Zhishang Chemical

Welcome to Zhishang Chemical      +86-176 5311 3209     Simon@sdzschem.com

Zhishang Chemical
Close this search box.

Acetophenone CAS 98-86-2

Molecular Formula: C8H8O

Formula Weight: 120.15

ZSpharmac: Acetophenone Supplier Manufacturers

Product Name: Acetophenone
CAS No: 98-86-2
Purity: 99%

Navigation Bar

Basic Info

Product Name:Acetophenone
Other Names:Acetyl-Benzen
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:Clear Colorless to Light Yellow Liquid
EINECS No.:202-708-7
Storage:Store Below +30°C.
Provide:Acetophenone MSDS;
Acetophenone COA

What is Acetophenone?

Acetophenone, additionally referred to as acetophenone, boiling point ( ° C): 202.3, loved one thickness (water=1): 1.03 (20 ° C), family member vapor thickness (air=1): 4.14, is the most basic aromatic ketone, among which The core (benzene ring) is straight connected to the carbonyl. It exists in the essential oils of some plants in a free state. The pure product is colorless crystal. Readily offered products are mostly light yellow oily fluid. Has a hawthorn-like aroma. Slightly soluble in water, easily soluble in different organic solvents, and can volatilize with steam. Molecular framework of acetophenone: the methyl C atom is bound by sp3 hybrid orbital, and also the benzene ring and also carbonyl C atom are adhered by sp2 hybrid orbital. Acetophenone can undertake carbonyl addition response, α-active hydrogen reaction, and also electrophilic substitution reaction on the benzene ring, generally generating meta-position products. Acetophenone can be prepared by responding benzene with acetyl chloride, acetic anhydride or acetic acid under the catalysis of light weight aluminum trichloride. Additionally, acetophenone is a byproduct during the catalytic oxidation of ethylbenzene to styrene. Acetophenone is generally utilized as a basic material for pharmaceuticals as well as other organic synthesis, and likewise for the prep work of seasonings. It is made use of to make soap and also cigarettes, and also can likewise be utilized as a solvent for cellulose ethers, cellulose esters, and resins, as well as a plasticizer for plastics. It has hypnotic properties. Presently, acetophenone is primarily obtained as byproducts of phenol as well as acetone by oxidation of cumene, and it can additionally be obtained by acetylation of benzene with acetyl chloride.

Acetophenone Property

Melting point 

19-20 °C (lit.)

Boiling point 

202 °C (lit.)


1.03 g/mL at 25 °C (lit.)

vapor density 

4.1 (vs air)

vapor pressure 

0.45 mm Hg ( 25 °C)

refractive index 

n20/D 1.534(lit.)


180 °F

storage temp. 

Store below +30°C.






Clear colorless to light yellow

Relative polarity



Pungent, floral odor

explosive limit


Odor Type


Water Solubility 

5.5 g/L (20 ºC)


Acetophenone Uses

When Acetophenone is used as a solvent, it has the qualities of high boiling point, security as well as positive scent. The solubility is similar to that of cyclohexanone, which can dissolve nitrocellulose; cellulose acetate; plastic material; coumarone resin; alkyd resin; glycerol alkyd material, etc. Typically with ethanol; Ketone; Esters and various other solvents blended. When made use of as seasonings, it is the blending raw material of hawthorn; mimosa; lilac as well as various other tastes, and is commonly made use of in soap tastes and tobacco tastes. Made use of in the synthesis of mandelic acid; α-phenylindole; ibuprofen, and so on, as well as likewise used as a plasticizer for plastics.
Normally taking place: Acetophenone exists in milk, cheese, cacao, raspberry, peas, and also Sri Lankan cinnamon oil.
Sensory account: Acetophenone has an almond smell similar to benzaldehyde, as well as it has a wonderful nutty and also fruity preference after dilution.
Suggested application: It can be made use of to prepare food tastes such as cherries, nuts, tomatoes, strawberries, apricots, and so on. It can additionally be used in cigarette tastes.
Recommended dosage: the focus in the last flavorful food has to do with 0.6-20mg/ kg.
Safety management condition: The FEMA variety of acetophenone is 2009, the FDA number is 172.515, and also the CoE number is 138. China GB2760-1996 accepted as food spices enabled to use.

Preparation of Acetophenone

Instruments and also medications.
Medicines: Acetic Anhydride Magnesium Benzosulfate Hydrochloride Aluminum Chloride Salt Hydroxide.
Instrument: round bottom flask condenser dropping channel purification gadget drying tube stirring gadget.
Rapidly include 13g (0.097 mol) powdered anhydrous Aluminum trichloride and 16ml (concerning 14g, 0.18 mol) of anhydrous benzene. Slowly include 4ml (concerning 4.3 g, 0.04 mol) of acetic anhydride into the three-necked flask from the dropping channel under stirring (include a few drops initially, after that continue to drop after the response occurs), and regulate the rate of addition of acetic anhydride It is suggested to make the three-necked flask somewhat warmer. After the enhancement (concerning 10 minutes), after the response is a little slow, stir as well as reflux in a boiling water bathroom till no more hydrogen chloride gas runs away.
Great the reaction mixture to room temperature level, and also put it right into a beaker including 18ml of concentrated hydrochloric acid and also 30g of crushed ice (in a fume hood) under stirring. If there are still solid insolubles, add an appropriate amount of concentrated hydrochloric acid to dissolve it entirely. The combination was transferred to a separatory funnel, the natural layer was divided (which layer?), and the aqueous layer was drawn out two times with benzene (8 mL each). The organic layers were integrated, cleaned together with 15 ml of 10% salt hydroxide and also 15 ml of water, and also dried out over anhydrous magnesium sulfate.
First distill and recover benzene on a water bathroom, after that heat and also distill off the residual benzene on an asbestos net, and then make use of an air condenser after a little cooling (why?) Distill and gather the distillate at 195-202 ° C, the yield has to do with 4.1 g (yield 85%). Pure acetophenone is a colorless transparent oily fluid.
1. The moment for dropping the mix of acetophenone as well as acetic anhydride is ideally 10 minutes, and the temperature is challenging to regulate if the decline is too fast.
2. The top quality of anhydrous light weight aluminum trichloride is the crucial to the success of this experiment. It is far better to utilize white powder to open the cover and produce a lot of smoke without load. If the majority of it turns yellow, it suggests that it has been hydrolyzed and can not be made use of.
3, AlCl3 ought to be ground as well as the rate ought to be fast.
4. When water down HCl is added, start to go down slowly, and after that gradually increase; the amount of thin down HCl (1:1, currently prepared) has to do with 140ml.
5. Absorption tool: Regarding 20% salt hydroxide solution, self-made, 200mL, pay unique focus to stop drawing back.
6. Analytical purity is much better for benzene, as well as it is best to dry it with nanofilament for greater than 24 hr prior to usage. 7. A percentage of water in the unrefined product is distilled out in the form of azeotrope with benzene during purification, and its azeotropic factor is 69.4 ° C. This is just one of the drying approaches for fluid substances.

Characteristics of Acetophenone Prepared by Friedel-Craffs Acylation

1. The catalyst utilized in the acylation reaction, light weight aluminum trichloride, considerably surpasses the amount of stimulant used in the alkylation reaction, and the acetophenone created kinds a facility with an equal amount of light weight aluminum chloride, and the by-product acetic acid generated in the reaction additionally It can create a salt with an equivalent amount of aluminum chloride, so in the acylation reaction, one particle of anhydride consumes greater than two molecules of aluminum chloride
2. The acetophenone/aluminum chloride complicated created in the reaction is stable in anhydrous tool. Only when the reaction mixture is hydrolyzed, the facility is destroyed, as well as acetophenone, aluminum chloride as well as styrene are separated out. After the ketone develops a facility, it no longer participates in the reaction Consequently, the quantity of light weight aluminum chloride is that after the formation of the complex, there is still a driver for the acylation response.
3. Since light weight aluminum chloride can develop a complicated with carboxyl-containing materials, the raw product acetic anhydride can additionally create a molecular complicated with light weight aluminum chloride and no more participate in the response, that is, acetic anhydride can not be quantitatively exchanged acetophenone; Additionally, in the reaction, when the amount of aluminum chloride is large, the acetate can be exchanged acetyl chloride, which can be made use of as an acylating representative to join the reaction.
4. In the response system, the quantity of benzene is likewise considerably excessive, due to the fact that benzene is not just used as a reaction reagent, however additionally as a solvent in the reaction, so acetyl is the benchmark reagent for the return.
5. The features of acylation response: pure product and high return (since the acyl team does not go through isomerization and also numerous replacements).

About Products:
If you need Acetophenone, a cosmetic raw material, please contact our service staff directly, and we will provide you with high-quality products at the best price.
As an experienced manufacturer and supplier of Acetophenone, ZSpharmac will provide Acetophenone raw materials to customers all over the world for a long time.
Over the years, the company has been adhering to the spirit of “integrity management, strict quality control, customer first”, and has won unanimous praise from domestic and foreign customers.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

Help China Chemicals to benefit the happiness of human life
Become the most trusted chemical supplier in the world
Striver – oriented, enrich employees, customer first, deep service, seek development
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Cosmetic raw materials
  • Products/Service:Cosmetic raw materials (flavors and fragrances,antioxidant products, moisturizing and hydrating, whitening agents, cosmetic additives)
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.


After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.


Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

Get Acetophenone Quotation