Zhishang Chemical

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Zhishang Chemical

Alpha-Cyclodextrin CAS 10016-20-3

Molecular Formula: C36H60O30

Formula Weight: 972.84

ZSpharmac: Alpha-Cyclodextrin Cosmetic Raw Material Suppliers

Product Name: Alpha-Cyclodextrin
CAS No: 10016-20-3
Purity: 99%

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Basic Info

Product Name:Alpha-Cyclodextrin
Other Names:Cyclohexapentylose
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:White Powder
EINECS No.:233-007-4
Provide:Alpha-Cyclodextrin MSDS;
Alpha-Cyclodextrin COA

What is Alpha-Cyclodextrin?

Cyclodextrins (usually abbreviated as CD) are a class of D-glucopyranose devices attached end-to-end via alpha-1,4-glycosidic bonds produced from starch or polysaccharides under the action of cyclodextrin glycosyltransferase. A general term for cyclic compounds. Typical molecules with 6, 7 and also 8 glucose units are called α-cyclodextrin, β-cyclodextrin and γ-cyclodextrin specifically. Considering that α-cyclodextrin can form incorporation facilities with several guest particles, thus changing the physical and chemical buildings of the guest molecules such as solubility, stability, and so on, it is commonly made use of in food, medicine, farming, fabrics, environmental protection, cosmetics, biotechnology and evaluation It has a large range of applications in areas such as chemistry.

Alpha-Cyclodextrin Property

Melting point >278 °C (dec.) (lit.)
Boiling point 784.04°C (rough estimate)
alpha [α]D25 +146~+151° (c=1, H2O) (After Drying)
density 1.2580 (rough estimate)
refractive index 1.7500 (estimate)
storage temp. 2-8°C
solubility H2O: 50 mg/mL
form powder
color White
PH5.0-8.0 (1% in solution)
Odorat 100.00?%. odorless
optical activity[α]20/D +136±3°, c = 10% in H2O
Water Solubility Soluble in water at 1%(w/v)


Alpha-Cyclodextrin Uses

Alpha-Cyclodextrin has an opening in the facility of the ring structure. There are -CH- oxygen atoms bound to glucoside inside, which is sulfur water. The -OH groups at settings 2, 3 as well as 6 of sugar are hydrophilic and can travel through Weak van der Waals forces intricate various other particles right into additions. There are several substances that can be included by cyclodextrin, consisting of uncommon gases, halogens, dyes, flavors, drugs, food, pesticides and preservatives. After encapsulation, its security, volatility, solubility as well as sensitivity are improved. This special function of cyclodextrin makes it a layer material with broad application value.
1. Usage in pharmaceutical sector
Alpha-Cyclodextrin can be made use of to develop inclusions (encapsulation) with medicines, which can stabilize (1) unsteady drugs; (2) deliquescent, adhesive or liquid drugs into powder; (3) poorly soluble or insoluble drugs Medication solubilization (solubilization), and so on
2. Usage in chemical sector
Alpha-Cyclodextrin is included and also supported, making certain chemicals immune to storage space and boosting insecticidal efficacy.
3. Use in food industry
Cyclodextrin is used in the food industry and also has the adhering to functions: (1) elimination and masking of particular odors; (2) improvement and also enhancement of food structure; (3) reduction as well as elimination of bitter taste; (4) antioxidant Feature; (5) Upkeep as well as optimization of flavor.
4. Usage in day-to-day chemical sector
Alpha-Cyclodextrin can also be made use of as an emulsifier as well as high quality improver in cosmetics manufacturing. It additionally has deodorizing (such as foul-smelling breath) as well as disinfectant effects, as well as can be used in the manufacture of tooth paste and also tooth powder.
5. Other usages
It can be utilized as a treatment representative for oily sewage in environmental management. The aqueous option of cyclodextrin is used to clean the oil tank, as well as the waste fluid can be recycled and also processed to obtain fuel oil.
6. Using cyclodextrin in the field of chemistry
Alpha-Cyclodextrin is a beneficial chemical reagent. When it exists, the fluorescence intensity of fluorescent dyes will increase substantially, so it can be used for the evaluation of proteins and also amino acids; it can additionally be made use of to separate long-chain natural substances, racemates, and so on. Furthermore, adsorbents made of cyclodextrin can be made use of for adsorption in chromatographic evaluation.

Alpha-Cyclodextrin Preparation

The methods for producing α-cyclodextrin primarily consist of chemical techniques and biological methods. The chemical approach is to react Marseille Light starch with tetrachloroethane to create unrefined α-cyclodextrin, which is after that filtered and steam distilled to obtain a product with relatively high purity. Higher α-cyclodextrin (Wang Jiaming; Production, Application as well as Market Leads of Cyclodextrin, Fine and also Specialized Chemicals, 1998( 02 ), 19-20). Because of the high solubility of α-cyclodextrin, chemical prep work is difficult and also will cause excellent contamination to the environment. Biological techniques are currently thought about to be a method with wonderful application capacity. Nevertheless, there are lots of records on the biological manufacturing of β-cyclodextrin, however there are less reports on the biological production of α-cyclodextrin. Chen Longran isolated a pressure of Bacillus licheniformis from the dirt. After the cyclodextrin glycosyltransferase (CGTase) fermented by the bacteria acts upon starch, the primary product is α-cyclodextrin, adhered to by β-cyclodextrin. The proportion between the two is 2.47:1, and the complete cyclodextrin yield is 29.8% (Chen Longran, Kang Pei, Feng Mingguang, Wang Yafen, Reproduction, enzyme manufacturing conditions as well as Enzymatic residential properties, Acta Microbiologica Sinica, 2005( 01 )). The primary issues in the current organic manufacturing of α-cyclodextrin are: 1. The absence of excellent bacterial strains as well as the lack of cyclodextrin glycosyltransferase (CGTase) with high yield as well as directional manufacturing of α-cyclodextrin on the market; 2. The absence of α-cyclodextrin The equivalent manufacturing procedure of cyclodextrin needs to establish a collection of efficient and also economical separation and extraction techniques to deal with the trouble of high solubility of α-cyclodextrin in water.

Alpha-Cyclodextrin Specific Methods:

1. Mix tapioca starch as well as distilled water right into a slurry at a concentration of 15%, as well as mix at 85 ° C for 15 mins to fully swell the starch granules.

2. Readjust the pH value to 5, include CGTase at a proportion of 200 systems per gram of starch, after that include n-decanol audit for 8% of the starch mass, and react for 6 hrs.

3. Use heavy steam distillation to different n-decanol in the reaction service.

4. Adjust the temperature to 50 ° C, then add CGT enzyme to make the ratio reach 400 systems per gram of starch; add ethanol audit for 20% of the starch volume, and afterwards respond for 10 hours.

5. Straight filter the reaction solution and collect the filter cake, which includes the complicated rainfall formed by ethanol as well as α-cyclodextrin and unreacted starch; re-dissolve the filter cake, usage vacuum distillation to eliminate the ethanol, and also await distillation After completion, filter the extract to get rid of unreacted starch to acquire an aqueous remedy of α-cyclodextrin; vaporize and also focus the aqueous option, and place it in a reduced temperature level setting of 2 ° C to acquire α-cyclodextrin crystals.

Results observed: The overall conversion rate of starch reached 73%, the percentage of α-cyclodextrin in the item was as high as 86.7%, and β-CGT represented 13.3%.

About Products:
If you need Alpha-Cyclodextrin, a cosmetic raw material, please contact our service staff directly, and we will provide you with high-quality products at the best price.
As an experienced Alpha-Cyclodextrin manufacturer and supplier, our company, ZSpharmac will provide Alpha-Cyclodextrin raw materials to customers around the world for a long time.
Over the years, the company has adhered to the spirit of “integrity management, strict quality control, and customer first” and has won unanimous praise from customers at home and abroad.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

Help China Chemicals to benefit the happiness of human life
Become the most trusted chemical supplier in the world
Striver – oriented, enrich employees, customer first, deep service, seek development
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Cosmetic raw materials
  • Products/Service:Cosmetic raw materials (flavors and fragrances,antioxidant products, moisturizing and hydrating, whitening agents, cosmetic additives)
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.


After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.


Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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