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Alpha-Arbutin CAS 84380-01-8

Molecular Formula: C12H16O7

Formula Weight: 272.25

ZSpharmac: Alpha-Arbutin Supplier

Product Name: Alpha-Arbutin
CAS No: 84380-01-8
Purity: 99%

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Basic Info

Product Name:Alpha-Arbutin
Other Names:Arbutin
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:White Powder
EINECS No.:209-795-0
Provide:Alpha-Arbutin MSDS;
Alpha-Arbutin COA

What is Alpha-Arbutin?

Alpha-Arbutin is a hydroquinone glycoside substance, the chemical name is 4-Hydroquinone-alpha-D-glucopyranoside (4-Hydroquinone-alpha-D-glucopyranoside), which exists in bearberry, bilberry as well as also numerous other plants. A developing non-irritating, non-allergic, as well as extremely appropriate natural bleaching active compound. There are 2 building in addition to practical teams in the molecular framework of Alpha-Arbutin: one is a sugar deposit; the numerous other is a phenolic hydroxyl group. The physical state of α-arbutin is white to light grey powder, which is conveniently soluble in water along with ethanol.

Alpha-Arbutin Property

Melting point 195-196°C
Boiling point 561.6±50.0 °C(Predicted)
density 1.556±0.06 g/cm3(Predicted)
storage temp. 2-8°C
solubility DMSO (Slightly), Methanol (Slightly)
form Solid
color White to Off-White


Alpha-Arbutin Efficacy and Role

1. Whitening and depigmentation
Tyrosine is the raw product for the formation of melanin, and tyrosinase is the main rate-limiting enzyme for the conversion of tyrosine to melanin, as well as its task determines the quantity of melanin developed. That is, the higher the task of tyrosinase in the body and the extra material, the less complicated it is to create melanin.

Alpha-Arbutin can competitively and also reversibly inhibit tyrosinase, thereby hindering the production of melanin, and accomplishing the effects of whitening, brightening as well as freckle elimination!

2. Sun block
Alpha-Arbutin additionally has the impact of absorbing ultraviolet rays. Some researchers have made a special test on sunscreen items included with α-Arbutin and located that Alpha-Arbutin exhibits UV absorption capacity.

Furthermore, it has been confirmed by countless scientific experiments that α-arbutin likewise has specific curative impacts in regards to anti-inflammatory, antibacterial, and also anti-oxidation.

If you utilize skin care products with included Alpha-Arbutin, if the impact is not obvious, it has to be the problem of inadequate focus. The dose of Alpha-Arbutin ought to be 3%. If it is less than this quantity, the inhibitory impact on the catalytic task of tyrosinase in the skin will certainly be weak, and also the lightening result will certainly not be noticeable.

Since α-arbutin is really costly, the majority of merchants add concentrations listed below 1% in skin treatment products! The impact is normally negative!

How Alpha-Arbutin Works

Alpha-Arbutin is a bleaching ingredient of selection due to the fact that it is a by-product of hydroquinone, one of the most reliable lightening as well as place lightening actives readily available. But while hydroquinone is a champ for gradually fading dark areas, its safety is a little doubtful. Below’s the trouble: Hydroquinone can be hazardous to living cells and also can have side effects such as melasma (a blue-black discoloration of skin cells) as well as inflammation, it said. That’s why you can only use an ingredient for a couple of months each time, as well as why it’s completely banned in the EU as well as Japan.

But back to Alpha-Arbutin: “It functions by gradually releasing hydroquinone over time, preventing tyrosinase, the vital enzyme in the skin in charge of the production of melanin, or pigment,” explains. To put it simply, less tyrosinase implies less pigment, which means less staining and much less unwanted dark spots. In addition to its excellent bleaching abilities, Alpha-Arbutin additionally has antioxidant as well as anti-inflammatory properties, she adds.

Now, you must be assuming: If Alpha-Arbutin released hydroquinone, wouldn’t it have the very same side effects? One of the most concise solution is no. “Due to the fact that hydroquinone is launched slowly, the skin is not subjected to excessive at any type of one time, minimizing the capacity for these adverse effects, so, commonly, arbutin is less poisonous than hydroquinone. Different, which is why you can utilize it constantly in your skincare routine without pausing.

Alpha-Arbutin Purification and Identification

The samples obtained by the reaction were first extracted with ethyl acetate, then extracted with n-butanol, evaporated to dryness by a rotary evaporator, and then centrifuged. HPLC chromatograms were compared to compare whether the sample and Alpha-Arbutin had the same retention time, and preliminarily deduced whether the sample contained α-Arbutin. The product after extraction and purification was identified by the positive ion mode of LC-ESI-MS/MS. By comparing the relative molecular mass of α-Arbutin product with that of Alpha-Arbutin standard, it can be determined whether the product is α-Arbutin.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

Help China Chemicals to benefit the happiness of human life
Become the most trusted chemical supplier in the world
Striver – oriented, enrich employees, customer first, deep service, seek development
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Cosmetic raw materials
  • Products/Service:Cosmetic raw materials (flavors and fragrances,antioxidant products, moisturizing and hydrating, whitening agents, cosmetic additives)
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.


After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.


Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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