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Zhishang Chemical

Acido Ribonucleico CAS 63231-63-0

Molecular Formula: N/A

Formula Weight: 0

ZSpharmac: Acido Ribonucleico Supplier

Product Name: Acido Ribonucleico
CAS No: 63231-63-0
Purity: 99%

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Basic Info

Product Name:Acido Ribonucleico
Other Names:Ribonucleic Acid
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:Off-White Lyophilized Powder
EINECS No.:277-256-7
Provide:Acido Ribonucleico MSDS;
Acido Ribonucleico COA

What is Acido Ribonucleico?

Acido Ribonucleico is a class of nucleic acid, named for its molecule containing ribose sugar, referred to as RNA. White powder. Has a strong absorption of ultraviolet rays. RNA exists in the cytoplasm and nucleus of all cells, and also exists in most known plant viruses, some animal viruses and some bacteriophages.

In 1869, when the Swiss chemist Mischel was studying the chemical properties of the cell nucleus, he made a chemical analysis of it and obtained an acidic organic compound, which was the three main substances in living organisms known at that time – sugar, fat and protein. A fourth substance other than At first he named this substance “nuclide”, and later it was detected that it was very acidic, so he changed its name to nucleic acid. At the beginning of the 20th century, German chemist Kossel hydrolyzed nucleic acid to find out that it is a natural polymer compound composed of phosphoric acid, bases (mainly adenine, guanine, cytosine and uracil) and five-carbon sugars. Later, Levin, a student of Kossel, further identified that there are two kinds of nucleic acids in cells, one is Acido Ribonucleico (the five-carbon sugar is ribose), and the other is deoxyribonucleic acid (the five-carbon sugar is deoxyribose).

Acido Ribonucleico Property

storage temp. 2-8°C
solubility H2O: 10 mg/mL, very faintly turbid, faintly yellow
form lyophilized powder
color Off-white to Pale Brown
Water Solubility It is soluble in water.


Acido Ribonucleico Uses

  1. Acido Ribonucleico is the fundamental compound of life and also exists in all biological cells. Ribonucleic acid as well as its degraded derivatives are extensively made use of in medicine, pesticides, feed and food (powerful umami), wellness and also appeal food, cosmetics, and so on.
  2. Acido Ribonucleico is used to treat pancreatic cancer cells, soft cells sarcoma, viral liver disease B and other illness.

Preparation of Acido Ribonucleico

1. Prepare the solution
(1) Extraction buffer (0.02M Tris-acetic acid buffer)
Add 2.42 grams of Tris to 900ml of purified water, adjust the pH to 5.0 with acetic acid, and dilute to 1000ml.

(2) Saturated phenol liquid
Melt phenol at 50°C, add an equal volume of extraction buffer, stir evenly to make a saturated phenol solution, and store in the dark.

(3) Precipitation buffer
3M sodium acetate solution, pH5.0

(4) Dissolving buffer
1M NaCl was dissolved in 0.05M Tris-HCl buffer, pH 9.5.

2. Extraction process
1. Raw material selection and pretreatment
Take 50 kg of calf pancreas (under 1.5 years old) and remove non-pancreatic tissues such as fascia, fat and connective tissue at about 25°C, clean it with purified water, and cut it into small pieces of 3-5 cm.

2. Destruction of tissues and cells
Grind the small piece of pancreas with a clean meat grinder, move the minced calf pancreas into a colloid mill, add an equal amount of extraction buffer, crush and grind at 200 μm for the first time, grind at 50 μm for the second time, and grind under vacuum The liquid should be easier to pass through the 200-mesh stainless steel mesh to obtain a homogenate of about 100kg.

3. Extraction of active ingredients
Add 1 times the volume of saturated phenolic liquid to the upper aqueous phase of the homogenate, add 0.5 times the volume of the lower layer phenolic phase of saturated phenolic liquid, heat to 60 ° C, keep the temperature for 120 minutes, cool rapidly, and centrifuge at 4 ~ 10 ° C (4000g, 30 minutes) , collect the supernatant, discard the precipitate (recovery of phenol).
Add 0.6 times volume of chloroform-isoamyl alcohol (volume ratio 24:1) to the supernatant, shake well for 15 minutes, centrifuge (4000g, 30 minutes) at 4-10°C, collect the supernatant of the upper layer, and discard the precipitate in the middle layer , recover the bottom chloroform layer.
Add 0.3 times the volume of chloroform-isoamyl alcohol (volume ratio 24:1) to the supernatant, shake well for 15 minutes, and centrifuge at 4000g at 4-10°C for 30 minutes), collect the supernatant containing Acido Ribonucleico, and discard the middle The layer was precipitated, and the bottom chloroform layer was recovered.
Add 1 volume of precipitation-promoting buffer to the supernatant, then add 2 volumes of ethanol (95%), shake well, place at 4°C overnight, centrifuge at 4-10°C (4000g, 30 minutes), collect the Acido Ribonucleico precipitate, the upper layer The supernatant liquid is ethanol, reclaims ethanol.
In order to further improve the purity of Acido Ribonucleico and reduce the impurity content, the Acido Ribonucleico precipitate was dissolved with a dissolution buffer, added ethanol to a final concentration of 75% (mass), and centrifuged (4000g, 30 minutes) at 4-10°C.
Repeatedly wash the precipitate twice with 75% ethanol, centrifuge at 4-10°C (4000g, 30 minutes), collect the ribonucleic acid precipitate, and place it in 50°C water until there is no alcohol smell (about 1 hour).
The extraction process of the above process can be completed within 16-18 hours, and the extraction rate of Acido Ribonucleico is 3.8g/kg pancreas, which greatly shortens the extraction time and increases the yield by 1-2 times compared with the existing Acido Ribonucleico extraction process. In the process of RNA extraction, there will always be a small amount of DNA impurities. Since DNA molecules are generally relatively large, it will indirectly cause allergic reactions when injected. Due to the improvement of ribonucleic acid extraction efficiency in the present invention, the RNA content in the Acido Ribonucleico product is about 99.7%, and the purity OD260/OD280>1.9, compared with the product extracted by the prior art (the RNA content is 95-96%), the product purity With great improvement, the content of deoxyribonucleic acid “contamination” is reduced, which can improve product safety; moreover, the batch yield in the extraction process is increased by about 30%, the batch scrap rate is reduced from 30% to zero, and the cost is reduced by about 70%.

A New Way Out For the Research of Acido Ribonucleico

In order to obtain the living Acido Ribonucleico structure, many scientists turned to dimethyl sulfate (DMS), a chemical that can penetrate into the cell, where it can bind to two of the four RNA nucleotides – adenocarcinamide. Purines and cytosines—reaction occurs, but only if the nucleotides are unpaired. The researchers then converted the RNA to DNA and sequenced it. The study found that any nucleotides that are changed under the action of DMS will prevent the conversion of RNA to DNA, so scientists can use the shortened fragments of DNA to distinguish unpaired nucleotides in advance.

Many scientists would like to see more Acido Ribonucleico folded in a cell, because they think the interacting proteins stabilize the RNA structure inside the cell. However, Weissman and team found the opposite. They now think that this phenomenon may be due to the fact that the messenger RNA in the cell is actively making the protein — and that the looser molecules are more readily available to the cell’s protein-synthesizing machinery.

However, the DMS method is also flawed in that it only reveals 2 nucleotides that can be paired. To obtain pairing information for each Acido Ribonucleico molecule in the cell, Chang and Spitale used a structure-probing technique called SHAPE. The technique, which allowed them to infer the structures of more than 19,000 RNA molecules in mouse embryonic stem cells, was published earlier this year. Common chemical modifications to the messenger Acido Ribonucleico could unlock the molecular’s structural features, the researchers say. They also detected unique structural “signatures” — features that predict where the protein binds to the RNA, thereby controlling the RNA’s shape.

Some researchers have already begun to adopt this technique. Assmann and Bevilacqua are using rice to probe the structure of RNA and plan to do the same with other important crops. They hope to find ways to manipulate the shape of Acido Ribonucleico to improve crop tolerance and yield.

At the same time, Rouskin is trying to study the Acido Ribonucleico in Drosophila to learn more about how these molecular structures affect embryonic development. “Now we finally have a research tool,” she said, “and we can finally ask questions that we couldn’t even imagine before.”

About Products:
If you need Acido Ribonucleico, the cosmetic raw material, please contact our service staff directly, we will provide you with high-quality products at the best price.
As an experienced Acido Ribonucleico manufacturer and supplier, ZSpharmac will provide Acido Ribonucleico raw materials for customers all over the world for a long time.
Over the years, the company has been adhering to the spirit of “integrity management, strict quality control, customer first”, and has won unanimous praise from domestic and foreign customers.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

Help China Chemicals to benefit the happiness of human life
Become the most trusted chemical supplier in the world
Striver – oriented, enrich employees, customer first, deep service, seek development
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Cosmetic raw materials
  • Products/Service:Cosmetic raw materials (flavors and fragrances,antioxidant products, moisturizing and hydrating, whitening agents, cosmetic additives)
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.


After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.


Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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