Zhishang Chemical

Welcome to Zhishang Chemical      +86-176 5311 3209     Simon@sdzschem.com

Zhishang Chemical
Close this search box.

Aescin CAS 6805-41-0

Molecular Formula: C55H86O24

Formula Weight: 1131.26

ZSpharmac: Aescin Supplement

Product Name: Aescin
CAS No: 6805-41-0
Purity: 99%

Navigation Bar

Basic Info

Product Name:Aescin
Other Names:Escin
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:White Powder
EINECS No.:229-880-6
Provide:Aescin MSDS;
Aescin COA

What is Aescin?

Aescin, also known as aescin, is a general term for total saponins, β-escin or isoescin, etc. extracted from the seeds of Aesculus plants, belonging to triterpenoid saponins. The water solubility of aescin is poor, in order to increase its solubility, it is often made into sodium salt. Aescin contains many kinds of saponin compounds. According to the national standard of my country, they are named aescin A, aescin B, aescin C and aescin D in turn. They are isomers of each other (see Figure 1), and the aescin sodium currently used clinically is composed of aescin A, aescin B, aescin C, aescin D and other components of sodium salt mixture.

Aescin Properties:

Melting point 224.5°C
Boiling point 764.81°C (rough estimate)
density 1.1200 (rough estimate)
refractive index 1.6500 (estimate)
solubility Soluble in methanol.
form powder
color white


Aescin Uses

  1. Aescin has anti-tissue edema, lowers vascular permeability, avoids water build-up in tissues, as well as rapidly eliminates thickness and stress triggered by local edema. It can deal with stomach-cold pain, abdominal distention, jungle fever, dysentery.
  2. Aescin promotes the synthesis of collagen, repair work damaged skin, can properly moisturize and also is rich in flavonoids, has all-natural solid anti-aging and anti-wrinkle results, can improve the blood circulation of some eye skin, as well as can additionally get rid of cellulite. Eye circles and bags under the eyes have some impact.
  3. Aescin has anti-inflammatory, vasoconstrictive, and vasoprotective impacts.

Aescin Contents of the Invention

The purpose of the here and now innovation is to give a sort of exclusive prep work technique of aescin B with high pureness and high yield. The approach has reduced devices demands, reduced purification cost, low toxicity and much less environmental pollution, as well as appropriates for industrial manufacturing.

Aescin B prep work method given by the development comprises the adhering to steps:
1) with sorrel seed as resources, essence with ethanol, gather remove and concentrate;
2) the concentrated option acquired in step 1) is gotten used to pH 2 ~ 3, after that drawn out with water-saturated n-butanol, the organic layer is separated and concentrated;

3) adding the focused service obtained in step 2) right into the acetone/methyl tert-butyl ether combined solution of 2 ~ 5 times the volume, heating to reflux under mixing, then cooling and also crystallization and also drying out;

4) Dissolving the dried out crystal in hot water, after that cooling down and crystallization once again as well as drying out;
5) the strong after the additional formation is liquified in the organic solvent, after that in the natural solvent, the L-proline that makes up 10-20% of the strong weight after the second formation is included, after refluxing 10 ~ 60min Be cooled down to 40-50 ℃ once again, add a percentage of aescin B as crystal seed currently, continue mixing as well as be cooled to 0-20 ℃ of crystallization, up until the white crystal is no more separated out, suction filtering or centrifugation, the solid is dried, That is, aescin B is acquired.

Preferably, the ethanol in step (1) is an aqueous ethanol option with a mass concentration of 30-70%.

Ideally, in the acetone/methyl tertiary butyl ether mixed service in step (3 ), the volume proportion of acetone to methyl tertiary butyl ether is 2-8:1.

Ideally, the organic solvent symphonious (5) is an ethanol/n-hexane mixed solvent, and the volume ratio of the ethanol to n-hexane is 10-30:1.

Ideally, in step (3 ), the L-proline represent 15% of the strong weight after the secondary condensation.

The beneficial effects of the present creation are:
Targeting at the problems existing in the preparation of aescin B monomers, the present innovation offers a special method for preparing high-purity aescin B. The approach embraces the chiral amino acid-L-proline to induce recrystallization, and also can acquire aescin B with high pureness and high yield, avoiding the use of column chromatography, ion exchange material as well as other approaches, with basic procedure as well as equipment demands. Inexpensive, low purification cost, reduced poisoning, less environmental pollution, good practicability as well as appropriate for commercial production.

Compared to aescin, the aescin B given by the present invention has much better anti-inflammatory, anti-edema pharmacological activity and also reduced muscle mass as well as mucous membrane inflammation, and also can fundamentally resolve the existing homogeneity of aescin item quality. and safety and security concerns.

Aescin Specific Implementation

1) extraction: get 1kg of sorrel powder and extract twice, each time with 1L mass concentration be 70% ethanol aqueous solution, 45 ° C stirring and extracting 2h, filter, the filtrate of twice filtration is merged, under reduced pressure conditions Swirl to recover solvent and concentrate to 2L.

2) extraction: the concentrated solution obtained in step 1) was adjusted to pH 2 with 1 mol/L hydrochloric acid, extracted 3 times with 2L of water-saturated n-butanol, combined organic layers and concentrated to 400 mL;

3) Crystallization for the first time: the concentrated solution obtained in step 2) was added to 960mL of acetone and 240mL of methyl tert-butyl ether mixed solvent, heated to reflux under stirring, then cooled to 20 ° C to separate out white precipitate, filtered, 45 °C drying to obtain 49g of white crystals;

4) Crystallization for the second time: the 49g crystals obtained in step 3) were dissolved in 200mL of hot water at 100°C, stirred for 20min, then the solution was cooled to 0°C to separate out a white solid, suction filtered, and the solid was Dry under 45 ℃ of conditions, obtain β-escin 32g;

5) preparation of finished product of aescin: the 32g3-escin that obtained in step 4) was dissolved in 300mL of ethanol and 15mL of n-hexane mixed solvent, 4.8gL-proline was added to the above-mentioned system, and the system was heated to reflux for 30min. Be cooled to 50 DEG C, add 0.2g purity aescin B at this moment and reach 98% as crystal seed, continue stirring and be cooled to 20 DEG C, crystallize, until white crystal is no longer separated out, suction filtration, the solid is baked at 45 DEG C Dry to obtain 12.5 g of aescin B white crystals.

In the present embodiment, the purpose of step 1) is to extract and separate the total saponins of Aesculus chinensis from Salvia japonica, and this is the conventional technique of the extraction of total saponins from Salvia japonicas, and the extraction method can adopt the reflux, soaking, leakage etc. commonly used in this area method. Among them, the concentration of ethanol will have an important impact on the purity and yield of total escin, too low ethanol concentration will lead to insufficient product extraction, and too high ethanol concentration will lead to increased impurity content.

The purpose of the extraction in step 2) and the two crystallizations in steps 3) and 4) is to purify the extract to obtain high-purity β-escin. Among them, the purpose of adjusting the pH is to improve the stability and extraction efficiency of aescin, and if the pH is too high, the water solubility of aescin will increase, and the n-butanol extraction efficiency will decrease; if the pH is too low, the stability of aescin will be reduced. The ratio of acetone to methyl tert-butyl ether in step (3) can affect the precipitation rate and yield of aescin crystals.

The organic solvent in step 5) can also select any mixing of one or more of methanol, ethanol, isopropanol, acetone, tetrahydrofuran, methyl tert-butyl ether, n-hexane, n-heptane, etc. β-Aescin can be dissolved well, and at the same time, it can better precipitate aescin B13 in the induced recrystallization. The amount of L-proline directly affects the separation and precipitation of aescin B. In this example seven Leaf saponin B can not only selectively and smoothly precipitate crystals, but also the yield and purity are relatively high, and the crystal morphology is good.

Adopt high performance liquid phase method to detect the aescin B in the product, and the specific conditions are: the chromatographic column is a C18 column, and the particle diameter is 5um; : 65, mobile phase PH=2.,5; detection wavelength is 220nm; flow rate is 1.0ml/min, injection volume is 10μ1;

The content of aescin B in the product is 99.7%, and the yield (the total amount of aescin B in the product accounts for the percentage of the total amount of aescin B in the feeding salvia seeds) is 61%.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

Help China Chemicals to benefit the happiness of human life
Become the most trusted chemical supplier in the world
Striver – oriented, enrich employees, customer first, deep service, seek development
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Additive , Chemical Auxiliary & Catalyst , Organic Chemicals
  • Products/Service: Organic Intermediate,Inorganic Chemistry, APIs, Dyestuffs And Pigments, Fragrance And Spices, Food Additives
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.


After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.


Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

Get Aescin Quotation