Skin wrinkles are the obvious signs and manifestations of skin aging, which are the result of the combined action of endogenous and exogenous factors. Among them, exogenous factors include active oxygen free radicals generated due to environmental factors such as sunlight, environmental pollutants, etc., which directly damage the DNA of skin cells and the collagen, elastin or mucopolysaccharide molecules of the extracellular matrix, thereby thinning the skin and reducing the epidermis. The interweaving with the dermis is weakened and the number of cells and blood vessels is reduced, resulting in facial wrinkles; due to stress, emotions and other reasons, the skin’s regulating function is damaged, resulting in wrinkles. Endogenous factors refer to the gradual aging of the skin as the age increases, the natural moisturizing factors in the epidermis stratum corneum continue to decrease, the skin water and capacity decrease, and the concentration of proteoglycan and hyaluronic acid in the skin decreases, and the dermal layer of the skin decreases. Decreased moisture, decreased activity of dermal fibroblasts, and decreased ability to synthesize collagen fibers, lead to dry skin, weakened skin elasticity, and finally wrinkles. At present, the main anti-wrinkle products on the market mainly focus on three aspects:
1) Remove free radicals from the skin;
2) By adding some moisturizing agents or nutrients from the outside to replenish the lost moisture and protein components of the skin;
3) Promote cell metabolism. Although the main problems of skin wrinkles can be solved through these three ways, there are still many problems that need to be solved. For example, for the loss of skin moisture and protein components, the main method now is to ingest small molecular weight peptides from the outside to supplement, such as among One is acetyl octapeptide-1.
Studies have shown that the anti-wrinkle effect of small molecule active peptides mainly comes through two ways. One is similar to botulinum toxin, blocking the transmission process of neurotransmitters, and reducing muscle contraction through signal regulation, thereby achieving the effect of wrinkle-removing. , such as acetyl hexapeptide-8, participates in the competition of SNAP-25 at the site of the fusion bubble complex, thereby affecting the formation of the SNARE complex, enabling it to effectively release neurotransmitters, thereby weakening muscle contraction and preventing the formation of wrinkles. Small-molecule active polypeptides with similar effects include acetylglutamyl heptapeptide-3 and palmitoyl hexapeptide-19, etc. The second is to promote protein synthesis in the skin and restore skin elasticity and plumpness, such as palmitoyl tripeptide-5, Through tissue growth factor (TGF-β) imitating the human body’s own mechanism to produce collagen, make the skin plump and smoothen wrinkles, the small molecule active polypeptide with similar effect is palmitoyl pentapeptide-3. However, the absorption amount of the skin is limited, so it is difficult to meet the needs of the skin; and the mechanism of skin wrinkle formation is relatively complex. Although the anti-wrinkle products developed for a single mechanism can exert a certain anti-wrinkle effect, the overall effect is not good. Therefore, in order to prescribe a more prominent effect of wrinkle removal, it needs to be carried out from multiple levels, multiple angles, and multiple approaches.
Acetyl octapeptide-1 can be used in the preparation of anti-wrinkle products and other cosmetic products. An example of the application of acetyl octapeptide-1 is as follows: a liposome composition containing a plant extract complex polypeptide, including the following components by weight: 1 to 15% of the plant extract; 0.1 to 0.5% of the complex small molecule active polypeptide; Lipid 5-20%; emulsifier 1-3%; buffer solution 50-75%; solvent 10-20%. The composite small molecule active polypeptide can be selected from acetyl hexapeptide-8, acetylglutamyl heptapeptide-3, acetyl octapeptide-1, palmitoyl hexapeptide-19, palmitoyl oligopeptide, palmitoyl tripeptide -5 and at least one of palmitoyl pentapeptide-3.
