Alpha-Bisabolol CAS 515-69-5

Molecular Formula: C15H26O

Formula Weight: 222.37

ZSpharmac: Alpha-Bisabolol Supplier

Product Name: Alpha-Bisabolol

CAS No: 515-69-5

Purity: 99%

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Basic Info

Product Name:	Alpha-Bisabolol
Other Names:	Bisabolol
CAS:	515-69-5
Place of Origin:	Shandong, China
Brand Name:	ZSpharmac
Type:	Cosmetic Raw Materials
Appearance:	Clear Colourless Liquid
EINECS No.:	208-205-9
Storage:	Refrigerator
Provide:	Alpha-Bisabolol MSDS； Alpha-Bisabolol COA

What is Alpha-Bisabolol?

The main resource of Alpha-Bisabolol is chamomile, which is likewise called chamomile. Bisabolol is the active ingredient removed from it. The material of chamomile crucial oil can be as high as 17%.

As a matter of fact, chamomile has actually been considered as a natural medicine for anti-bacterial, anti-inflammatory and pain alleviation because ancient times when medication was underdeveloped. With the advancement of scientific research and also innovation, the research on Matricaria has actually been deepened, as well as its possible medical value and also efficacy have been progressively confirmed, such as anti-inflammatory effect.

Della et al. (1990) contrasted the anti-inflammatory impacts of Bian Damin hydrochloride, fresh marigold eliminate as well as likewise dried marigold essence on edema computer mice, along with discovered that the anti-inflammatory outcome of Bian Damin hydrochloride as well as fresh marigold extract coincided, The anti-inflammatory effect of the dried out marigold essence was a little reduced; the major elements of the fresh marigold as well as dried out marigold essences in the examination were Alpha-Bisabolol, Matricine and Apigenin. It can be seen that marigold has an anti-inflammatory outcome, and likewise the primary elements that use this result are bisabolol, marigoldin and apigenin.

As a result of the pure as well as environmentally friendly active components of natural items, plant eliminates have actually thrived in the aesthetic market. Chamomile is considered to have monetary value, especially Alpha-Bisabolol, which has wide application leads.

Alpha-Bisabolol (Bisabolol), also called enjoyable bisabolol and parsnipol, is among the most bountiful sesquiterpene materials in nature. It has 2 structures, α-body and β-body, as well as its molecular formula is C15H26O.It is primarily discovered in chamomile crucial oil, poplar important oil, as well as some crucial oils of the genus Bitteria as well as sage.

Alpha-Bisabolol Property

Melting point	25°C
Boiling point	154-156°C
density	0.93 g/mL at 20 °C(lit.)
refractive index	n20/D 1.496
Fp	135°C
storage temp.	Refrigerator
solubility	Chloroform (Slightly), DMSO (Slightly), Ethyl Acetate (Slightly)
pka	15.04±0.29(Predicted)
form	Liquid
color	Clear Colourless
Water Solubility	Soluble in alcohol, natural, mineral and synthetic oils. Insoluble in water.

Alpha-Bisabolol Features and Efficacy

1. Anti-inflammatory as well as antispasmodic impacts. All-natural Alpha-Bisabolol works twice in addition to synthetics in this feature. It can reduce the launch of leukotriene LTB4 as well as interleukin IL-1α caused by PMA, decrease the skin inflammation caused by salt hydroxide and SDS, therefore preventing as well as hindering inflammation.

2. Eliminates irritation and also analgesic fixing impact. It has a skin care result on allergic skin or youngsters’s skin treatment. It likewise safeguards the skin from daily stress and speeds up the skin recovery process.
If your skin is mistakenly damaged by some “solid medicine”, you can choose skin treatment products including Alpha-Bisabolol as a repair work product.

3. Relaxing as well as anti-sweat effect. For that reason, it is often made use of in sunscreen items as well as ointments for the treatment of sunburn and sunburn.

4. Broad-spectrum anti-bacterial buildings. Contributing to toothpaste and also mouth wash can decrease plaque as well as periodontal irritability, avoid foul-smelling breath, and refresh breath.

5. The scent is light and also enjoyable. Alpha-Bisabolol is also a reasonably stable fixative, so it is additionally commonly made use of in tastes as well as scents.

6. High leaks in the structure of the cortex. The result of Alpha-Bisabolol is loads of times that of usual penetrants. It can be utilized as the major representative or auxiliary representative to avoid and deal with skin diseases such as acne, and it also has a conditioning impact on the skin.

7. Excellent stability. Consequently, it is very suitable for usage in cosmetics. Alpha-Bisabolol will not alter color in long-lasting storage space, neither will certainly it ooze out of plastic containers, as well as there will certainly be no worry in using it.

Pharmacological and Biological Effects of Alpha-Bisabolol

Alpha-bisabolol (α-bisabolol) is an unsaturated monocyclic sesquiterpene alcohol referred to as among the “most typically made use of natural active ingredients” on the planet. Numerous restorative and also organic properties of α-bisabolol have been reported for the avoidance of oxidative tension, inflammatory illness, infections, neurodegenerative diseases, cancer cells, as well as metabolic disorders. In this testimonial, we examine brand-new searchings for on the molecular mechanism of α-bisabolol published in PubMed, Science Direct, as well as Scopus from 2010 to 2021. The antioxidant device of α-bisabolol is mostly related to the reduction of ROS/RNS, MDA and GSH intake, MPO activity, and the boost of turf and pet cat. In addition, up-regulation of bcl-2 expression as well as inhibition of bax, p53, APAF-1, caspase-3, and also caspase-9 tasks recommend the anti-apoptotic effect of α-bisabolol. It has anti-inflammatory results by minimizing TNF-α, IL-1β, IL-6, iNOS and also COX-2, and inhibits the activation of ERK1/2, JNK, NF-κB and also p38. Anti-bacterial effect is moderated by preventing viability of infected cells and improves cognitive feature by down-regulating bax, cleaved caspase-3 as well as 9 levels, beta-secretase, cholinesterase activity and also up-regulating bcl-2 levels. Lastly, due to its diverse biological activities, alpha-bisabolol is entitled to medical tests to gain brand-new understandings into its advantageous results on human health. Anti-bacterial effect is moderated by preventing viability of infected cells and boosts cognitive function by down-regulating bax, cleaved caspase-3 as well as 9 degrees, beta-secretase, cholinesterase task as well as up-regulating bcl-2 degrees. Finally, as a result of its varied organic activities, alpha-bisabolol should have scientific trials to get new understandings right into its beneficial effects on human health. Anti-bacterial result is mediated by preventing stability of contaminated cells and enhances cognitive feature by down-regulating bax, cleaved caspase-3 and also 9 levels, beta-secretase, cholinesterase activity and up-regulating bcl-2 levels. Lastly, as a result of its varied biological activities, alpha-bisabolol is entitled to professional tests to get new understandings right into its helpful effects on human wellness.

Renal Protective Effect of α-Bisabolol on Acute Kidney Injury in Mice

Cisplatin (CP) treatment has actually long been connected with the growth of extreme kidney injury (AKI) with gadgets involving swelling in addition to oxidative stress and anxiety. Alpha-bisabolol (BIS), a sesquiterpene alcohol divided from the essential oils of different plants, consisting of chamomile, has lately acquired popularity due to its anti-oxidant, anti-inflammatory, and also anticancer residential properties. Because of that, we looked into the nephroprotective effect of BIS in a CP-induced AKI computer mouse version and likewise its concealed device of activity. BALB/c computer system mice were by mouth accomplished BIS at a dose of 25 mg/kg for 7 days. On day 7, they accomplished a single dose of CP at a dosage of 20 mg/kg intraperitoneally. BIS treatment continued for an added 3 days. Pet dogs were surrendered at the end of the experiment (day 11). Kidneys, plasma as well as likewise pee were collected, along with consequently, different physical, biochemical and histological specifications were examined. BIS has actually dramatically normalized adjustments in water consumption, urine output, member of the family kidney weights, urea as well as creatinine emphasis, as well as likewise CP treatment-induced modifications in creatinine clearance. BIS significantly undermined the effects of CP-induced kidney injury by reducing kidney injury bit 1, neutrophil gelatinase-associated lipocalin, adiponectin, as well as also cystatin C. Also, renal focus of pro-inflammatory cytokines, growth death aspect alpha, interleukin (IL)-6 as well as likewise IL-1β, which rose in the CP team, were substantially decreased in computer mice treated with BIS in addition to CP. Comparable significant reductions were observed in CP-induced increases in oxidative anxiety and anxiousness pens, in addition to in the metabolite pteridine. Additionally, BIS considerably decreased CP-induced kidney DNA damage as well as likewise dramatically attenuated severe tubular death observed in kidney histology. Furthermore, BIS considerably minimized CP-induced rise in phosphorylated nuclear aspect κB (NFκB) in kidneys. These details extremely recommend that BIS exerts a safety effect versus CP-induced nephrotoxicity by lowering inflammation and also oxidative anxiety by preventing NFκB activation. No recognizable damaging feedbacks were discovered in BIS treatment. Extra research studies should be accomplished to think about BIS as a reliable CP nephroprotectant. BIS considerably decreased CP-induced rise in phosphorylated nuclear facet κB (NFκB) in the kidney. These data strongly suggest that BIS puts in a security impact versus CP-induced nephrotoxicity by decreasing swelling as well as oxidative anxiety and anxiousness by hindering NFκB activation. No noticeable undesirable responses were found in BIS therapy. Included looks into need to be performed to consider BIS as an effective CP nephroprotectant. BIS substantially decreased CP-induced boost in phosphorylated nuclear component κB (NFκB) in the kidney. These information strongly suggest that BIS applies a protective outcome versus CP-induced nephrotoxicity by reducing swelling along with oxidative stress as well as stress and anxiety by hindering NFκB activation. No visible unfavorable responses were discovered in BIS treatment. Additional research studies must be carried out to think about BIS as a reliable CP nephroprotectant.

About Products:
If you need Bisabolol, a cosmetic raw material, please contact our service staff directly, we will provide you with high-quality products at the best price.
As an experienced Bisabolol manufacturer and supplier, ZSpharmac will provide Bisabolol raw materials to customers all over the world for a long time.
Over the years, the company has been adhering to the spirit of “integrity management, strict quality control, and customer first”, and has won unanimous praise from domestic and foreign customers.

Company Profile and Corporate Culture

Company Profile：

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture：

OUR MISSION
Help China Chemicals to benefit the happiness of human life
OUR VISSION
Become the most trusted chemical supplier in the world
OUR BUSINESS PHILOSOPHY
Striver – oriented, enrich employees, customer first, deep service, seek development
OUR VALUES
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info

Business Type: Manufacturer
Product Range: Cosmetic raw materials
Products/Service:Cosmetic raw materials (flavors and fragrances,antioxidant products, moisturizing and hydrating, whitening agents, cosmetic additives)
Total Employees: 51~100
Capital (Million US $): 10000000RMB
Year Established: 2016

Production Capacity

No. of Production Lines : 8
No. of QC Staff : 5 -10 People
OEM Services Provided : yes
Factory Size (Sq.meters) : 3,000-5,000 square meters
Certificate: ISO9001 , CE , GMP , API , MSDS
Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.

Service

Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.

After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.

FAQ

Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.

HOW TO CONFIRM THE PRODUCT QUALITY BEFORE PLACING ORDERS?

You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

Is there a discount?

Different quantity has different discount.

Shipping

1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.