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Amine Oxide CAS 70592-80-2

Molecular Formula: C10H13Br2N

Formula Weight: 0

ZSpharmac: Amine Oxide Cosmetic Raw Material Supplier

Product Name: Amine Oxide
CAS No: 70592-80-2
Purity: 99%

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Basic Info

Product Name:Amine Oxide
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:Colorless Liquid
EINECS No.:2746872
Provide:Amine Oxide MSDS;
Amine Oxide COA

What is Amine Oxide?

Amine oxide is a product gotten by oxidizing tertiary amines with hydrogen peroxide or peroxyacid. This type of compound was examined as early as 1900. In 1939, the license of dodecyl dimethyl amine oxide was published. In the 1960s, its use in detergent formulas was uncovered. In aqueous option, amine oxide can show non-ionic (neutral or alkaline problems) or cationic (acidic problems) relying on the pH value. Amine oxide has exceptional lathering as well as stabilizing efficiency, and also is one of the most reliable thickener, as well as has conditioning impact, plus its low poisoning and reduced inflammation, and can be utilized in hair shampoos, bath liquids as well as top-quality detergents. The most typically made use of ones are dodecyldimethylamine oxide, brand name OA-12, octadecyldimethylamine oxide and amidopropylamine oxide.

Amine Oxide Property

Amine oxide has a tetrahedral configuration, with the nitrogen atom at the center of the tetrahedron. Therefore, when the three teams on the nitrogen are various, a pair of photoactive enantiomers will certainly be generated. When the team on the nitrogen is bigger, both enantiomers can occasionally be resolved.

Amine oxides are highly polar, with a dipole moment similar to that of quaternary ammonium salts. Consequently, most low-level amine oxides have high melting points, are insoluble in benzene as well as ether, and also are quickly soluble in water.

Amine oxide is weakly standard (pKa = ~ 4.5), and its conjugate acid is R3N+-OH, which can be regarded as the alkylation product of hydroxylamine.

Amine oxides can be used as safety teams for amines and also as intermediates in organic synthesis. Amine oxides are frequently metabolites of amine medicines and also medications (such as pure nicotine and morphine). Oxides of long-chain fatty amines are likewise utilized as nonionic surfactants as well as foam stabilizers.


Amine Oxide Applications

1. Application in the daily chemical industry. As a non-toxic, light, soft as well as moisturizing surfactant, amine oxide has actually brought in the interest of the day-to-day chemical sector and also is made use of to prepare shampoos as well as bath soaps. as well as dishwashing cleaning agents, and so on. Hair shampoo is an essential application location for amine oxides, which can thicken items, create pearlescent impacts and solubilize scents. Hair shampoos formulated with amine oxide as an element can make hair soft and smooth, and can lower the irritation of some medications. This is because amine oxide can directly communicate with the hydroxyl teams on the hair and skin under specific pH conditions. The long-chain alkyl part of the amine oxide can impart soft qualities, eliminate static electrical power from the hair, make it simpler to comb, and also make the hair black and shiny. Although cationic surfactants can also combine with the hydroxyl groups on hair and skin and play a role in combing, softening and reducing fixed power, they are extremely irritating to the eyes as well as skin, and lasting usage can bring about extreme degreasing of hair and skin. And also it is not compatible with the anionic surfactants used in huge quantities in shampoos.

Utilizing amine oxide to prepare fluid bathroom soap can boost the roughness of the skin, because amine oxide has superb frothing and also foam supporting impacts. It is reported that to obtain equivalent foam supporting capacity, the dosage of amine oxide should be one-third that of alkanolamide. The foam created by amine oxide is fine as well as creamy, and also is non-irritating to the eyes and skin. These residential properties are specifically appropriate for creating infant bath soaps. When utilized in solution with AES, it has a synergistic effect, significantly improving the general cleansing impact. Food cleaning is the largest customer of amine oxide, accounting for 90% of total amine oxide intake in the USA. Amine oxide is used as the base material of dishwashing cleaning agents since it has superb emulsifying power versus oil discolorations, is non-irritating to the skin, has low physiological poisoning, and also has excellent biodegradability. Amine oxide first opened sales in the united state market through the preparation of dishwashing cleaning agents, and also such products are still popular today.

2. Application in the fabric auxiliary sector Amine oxide is likewise a basic material for textile printing and also dyeing auxiliaries. It is frequently made use of to prepare fabric antistatic representatives and conditioners and also solubilizers for dyes. The formula (w/%) of amine oxide as an antistatic representative for polyester staple fibers is as adheres to: paraffin oil (thickness at 20 ° C, 2.95 Pa?s) 60%; oleyl alcohol polyoxyethylene ether 30%; coco-based dimethyl amine oxide 10%. The antistatic worth determined at space temperature is 10 × 106Ψ, and the antistatic value determined at 250 ° C for 1 hour is 11.5 × 107Ψ. The antistatic system of amine oxide can be discussed from two aspects: initially, the amine oxide affixed to the fiber has a soft and smooth impact, which decreases the friction coefficient of the fiber surface area throughout relative movement, hence lowering the accumulation of static fee; on the other hand, Since the N → O polar chain in amine oxide has incredibly strong water absorption, it can conduct away the electrostatic costs accumulated on the fiber surface area in a timely fashion. Compared to various other antistatic representatives, amine oxide has little adjustment in antistatic impact with the adjustment of ambient humidity, and also it reveals great antistatic impact also at really low humidity. On top of that, amine oxide can likewise be utilized in conjunction with other lubricating substances and also emulsifiers.

3. Other amine oxides likewise have lots of application instances in the clinical field. A lot of these amine oxides are aromatic as well as benzene ring derivatives. They can be utilized as analgesics, coughing suppressants and anesthesia boosters. and various other effects. For instance, dedecyl dihydroxyethyl amine oxide has a great inhibitory impact on Staphylococcus aureus, and it likewise has certain alleviative impacts on skin diseases caused by fungal infections. Furthermore, amine oxide can also be used as coagulant in metal plating service, as initiator and inhibitor in polymerization reaction, as emulsifier and also moisturizer in cosmetics. As the understanding of the residential or commercial properties of amine oxide grows, its usages will increasingly increase.

Amine Oxide Preparation Method

1. Prepared by straight oxidation with air or oxygen. Amine oxide is prepared by oxidizing tertiary amines with an oxidizing agent. There are two synthesis process courses. The response formula is as follows:

R1R2R3N+ O2 → R1R2R3N → O.

Pass oxygen or air into an autoclave with water, alcohol solvent and tertiary amine, and also respond for 16-64 hrs under the problems of 100-150 ° C and also 15-70MPa to produce amine oxide items with a material of 30% -80%. 2. Prepared by using nitrogen peroxide or peroxyorganic acid as oxidizing representative.

The reaction formula is as complies with:.

R1R2R3N+ H2O2 → R1R2R3N → O.

Liquify the tertiary amine in water (or alcohol solvent), add a percentage of citric acid and salt and also disodium EDTA. Warm up to 60-70 ° C as well as add excess 30% hydrogen peroxide dropwise for 1 hour, after that remain to warm up to 75-80 ° C for 3 hours, cool off to 60 ° C and also add sodium bisulfite to disintegrate the recurring oxygen, then discharge A liquid product with 30% energetic content is acquired. The conversion rate of tertiary amine can reach more than 98%. Included citric acid works as a hydrogen peroxide stabilizer, and disodium EDTA acts as a steel ion complex. Both of them likewise function as a driver to boost the conversion price of tertiary amines.

Amine Oxide Reaction

Heat elimination reaction (Cope elimination reaction). Amine oxides with hydrogen on the β-carbon undergo cis elimination to form hydroxylamine and alkenes when heated to 150-200°C.

Reduction to amine. Amine oxides can be reduced to the corresponding amines by lithium aluminum hydride, sodium borohydride, zinc/hydrochloric acid, iron/acetic acid and catalytic hydrogenation. Pyridine-N-oxide can be reduced to pyridine by phosphorus trichloride.

O-alkylation reaction. Pyridine-N-oxide reacts with alkyl halides to form N-alkoxypyridine, which decomposes into pyridine and aldehydes when treated with alkali or heated.

Meisenheimer rearrangement reaction: Certain amine oxides with the general formula R1R2R3N+O− can rearrange to form hydroxylamine derivatives with the general formula R2R3N-O-R1.

About Products:
If you need Amine oxide as a cosmetic raw material, please contact our service staff directly and we will provide you with high-quality products at the best price.
As an experienced Amine oxide manufacturer and supplier, our company, ZSpharmac, will provide Amine oxide raw materials to customers around the world for a long time.
Over the years, the company has adhered to the spirit of “integrity management, strict quality control, and customer first” and has won unanimous praise from customers at home and abroad.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

Help China Chemicals to benefit the happiness of human life
Become the most trusted chemical supplier in the world
Striver – oriented, enrich employees, customer first, deep service, seek development
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Cosmetic raw materials
  • Products/Service:Cosmetic raw materials (flavors and fragrances,antioxidant products, moisturizing and hydrating, whitening agents, cosmetic additives)
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.


After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.


Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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