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All-Trans-Retinol CAS 68-26-8

Molecular Formula: C20H30O

Formula Weight: 286.45

ZSpharmac: All-Trans-Retinol Supplier

Product Name: All-Trans-Retinol
CAS No: 68-26-8
Purity: 99%

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Basic Info

Product Name:All-Trans-Retinol
Other Names:Retinol Palmitate
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:Yellow to Orange Crystalline
EINECS No.:200-683-7
Provide:All-Trans-Retinol MSDS;
All-Trans-Retinol COA

What is All-Trans-Retinol?

All-Trans-Retinol is a fat-soluble vitamin, which exists in animal foods in the form of cost-free aldehydes or esters, and is plentiful in fat, protein, milk, as well as liver. Plants do not include vitamin A, nevertheless include the precursor of vitamin A (provitaminA), which exists in veggies such as carrots as well as tomatoes, and likewise can be exchanged vitamin A after being absorbed by pets and pets. All-Trans-Retinol is required for the maintenance of human growth, growth, leisure as well as additionally the security of cell membrane layers, and plays a necessary role in the process of vision. Retinal is restored as well as eaten in the body as a result of consistent metabolic process, as well as calls for to be supplemented by oxidized vitamin A in time. Vitamin A is related to the typical framework as well as likewise attribute of the top as well as lower cells. When it wants, it will absolutely create dry skin, inflammation, as well as also loss of view of the conjunctiva in addition to cornea. Slow-moving and also extra. Vitamin A oil as a nutritional supplement is fatty oil or its concentrate gotten from the liver and likewise pylorus of marine pets. Squash the fresh fish liver as well as pylorus, include 1-2% salt hydroxide solution to pH8-9. Retinol can be made use of in sausage, margarine, bread, milk things, fruit juice powder, peanut butter, and so on.

All-Trans-Retinol Property

Melting point 61-63 °C(lit.)
Boiling point 368.81°C (rough estimate)
density 0.9933 (rough estimate)
refractive index 1.641
Fp -26 °C
storage temp. -20°C
solubility Chloroform (Slightly), Methanol (Slightly)
form crystalline
color yellow to orange
Water Solubility Practically insoluble inwaterorglycerol; soluble in absolute alcohol,methanol,℃hloroform, ether, fats and oils.


All-Trans-Retinol Uses

  1. All-Trans-Retinol is made use of in pharmaceutical tablets and also pills, and also in the feed industry as a vitamin-like feed additive.
  2. All-Trans-Retinol belongs of photosensitive substances in aesthetic cells, which can guarantee the honesty as well as wellness of epithelial tissue framework and also promote the growth and also growth of the body. When it is lacking, growth as well as growth will be impeded, reproductive feature will certainly decline, and also “evening blindness” will easily take place. Generally, retinyl acetate [127-47-9] is added to the feed.
  3. All-Trans-Retinol is a fat-soluble vitamin, which exists in animal foods in the form of cost-free aldehydes or esters, in addition to is plentiful in fat, healthy protein, milk, as well as liver. Plants do not consist of vitamin A, nonetheless have the precursor of vitamin A (provitaminA), which exists in veggies such as carrots and also tomatoes, as well as can be exchanged vitamin A after being absorbed by animals and pets. Vitamin A is required to protect human growth, development, leisure and also the security of cell membrane layers, and also plays an important feature in the aesthetic procedure.

All-Trans-Retinol Production Method and Physiological effect

Production Method :

Natural item
All-natural vitamin A is removed from cod liver oil. Amongst them, retinol (vitamin A1) is removed from the liver of marine fish, as well as 3-dehydroretinol, particularly vitamin A2, is removed from the liver of freshwater fish.

There are lots of man-made synthesis paths of All-Trans-Retinol and its derivatives, the usual one is the Isler route, namely C13-C14-C20.

Citral as well as acetone undergo aldol condensation under alkaline problems to acquire pseudo-ionone, which is cyclized under the activity of sulfuric acid to end up being ionone, in which β-ionone is the C13 referred to in the path. C13 is compressed by Darzens to obtain glycidyl ester, and afterwards hydrolyzed, decarboxylated as well as repositioned to get C14 aldehyde. Then condense with the Grignard reagent prepared by C6 alcohol to obtain C20, which is the primary chain of All-Trans-Retinol. After a collection of reformations, retinol is lastly gotten.

Physiological effect :

Function in the human body: Contain photosensitive materials in visual cells: all-trans retinal can be catalyzed by retinal isomerase into 4-cis-retinal, and 4-cis-retinal can be combined with opsin End up being rhodopsin (rhodopsin). When rhodopsin experiences light, the 4-cis-retinal in it ends up being all-trans retinal, as a result of the conformational change, it promotes the optic nerve and also activates vision. The rhodopsin after exposure to light is unsteady, as well as it is swiftly decayed into opsin and also all-trans retinal, and also the entire cycle process is restarted.

Preserve the honesty and also integrity of the epithelial framework: All-Trans-Retinol as well as retinoic acid can control genetics expression, compromise the distinction of epithelial cells right into squamous cells, as well as increase the number of epithelial growth element receptors.

Promote development as well as advancement: This is likewise related to the law of genetics by retinol, as well as retinol has the result equivalent to steroid hormonal agents, which can advertise the synthesis of glycoproteins.

Preparation Method of All-Trans-Retinol

Retinal (retinal, retinalaldehyde, A aldehyde) is an intermediate in the process of converting All-Trans-Retinol into retinoic acid (A acid). Retinol is much more common. For example, it is the main ingredient in the popular Neutrogena Alcohol Night Cream. The conversion of retinal to retinoic acid is much more efficient. In the experiment, it was also found that A aldehyde is less irritating than A acid, and theoretically it will be more effective than A alcohol of the same concentration.

A supramolecular preparation of All-Trans-Retinol and derivatives thereof, characterized in that:

Composed of the following components by mass percentage: 3.00-25.0% retinol and its derivatives, 36.5-91.0% hydroxypropyl γ-cyclodextrin, 4.00-32.0% hydroxypropyl methylcellulose stearyl ether , 2.00-8.0% PEG/PPG/Polybutylene Glycol-8/5/3 Glycerin, of which PEG/PPG/Polybutylene Glycol-8/5/3 Glycerin and Hydroxypropyl Methyl Cellulose Stearyl Ether The mass ratio is 1:2-4; the retinol and its derivatives are retinol, retinyl propionate, retinyl retinoate, retinyl linoleate, retinol Acetate, retinyl palmitate, retinal, hydroxypinacolone retinoate or a mixture thereof in any ratio.

All-Trans-Retinol Identification Test

Take 0.5g of the sample, grind it in a mortar, add 10ml of warm water, stir well to form an opacity, add 10ml of ethanol to break the emulsification, transfer it to a flask, add 20ml of benzene, shake it well and let it stand still, or Separated into two layers by centrifugation. Take the benzene layer, shake and wash it with 20ml of water, separate the water layer, and evaporate the benzene layer to dryness under reduced pressure. Dissolve the residue in chloroform to make about 10 IU of vitamin A per ml. Take 1 ml of it and add 5 ml of antimony trichloride test solution (TS-33). It should turn blue and fade immediately.

About Products:
If you need All-Trans-Retinol, a cosmetic raw material, please contact our service staff directly, and we will provide you with high-quality products at the best price.
As an experienced manufacturer and supplier of All-Trans-Retinol, ZSpharmac will provide All-Trans-Retinol raw materials for customers all over the world for a long time.
Over the years, the company has been adhering to the spirit of “integrity management, strict quality control, customer first”, and has won unanimous praise from domestic and foreign customers.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

Help China Chemicals to benefit the happiness of human life
Become the most trusted chemical supplier in the world
Striver – oriented, enrich employees, customer first, deep service, seek development
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Cosmetic raw materials
  • Products/Service:Cosmetic raw materials (flavors and fragrances,antioxidant products, moisturizing and hydrating, whitening agents, cosmetic additives)
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.


After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.


Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

Get All-Trans-Retinol Quotation