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Adenine Nucleoside CAS 58-61-7

Molecular Formula: C10H13N5O4

Formula Weight: 267.24

ZSpharmac: Adenine Nucleoside Raw Material Supplier

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Product Name: Adenine Nucleoside
CAS No: 58-61-7
Purity: 99%

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Basic Info

Product Name:Adenine Nucleoside
Other Names:Adenosine
CAS:58-61-7
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:White Crystalline Powder
EINECS No.:200-389-9
Storage:2-8°C
Provide:Adenine Nucleoside MSDS;
Adenine Nucleoside COA

What is Adenine Nucleoside?

Adenosine is a purine nucleoside, a substance composed of N-9 of adenine and C-1 of D-ribose linked with a β-glycosidic bond. D-Adenine nucleoside (Nucleosid) is a type of glycosylamine particle, composed of nucleic acid bases plus ribose (Ribose) or deoxyribose (Deoxyribose). The bases include purine (Purine) and pyrimidine (Pyrimidine) 2 types, purines include guanine (Guanine) and adenine (Adenine), pyrimidines include cytosine (Cytosine), thymine (Thymine) and uracil (Uracil), ribose and nucleic acid bases are attached by β-N glycosidic bonds form make-up.

Adenine Nucleoside Property

Melting point 234-236 °C (lit.)
alpha D11 -61.7° (c = 0.706 in water); 9D -58.2° (c = 0.658 in water)
Boiling point 410.43°C (rough estimate)
density 1.3382 (rough estimate)
refractive index 1.7610 (estimate)
storage temp. 2-8°C
solubility Slightly soluble in water, soluble in hot water, practically insoluble in ethanol (96 per cent) and in methylene chloride. It dissolves in dilute mineral acids.
form Crystalline Powder
pka3.6, 12.4(at 25℃)
color White
optical activity[α]20/D 70±3°, c = 2% in 5% NaOH
Water Solubility Soluble in water, ammonium hydroxide and dimethyl sulfoxide. Insoluble in ethanol.

 

Adenine Nucleoside Uses

1. Offers us energy and sustains our metabolic process
ATP stores power within cells and introduces it as required, especially during exhausting physical activity. It is a considerable part of metabolic process, power degrees, and weight because of the fact that it assists change the food you eat into fuel that can be taken advantage of to power your muscle mass, body organs, and cells.

2. Promote heart wellness
What effect does Adenine Nucleoside carry the heart? In prescription type, it is offered intravenously to help correct irregular heartbeats, particularly a type called paroxysmal supraventricular tachycardia (PVST). It does this by slowing conduction time through the AV node (the electric “relay terminal” that regulates the heart beat) and interrupting reentrant courses.
Adenosine sits back vascular smooth muscle mass by minimizing calcium uptake and activating adenylyl cyclase in smooth muscular tissue cells. It somewhat lowers systolic, diastolic and indicate arterial blood stress and anxiety. It boosts blood flow in regular coronary arteries while safeguarding against the boost in tightened arteries.
Physicians furthermore utilize adenosine throughout “cardiovascular test” on risky people to assist identify heart blockages, embolism and various other associated problems. Adenosine is a medication that impacts the heart like exercise, so it is one of one of the most extensively used drug in this sort of assessment. It can aid expand blood vessels, much like workout, making dysfunction a great deal extra apparent.

3. Aids kick back and remainder
What is the function of Adenine Nucleoside in advertising and marketing relaxing rest? When it binds to A1 receptors in your mind, you really feel calmer and sleepier. Your muscles actually feel extra unwinded and your mind truly feels less alert. Adenosine can also bind to A2A receptors in the mind, interfering with the release of neurotransmitters that influence frame of mind, containing dopamine.
Adenosine bits are metabolized during rest at night. This helps you get up feeling rejuvenated. High Degrees Of High Levels Of Caffeine and Adenine Nucleoside are competitors, so it makes sense that adenosine makes you really feel a lot extra tired, while high degrees of caffeine makes you feel extra alert. High levels of caffeine does this by stopping adenosine from binding to particular receptors psychological.

4. Support skin health and wellness
What duty does ATP play in skin therapy? AMP can be instilled into muscle mass cells to maintain injury healing. It aids advertise healthy blood circulation, reduces swelling and fluid retention, and reduces symptoms and signs such as inflammation, inflammation, and abscess development.
AMP is taken advantage of medically to handle floor tiles. Some research study suggests adenosine could furthermore operate in reducing herpes signs and colds, yet extra research study is called for to verify this.

5. Enhance sports performance and recovery
ATP is used in supplement kind to sustain muscular tissue mass recovery and endurance, partly due to its impacts on promoting blood circulation and decreasing pain. Physician may additionally infuse adenosine right into muscular tissue mass to minimize swelling and treat issues such as tendonitis or bursitis.

6. Helps reduce cancer-related symptoms and signs
Intravenous ATP is used to help in reducing weight decrease in clients with sophisticated cancer cells as a result of the reality that it elevates cravings and food intake.

Adenine Nucleoside Physiological Functions

Adenosine is an energetic substance with nucleosides and purine as its standard framework. It is a nucleoside developed by combining adenine with D-ribose with a β-glycosidic bond. It is extensively present in all sorts of cells and is present in nucleic acids. Nevertheless, they can additionally be complimentary or combined nucleosides. Adenosine phosphates like ATP are essential energy carriers in biochemical responses.
Adenosine is a natural nucleotide, an intermediate product of body metabolic rate, and one of the vital active ingredients in the body. Its activity is achieved by turning on adenosine receptors (A receptors). In the room, sinoatrial node and atrioventricular node, adenosine turns on G protein-coupled potassium networks by binding to A receptors, boosting K+ outflow, hyperpolarizing the cell membrane and decreasing automaticity. It can also significantly increase cGMP levels, extend the ERP of the atrioventricular node and slow down conduction, prevent very early and late depolarization triggered by sympathetic nerves or isoproterenol, and put in anti-arrhythmic results. This product has not yet been identified right into Course I ~ IV Chemicalbook antiarrhythmic drugs.
Adenosine is a repressive neuromodulator in the main nervous system that supplies signals to achieve a balance between the mind’s energy shops and energy requirements. Under regular situations, the extracellular adenosine focus is preserved at 40 to 400 nmoL. When ischemia and hypoxia happen, glucose and glycogen are disintegrated at an increased price to produce ATP to satisfy energy demands. ATP is then deteriorated, causing a sharp rise in intracellular adenosine levels, and is launched outside the cell to exert its governing impact. Throughout the hypoxic recuperation stage, endogenous adenosine works as the precursor for ATP synthesis and can be regenerated into ATP under the catalysis of adenosine kinase (AK) to prolong the survival time of cells.
Adenosine dilates coronary arteries and lowers myocardial contractility. It is medically suitable for the treatment of angina pectoris, hypertension, cerebrovascular disorders, stroke sequelae, modern muscle degeneration, etc. Intravenous injection is utilized to treat supraventricular tachycardia and 201Tl myocardial imaging.

Adenine Nucleoside Preparation

(1) Prep work of D-adenine nucleoside production enzyme: Paralyze D-adenine nucleoside production enzyme on an incapacitated service provider, utilizing adenosine kinase (EC2.7.1.20, Ark), adenylate kinase (EC2. It can be synthesized by three chemical reactions: 7.4.3, Adk) and polyphosphate-adenylate phosphotransferase (EC2.7.4.-, Pap);.

( 2) Debilitated D-adenine nucleoside production enzyme: Use incapacitated D-adenine nucleoside production enzyme, militarize adenosine to prepare adenosine triphosphate response service, filter and gather the provider, and obtain debilitated D-adenine nucleoside manufacturing enzyme;.

( 3) Separation of items: The above-mentioned incapacitated D-adenine nucleoside manufacturing enzyme is straight separated in the reaction storage tank. The apart reaction liquid is recovered through the filter bag and the immobilized D-adenine nucleoside manufacturing enzyme is travelled through the fluid with the layer. After splitting up and drying out of the crystals, D-adenine nucleoside completely dry product is gotten.

About Products:
If you need the cosmetic raw material Adenine Nucleoside, please contact our service staff directly, we will provide you with high-quality products at the best price.
Our company, as an experienced Adenine Nucleoside manufacturer and supplier, ZSpharmac will provide Adenine Nucleoside raw materials to customers around the world for a long time.
Over the years, the company has adhered to the spirit of “integrity management, strict quality control, and customer first” and has won unanimous praise from customers at home and abroad.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

OUR MISSION
Help China Chemicals to benefit the happiness of human life
OUR VISSION
Become the most trusted chemical supplier in the world
OUR BUSINESS PHILOSOPHY
Striver – oriented, enrich employees, customer first, deep service, seek development
OUR VALUES
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Cosmetic raw materials
  • Products/Service:Cosmetic raw materials (flavors and fragrances,antioxidant products, moisturizing and hydrating, whitening agents, cosmetic additives)
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.

Service

Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.

 

After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.

FAQ

Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.

 

HOW TO CONFIRM THE PRODUCT QUALITY BEFORE PLACING ORDERS?

You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.

Shipping

1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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