Zhishang Chemical

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Zhishang Chemical

9-Fluorenone CAS 486-25-9

Molecular Formula: C13H8O

Formula Weight: 180.2

ZSpharmac: 9-Fluorenone Supplier

Product Name: 9-Fluorenone
CAS No: 486-25-9
Purity: 99%

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Basic Info

Product Name:9-Fluorenone
Other Names:9H-FLUOREN-9-ONE
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:Yellow Crystalline Powder or Flakes
EINECS No.:207-630-7
Storage:Store Below +30°C.
Provide:9-Fluorenone MSDS;
9-Fluorenone COA

What is 9-Fluorenone?

9-fluorenone is an important intermediate in organic synthesis, which can be utilized to manufacture a variety of fine chemicals, generally used in the synthesis of polymer products, bisphenol fluorene, fluorenyl benzoxazine material, acrylate resin, polyester, Modifier for polycarbonate and epoxy resin. Busy, fluorene is utilized as resources, dimethyl sulfoxide is used as solvent, sodium hydroxide is made use of as driver, and oxygen is utilized as oxidant. The oxidation response is performed in a tower loaded reactor. The reaction liquid is cooled as well as filteringed system to acquire crude oil with a material of 93%. Fluorenone, the filtrate can recuperate 94% of the solvent as well as some unrefined fluorenone after purification. The crude fluorenone can be cleansed by directional formation to obtain yellow flake fluorenone with a pureness of greater than 99.8%.

9-Fluorenone Property

Melting point 80-83 °C (lit.)
Boiling point 342 °C (lit.)
density 0,9 g/cm3
vapor pressure 0.005-0.2Pa at 20-50℃
refractive index 1.6309 (estimate)
Fp 163 °C
storage temp. Store below +30°C.
solubility DMSO (Slightly), Methanol (Slightly)
form Crystalline Powder or Flakes
color Yellow
Water Solubility insoluble


The Preparation Technology of 9-Fluorenone

At present, there are three main methods for the preparation of 9-Fluorenone: gas phase oxidation, liquid phase oxidation and air liquid phase oxidation.

The main synthesis processes of air liquid phase oxidation method are:

1. Use potassium hydroxide as a catalyst, add fluorene to dimethyl sulfoxide, and obtain crude fluorenone after air oxidation or use tetrahydrofuran as a solvent and potassium hydroxide as a catalyst to produce fluorenone; the above method uses The alkali is mostly potassium hydroxide, which is expensive, and the boiling point of tetrahydrofuran is low, the recovery rate is low, and the washing process is miscible with water, and a large amount of waste water is introduced, which is difficult to handle;

2. Use benzene-based solvent solution, sodium hydroxide as a catalyst, add quaternary ammonium salt as a phase transfer catalyst, and oxidize by blowing air at a higher temperature near the boiling point of the solution to obtain fluorenone; the disadvantage of this reaction is that it does not In the case of adding water, the quaternary ammonium salt is difficult to play the role of transfer catalyst, toluene is highly toxic, the reaction temperature is high, and the solvent loss is large;

3. Pyridine is used as solvent for dissolution, no phase transfer catalyst is needed for the reaction, the reaction temperature is higher than 110°C, the reaction time is long, and pyridine has a foul smell, which causes great environmental pollution;

Existing equipment for preparing 9-Fluorenone requires large investment, large land occupation, complex reactor structure, and low purity of the finished product.

Synthetic Process of 9-Fluorenone

Using industrial fluorene as raw material, sodium hydroxide as catalyst, and dimethyl sulfoxide as solvent, the material enters the reactor to be heated and dissolved, passes through the external circulation of the reactor, and returns to the reactor to react through the microbubble generator. After the reaction The material obtained by cooling crystallization, separation, washing and recrystallization to 9-Fluorenone;

Specific steps are as follows:

1) In the reaction kettle, dissolve the industrial fluorene in the dimethyl sulfoxide solvent at a temperature of 40-80°C, add the catalyst sodium hydroxide, and stir in the reaction kettle under normal pressure until it is completely dissolved;

2) The circulation pipeline connected to the reaction kettle starts to be fed with oxygen for oxidation, and the material flowing out from the bottom of the reaction kettle, together with oxygen, returns to the reaction kettle through the microbubble generator on the circulation pipeline for reaction. The microbubble generator uses gas, During the liquid mixing process, the gas is crushed into bubbles, so that the gas and the liquid are fully dissolved, and the high-speed rotating pump impeller mixes the liquid and the gas;

3) After the reaction is finished, the material is cooled and crystallized, and the crystals and mother liquor are separated by a centrifuge;

4) washing the crystals in step 3 with water to obtain crude fluorenone; the mother liquor is subjected to vacuum distillation treatment through a still, the top of the distillation is to recover dimethyl sulfoxide, and the bottom of the still is crude fluorenone;

5) Recrystallize the crude fluorenone obtained in step 4 and step 5 to obtain fluorenone, and then dry it to obtain the finished product 9-fluorenone.

The flow rate of oxygen is 0.04m3/h-1m3/h, and the oxidation time is 1-5 hours; the mass ratio of materials is fluorene: dimethyl sulfoxide: sodium hydroxide = 1:0.8-4:0.01-0.1.

The purity of the finished 9-fluorenone is >99%, and the yield of 9-fluorenone is >85%.

Compared with prior art, the beneficial effect of the present invention is:

The solvent of the present invention is non-benzene and pyridine solvents, which are low-toxic and environmentally friendly; the catalyst is a commonly used industrial catalyst, which is cheap and easy to obtain, and the production process is optimized, which greatly reduces the amount of catalyst and solvent used, and the solvent can be recycled to achieve repeated use; The invention has mild reaction conditions, simple and effective reaction equipment, sufficient reaction, fast rate, high yield of fluorenone, purity greater than 99%, and yield can reach more than 85%.

About Products:
If you need 9-Fluorenone as a cosmetic raw material, please contact our service staff directly, we will provide you with high-quality products at the best price.
As an experienced 9-Fluorenone manufacturer and supplier, ZSpharmac will provide 9-Fluorenone raw materials for customers all over the world for a long time.
Over the years, the company has been adhering to the spirit of “integrity management, strict quality control, customer first”, and has won unanimous praise from domestic and foreign customers.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

Help China Chemicals to benefit the happiness of human life
Become the most trusted chemical supplier in the world
Striver – oriented, enrich employees, customer first, deep service, seek development
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Cosmetic raw materials
  • Products/Service:Cosmetic raw materials (flavors and fragrances,antioxidant products, moisturizing and hydrating, whitening agents, cosmetic additives)
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.


After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.


Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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