Zhishang Chemical

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Zhishang Chemical

All-Trans-Retinol CAS 68-26-8

Molecular Formula: C20H30O

Formula Weight: 286.45

ZSpharmac: All-Trans-Retinol Supplement

Product Name: All-Trans-Retinol
CAS No: 68-26-8
Purity: 99%

Basic Info

Product Name:All-Trans-Retinol
Other Names:Vitamin A
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Pharmaceutical Raw Materials
Appearance:Yellow to Orange Crystalline Liquid
EINECS No.:200-683-7
Provide:All-Trans-Retinol MSDS;
All-Trans-Retinol COA

What is All-Trans-Retinol?

All-Trans-Retinol is a fat-soluble vitamin, which exists in animal foods in the form of cost-free aldehydes or esters, as well as is abundant in fat, healthy protein, milk, as well as liver. After being soaked up by animals, it can be converted into vitamin A. All-Trans-Retinol is necessary for preserving the stability of human growth, advancement, recreation, and cell membrane layers, as well as plays an essential function in the visual procedure. Retinal is eaten in the body as a result of continuous metabolic rate, as well as requires to be supplemented by oxidized vitamin A in time.

Vitamin A is connected to the typical structure and also feature of the upper as well as reduced cells. When it is lacking, it will certainly lead to conjunctiva, completely dry cornea, swelling, and also blindness. It will certainly likewise create damages to the breathing epithelium, which is prone to respiratory infections, loss of hair, and also infant development. delay etc. As a dietary supplement, vitamin A oil is a fatty oil gotten from the liver as well as pylorus of marine animals or its concentrate. Crush the fresh fish liver and pylorus pendant, include 1-2% sodium hydroxide remedy to pH 8-9. Retinol can be made use of in sausage, margarine, bread, milk products, fruit juice powder, peanut butter, and so on.

All-Trans-Retinol Properties:

Melting point 61-63 °C(lit.)
Boiling point 368.81°C (rough estimate)
density 0.9933 (rough estimate)
refractive index 1.641
Fp -26 °C
storage temp. -20°C
form crystalline
color yellow to orange
Water Solubility Practically insoluble inwaterorglycerol; soluble in absolute alcohol,methanol,℃hloroform, ether, fats and oils.


All-Trans-Retinol Uses

  1. All-Trans-Retinol development as well as growth will certainly be obstructed, reproductive feature will decrease, as well as “evening blindness” will certainly be easily triggered. Normally, retinol acetate [127-47-9] is added to the feed.
  2. All-Trans-Retinol is used in pharmaceutical tablet computers and capsules and also as a vitamin-based feed additive in the feed sector.
  3. All-Trans-Retinol can be utilized in salad oil, sesame oil and also margarine in my nation, and also the dosage is 4.0-8.0 mg/kg; the maximum dosage in strong drinks is 4-8mg/ kg; in baby food as well as dairy items The dosage is 3.0-9.0 mg/kg; the optimum dose in gelato is 0.6-1.2 mg/kg; the dosage in milk as well as milk drinks is 0.6-1.0 mg/kg. Conversely, fortify with retinyl acetate, retinyl palmitate, or beta-carotene. When β-carotene is utilized to strengthen β-carotene beverages, the optimum use amount is 20-40 mg/kg; in strong drinks, the optimum use quantity is 3-5 mg/kg.
  4. All-Trans-Retinol is a fat-soluble vitamin, which exists in animal food in the form of cost-free aldehyde or ester, as well as is plentiful in fat, protein, milk, and liver. Plants do not contain vitamin A, however the precursor of vitamin A (provitamin A) exists in carrots, tomatoes as well as various other veggies. After being absorbed by pets, it can be exchanged vitamin A. Vitamin A is essential for maintaining the stability of human growth, development, reproduction, and also cell membrane layers, as well as plays an essential function in the aesthetic process.

Preparation Method of All-Trans-Retinol

All-Trans-Retinol (vitamin A) can be obtained from cod liver oil by molecular distillation and chromatography, but the method to obtain pure product is chemical synthesis. Usually, the Iserl route (ie the tetradecaldehyde route) is used, that is, the tetradecanol is obtained by first condensing p ionone with ethyl monochloroacetate in a sodium methoxide medium, hydrolyzing in sodium hydroxide and methanol, and decarboxylating. In addition, 3-methylpentyne (4) alkene (2) alcohol (1) is produced by the condensation of sodium acetylene and methyl ketene below 140 ℃; then Grignard reaction with ethyl magnesium bromide is carried out to produce double bromide magnesium compound ; Then condensed with tetradecanoic aldehyde, hydrolyzed to obtain hydroxydehydrovitamin A; then through catalytic hydrogenation to obtain hydroxyvitamin A, in pyridine with acetyl chloride to obtain hydroxyvitamin acetate, and then under alkaline (soda ash) conditions bromine Debromination and debromination to obtain vitamin acetate.

The Role and Function of All-Trans-Retinol

Help with vision loss
All-Trans-Retinol has many important functions in the human body. It plays an important protective role on the retina, and has a stabilizing effect on various cell membranes, thereby regulating the permeability of the retina. In vitamin A, retinal acts on vision. Once vitamin A is deficient, retinal will be reduced, and sufficient rhodopsin cannot be synthesized, and night blindness will occur naturally.
Timely supplementation of All-Trans-Retinol, our retina will be well protected. Office workers who often use computers should pay attention to protecting their eyesight. In addition to taking regular breaks and paying attention to vitamin A supplementation, it is also very important for the eyes to look far away and do eye exercises.
Respiratory disease timely remedy
All-Trans-Retinol can prevent respiratory diseases, and also has a good protective effect on the respiratory tract and gastrointestinal mucosa. Nutrition experts point out that vitamin A supplementation from food is a safe and effective way of health care. The changeable climate in spring will directly affect the defense function of the respiratory mucosa, so vitamin A supplementation is very beneficial to the body.
Effective against cancer
All-Trans-Retinol protects against cancer and cardiovascular disease. To prevent cancer, in addition to not smoking, not eating betel nut, not drinking too much alcohol, controlling the intake of salt and fat, but also avoiding the entry of carcinogens into the body, vitamin A supplementation can reduce the toxicity of carcinogens and inhibit the production of free radicals (active oxygen species). Regular intake of vitamin A with antioxidant effect, combined with healthy living habits, can effectively reduce the incidence of cancer. Biology believes that the best time to consume vitamin A is 6:00-10:00 am.
Improve memory
Fast-paced life, high-level work with brains, busy intersections, insufficient rest… Memory is imperceptibly damaged. Some data show that modern women generally suffer from memory loss, insomnia, irritability and other symptoms. Long-term exposure to computers, radiation damages their health. At this time, vitamin A can help you. Actors and musicians are most suitable for All-Trans-Retinolsupplementation. Reciting lines and musical scores requires a lot of mental effort, so sufficient vitamin A must be supplemented. Vitamin A has a very obvious refreshing effect, which can make people sane and clear, and it will be more and more favored by actors and musicians, becoming their darling.
Suffering from memory loss, you should supplement All-Trans-Retinol from now on!
PS: Among animal foods, the content of vitamin A in animal liver, egg yolk and milk is the most abundant. Plant foods contain the most carotene, in addition to carrots, there are alfalfa, spinach, pea shoots, peppers and fruits such as apricots, persimmons, mangoes, etc.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

Help China Chemicals to benefit the happiness of human life
Become the most trusted chemical supplier in the world
Striver – oriented, enrich employees, customer first, deep service, seek development
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Additive , Chemical Auxiliary & Catalyst , Organic Chemicals
  • Products/Service: Organic Intermediate,Inorganic Chemistry, APIs, Dyestuffs And Pigments, Fragrance And Spices, Food Additives
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.


After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.


Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

Get All-Trans-Retinol Quotation