Zhishang Chemical

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Zhishang Chemical

Acido Adipico CAS 124-04-9

Molecular Formula: C6H10O4

Formula Weight: 146.14

ZSpharmac: Acido Adipico Supplier

Product Name: Acido Adipico
CAS No: 124-04-9
Purity: 99%

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Basic Info

Product Name:Acido Adipico
Other Names:Adipic Acid
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:White Solid
EINECS No.:204-673-3
Storage:Store Below +30°C.
Provide:Acido Adipico MSDS;
Acido Adipico COA

What is Acido Adipico?

Acido Adipico, additionally called fatty acid, is a carboxylic acid natural compound, which can be used as a chemical reagent, and likewise made use of in plastics and also natural synthesis. It is a white crystalline powder, somewhat soluble in water and also acidic when dissolved in water. As the basic system of numerous chemical products, Acido Adipico is the most crucial aliphatic dicarboxylic acid in industrial production until now. Additionally, Acido Adipico is additionally an artificial polyester, polyurethane, lube, plasticizer, adiponitrile, and also a gelling help for flavor in food.

Acido Adipico Property

Melting point 

151-154 °C(lit.)

Boiling point 

265 °C100 mm Hg(lit.)


1,36 g/cm3

vapor density 

5 (vs air)

vapor pressure 

1 mm Hg ( 159.5 °C)

refractive index 



385 °F

storage temp. 

Store below +30°C.


methanol: 0.1 g/mL, clear, colorless


4.43(at 25℃)






3.74(1 mM solution);3.22(10 mM solution);2.71(100 mM solution);

Water Solubility 

1.44 g/100 mL (15 ºC)



Acido Adipico Uses

  1. Acido Adipico is used as an intermediate in natural synthesis in the fields of lubes, plasticizers, wet strength resins, layers, adhesives, sealers and also elastomers, perfumes and also cosmetics. In addition, adipic acid is used in formulas in the field of pH adjusters and also barriers, and also as a lab chemical.
  2. Acido Adipico is primarily used as a basic material for nylon 66 and engineering plastics, and also is additionally used for the production of numerous ester items, as well as is likewise made use of as a basic material for polyurethane elastomers.
  3. Acido Adipico can be made use of in jelly powder and also strong beverage powder, the maximum dosage is 0.15 g/kg and 0.01 g/kg specifically.
  4. Acido Adipico is used as a raw material for nylon 66 as well as engineering plastics. Secondly, it is used in the manufacturing of numerous ester items, utilized as plasticizers and also advanced lubricants. Additionally, adipic acid is also used as a raw material for polyurethane elastomers, as an acidulant for different foods and drinks, and its result is occasionally much better than that of citric acid as well as tartaric acid. Adipic acid is likewise a basic material for medication, yeast purification, pesticides, adhesives, synthetic leather, synthetic dyes and also fragrances.

Preparation of Acido Adipico

Acido Adipico is generally synthesized by oxidation of a cyclohexanone/cyclohexanol mixture with nitric acid in the presence of an oxidation catalyst such as vanadium and copper.

The resulting Acido Adipico is purified and recovered by successive crystallization operations in which it is necessary, inter alia, to separate adipic acid from other dicarboxylic acids formed, such as glutaric and succinic acids.

Adipic acid obtained after crystallization is usually oblong and has an uneven surface.

Typically, Acido Adipico is stored in large tanks or containers and optionally transported to the point of application, for example to a polyamide manufacturer or a hexamethylenediamine adipate manufacturer.

Caking often occurs during storage and optionally transport. That is, several crystals stick together. This phenomenon is very harmful because the fluidity of adipic acid crystals is greatly reduced when feeding a plant such as a polymerization plant.

US 5,471,001 provides a specific method for crystallizing Acido Adipico using ultrasound. The resulting crystals exhibit better fluidity and are not prone to “caking” during storage and transportation.

One of the objects of the present invention is to provide a method that enables the preparation of adipic acid crystals exhibiting a specific shape and a specific surface condition, with the aim of obtaining a good Liquidity, and reduce “caking” phenomenon.

For this purpose, the present invention provides a method for the preparation of Acido Adipico crystals, comprising the following treatment of the crystals obtained after crystallization, the treatment steps comprising: dispersing said crystals in a liquid matrix, stirring said liquid matrix for a predetermined period of time, In order to obtain the desired shape and surface condition of the crystal, the processed crystal is then separated from the liquid matrix.

According to another characteristic of the invention, said liquid base is preferably water or a water/acetic acid mixture in various proportions.

The temperature conditions during processing, especially during agitation of the liquid matrix, are not critical.

However, it is preferred that the adipic acid has a low solubility in the liquid matrix in the selected temperature range, for example a solubility of less than 2 g/l at 20°C. The preferred temperature range of the present invention is 20°C-70°C, preferably 20°C-60°C.

Advantageously, in some cases, the temperature of the liquid matrix is lowered to below 20°C before the crystals separate from the liquid matrix.

Similarly, the stirring intensity should be sufficient to prevent excessive concentration gradients of Acido Adipico or other compounds in the matrix. However, the stirring intensity should not be too high, so as to avoid destroying the crystals.

According to a novel feature of the invention, the percentage by weight of Acido Adipico crystals in the liquid matrix is higher than 5% (ratio solid matter/solid matter+liquid matter), preferably 5-60% by weight.

The concentration of crystals can affect processing results. This is because the greater the number of crystals, the greater the smoothing effect on their surface. However, too high a concentration is detrimental to the method, since the smoothing effect may be too strong, which may cause mutual agglomeration of the crystals.

According to the invention, it is preferred that the Acido Adipico crystals for being dispersed exhibit an average particle size of from 100 μm to 1000 μm, advantageously from 200 to 700 μm.

If the average particle size after crystallization is too large, these crystals can be initially milled.

After being treated according to the method of the present invention, the average particle size of the crystals is about 50 μm-1000 μm.

However, the average particle diameter specifically indicated here is illustrated only by way of example, and only corresponds to a preferred range. It is also possible to apply the method of the present invention to crystals of lower or higher average particle size.

According to a preferred embodiment of the invention, the crystals are processed by putting the liquid matrix in motion. Putting the liquid base in motion may be agitation of the liquid base with one or more stirrers exhibiting the various forms of motion conventionally used in the field of stirring suspensions.

In order to improve the treatment effect, baffles can be placed in the reactor containing the liquid matrix.

The liquid substrate can also be set in motion by spinning the liquid substrate in a centrifuge-type apparatus.

Finally, the invention generally includes any apparatus and apparatus capable of moving liquids in a reactor or vessel. This is because plants or equipment other than those described above may be applied without departing from the scope of the present invention.

Production Method of Acido Adipico

One-step oxidation of cyclohexane
Using cyclohexane as raw material, acetic acid as solvent, cobalt as well as bromide as catalyst, in 2MP. Respond at 90 ° C for 10-13 hours. Return 75%.
2 Cyclohexane fractional oxidation technique
( 1) The prep work of KA oil can be directly oxidized with air at 1.0 ~ 2.5 MPa as well as 145 ~ 180 ℃, and also the return can get to 70%~ 75%. Metaboric acid can also be used as a stimulant, air oxidation at 1.0-2.0 MPa and 165 ° C, the yield can get to 90%, and also the proportion of alcohol and ketone is 10:1; the reactants can be treated with warm water to hydrolyze and stratify the ester, as well as the water Boronic acid is recouped from the layer, and metaboric acid is reused via dehydration; the natural layer is saponified with caustic soda to get rid of the acid, as well as the alcohol and ketone mix is obtained after purification and also recovery of cyclohexane.
( 2) Oxidation of KA oil Oxidize KA oil at 60-80 ° C and 0.1-0.4 MPa in a two-stage collection reactor with an unwanted of 50% to 60% nitric acid. The catalyst is copper-vanadium series (copper 0.1%-0.5%, vanadium 0.1%-0.2%), and the yield is 92%-96% of the theoretical value. After the nitric acid is evaporated from the catalyst, high-purity Acido Adipico can be obtained through 2 condensation improvements.

About Products:
If you need Acido Adipico, the cosmetic raw material, please contact our service staff directly, we will provide you with high-quality products at the best price.
As an experienced Acido Adipico manufacturer and supplier, ZSpharmac will provide Acido Adipico raw materials for customers all over the world for a long time.
Over the years, the company has been adhering to the spirit of “integrity management, strict quality control, customer first”, and has won unanimous praise from domestic and foreign customers.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

Help China Chemicals to benefit the happiness of human life
Become the most trusted chemical supplier in the world
Striver – oriented, enrich employees, customer first, deep service, seek development
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Cosmetic raw materials
  • Products/Service:Cosmetic raw materials (flavors and fragrances,antioxidant products, moisturizing and hydrating, whitening agents, cosmetic additives)
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.


After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.


Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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