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Zhishang Chemical

Amino-2-Propanol CAS 78-96-6

Molecular Formula: C3H9NO

Formula Weight: 75.11

ZSpharmac: Amino-2-Propanol Supplement

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Product Name: Amino-2-Propanol
CAS No: 78-96-6
Purity: 99%

Basic Info

Product Name:Amino-2-Propanol
Other Names:DL-IsopropanolaMine
CAS:78-96-6
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Organic Chemical Raw Materials
Appearance:Clear Liquid
EINECS No.:201-162-7
Storage:Warehouse Ventilation Low Temperature Drying 2-8 ° C
Provide:Amino-2-Propanol MSDS;
Amino-2-Propanol COA

What is Amino-2-Propanol?

1-Amino-2-propanol (MIPA) is an important fine chemical raw material with a wide range of uses. It is commonly used as surfactants, metal working fluids, paints and coatings, textile printing and dyeing, personal care products, water treatment agents, and intermediates of pharmaceuticals and pesticides. One of the raw materials of the body.

Amino-2-Propanol Properties:

Melting point -2 °C (lit.)
Boiling point 160 °C (lit.)
density 0.973 g/mL at 25 °C (lit.)
vapor density 2.6 (vs air)
vapor pressure <1 mm Hg ( 20 °C)
refractive index n20/D 1.4478(lit.)
FEMA 3965 | 1-AMINO-2-PROPANOL
Fp 165 °F
storage temp. 2-8°C
pka12.92±0.35(Predicted)
form Liquid
color Clear
Odorslt ammonia odor
PH11.3 (10g/l, H2O, 20℃)
explosive limit1.9-10.4%(V)
Water Solubility freely soluble

 

Amino-2-Propanol Uses

  1. 1-Amino-2-propanol is used as surfactant, rubber vulcanization accelerator and solvent, as well as fiber industry refining agent, antistatic agent, dyeing auxiliary and fiber wetting agent, etc.
  2. 1-Amino-2-propanol is soluble in water and ethanol. The aqueous solution is alkaline. It can react with acids to form esters and acid halides to form amide compounds. It can also be used in synthetic detergents, cosmetics, lubricating oils, cutting oils, Preparation of plasticizers, emulsifiers, and solvents. In textile, printing and dyeing, it can be processed to produce auxiliaries. It can be used in electroplating cleaning, surfactants, medicine, etc.
  3. (1) The reaction with fatty acid generates fatty acid isopropanolamide (alkyl isopropanolamide) and ester, which can be used as industrial synthetic detergent due to its excellent foaming property, foam stability and ability to dissolve grease.
    (2) The product obtained from thioglycolic acid can be used as a cosmetic base.
    (3) Due to its good hygroscopicity and weak alkalinity, it can be used as a raw material for surfactants, and can be used as refining agents, antistatic agents, dyeing auxiliaries and fiber wetting agents in the fiber industry.
    (4) Its phosphate Chemicalbook and nitrite can be used as antioxidants for various lubricating oils and cutting oils.
    (5) The reaction products with various acids and higher aliphatic ketones can be used as plasticizers, emulsifiers and solvents. The isopropanolamine mixture has a particularly strong dissolving ability to hydrocarbons. Stir kerosene, halogenated hydrocarbons, naphtha, etc. together with isopropanolamine (4%) and oleic acid (15%) in water to obtain a stable emulsion . The salts formed with long-chain fatty acids can be used as emulsifiers for vinyl acetate resins, with good emulsion stability and stable color.

Preparation of Amino-2-Propanol

report one,
Propylene oxide and ammonia water with a concentration of 95wt% in a molar ratio of 1:1.0 were respectively input into the mixer with a metering pump, and the temperature in the mixer was controlled to be 0°C and the pressure was 3.0MPa; the mixture was continuously fed into the microchannel for reaction In the reactor, the material reacts in the channel of the reaction section of the reactor, the temperature is 60 °C, the pressure is 3.0 MPa, and after staying for 0.1 s, it enters the cooling section of the microchannel reactor to rapidly cool down to terminate the reaction, the outlet temperature is 0 °C, and the temperature is 0 °C. The time is 2S, and the specific cooling rate is controlled at about 1800-2000°C/min. Then, the low boilers are removed through a stripping tower to obtain the product 1-amino-2-propanol with a content of 99.2%. In this embodiment, the microchannel reactor is specifically made of stainless steel, wherein the inner diameter of the microchannel is 0.05mm, and the length of the microchannel is 0.8m.
report two,
A preparation method of (S)-1-amino-2-propanol, specifically comprises the steps:
(1) Dissolve sodium tert-butoxide (230g, 2.39mol) in tetrahydrofuran (2L), slowly add trifluoroacetamide (226g, 2mol) under ice bath, stir for 30min; then add (S)- Propylene oxide (128 g, 2.2 mol) was naturally heated to room temperature, continued to stir for 10 h, and was stirred for 2 h at 35 °C; after the reaction, 2N (equivalent) hydrochloric acid was added dropwise to the system for a total of 1 L for neutralization, and then replenished 1 L of water was added, the layers were left to stand, the aqueous phase was extracted with dichloromethane, the organic phases were combined, dried over anhydrous sodium sulfate, and concentrated under reduced pressure to obtain a total of 318 g of intermediate product I with a yield of 93%. 1H-NMR (CDCl3, 400MHz) of intermediate I: δ 1.08 (d, 3H), 3.37 (m, 2H), 4.0 (m, 1H), 7.12 (brs, 1H).
(2) The intermediate product I (310 g, 1.81 mol) obtained in step (1) was dissolved in methanol (1.5 L), 200 mL of water and potassium carbonate (550 g, 4 mol) were added, stirred at room temperature for 6 h, filtered, and concentrated to dryness, The obtained product was dissolved in dichloromethane, filtered to remove insoluble matter, dried over anhydrous sodium sulfate, concentrated, and distilled under reduced pressure to obtain the target product (S)-1-amino-2-propanol, a total of 122 g, with a yield of 90%. .
1H-NMR (CDCl3, 400MHz): δ 1.15 (d, 3H), 2.43 (dd, 1H), 2.64 (dd, 1H), 3.53-3.64 (m, 1H), 3.77 (brs, 3H). report three.
A preparation method of (R)-1-amino-2-propanol, specifically comprises the steps:
(1) Dissolve sodium tert-butoxide (300g, 3.12mol) in tetrahydrofuran (2L), slowly add trifluoroacetamide (294g, 2.6mol) under ice bath, stir for 30min; then add (R) under ice bath – Propylene oxide (166g, 2.96mol) was naturally heated to room temperature, continued to stir for 10h, and then stirred for 2h at 35°C; after the reaction, a total of 1.3L of 2N (equivalent) hydrochloric acid was added dropwise to the system for neutralization, Then 1.3 L of water was added, the layers were left to stand, the aqueous phase was extracted with dichloromethane, the organic phases were combined, dried over anhydrous sodium sulfate, and concentrated under reduced pressure to obtain a total of 423 g of intermediate product I with a yield of 95%.
1H-NMR (CDCl3, 400 MHz) of intermediate I: δ 1.07 (d, 3H), 3.36 (m, 2H), 3.99 (m, 1H), 7.11 (brs, 1H).
(2) Dissolve the intermediate product I (420g, 2.45mol) obtained in step (1) in methanol (2L), add 350mL of water and potassium carbonate (744g, 5.4mol), stir at room temperature for 6h, filter, and concentrate to dryness, The obtained product was dissolved in dichloromethane, filtered, insoluble matter was removed, dried over anhydrous sodium sulfate, concentrated, and distilled under reduced pressure to obtain the target product (R)-1-amino-2-propanol, a total of 171 g, with a yield of 93% .
1H-NMR (CDCl3, 400 MHz): δ 1.17 (d, 3H), 2.45 (dd, 1H), 2.66 (dd, 1H), 3.54-3.67 (m, 1H), 3.76 (brs, 3H).

Company Profile and Corporate Culture

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

OUR MISSION

Help China Chemicals to benefit the happiness of human life

OUR VISION

Become the most trusted chemical supplier in the world

OUR BUSINESS PHILOSOPHY

Striver – oriented, enrich employees, customer first, deep service, seek development

OUR VALUES

Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Additive , Chemical Auxiliary & Catalyst , Organic Chemicals
  • Products/Service: Organic Intermediate,Inorganic Chemistry, APIs, Dyestuffs And Pigments, Fragrance And Spices, Food Additives
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.

Service

Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.

 

After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.

FAQ

Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.

 

HOW TO CONFIRM THE PRODUCT QUALITY BEFORE PLACING ORDERS?

You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.

Shipping

1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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