Zhishang Chemical

Aloe Emodin CAS 481-72-1

Molecular Formula: C15H10O5

Formula Weight: 270.24

ZSpharmac: Aloe Emodin Supplement

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Product Name: Aloe Emodin
CAS No: 481-72-1
Purity: 99%

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Basic Info

Product Name:Aloe Emodin
Other Names:Aloe-Emodin 98%
CAS:481-72-1
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:Orange to Dark Orange Neat
EINECS No.:207-571-7
Storage:2-8°C
Provide:Aloe Emodin MSDS;
Aloe Emodin COA

What is Aloe Emodin?

Aloe Emodin is an anti-bacterial active ingredient of rhubarb. It is a chemical substance with orange needle-like crystals (toluene) or khaki crystalline powder. It can be drawn out from aloe vera because of its high activity, antitumor task, anti-bacterial activity and resistance. Inhibitory result and also purgative effect are normally extensively utilized in the fields of medicine as well as chemical sector, artificial additive as well as aesthetic raw materials, especially as a natural anti-tumor medication component, which can induce GDNA to create a G-quadruplex framework to a specific level or interact with it. G-quadruplex particularly binds.

Aloe Emodin Property

Melting point 223-224°C
Boiling point 373.35°C (rough estimate)
density 1.3280 (rough estimate)
refractive index 1.5000 (estimate)
storage temp. 2-8°C
solubility Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly, Heated)
pka6.30±0.20(Predicted)
form neat
color Orange to Dark Orange

 

The role of Aloe Emodin

  1. Antitumor Task
    In the last couple of years, scholars in your house as well as likewise abroad have desired the anti-tumor result of Aloe Emodin. The main anti-tumor activities are concentrated in neuroectodermal lumps, liver cancer cells, lung squamous cell cancer, skin Merkel cell cancer, gastric cancer cells, leukemia and also numerous other lumps, anti-tumor task A variety of cancers cells, Aloe Emodin has repressive effect on P388 leukemia cells along with expands survival. Amongst its devices of task is to inhibit the biosynthesis of DNA, RNA as well as healthy and balanced proteins in cancer cells.
  2. Antibacterial Activity.
    At a focus of 1.5-25mg/ ml, Aloe Emodin has repressive impacts on Staphylococcus, Streptococcus, Diphtheria, Bacillus subtilis, Anthrax, Paratyphoid Bacillus, Shigella, and so forth. Amongst them, Staphylococcus as well as Streptococcus are the most sensitive in addition to bacteriostatic. The dependable emphasis is 15-25ug/ ml. The anti-bacterial focus of Staphylococcus aureus 209P, Escherichia coli as well as additionally Shigella flexneri artificial insemination were 7.5 mg/L as well as additionally 600mg/L, respectively, as well as likewise their antibacterial effects were all bacteriostatic rather than antiseptic. Amongst its systems of task is to hinder electron transportation in the mitochondrial breathing chain. Aloe-emodin has a solid repressive effect on the nucleic acid and healthy protein synthesis of Staphylococcus aureus. Aloe-emodin has a solid inhibitory effect on common scientific anaerobic bacteria, which can hinder the development of 90% to 100% of the usual Bacillus fragilis, and also its MIC is a bit more than that of metronidazole. At the emphasis of 8μg/ ml, 76% to 91% of anaerobic bacteria can be avoided.
  3. Immunosuppression
    Aloe Emodin can hinder the production of organic antibodies, hinder the clearance of carbon bits, reduce the weight of immune body organs, minimize the variety of leukocyte, in addition to reduced the attribute of peritoneal macrophages. In vitro at 100μg/ ml emphasis, [3H] -TDR along with [3H] Urd were considerably hindered right into lymphocytes.
  4. laxative Outcome
    Aloe-emodin has strong laxative job, in addition to digestive tract microorganisms metabolize aloe-emodin, rhein, and rhein anthrone, and also the last has a strong laxative effect. Medically made use of as a laxative, it has the influence of improving food cravings in addition to laxative outcome of the big digestive tract. According to international clinical reports, aloe verain is hydrolyzed right into aloe-emodin under the activity of parasitic microbes in the body. This aloe-emodin promotes the peristalsis of the intestinal system wall surface area. At the same time, as a result of the change of osmotic anxiety, it contributes to the removal of wastes in the intestinal system, consequently accomplishing irritability. Laxative, this promoting laxative outcome has a special impact on uneven bowel movements as well as additionally piles. Specifically for middle-aged and likewise senior irregularity, the treatment influence is a lot more evident.

Preparation Process of Aloe Emodin

At present, aloe-emodin is mainly obtained by extracting the crude product of aloe vera juice dried at low temperature with ethyl acetate, and then eluting and refining by silica gel column chromatography (petroleum ether-ethyl acetate). However, the amount of aloe-emodin obtained by this method is small, the product purity is not high, and the processing technology is complicated, so it cannot be widely used in fields such as biomedicine and chemical industry.

A kind of preparation technology of aloe-emodin, is characterized in that:

Including step a) using aloe extract as raw material to obtain aloe-emodin crude product through hydrolysis and oxidation;

In step b), the crude aloe-emodin product is purified to obtain the aloe-emodin product.

Preferably, the step a) comprises dissolving the aloe vera extract, leaving the dissolving solution at rest, filtering to remove the filter residue, transferring the clear liquid obtained by filtration, carrying out oxidation treatment of the clear liquid, cooling and crystallization of the oxidized clear liquid and centrifuging, and the obtained precipitate is Aloe-emodin crude O

Preferably, the dissolving aloe extract is carried out in an enamel dissolving kettle or an enamel hydrolysis kettle, and the dissolving environment is a mixed solution with a molar ratio of water and hydrochloric acid of (10:1) to (1:10) as a solvent, and the dissolution temperature 30°C -50°C.

Preferably, the oxidation treatment is to add ferric chloride to the clear liquid for stirring, and the amount of ferric chloride added is 1.2-2 times the weight of the aloe extract.

Preferably, the use time of the standing dissolving solution is 1-10h.

Preferably, the step b) comprises heating and dissolving the crude aloe-emodin product, press-filtering the dissolving solution to obtain the filtrate to remove the filter residue, cooling the filtrate for crystallization, and centrifuging the precipitate to leave the mother liquor to obtain the wet product of aloe-emodin.

Further preferably, the step b) further includes repeating step b) for purification of the filter residue obtained by pressure filtration and the mother liquor left by centrifugation, and the repetition times are preferably more than 2 times.

Further preferably, the temperature of the described heating dissolving aloe-emodin crude product is 40 ℃-50 ℃, and the solvent is toluene, and the quality of toluene is 10-15 times of the aloe-emodin crude product.

Further preferably, the step b) also includes adding methanol to the wet product of the aloe-emodin obtained by centrifugation, centrifuging and drying to obtain the aloe-emodin product, pulverizing the aloe-emodin product after sieving and packaging; The filtrate can be recovered by multiple combined distillations.

Further preferably, the centrifugal rotation speed is 500r/min-1000r/min.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

OUR MISSION
Help China Chemicals to benefit the happiness of human life
OUR VISSION
Become the most trusted chemical supplier in the world
OUR BUSINESS PHILOSOPHY
Striver – oriented, enrich employees, customer first, deep service, seek development
OUR VALUES
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Additive , Chemical Auxiliary & Catalyst , Organic Chemicals
  • Products/Service: Organic Intermediate,Inorganic Chemistry, APIs, Dyestuffs And Pigments, Fragrance And Spices, Food Additives
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.

Service

Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.

 

After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.

FAQ

Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.

 

HOW TO CONFIRM THE PRODUCT QUALITY BEFORE PLACING ORDERS?

You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.

Shipping

1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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