Adenosine Acls is an active compound with nucleoside as well as purine as the basic structure. It is a nucleoside developed by adenine combined with D-ribose with β-glycosidic bond. It exists commonly in all sorts of cells. Nonetheless, cost-free can additionally be incorporated nucleosides. Adenosine phosphates like ATP are very important energy carriers in biochemical responses.
Adenosine Acls is a natural nucleotide, an intermediate product of body metabolic process, as well as one of the important active elements in the body. Its activity is attained by activating adenosine receptors (A receptors). In the atrium, sinoatrial node, as well as atrioventricular node, adenosine triggers G protein-coupled potassium networks by binding to A receptors, boosting K+ efflux, hyperpolarizing the cell membrane layer and minimizing autonomicity. It can additionally substantially raise the level of cGMP, prolong the ERP of the atrioventricular node and reduce the conduction, prevent the very early as well as late depolarization triggered by sympathetic nerve or isoproterenol and also play an antiarrhythmic effect. This product has actually not been classified in course I to IV antiarrhythmic drugs.
Adenosine Acls is an inhibitory neuromodulator in the central nervous system that signals a balance between the brain’s energy storage and energy needs. Under normal circumstances, the concentration of extracellular adenosine is maintained at 40-400 nmoL. During ischemia and hypoxia, both glucose and glycogen are rapidly decomposed to produce ATP in response to energy demand. ATP is then degraded, resulting in a sharp increase in the level of intracellular adenosine, which is released outside the cell to play its regulatory role. During the hypoxia recovery stage, endogenous adenosine acts as a precursor for ATP synthesis, which can be regenerated into ATP under the catalysis of adenosine kinase (AK) to prolong the survival time of cells.
Adenosine Acls has the effect of dilating coronary vessels and reducing myocardial contractility. It is clinically suitable for the treatment of angina pectoris, hypertension, cerebrovascular disorders, stroke sequelae, progressive muscular dystrophy, etc. Intravenous injection for the treatment of supraventricular tachycardia and 201Tl myocardial imaging.