Zhishang Chemical

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Acetyl Hexapeptide-8 CAS 616204-22-9

Molecular Formula: C34H60N14O12S

Formula Weight: 889

ZSpharmac: Acetyl Hexapeptide-8 Cosmetic Raw Material Suppliers

Product Name: Acetyl Hexapeptide-8
CAS No: 616204-22-9
Purity: 99%

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Basic Info

Product Name:Acetyl Hexapeptide-8
Other Names:Argireline
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:White Lyophilized Solid
EINECS No.:1592732-453-0
Provide:Acetyl Hexapeptide-8 MSDS;
Acetyl Hexapeptide-8 COA

What is Acetyl Hexapeptide-8?

Argireline, additionally known as botulinum toxin, is an oligopeptide that mimics the N-terminal 6 amino acids of SNAP-25 protein. Akirelin is among the generally utilized resources in premium cosmetics. Its primary function is to decrease creases triggered by face contraction, and has an ideal impact on eliminating creases on the forehead or around the eyes.
Aquirelin is a more secure, more affordable, milder alternative to Botox. Akirelin competes for the site of SNAP-25 in the combination vesicle facility, consequently impacting the formation of the blend vesicle complex, triggering the vesicles to be unable to successfully release neurotransmitters, weakening muscle contraction, thus loosening up muscles and comforting fine lines. It makes the skin clear and remarkable, and can additionally advertise cell regeneration and recover softness and flexibility to the skin. Therefore, it is commonly made use of in the prep work of cosmetics and wellness products.

Acetyl Hexapeptide-8 Property

density 1.54
storage temp. -20°C
solubility water soluble
solubility water soluble
form lyophilized solid
color white


The Efficacy and Role of Acetyl Hexapeptide

It can hinder the launch of the neurotransmitter acetylcholine, deteriorate contraction, therefore reducing the incident of creases. It can additionally increase elastin activity, improve skin leisure, and make the skin smooth and firm.

To place it simply, the nerves inform the muscular tissues to obtain thrilled! The skin has no choice yet to adhere to the muscles. Excessive tightening of the skin causes wrinkles. Acetyl hexapeptide-8 can block the nerves from giving instructions to the muscular tissues. When the muscular tissues are calm, wrinkles will certainly not form on the skin.

The difference between “botulinum toxic substance” and botulinum toxic substance
Botulinum contaminant is a biotoxin muscle relaxant that prevents the release of acetylcholine (Ach) by destroying the neuromuscular junction (NMJ) body-associated healthy protein (SNAP-25) in the skin, obstructing neuromuscular transmission, causing muscle Flaccid paralysis hinders contraction to accomplish crease removal effect.

However, this sort of botulinum contaminant, which destroys the neuromuscular junction healthy protein mechanism, can trigger excessive muscular tissue paralysis in the form of injection if not properly controlled, leading to poisoning and infection. In extreme instances, it might result in facial paralysis, which positions specific security risks.

Acetyl hexapeptide-8 is a high-quality anti-wrinkle active ingredient that has anti-wrinkle and anti-aging impacts comparable to those of Botox. It additionally avoids the disadvantages of Botox needing injections, high cost and a series of negative effects, so it is called The credibility of “botulinum toxin-like”.

Clinically proven: Creases around the eyes are minimized by up to 17% after 15 days of use and 27% after 30 days of use, demonstrating its incredible result in anti-wrinkle task. And since it has nothing else adverse effects, it is safer than botulinum toxic substance and better for lasting use, so it has ended up being a core active ingredient made use of in top cosmetics on the marketplace.

Acetyl Hexapeptide-8 Preparation

A preparation strategy of Acetyl Hexapeptide-8, including the complying with actions:
Action 1: Take the resin and trigger it to get amino material;
Activity 2: Take the amino resin obtained symphonious 1, initially step-by-step pair guanidino-protected L-arginine, guanidino-protected L-arginine, and side chain amino-protected L-glutamine to get a tripeptide material;
Step 3: Take the tripeptide material gotten in step 2, and secondly couple L-methionine, side-chain carboxyl-protected L-glutamic acid, and side-chain carboxyl-protected N-acetyl-L-glutamic acid detailed to get Hexapeptide material;
Idea 4: Divide the hexapeptide resin got symphonious 3 to acquire the first product;
Idea 5: Take the first item gotten in step 4 and cleanse it.

Contact Us

About Products:
If you need Acetyl Hexapeptide-8, a cosmetic raw material, please contact our service staff directly, and we will provide you with high-quality products at the best price.
As an experienced manufacturer and supplier of Acetyl Hexapeptide-8, our company, ZSpharmac will provide Acetyl Hexapeptide-8 raw materials to customers around the world for a long time.
Over the years, the company has adhered to the spirit of “integrity management, strict quality control, and customer first” and has won unanimous praise from customers at home and abroad.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

Help China Chemicals to benefit the happiness of human life
Become the most trusted chemical supplier in the world
Striver – oriented, enrich employees, customer first, deep service, seek development
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Cosmetic raw materials
  • Products/Service:Cosmetic raw materials (flavors and fragrances,antioxidant products, moisturizing and hydrating, whitening agents, cosmetic additives)
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.


After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.


Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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