Zhishang Chemical

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Zhishang Chemical

Allantoin Vivant CAS 97-59-6

Molecular Formula: C4H6N4O3

Formula Weight: 158.12

ZSpharmac: Allantoin Vivant Supplement

Product Name: Allantoin Vivant
CAS No: 97-59-6
Purity: 99%

Basic Info

Product Name:Allantoin Vivant
Other Names:Allantoin
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Plant Extracts
Appearance:White Powder
EINECS No.:202-592-8
Provide:Allantoin Vivant MSDS;
Allantoin Vivant COA

What is Allantoin Vivant?

Allantoin Vivant (Allantoin) is an imidazole heterocyclic compound, a by-product of uric acid, and is an all-natural component of human skin. As an antioxidant, uric acid creates Allantoin Vivant after the activity of free radicals. In 1912, Mocllster removed Allantoin Vivant from the underground stems of comfrey plants. Allantoin Vivant promotes cell cells development, metabolic rate, as well as softens stratum corneum healthy proteins. These homes are particularly noticeable when Allantoin Vivant is related to ulcerated and purulent skin, so it has the capacity to speed up wound healing and also is a superb active agent for skin damages. Allantoin Vivant was once called an anti-irritant, which can effectively reduce the excitement of irritants; at the same time, it is additionally an anti-oxidant. Like some other water-soluble vitamins, its ability to collect totally free radicals resembles that of vitamin C, so it can boost the cell’s Antioxidant ability. For that reason, the United States Fda (FDA) has provided it as the very first type of high-efficiency energetic component skin treatment agent, which is non-toxic, non-irritating, and non-allergic.

Allantoin Vivant Properties:

Melting point 230 °C (dec.) (lit.)
Boiling point 283.17°C (rough estimate)
density 1.6031 (rough estimate)
refractive index 1.8500 (estimate)
Fp 230-234°C
storage temp. 2-8°C
solubility H2O: soluble0.1g/10 mL, clear, colorless
form Powder
pka8.96(at 25℃)
color White
Water Solubility Slightly soluble in water. Freely soluble in alkalis


Allantoin Vivant Uses

  1. Allantoin Vivant is used in skin care, oral products, anti-allergy, treatment of skin ulcers and promotion of wound healing.
  2. Allantoin Vivant is widely used in the treatment of various skin ulcers, wounds and additives for nutritional cosmetics.
  3. Allantoin Vivant as a potent biomarker for oxidative stress; for the synthesis of Mannich bases as antibacterial agents; for the synthesis of sulfochlorophenylurea analogs as antineoplastic agents; as plant growth regulators.
  4. Allantoin Vivant has amphoteric properties and can form metal salts and adducts with many substances and maintain the original properties. Its saturated aqueous solution (0.6%) is slightly acidic (pH=6), stable in an aqueous solution of pH=4~9, and decomposes in alkaline solution and when it is boiled for a long time. The pH of the saturated aqueous solution was 5.5.
  5. Purine metabolites of Allantoin Vivant via the uric acid pathway. Uric acid can also react with free radicals to form allantoin, so allantoin can be a useful biomarker of oxidative stress.

Allantoin Vivant Production Method

Allantoin Vivant exists in cystic liquid, fetal urine as well as some plants. However the expense of drawing out capsules from these substances is expensive. Currently, the methods of manufacturing Allantoin Vivant consist of: potassium permanganate oxidation urea acid technique; dichloroacetic acid as well as urea home heating to synthesize allantoin; glyoxylic acid and also urea direct condensation approach.
1. The procedure of using dichloroacetic acid and urea as resources is as follows: put salt methoxide option and also methanol right into the reaction storage tank, warm to 40-50 ° C, slowly include dichloroacetic acid dropwise, and reflux for 2 hrs after the enhancement.It was cooled to room temperature level, filtered, cleaned with methanol, and the filtrate was integrated and also washed with methanol service of salt dimethoxy. The remedy was reduced to dryness under lowered pressure, 2.8 parts of hydrochloric acid was added, heated up on a water bathroom as well as mixed right into a paste.After that heat up to 90 ° C, after that awesome to about 10 ° C, filter, add 0.25 parts of hydrochloric acid and urea to the little fluid, warm to dissolve, and also react at 80 ° C for 2 hours. Amazing and also crystallize, after that keep at 0 ° C for greater than 3 hours, centrifuge, clean with water, rotate dry, as well as completely dry to acquire a fine product. The unrefined product was recrystallized with 15 times of water to obtain allantoin. The complete return of p-dichloroacetic acid was 30.3%.
2. Operation example of straight condensation of glyoxylic acid as well as urea (glyoxylic acid is gotten by oxidation of glyoxal):.
( 1) Oxidation In a 500ml four-necked flask equipped with a mechanical mixing, a condenser, a thermometer as well as a going down channel, include 193g (1mol) of 30% glyoxal aqueous solution, and also add 135.5 g dropwise under mixing at a temperature level of 40 ± 2 ° C.( Chemicalbook 1mol) 45% nitric acid, remain to stir and also react at this temperature for 2-3h after the addition, until the reddish-brown oxidation no longer gets away, and also the reaction solution is turquoise as well as goes away. Change to a basic purification gadget, vapor about 125g of water at about 2.76 kPa as well as the exterior temperature level does not surpass 60 ℃, the focused option is maintained area temperature overnight, as well as the precipitated oxalic acid crystals (19g after drying, amounting to 0.21 mol), the focus is 39% ). Remain to stir the reaction at an internal temperature level of 40 ± 2 ° C for about 8 hrs, as well as the oxidation reaction is completed.
( 2) Condensation In a 500ml three-necked flask outfitted with a mechanical mixing, a condenser as well as a thermostat, add the above-mentioned 150g glyoxylic acid aqueous option, then include 170g (2.83 mol) urea and also 23.3 g concentrated hydrochloric acid, and also warmth to an interior temperature of 80 ° C under mixing. ° C. After around 15 minutes, the urea was dissolved, and the catalyst was a clear liquid. After about 30-45 minutes, the reactant showed up gloomy, and then the white precipitate slowly enhanced. Stir at an internal temperature of 80 ° C for 1 hr, quit heating and also cool down the reactant to space temperature. The white precipitate was gathered with a Buchner funnel and also precipitated with cold water for numerous times to acquire crude Allantoin Vivant. Recrystallize with 1000ml of distilled water. Get white great crystalline allantoin 60-63%, melting point 236 ℃ (disintegration). The return of Allantoin Vivant was 38-40% of concept based on glyoxal (103-108% by weight).

Allantoin Vivant Skincare Benefits

1 Hydrating: Allantoin Vivant functions as an emollient to rescue your skin from dry skin and also pain as well as maintain it hydrated.

2 Calms the skin: It is a superb soothing and also soothing component that can protect the skin.

3 Enhances skin healing: Aids calm hurt skin and also promote wound recovery, most effective for skin irritability and rashes.

4 Exfoliating: He can also help drop the outermost membrane or skin tissue layer from the inside out if medical quality peeling is wanted.

5 Hydration: It can break down the keratin, this procedure can enhance the water material of the cells, can battle the epidermal water loss (TEWL) in the dermis, and also make the skin look plump, hydrated as well as vibrant.

6 Boosts dull skin: Allantoin Vivant advertises cell spreading, a process that enables total skin makeover. If the item we’ve used prior to is stressing the skin, the skin’s reaction is to attempt to recover itself, yet it can not transform the cells over. Allantoin raises the price of skin cell turn over, making the skin look better and also even more glowing.

7 Smoothes the skin: Removes surface dead skin cells (stratum corneum), it likewise assists keep the skin smooth and soft.

8 Revitalizes cells: Although light, it can still be an efficient anti-aging ingredient. Allantoin Vivant promotes collagen synthesis and when it stimulates fibroblasts (cells responsible for generating collagen), it likewise advertises the synthesis of extracellular matrix, which is why it is an effective regenerative active ingredient.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

Help China Chemicals to benefit the happiness of human life
Become the most trusted chemical supplier in the world
Striver – oriented, enrich employees, customer first, deep service, seek development
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Additive , Chemical Auxiliary & Catalyst , Organic Chemicals
  • Products/Service: Organic Intermediate,Inorganic Chemistry, APIs, Dyestuffs And Pigments, Fragrance And Spices, Food Additives
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.


After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.


Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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