium Glycyrrhizinate

Aesthetic Application
The main features of ammonium glycyrrhizinate in cosmetics as well as skin treatment items are antioxidants, anti-inflammatory agents, bleaching as well as freckle removal, with a risk factor of 1, which is fairly safe as well as can be made use of with confidence. Normally, it has no impact on expecting women. Ammonium glycyrrhizinate has no acne-causing properties.

Drawn out from licorice, it has high sweet taste, foaming, safe and also safe. It has anti-inflammatory, anti-oxidant, antibacterial, efficient scavenging of superoxide ions as well as hydroxyl radicals, as well as significantly hinders liposome peroxides. At the same time, it can inhibit the task of melanin, and has the impact of bleaching and also eliminating places. It has a variety of compatibility in cosmetics, as well as is often shared with other energetic representatives, which can accelerate the skin’s absorption of them and raise their effectiveness. It can be utilized for sun security, lightening, conditioning, antipruritic and also hair development treatment. Key application: in the cosmetics industry, it can be formulated into skin lotion, blemish lotion, top-quality pearl cream, etc, which not just has the features of charm and also skin care, but also anti-inflammatory, anti-allergic, as well as therapy of skin diseases; in the pharmaceutical market, it can be used for eye declines as well as stomatitis lotion; in the day-to-day chemical market, it can be made use of in tooth paste.

Medicinal efficiency
Ammonium glycyrrhizinate is a chemical compound, as well as this item is mainly made use of for the treatment of persistent changing hepatitis, chronic active liver disease, liver poisoning, as well as very early liver cirrhosis. Additionally known as monoammonium glycyrrhizinate hydrate; monoammonium glycyrrhizinate hydrate; monoammonium glycyrrhizinate; monoammonium oxalate;

Acanthopanax ammonium glycyrrhizinate shot is generally made use of to treat sensitive illness. It can be utilized to deal with eczema, urticaria, as well as sensitive asthma. If the erythema on the body is triggered by this reason Yes, it can also be treated with Acanthopanax Ammonium Glycyrrhizinate Shot, yet this type of medicine needs to be treated in a trusted healthcare facility, and also can not be utilized on its own.

Acanthopanax ammonium glycyrrhizinate shot has adrenal hormone-like impacts, can be anti-infective, anti-allergic, and can additionally be utilized for cleansing, adjuvant therapy of viral infectious liver disease and tumor radiotherapy and also radiation treatment, as well as is presently made use of in the treatment of allergic reactions conditions, such as dermatitis, urticaria or allergic asthma, etc, additionally, it can also be made use of to treat hazardous liver disease as well as viral hepatitis, and can additionally prevent hematopoietic disorder or headache, queasiness and vomiting brought on by radiotherapy as well as chemotherapy, Vomiting and opposite side effects.

The method of application can be subcutaneous cells injection or intramuscular shot, 1 to 2 tubes each time, 1 to 2 times a day, furthermore, it can also be infused intravenously. Typically, intravenous mixture prevails in seriously ill people. Some clients may experience edema, hypokalemia or enhanced high blood pressure when the dosage is made use of.

Additionally, throughout the training course of taking the medication, some sensitive people may go into shock, so when using it, it needs to be utilized under the advice of a physician. Additionally, if the medication is utilized in huge amounts for a very long time, routine blood examinations must be done. Potassium as well as its modifications in blood pressure.

Extent of manufacturing of injections 1. Sensitive conditions: eczema, urticaria, rheumatism, allergic asthma as well as allergic reactions triggered by sulfonamides, anesthetics and also other medicines. 2. Poisoning of drugs and compounds: It has detoxing impact on poisoning symptoms of medications or compounds such as nitro compounds of benzene, hydroxyl substances of benzene, formic acid, aromatic acids, as well as heavy metals exceeding the standard. 3. Prior to intravenous shot or in addition to intravenous shot, intramuscular injection of this item can prevent adverse effects such as fever, nausea as well as vomiting. 4. This item can treat toxic hepatitis, stressful liver disease, viral liver disease and stop liver death. 5. This item can prevent hematopoietic dysfunction, leukopenia, bad hunger, exhaustion, frustration, nausea, vomiting, liver ascites, loss of hair and opposite impacts brought on by radiotherapy and radiation treatment, and also can boost its efficiency.

Use of Ammonium Glycyrrhizinate

Ammonium glycyrrhizinate can be used as a sweetener. Application scope and usage amount:

(1) my country’s “Hygienic Standards for the Use of Food Additives” (GB2760-1996) stipulates that it can be used in an appropriate amount for canned meat, seasonings, candies, biscuits, preserved fruits and beverages according to production needs.

(2) FEMA. Regulations: the maximum dosage is soft drinks, 51mg/kg; candies, 5.0~6.2mg/kg; baked goods, 5.0mg/kg.

(3) Reference for actual use: for specific use, the usage amount is chocolate, 0.4~0.98g/kg; biscuit, 0.25~0.6g/kg; orange juice, tomato juice, beverage, 0.4~0.7g/L, when making ingredients join in. Wine, 0.3~0.5g/L, added after fermentation.

In addition, ammonium glycyrrhizinate can also form a compound preparation. The combined compound preparation of ammonium glycyrrhizinate, glycine, and L-cysteine hydrochloride has adrenocortical hormone-like effects, but has no hormone-like side effects; and stabilizes the cell membrane to antagonize allergies media and other ways to exert its anti-inflammatory and anti-allergic effect; it can also be used for adjuvant treatment of detoxification, viral hepatitis, and tumor radiotherapy and chemotherapy. It can be used for allergic diseases: eczema, urticaria, rheumatism, allergic asthma, and allergies caused by drugs such as sulfonamides and anesthetics.

Drug and chemical substance poisoning: It has detoxification effect on the poisoning of drugs or chemical substances such as nitro compounds of benzene, amino compounds of benzene, phenol, aromatic acids, and heavy metals. Before or at the same time of blood transfusion, intramuscular injection of this product can prevent side effects such as fever, nausea, and vomiting. This product can treat toxic hepatitis, traumatic hepatitis, viral hepatitis and prevent liver necrosis. This product can prevent hematopoietic dysfunction, leukopenia, loss of appetite, fatigue, headache, nausea, vomiting, ascites, hair loss and other side effects caused by radiotherapy and chemotherapy, and can strengthen its curative effect. Subcutaneous or intramuscular injection: 1 to 2 times a day, 1 to 2 tubes each time, half for children or as directed by the doctor. Intravenous infusion: suitable for severe patients, once a day, 40-80m1 each time, diluted with 5% or 10% glucose injection and instilled slowly, half of the amount for children.

In addition, ammonium glycyrrhizinate can effectively protect colonic damage in mice with inflammatory bowel disease, and its mechanism may be related to enhancing the antioxidant capacity of tissues. Compared with the current main drug for the treatment of inflammatory bowel disease, Edissa, the curative effect is more significant . Diammonium glycyrrhizinate is mainly used in the treatment of liver diseases. Long-term clinical application shows that it has a wide range of safety, less toxic and side effects, no systemic side effects of hormones, and no immunosuppressive effect of immunosuppressants. The dose of ammonium glycyrrhizinate used in the treatment of inflammatory bowel disease in the present invention is within the range of commonly used clinical doses, which shows that the ammonium glycyrrhizinate is not only effective in treating inflammatory bowel disease, but also safe and has little side effects.

There is research and development of a traditional Chinese medicine compound injection and its preparation process, which includes Panax notoginseng saponins, ammonium glycyrrhizinate (monoammonium salt or diammonium salt), sodium chloride, glucose, mannitol, lactose, sorbitol, dextran, etc. Acceptable pH regulators, osmotic pressure regulators, freeze-dried excipients and water for injection. The above pharmacological components are used to prepare injections, large volume injections and freeze-dried powder injections. Each preparation unit contains 60~200mg of Panax notoginseng saponins and 80~200mg of ammonium glycyrrhizinate.

Take the prescribed amount of Panax notoginseng saponins and ammonium glycyrrhizinate, add an appropriate amount of water, stir and heat in a water bath at 60°C to dissolve, adjust the pH to 6.5~8.0, add activated carbon to decolorize and remove pyrogens, filter, and add water for injection to the full amount Afterwards, filter through a microporous membrane, melt seal in an ampoule, and sterilize by autoclaving at 105°C. The invention can be used for treating chronic hepatitis, active liver cirrhosis and preventing and treating liver fibrosis.

The Production Method of Ammonium Glycyrrhizinate

It is obtained by refining glycyrrhizic acid crude product (content about 50%, weight method) as raw material and acidic ethanol as extractant. Add 50g of crude glycyrrhizic acid to 170mL of 95% ethanol acidified with hydrochloric acid (Ph value 3.5-4.0), and stir and extract at 40-50°C for 4h. After filtration, the filter residue was extracted with 100mL ethanol for 3h under the same conditions. Combine the extracts, add ammonia water dropwise or pass through ammonia gas under stirring, so that the pH value of the solution is 7.2-7.5, and stand at room temperature for 0.5h to completely precipitate. Precipitate is triammonium glycyrrhizinate, disperse it into a paste with an appropriate amount of glacial acetic acid, heat it slightly if necessary, let it stand for 1 hour, and filter to convert it into monoammonium salt. After the crystallization was separated, it was washed with a small amount of glacial acetic acid for 1-2 times to obtain a pale yellow crude product. 75% ethanol was used for decolorization and recrystallization of activated carbon to obtain 15.5 g of white crystalline ammonium glycyrrhizinate with a yield of 61% and a purity of ≥98%.

About That Product:
If you need Ammonium Glycyrrhizinate as a cosmetic raw material, please contact our service staff directly, and we will provide you with high-quality products at the best price.
As an experienced Ammonium Glycyrrhizinate manufacturer and supplier, ZSpharmac will provide Ammonium Glycyrrhizinate raw materials to customers all over the world for a long time.
Over the years, the company has been adhering to the spirit of “integrity management, strict quality control, customer first”, and has won unanimous praise from domestic and foreign customers.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

Help China Chemicals to benefit the happiness of human life
Become the most trusted chemical supplier in the world
Striver – oriented, enrich employees, customer first, deep service, seek development
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Cosmetic raw materials
  • Products/Service:Cosmetic raw materials (flavors and fragrances,antioxidant products, moisturizing and hydrating, whitening agents, cosmetic additives)
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.


After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.


Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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