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Alpha-Cyclodextrin CAS 10016-20-3

Molecular Formula: C36H60O30

Formula Weight: 972.84

ZSpharmac: Alpha-Cyclodextrin Cosmetic Raw Material Suppliers

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Product Name: Alpha-Cyclodextrin
CAS No: 10016-20-3
Purity: 99%

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Basic Info

Product Name:Alpha-Cyclodextrin
Other Names:Cyclohexapentylose
CAS:10016-20-3
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:White Powder
EINECS No.:233-007-4
Storage:2-8°C
Provide:Alpha-Cyclodextrin MSDS;
Alpha-Cyclodextrin COA

What is Alpha-Cyclodextrin?

Alpha-Cyclodextrin (α-cyclodextrin) is a cyclic oligosaccharide with a cyclic structure composed of six D-glucopyranose units connected head to tail through α-1,4-glycosidic bonds. Its molecular formula is C36H60O30. Its appearance is usually white crystalline powder. It has certain hygroscopicity and weak ability to dissolve in water, but its solubility will increase in hot water, acidic or alkaline solutions.

Alpha-Cyclodextrin has a hollow cylindrical structure, which is hydrophobic on the inside and hydrophilic on the outside. This characteristic allows it to envelop and embed hydrophobic molecules of appropriate size to form inclusion complexes, thereby changing the physical and chemical properties of the enclosed substance. .

Alpha-Cyclodextrin Property

Melting point >278 °C (dec.) (lit.)
Boiling point 784.04°C (rough estimate)
alpha [α]D25 +146~+151° (c=1, H2O) (After Drying)
density 1.2580 (rough estimate)
refractive index 1.7500 (estimate)
storage temp. 2-8°C
solubility H2O: 50 mg/mL
form powder
pka11.77±0.70(Predicted)
color White
PH5.0-8.0 (1% in solution)
Odorat 100.00?%. odorless
optical activity[α]20/D +136±3°, c = 10% in H2O
Water Solubility Soluble in water at 1%(w/v)

 

Alpha-Cyclodextrin Uses

Food industry:
As a food additive, α-cyclodextrin can coat and mask bitter and off-flavor components in food or beverages, improving the taste and acceptance of the product.
As a stabilizer, it can improve the stability of food, extend the shelf life of food, and reduce the oxidative loss of nutrients.
As an emulsifier and thickener, alpha-cyclodextrin helps form stable emulsions and improve the consistency of food products.

Pharmaceutical industry:
α-Cyclodextrin can be used as a drug carrier to increase the solubility of poorly soluble drugs through inclusion technology and improve the bioavailability of drugs.
The release rate of drugs in the body can be controlled to achieve sustained release or targeted drug delivery.
For some oral drugs, it can improve the taste of the drug, mask the bitter taste of the drug, and improve the patient’s medication compliance.

Cosmetics and personal care:
In cosmetics, α-cyclodextrin can be used as a stabilizer and moisturizer to improve the stability and moisturizing effect of cosmetics.
Through inclusion technology, the essence can be slowly released and the fragrance retention time of the fragrance product can be extended.
Helps improve the stability of certain active ingredients in cosmetic formulations.

Environmental protection and industrial applications:
In water treatment, α-cyclodextrin can adsorb and remove toxic heavy metal ions in water and play a certain purification role.
In chemical production, it can be used as a building block for new materials, such as preparing cyclodextrin polymers or cyclodextrin-based nanomaterials for adsorption, separation, catalysis and other fields.

Agriculture and feed industry:
In feed additives, alpha-cyclodextrin can improve the stability and absorption rate of certain nutrients, or be used to encapsulate and deliver drugs needed by animals.

Alpha-Cyclodextrin Features

Structural features: α-cyclodextrin is composed of six D-glucopyranose molecules connected by α-1,4-glycosidic bonds, forming a hollow cylindrical structure with internal hydrophobicity and external hydrophilic characteristics. This structure allows α-cyclodextrin to envelop smaller hydrophobic molecules to form inclusion complexes.

Inclusion ability: Due to its cavity structure, α-cyclodextrin can encapsulate various organic and inorganic small molecules, including drug molecules, spice molecules, food additives, etc., thereby changing the solubility, stability, and bioavailability of these molecules. degree and taste.

Solubility: The solubility of α-cyclodextrin in water is relatively low, but its solubility increases in hot water, alkaline solutions, or in the presence of certain solvents. Its solubility in organic solvents is relatively good.

Biocompatibility and safety: α-cyclodextrin is a biodegradable macromolecule with good biocompatibility and safety, and has been approved for use as a food additive and pharmaceutical excipient.

Application Diversity: Widely used in many fields, including food industry (as stabilizer, thickener, emulsifier, flavor carrier), pharmaceutical industry (to improve drug solubility, sustained release and targeted drug delivery), Cosmetics and personal care products (stabilizes and releases active ingredients), environmental protection (acts as an adsorbent to treat pollutants), etc.

Adjustable functions: Chemical modifications (such as substitution, grafting, etc.) can change the properties of α-cyclodextrin and expand its application range and performance in different fields.

References

Gatiatulin, A.K., Osel’skaya, V.Y., Ziganshin, M.A. et al. Guest exchange in anhydrous inclusion compounds of α-cyclodextrin and its amorphization. J Therm Anal Calorim 146, 2417–2422 (2021). https://doi.org/10.1007/s10973-020-10428-0

As a company specializing in the production and supply of Alpha-Cyclodextrin raw materials, we are committed to providing customers with high-quality products and preferential prices. We have rich experience and technology to ensure product quality and stable supply. No matter where you are, we can provide you with the Alpha-Cyclodextrin raw materials you need to support your production and research and development.

We always adhere to the principle of honest operation, strictly control product quality, and serve every customer with a customer-first attitude. Over the years, we have established good cooperative relationships with customers at home and abroad and won their trust and praise.

If you have needs or are interested in our products, please contact our service staff directly, we will wholeheartedly provide you with the best quality services and products. Looking forward to cooperating with you and developing together!

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

OUR MISSION
Help China Chemicals to benefit the happiness of human life
OUR VISSION
Become the most trusted chemical supplier in the world
OUR BUSINESS PHILOSOPHY
Striver – oriented, enrich employees, customer first, deep service, seek development
OUR VALUES
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Cosmetic raw materials
  • Products/Service:Cosmetic raw materials (flavors and fragrances,antioxidant products, moisturizing and hydrating, whitening agents, cosmetic additives)
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.

Service

Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.

 

After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.

FAQ

Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.

 

HOW TO CONFIRM THE PRODUCT QUALITY BEFORE PLACING ORDERS?

You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.

Shipping

1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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