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Ambroxan Sauvage CAS 6790-58-5

Molecular Formula: C16H28O

Formula Weight: 236.39

ZSpharmac: Ambroxan Sauvage Supplement

Product Name: Ambroxan Sauvage
CAS No: 6790-58-5
Purity: 99%

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Basic Info

Product Name:Ambroxan Sauvage
Other Names:(-)-AMbroxide
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:Grey Solid
EINECS No.:229-861-2
Storage:Sealed in Dry,Room Temperature
Provide:Ambroxan Sauvage MSDS;
Ambroxan Sauvage COA

What is Ambroxan Sauvage?

Ambroxan Sauvage is one of the most important active ingredients of natural ambergris tincture, with a soft, long-lasting and stable animal-type ambergris aroma and mild woody aroma. Ambroxan Sauvage has several different stereoisomeric structures, and there are certain differences in aroma characteristics between the isomers. Ambroxan Sauvage isomer a has a mild woody aroma, coarser potato-cellar taste and aroma intensity 100 times lower than ambroxan; isomer c has aroma intensity comparable to ambroxan, but There is a faint rich and complex wine aroma; isomers e and g have weak camphor wood aroma, with almost indistinguishable ambergris aroma; isomer f has a weak ambergris-like aroma, but Overshadowed by a sweaty odor; isomeric h-woody aroma is stronger, but lacks warm animality. Different aroma characteristics of Ambroxan Sauvage, different raw materials used for the production of compounds with the same chemical structure will also cause different aroma differences. For example, the solvent can slightly change the aroma of the final product, and the different crystallization methods will also cause different aromas. difference.

Ambroxan Sauvage Properties:

Melting point 

74-76 °C (lit.)


-30 º (c=1% in toluene)

Boiling point 

273.9±8.0 °C(Predicted)



storage temp. 

Sealed in dry,Room Temperature


Ambroxan Sauvage Uses

Ambroxan Sauvage “Ambroxan impact” can considerably enhance the diffusion effect of fragrance, used in the scent of high-end perfumes as well as cosmetics, without irritation to the human body, suitable for the scent of skin, hair and also materials, such as soap, baby powder, cream As well as shampoo as well as various other fragrance and set the scent. The application of ambergris scent resources in cigarettes Labradors are the key fragrance elements of asian cigarettes, and ambroxol is a flavor with a specifically popular impact, which has an important payment to the smoke of mixed cigarettes. Ambroxan is additionally commonly utilized in flue-cured cigarettes and also fragrance industries. Ambroxan Sauvage is used in the cigarette industry as a flavoring product. It integrates with the particular aroma of cigarette, as well as can mask miscellaneous air. Even if a percentage is used, it can improve the taste quality of tobacco. It is specifically suitable for flavoring mixed cigarettes as well as boosting asian cigarette. taste. R. J. Reynols TobaccoCompany (Reynolds Cigarette Business) has made use of sclareolide, ambroxol as well as ambroxan to be packed in a solvent and also splashed on cut cigarette at an application rate of five to three thousandths to improve cigarettes. flavor. As a result of the small molecular weight, solid volatility as well as low threshold of Ambroxan Sauvage. Givavdan-Route (International) SA, a Swiss Givaudan fragrance business, prepared ambroxil right into a carbonate (Carbonate-I, Chart2) unrealized scent material, which has a huge molecular weight as well as is not easily unpredictable. In the process of cigarette smoking, the scent forerunner ambroxan sauvage is disintegrated at high temperature and also cyclized to produce Ambroxan Sauvage. The cigarette smoke has evident woody and also amber scents. Hunan China Tobacco Sector Co., Ltd. prepared ambroxil into the form of oxalate (Oxalate-II, Chart2) hidden aroma compound, and then added it to the cigarette. In the process of smoking and burning cigarettes, the fragrance materials of ambroxan are uniformly launched, to make sure that the cigarettes have obvious ambergris aroma.

How Ambroxan Sauvage is Made

Ambroxan Sauvage is an artificial spice with an unique fragrance of all-natural ambergris. All-natural ambergris (Ambergris) is a valuable pet flavor. It is a sort of stone in the tummy of sperm whale. It is vomited or secreted on the sea surface by the whale, as well as it emits an unique fragrance airborne for a very long time. The synthesis of Ambroxan Sauvage utilizes perillyl alcohol as basic material, as well as is oxidized by KMnO4 in two actions (Switzerland utilizes ozone oxidation, Russia makes use of sodium chromate oxidation). That is (1) alkaline oxidation; (2) weak acid oxidation. The oxide is gotten, and then the oxide is soaped, dehydrated and lactonized to obtain ambroxolide. The lactone is minimized to ambroxol utilizing lithium aluminum hydride in ether (or borane in tetrahydrofuran).

Technique 1: Usage sclareol as raw material to execute two-step oxidation, namely alkaline oxidation and weak acid oxidation. The oxidant can be potassium permanganate, ozone or salt (or potassium) dichromate sulfuric acid option, and then oxidize Saponification, dehydration, and also lactonization of the material are utilized to obtain ambroxolide. The lactone is then minimized to ambroxol using lithium aluminum hydride in ether (or borane in tetrahydrofuran). Ambroxan can be prepared by utilizing D-camphor-β-sulfonic acid as a cyclizing agent, decyclizing the diol, and then dehydrating it under the activity of light weight aluminum oxide. In addition to getting Ambroxan Sauvage by this technique, bicyclic homofarnesol, an isomer of ambroxan, can also be acquired, that is, lipid-6-en-12-ol (anemic crystal, melting point 20 ° C, There is also ambergris taste).

Technique 2: Artificial course utilizing diol 2 as an intermediate
Ambroxan Sauvage was synthesized synthetically for the very first time from (-)- sclareol 3 in sclare remove, with a total yield of 52%. Sclareol 3 is oxidized with chromium trioxide and broken down to lactone 4, and lactone 4 is reduced by tetrahydroaluminum lithium to acquire diol 2; diol substance 2 is triggered by p-toluenesulfonyl chloride, and after that performed under the action of alkali salt hydride. Intramolecular cyclization gave Ambergris 1. The drawback of this path is that it needs to make use of chromium trioxide as an oxidant, which will create a large amount of seriously polluted chromium-containing wastewater, and also at the same time, it requires to utilize lithium tetrahydroaluminum as well as sodium hydride with high threat.
Opportunity to synthesize Ambroxan Sauvage by stereoselective cyclization using nerolidol 5 as beginning product. Beginning with nerolidol 5, with bromination, nitrification and also hydrolysis, (E, E)- homofacamic acid 8 and also one more isomer were obtained in a ratio of 8:2. Acid 8 was cleansed by column chromatography by creating an ethyl ester, as well as the ester of 8 was hydrolyzed under basic conditions to generate the acid in 98% pureness. Acid 8 was reacted with boron trifluoride ether as Lewis acid in dichloromethane at -20 ° C for 60 mins to acquire cyclized product 4 with a yield of 38%. After that, substance 4 is decreased with lithium aluminum tetrahydrogen to get diol 2, as well as diol 2 is heated in the existence of driver p-toluenesulfonic acid making use of pyridine as a solvent, as well as cyclized to obtain ( ±) ambroxan 1, which is obtained The rate is 75%.

Technique 3: Artificial course without intermediate diol 2
Beginning with dihydro β-ionone 35, 4-(2,2,6-trimethyl-1-cyclohexene)-2-methylbutanal 47 was gotten by Darzens reaction, which was after that reacted with malonic acid to get 48, and after that after numerous actions of response, ambroxan 1 is acquired. The item gotten right here is a racemate with a somewhat different fragrance quality from (-)-Ambroxan Sauvage.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

Help China Chemicals to benefit the happiness of human life
Become the most trusted chemical supplier in the world
Striver – oriented, enrich employees, customer first, deep service, seek development
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Additive , Chemical Auxiliary & Catalyst , Organic Chemicals
  • Products/Service: Organic Intermediate,Inorganic Chemistry, APIs, Dyestuffs And Pigments, Fragrance And Spices, Food Additives
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.


After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.


Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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