Zhishang Chemical

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Zhishang Chemical

Acetyl Tetrapeptide CAS 820959-17-9

Molecular Formula: C20H28N8O7

Formula Weight: 492.49

ZSpharmac: Acetyl Tetrapeptide Supplement

Product Name: Acetyl Tetrapeptide
CAS No: 820959-17-9
Purity: 99%

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Basic Info

Product Name:Acetyl Tetrapeptide
Other Names:Acetyl Tetrapeptide-5
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:White Powder
EINECS No.:1312995-182-4
Provide:Acetyl Tetrapeptide MSDS;
Acetyl Tetrapeptide COA

What is Acetyl Tetrapeptide?

Acetyl Tetrapeptide It lowers the permeability of blood vessels, thus lowering the accumulation of dampness in the eyelid tissue. It can also hinder ACE (angiotensin-converting enzyme) activity, prevent angiotensin II, and also soothe blood vessel pressure, therefore enhancing eye bags and dark circles. Additionally, it inhibits glycation as well as lowers collagen cross-linking, consequently decreasing under-eye bags and also anti-wrinkle. For that reason, SpecPedAT5P can be suggested for usage in eye care items to reduce edema, boost eye bags and dark circles.

Acetyl Tetrapeptide Property

Boiling point 1237.3±65.0 °C(Predicted)
density 1.443
storage temp. 2-8°C


Acetyl Tetrapeptide Application

CN201510120523.4 provides a firming eye cream, which can promptly smooth the fine lines of the skin around the eyes as well as tighten the skin around the eyes. A firming eye cream is characterized because it is made up of the complying with components by weight: polysiloxane-11 5.0% -27.0%, cyclopolydimethylsiloxane 2% -10%, butanediol 1%- 6%, glycerin 1% -6%, dioctyl carbonate 1% -8%, trimethylsiloxysilicate 1.5-3%, phenyl trimethicone 0.5% -4%, poly Dimethicone 1.0% -2.0%, Cyclopentasiloxane 0.5% -1.0%, Arachidyl Glucoside 1.5% -3.0%, Glyceryl Stearate 0.5% -1.0%, PEG- 100 Stearate 0.5% -1.0%, Cetearyl Alcohol 0.5% -1.5%, Acetyl Tetrapeptide 0.5% -1.5%, Purslane Extract 0.05% -2.5%, Panthenol 0.1% -1.5%, Vitamins E 0.5% -1.5%, ginger origin extract 0.05% -0.30%, bisabolol 0.01% -0.5%, phenoxyethanol 0.1% -0.5%, methylparaben 0.01% -0.25%, acrylic acid (ester) class/C10 -30 alkanol acrylate cross-linked polymer 0.1% -0.25%, propylparaben 0.01% -0.15%, aminomethyl propanol 0.06% -0.15%, coenzyme Q10 0.01% -0.20%, Sodium hyaluronate 0.01-0.30%, significance 0.01% -0.0.30%, disodium EDTA 0.01% -0.1%, deionized water to 100%.

Beneficial effects: the firming eye cream of the here and now innovation consists of high-efficiency dietary ingredients such as acetyl tetrapeptide, purslane essence, panthenol, vitamin E, ginger origin extract, bisabolol, coenzyme Q10, sodium hyaluronate, and so on. It can boost skin flexibility by promoting cell differentiation as well as collagen synthesis; it can additionally promote the metabolic process of the skin’s stratum corneum, making the skin softer and also smoother, as well as effectively promote skin regrowth, so regarding lower wrinkles and firm the skin; at the same time, polysilicon Oxane-11 promptly smoothes the fine lines of the skin around the eyes and tightens up the skin around the eyes.

CN201710000327.2 proposes a polypeptide redness getting rid of essence. The peptide soreness removing essence utilizes a variety of cosmetic peptides as the major energetic ingredients, which play a synergistic effect to enhance the elasticity of blood vessels, lower the leaks in the structure of veins, remove inflammation, shrink dilated capillaries, as well as restore normal microcirculation. Has a good effect of getting rid of soreness. In order to attain the above item, the here and now innovation embraces the complying with technological services:

A polypeptide essence cosmetic for eliminating soreness and also blood, making up the adhering to parts by weight portion:
Nonapeptide-1 1|10%.

Decapeptide-4 1|10%.

Angiotensin 1|10%.

Hexapeptide-9 1|10%.

Acetyl tetrapeptide 1-10%.

2% Carbomer 940 1|10%.

Aloe Vera Essence 1|5%.

Xanthan Gum 0.01|0.1%.

Glycerin 1|5%.

Butanediol 1|5%.

Hyaluronic acid 0.01|0.1%.

Methylparaben 0.01|0.2%.

Genma 0.01|0.2%.

water balance.

The preparation approach consists of the following actions:.

1) Include water, 2% carbomer 940, aloe vera remove, xanthan periodontal, glycerin, butylene glycol, hyaluronic acid, methylparaben, and Gemma right into the response container, activate stirring, and also warm to 75|80 ℃, mix as well as distribute evenly;.

2) Continue mixing as well as cooling down to listed below 40 ° C, add nonapeptide-1, decapeptide-4, angiotensin, hexapeptide-9, acetyl tetrapeptide into the reaction storage tank, co-opt for 2-3 minutes, as well as stir to liquify entirely, over.

In today invention, acetyl tetrapeptide: can enhance inadequate lymphatic circulation and also extreme capillary leaks in the structure, inhibit glycation, get rid of edema, and improve skin flexibility and level of smoothness. It has the adhering to useful impacts: 1) This item has a high material of cosmetic polypeptides, which can successfully get rid of face soreness, promote skin metabolism, brighten as well as company skin, make skin moist, smooth, flexible, as well as improve skin youthfulness. 2) The polypeptide inflammation eliminating essence of the present development is safe and secure, has great permeability, is very easy to absorb, and also the face is rejuvenating and non-sticky after usage; the preparation approach is simple, the procedure is secure, and can be popularized and also used. 3) After 2 week of continuous use of the polypeptide soreness eliminating essence, it can effectively tighten the skin blood vessels and thin down the facial redness.

CN201710000339.5 suggests a polypeptide anti-radiation significance. The polypeptide anti-radiation essence makes use of a variety of cosmetic polypeptides as the primary active elements, which play a collaborating role and also play the role of blocking, safeguarding and fixing light radiation and electromagnetic radiation. In order to achieve the above item, the present creation em

braces the following technical solutions:.

A polypeptide anti-radiation significance cosmetic product, by weight percent, makes up the adhering to components:.

Tripeptide-33 1|10%.

Acetyl Hexapeptide-49 1|10%.

Acetyl tetrapeptide 1-10%.

Nonapeptide-1 1|8%.

Decapeptide-4 1|8%.

2% Carbomer 940 1|10%.

Aloe Vera Essence 1|5%.

Xanthan Gum 0.01|0.1%.

Glycerin 1|5%.

Butanediol 1|5%.

Hyaluronic acid 0.01|0.1%.

Methylparaben 0.01|0.2%.

Genma 0.01|0.2%.

water balance.

The prep work technique includes the following steps:.

1) Include water, 2% carbomer 940, aloe vera extract, xanthan periodontal, glycerin, butylene glycol, hyaluronic acid, methylparaben, as well as Gemma right into the response storage tank, turn on stirring, as well as warm to 75|80 ℃, mix and disperse evenly;.

2) Continue mixing and also cooling down to listed below 40 ° C, add tripeptide-33, acetyl hexapeptide-49, acetyl tetrapeptide, nonapeptide-1, and also decapeptide-4 into the response container, co-opt for 2-3 mins, Mix to dissolve totally and end.

Compared with the existing products, the significance of the present innovation has the adhering to helpful effects: 1) The item has a high web content of cosmetic polypeptide elements, which can properly stand up to radiation, advertise skin metabolic process, brighten as well as company skin, make skin wet, smooth and flexible, Enhance skin youthfulness. 2) The polypeptide anti-radiation significance of the present invention is risk-free and steady, has good permeability, is simple to take in, as well as the face is rejuvenating and non-sticky after usage; the prep work approach is simple, the procedure is secure, and can be popularized as well as applied.

Hydrogen Peroxide-Induced Effects of Acetyl Tetrapeptide on Human Skin

Skin aging usually leads to a series of inflammatory processes such as excessive deterioration of the dermal extracellular matrix, loss of antibacterial function, and loss of skin barrier function. Bioactive peptides are widely used in cosmetics for their protective effects on the skin and efficient absorption. Combinations of different peptides may produce synergistic or antagonistic effects, thus requiring appropriate design and testing of different formulations. In this study, we tested the individual and mixed activities of 5 functional cosmeceutical peptides to detect suitable anti-aging and protective formulations from our experiments. After individual activity testing, the optimal concentration for superoxide dismutase (SOD) activity was 200 μg/mL carnosine, and the optimal concentration for hydroxyproline (HYP) content activity was 200 μg/mL GHK peptide, 100 μg/mL Acetyl Tetrapeptide for ACE 1 activity, 400 μg/mL Hexapeptide-11 for HYP content activity, and 400 μg/mL Acetyl Hexapeptide-3 for catecholamine content activity. Based on the optimal concentrations of these 5 cosmeceutical peptides, 6 peptide mixture formulations were designed and tested for their anti-aging activity and protection against hydrogen peroxide-induced premature aging of human skin fibroblasts. One of the cosmeceutical peptide blends (carnosine + acetyltetrapeptide + hexapeptide-11 + acetylhexapeptide-3) significantly reduced intracellular levels of malondialdehyde and hydroxyl radicals and increased HYP and human elastin content as well as the enzymatic activity of SOD and glutathione peroxidase.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

Help China Chemicals to benefit the happiness of human life
Become the most trusted chemical supplier in the world
Striver – oriented, enrich employees, customer first, deep service, seek development
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Additive , Chemical Auxiliary & Catalyst , Organic Chemicals
  • Products/Service: Organic Intermediate,Inorganic Chemistry, APIs, Dyestuffs And Pigments, Fragrance And Spices, Food Additives
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.


After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.


Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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