Zhishang Chemical

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Zhishang Chemical

Adenosine Acls CAS 58-61-7

Molecular Formula: C10H13N5O4

Formula Weight: 267.24

ZSpharmac: Adenosine Acls Supplier

Product Name: Adenosine Acls
CAS No: 58-61-7
Purity: 99%

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Basic Info

Product Name:Adenosine Acls
Other Names:Adenosine
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:White Crystalline Powder
EINECS No.:200-389-9
Provide:Adenosine Acls MSDS;
Adenosine Acls COA

What is Adenosine Acls?

Adenosine Acls (Nucleosid) is a class of glycosylamine molecules, consisting of nucleic acid bases plus Ribose or Deoxyribose. The bases include purine and pyrimidine. Purine Including guanine (Guanine) and adenine (Adenine), pyrimidine including cytosine (Cytosine), thymine (Thymine) and uracil (Uracil), ribose and nucleic acid base in the form of β-N glycosidic bond.

Adenosine Acls Property

Melting point 234-236 °C (lit.)
alpha D11 -61.7° (c = 0.706 in water); 9D -58.2° (c = 0.658 in water)
Boiling point 410.43°C (rough estimate)
density 1.3382 (rough estimate)
refractive index 1.7610 (estimate)
storage temp. 2-8°C
solubility Slightly soluble in water, soluble in hot water, practically insoluble in ethanol (96 per cent) and in methylene chloride. It dissolves in dilute mineral acids.
form Crystalline Powder
pka3.6, 12.4(at 25℃)
color White
optical activity[α]20/D 70±3°, c = 2% in 5% NaOH
Water Solubility Soluble in water, ammonium hydroxide and dimethyl sulfoxide. Insoluble in ethanol.


Adenosine Acls Uses

  1. Adenosine Acls is an antiarrhythmic medicine that transforms paroxysmal supraventricular tachycardia to sinus rhythm. For supraventricular arrhythmias connected with atrioventricular.
  2. Adenosine Acls is mostly utilized in the pharmaceutical market to produce adenosine arabinoside; adenosine triphosphate; coenzyme along with its collection of products such as cyclic adenosine monophosphate and various other primary raw materials.
  3. Adenosine Acls is used in the manufacture of ATP, vidarabine, coenzyme A, and more.
  4. Adenosine Acls is made use of for the therapy of angina pectoris, heart attack, coronary lack, arteriosclerosis, vital high blood pressure, cerebrovascular conditions, stroke sequelae, progressive muscular tissue mass degeneration, etc. It is contraindicated in people with atrioventricular block and acute myocardial infarction.
  5. Adenosine Acls is an endogenous natural chemical.
    In the pharmaceutical sector, it is mainly used to make arabinoside (Ara-AR); adenosine triphosphate (ATP); coenzyme A (COASH) and its collection of things such as cyclic adenosine monophosphate (CAMP) and also numerous other main basic materials.
  6. Adenosine Acls generates apoptosis in human leukemia HL-60 cells. It additionally has antiarrhythmic homes. A natural chemical that acts as the popular endogenous agonist by any means subtypes of adenosine A receptors.
  7. Adenosine Acls is a skin care ingredient that may have anti-aging, soothing, repairing and restorative properties.

Physiological Function of Adenosine Acls

Adenosine Acls is an active compound with nucleoside as well as purine as the basic structure. It is a nucleoside developed by adenine combined with D-ribose with β-glycosidic bond. It exists commonly in all sorts of cells. Nonetheless, cost-free can additionally be incorporated nucleosides. Adenosine phosphates like ATP are very important energy carriers in biochemical responses.
Adenosine Acls is a natural nucleotide, an intermediate product of body metabolic process, as well as one of the important active elements in the body. Its activity is attained by activating adenosine receptors (A receptors). In the atrium, sinoatrial node, as well as atrioventricular node, adenosine triggers G protein-coupled potassium networks by binding to A receptors, boosting K+ efflux, hyperpolarizing the cell membrane layer and minimizing autonomicity. It can additionally substantially raise the level of cGMP, prolong the ERP of the atrioventricular node and reduce the conduction, prevent the very early as well as late depolarization triggered by sympathetic nerve or isoproterenol and also play an antiarrhythmic effect. This product has actually not been classified in course I to IV antiarrhythmic drugs.
Adenosine Acls is an inhibitory neuromodulator in the central nervous system that signals a balance between the brain’s energy storage and energy needs. Under normal circumstances, the concentration of extracellular adenosine is maintained at 40-400 nmoL. During ischemia and hypoxia, both glucose and glycogen are rapidly decomposed to produce ATP in response to energy demand. ATP is then degraded, resulting in a sharp increase in the level of intracellular adenosine, which is released outside the cell to play its regulatory role. During the hypoxia recovery stage, endogenous adenosine acts as a precursor for ATP synthesis, which can be regenerated into ATP under the catalysis of adenosine kinase (AK) to prolong the survival time of cells.
Adenosine Acls has the effect of dilating coronary vessels and reducing myocardial contractility. It is clinically suitable for the treatment of angina pectoris, hypertension, cerebrovascular disorders, stroke sequelae, progressive muscular dystrophy, etc. Intravenous injection for the treatment of supraventricular tachycardia and 201Tl myocardial imaging.

Preparation of Adenosine Acls

(1) Preparation of D-adenosine production enzyme: The D-adenosine production enzyme was immobilized on the immobilized carrier, and adenosine kinase (EC2.7.1.20, Ark), adenylate kinase (EC2. 7.4.3, Adk) and polyphosphate-adenylate phosphotransferase (EC2.7.4.-, Pap) three enzymatic reactions can be synthesized;

(2) Immobilized D-adenosine production enzyme: using immobilized D-adenosine production enzyme, adenosine is catalyzed to prepare adenosine triphosphate reaction solution, and the carrier is collected by filtration to obtain immobilized D-adenosine nucleoside production enzymes;

(3) separation product: the above-mentioned immobilized D-adenosine production enzyme is directly separated in the reaction tank, and the separated reaction solution is recovered by filter bag immobilized D-adenosine production enzyme, and the permeate through the layer After the separated crystals were separated and dried, the D-adenosine dry product was obtained.

Biochemistry of Adenosine Acls

Adenosine, also known as Adenosine Acls, is a purine nucleoside that is ubiquitously distributed in nature and is a degradation product of AMP (adenosine 5′-monophosphate). Adenosine can induce apoptosis in human leukemia HL-50 cells and has antiarrhythmic properties. Adenosine is an endogenous neurotransmitter at the adenosine receptor, and its cardioprotective effect may be related to the activation of the A1 adenosine receptor, and the antiplatelet and anti-inflammatory effects of adenosine can be mediated through the A2 adenosine receptor. Adenosine is an activator of adenosine A2A-R and also adenosine A1-R. Adenosine works as a pro-inflammatory moderator in asthma as well as chronic obstructive pulmonary illness (COPD).

Adenosine Acls is a kind of nucleoside, which is made up of ribose (ribofuranose) as well as a part of adenine, linked by β-N9-glycosidic bond in the center. Adenosine plays critical duties in biochemistry, including energy transfer as adenosine triphosphate (ATP) or adenosine diphosphate (ADP), or signaling as cyclic adenosine monophosphate (cAMP). Adenosine is in addition a repressive neurotransmitter and may promote sleep.

About Products:
If you need Adenosine, a cosmetic raw material, please contact our service staff directly, we will provide you with high-quality products at the best price.
As an experienced Adenosine manufacturer and supplier, ZSpharmac will provide Adenosine raw materials to customers all over the world for a long time.
Over the years, the company has been adhering to the spirit of “integrity management, strict quality control, and customer first”, and has won unanimous praise from domestic and foreign customers.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

Help China Chemicals to benefit the happiness of human life
Become the most trusted chemical supplier in the world
Striver – oriented, enrich employees, customer first, deep service, seek development
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Cosmetic raw materials
  • Products/Service:Cosmetic raw materials (flavors and fragrances,antioxidant products, moisturizing and hydrating, whitening agents, cosmetic additives)
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.


After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.


Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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