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Zhishang Chemical

Allantoin Powder CAS 97-59-6

Molecular Formula: C4H6N4O3

Formula Weight: 158.12

ZSpharmac: Allantoin Powder Cosmetic Raw Material Suppliers

Product Name: Allantoin Powder
CAS No: 97-59-6
Purity: 99%

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Basic Info

Product Name:Allantoin Powder
Other Names:Allantoin
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:White Powder
EINECS No.:202-592-8
Provide:Allantoin Powder MSDS;
Allantoin Powder COA

What is Allantoin Powder?

Allantoin is an imidazole heterocyclic compound, a by-product of uric acid, and a natural element of human skin. Uric acid works as an antioxidant and reacts with complimentary radicals to create allantoin. In 1912, Mocllster drawn out allantoin from the below ground stems of Boraginaceae plants. Allantoin can advertise cell tissue development, metabolism, and soften follicle healthy proteins. These properties are especially apparent when allantoin is related to ulcerous and purulent skin, so it has the ability to quicken injury healing and is a great energetic agent for dealing with skin damage.

Allantoin was once called a counter-irritant, which can properly minimize the irritation of irritants; it is also an antioxidant, like various other water-soluble vitamins, its capability to collect cost-free radicals is similar to that of vitamin C, so it can enhance cells antioxidant capacity. Consequently, the U.S. Fda (FDA) classifies it as an excellent high-efficiency energetic component skin care representative, which is non-toxic, non-irritating, and non-allergic.

Allantoin Powder Property

Melting point 230 °C (dec.) (lit.)
Boiling point 283.17°C (rough estimate)
density 1.6031 (rough estimate)
refractive index 1.8500 (estimate)
Fp 230-234°C
storage temp. 2-8°C
solubility H2O: soluble0.1g/10 mL, clear, colorless
form Powder
pka8.96(at 25℃)
color White
Odorodorless, tasteless
Water Solubility Slightly soluble in water. Freely soluble in alkalis


Application of Allantoin Powder

1. Made use of in medication
Allantoin Powder has physical functions such as marketing cell advancement, increasing injury recovery, softening keratin, and so on. It is a great healing agent and anti-ulcer representative for skin wounds. It can be made use of to relieve and deal with totally dry skin, flaky skin diseases, skin abscess, gastrointestinal system abscess and inflammation. It has fantastic results on osteomyelitis, diabetic issues, liver cirrhosis and acne.

2. Utilized in cosmetics
Because Allantoin Powder is an amphoteric compound that can include with a variety important to develop a complex salt, it has the impacts of securing from light, disinfecting and anti-bacterial, analgesic, and antioxidant. It can keep the skin hydrated, moisturized, and soft. It is an unique additive for cosmetics such as charm and hairdressing., generally made use of as active ingredients in imperfection cream, acne liquid, hair shampoo, soap, tooth paste, reducing cream, hair conditioner, astringent, anti-sweat and deodorant lotion, etc. Cosmetics included with allantoin have the features of guarding tissues, being hydrophilic, absorbing water, and stopping dampness from spreading out; hair creams, creams, and hair shampoos added with allantoin have a safety impact on the hair and can keep the hair from splitting and expanding continually. Hair; lipsticks and face creams included with allantoin can make the skin and lips soft, adaptable, and have a sensational gleam. Allantoin advertises cells development, cell metabolic rate, and softens cuticle healthy and balanced proteins.

3. Made use of in farming
Allantoin Powder is an exceptional plant advancement regulator that can increase plant advancement. It has a significant yield-increasing result on wheat, citrus, rice, veggies, soybeans, and so forth, and has fruit-fixing and early-ripening effects.

The Efficacy of Allantoin Powder in Cosmetics

1 Hydrating and fixing effect
Allantoin has a great emollient result, specifically for chapped and harsh skin, which can restore smoothness and dampness. It can also improve the water absorption ability of the outer layer of skin and hair, enhance the hydrophilicity of keratin molecules, and avoid damaged skin. The follicle is fixed and its all-natural water absorption capability is recovered.

2 Moisturizing effect
Allantoin not only advertises the water absorption capacity of the outer layer of skin and hair and decreases the evaporation of skin water, however additionally creates a lubricating movie on the skin surface area to seal in water, thus accomplishing the effect of moisturizing the skin.

3 Softening cutin effect
Allantoin has one-of-a-kind keratin-lysing residential or commercial properties, so it has the effect of softening keratin. It peels metabolic waste keratin and fills the intercellular areas with water, making the skin moist and glossy.

4 Anti-inflammatory and antioxidant results
Because allantoin is an amphoteric compound, it can incorporate with numerous materials to form an intricate salt, which has the features of securing versus light, decontaminating and antibacterial, analgesic, and antioxidant. It is commonly used as blemish cream, acne fluid, shampoo, soap, toothpaste, shaving lotion, etc. Used as ingredients in hair conditioners, astringents, anti-perspirant and deodorant creams, etc.

Allantoin Powder Production Method

Allantoin Powder is uncovered in vesicular liquid, fetal urine and some plants. Nevertheless doing away with sores from these substances is also expensive. The existing techniques for generating allantoin consist of: potassium permanganate oxidation of urea acid technique: home heating dichloroacetic acid and urea to manufacture allantoin; right condensation approach of glyoxylic acid and urea. 1. The treatment using dichloroacetic acid and urea as basic materials is as comply with: Put salt methoxide choice and methanol right into the reaction tank, relaxing to 40-50 ° C, gradually add dichloroacetic acid dropwise, and afterwards reflux for 2 hours after the addition. Terrific to location temperature, filter, neat with methanol, integrate the filtrate and add salt dimethoxylate methanol choice. The option was reduced to entirely dry skin under lowered pressure, included 2.8 parts of hydrochloric acid, warmed up on a water restroom and mixed right into a paste. After that raise the temperature to 90 ° C, after that awesome to around 10 ° C, filter, consist of 0.25 parts of hydrochloric acid and urea to the little liquid, warm to liquify, and react at 80 ° C for 2 hours. Outstanding and materialize, later on maintain it at 0 ° C for higher than 3 hours, centrifuge, clean with water, rotate dry, and dry to get a great thing. The crude thing is recrystallized with 15 times of water to get allantoin. The total return of dichloroacetic acid is 30.3%. 2. Straight condensation of glyoxylic acid and urea (glyoxylic acid is managed oxidation of glyoxal) Procedure circumstances: (1) Oxidation in a 500ml four-neck container gotten ready with mechanical mixing, condenser, thermostat and going down network, Include 193g (1mol) 30% glyoxal liquid treatment, and include 135.5 g (1mol) 45% nitric acid dropwise with mixing while handling the inner temperature level to 40 ± 2 ° C. After the enhancement, continue the stirring feedback at this temperature degree for 2-3 hours up until the red-brown oxidation stops. Retreat, the response treatment adjustments blue-green and vanishes. Adjustment to a basic filtration gadget, simplify out concerning 125g of water at pertaining to 2.76 kPa and the outside temperature level does not surpass 60 ° C. The concentrated remedy is enabled to stand at room temperature level over evening. The precipitated oxalic acid crystals (19g after drying, totaling up to 0.21 mol) have an emphasis of 39%. ). Remain to mix and react at an internal temperature level degree of 40 ± 2 ° C for worrying 8 hours, and the oxidation reaction will most definitely be ended up. (2) Condensation In a 500ml three-necked flask furnished with a mechanical stirrer, condenser and thermostat, include the above 150g glyoxylic acid liquid remedy, then include 170g (2.83 mol) urea and 23.3 g concentrated hydrochloric acid, and warm with mixing up till the internal temperature degree gets to 80 ℃. After around 15 mins, the urea liquifies and the catalyst ends up being a clear liquid. After concerning 30-45 minutes, the catalyst comes to be white and turbid, and later on the white precipitate progressively elevates. Stir for 1 hour at an inner temperature degree of 80 ° C. Quit home heating and cool down the driver to area temperature degree. Make use of a Buchner channel to build up the white precipitate and accelerate with cold water a variety of times to get raw allantoin. Recrystallize with 1000ml pure water. 60-63% of white great crystalline allantoin is obtained, with a melting point of 236 ° C (deterioration). Based upon glyoxal, the allantoin yield is 38-40% of the principle (weight yield is 103-108%).

About Products:
If you need the cosmetic raw material Allantoin Powder, please contact our service staff directly, we will provide you with high-quality products at the best price.
As an experienced Allantoin Powder manufacturer and supplier, ZSpharmac will provide Allantoin Powder raw materials to customers around the world for a long time.
Over the years, the company has adhered to the spirit of “integrity management, strict quality control, and customer first” and has won unanimous praise from customers at home and abroad.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

Help China Chemicals to benefit the happiness of human life
Become the most trusted chemical supplier in the world
Striver – oriented, enrich employees, customer first, deep service, seek development
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Cosmetic raw materials
  • Products/Service:Cosmetic raw materials (flavors and fragrances,antioxidant products, moisturizing and hydrating, whitening agents, cosmetic additives)
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.


After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.


Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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