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6-Methylquinoline CAS 91-62-3

Molecular Formula: C10H9N

Formula Weight: 143.19

ZSpharmac: 6-Methylquinoline Supplier Manufacturers

Product Name: 6-Methylquinoline
CAS No: 91-62-3
Purity: 99%

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Basic Info

Product Name:6-Methylquinoline
Other Names:P-Methylquinoline
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:Green-Yellow Liquid
EINECS No.:202-084-6
Storage:Store Below +30°C.
Provide:6-Methylquinoline MSDS;
6-Methylquinoline COA

What is 6-Methylquinoline?

6-Methylquinoline is a chemical substance that can be used in the synthesis of c-Met preventions such as 1-(quinolin-6-ylmethyl)-3 H- [1,2,3] triazole established by Pfizer [4,5-b] pyrazine compound PF-04217903, 3-(quinolin-6-ylmethyl)-3 H- [1,2,4] triazole [4,3-b] developed by Janssen Pyridazine substances JNJ-38877605 and so on. As most of us understand, the recrystallization method is generally used to remove high-purity 6-methylquinoline. The key to this approach is to choose an appropriate recrystallization solvent to ensure that as much as feasible can be dissolved while the 6-methylquinoline salt is crystallized. Pollutants.

The original technique used outright ethanol as the recrystallization solvent. Add 98% concentrated sulfuric acid to the ethanol remedy of 6-methylquinoline to respond with it to create sulfonate, then great and also crystallize, and also filter. The resulting salt crystals were then recrystallized with three times the weight of ethanol. At area temperature, use a solid alkali option to decay the recrystallized crystals to pH = 8, and ultimately rectify them to get greater than 95% of 6-methylquinoline.

However the drawback of prior this approach is: the pureness of prepared 6 methylquinoline is lower, can not meet the requirements of item, and also 6 methylquinoline is really little solubility in ethanol, three times of weight of ethanol can not Entirely dissolves its sulfonate. In summary, in view of the above issues, the invention of a technique for extracting high-purity 6-methylquinoline with great practicability as well as higher operability is necessary.

6-Methylquinoline Property

Melting point 


Boiling point 

256-260 °C (lit.)


1.067 g/mL at 20 °C (lit.)

vapor density 

>1 (vs air)

refractive index 

n20/D 1.614(lit.)


>230 °F

storage temp. 

Store below +30°C.


Chloroform (Slightly), Methanol (Slightly)








blossom odor, sweet, animalic upon dilution

Odor Type


Water Solubility 

Not miscible or difficult to mix with water.

6-Methylquinoline Application

6-methylquinoline is mainly used in organic synthesis, such as the prep work of 6-aminomethylquinoline. The artificial technique reported in the literary works is to make use of 6-quinoline formic acid as resources to acquire 6-quinoline carboxamide through amination reaction, and afterwards Dehydration response gets 6-cyanoquinoline, and ultimately obtains 6-aminomethylquinoline under Raney nickel reduction, and the complete yield of this reaction gets to 44.4%, but there are many action in this response, and also the N used in the amination response, N-carbonyldiimidazole is costly, as well as Raney nickel is made use of in 6-cyanoquinoline, which requires high response as well as troublesome procedure. As a result, it is of excellent relevance to find as well as optimize the preparation route of 6-aminomethylquinoline.

There are research studies, using 6-methylquinoline, bromosuccinimide, potassium phthalimide, as well as hydrazine moisturize as basic materials to obtain 6-aminomethylquinoline through bromination and Gabriel response, and also the synthesis steps of the technique less, the response conditions are moderate, the Gabriel reaction with hydrazine hydrate has a greater yield than the acid-base decrease, and the side responses are fairly much less, which provides a brand-new reference technique for the prep work of 6-aminomethylquinoline.

The specific approach is as adheres to:
1) Synthesis of 6-bromomethylquinoline: In a three-necked flask geared up with a reflux condenser as well as a drying out tube, add 240 mL of carbon tetrachloride, slowly warm to 50 ° C, and after that include 6-methylquinoline (5.72 g, 0.04 mol), N-bromosuccinimide (7.12 g, 0.04 mol), azobisisobutyronitrile (0.656 g, 0.004 mol), mixed and refluxed at 80 ° C for 12 h, TLC detected completion of the reaction (The eluent is ethyl acetate-petroleum ether-triethylamine, the quantity proportion is 3:1:0.1), cooled down to room temperature level, filteringed system, the filtrate was cleaned 3 times with saturated NaCl service, the mixed organic layers were dried over anhydrous Na2SO4, filteringed system, and also recovered carbon tetrachloride under minimized stress to obtain 7.876 g of a yellow solid with a return of 88.7% and also a melting point of 73-75 ° C.

2) Synthesis of quinoline 6-methylphthalimide: Add 6-bromomethylquinoline (6.7 g, 0.03 mol), o- Phthalimide potassium salt (4.5 g, 0.03 mol), N,N-dimethylformamide 50 mL, gradually heat up to 60 ° C, respond for 3 h, stir at room temperature level for 12 h, as well as find completion factor of the response by thin-layer chromatography (The eluent is ethyl acetate-petroleum ether-triethylamine, quantity proportion 3:1:0.1), include 40 mL of chloroform, 120 mL of water, mix well, filter, different the natural layer, and also clean the water layer with trichloromethane Wash with methane (10 mL × 2), integrate the organic layers, laundry with 0.2 mol/L NaOH option, clean with water successively, completely dry with anhydrous Na2SO4, filter, recuperate chloroform under minimized pressure, include 25 mL of anhydrous ether, stir well, It was filteringed system and also dried in vacuo to obtain 3.5 g of strong with a return of 40.0% as well as a melting point of 163-165 ° C.
3) Synthesis of 6-aminomethylquinoline: In a three-necked flask with a reflux condenser, add quinoline 6-methylphthalimide (2.88 g, 0.01 mol) as well as 80% hydrazine hydrate (1.3 mL, 0.02 mol) and also 50 mL of methanol, stirred and refluxed at 70 ° C for 4 h, as well as the end factor of the reaction was detected by thin-layer chromatography (the eluent was ethyl acetate-petroleum ether-triethylamine, the quantity ratio was 3:1: 0.1), trendy, include 20 mL of water, recover methanol under decreased pressure, include 25 mL of focused HCl, reflux at 80-90 ° C for 1 h, amazing to 0 ° C, filter, recuperate focused HCl under lowered stress, include 50 mL of water, filter, as well as make use of the filtrate Readjust the pH to 8-9 with 2 mol/L NaOH, cool at 0 ° C for 12 h, filter, as well as dry in vacuo to get 1.569 g of solid with a yield of 98.7% as well as a melting point of 165-167 ° C.

On top of that, 6-methylquinoline can also be utilized to prepare insect repellents. Over the last few years, study has been conducted on methods for fending off bugs by using adjustments to the chemosensory system possessed by the insects to deteriorate the cognitive sensations of the bugs. And use N,N-diethyl-3-methylbenzamide (DEET) or p-menthane-3,8-diol (PMD) as well as various other materials that act on olfactory receptors as repellents. Nonetheless, DEET has an undesirable smell as well as high skin penetration, so there is a problem that use to babies or individuals with sensitive skin is restricted, and also the period is just 2 to 3 hrs.

Some research studies have established an insect repellent, in which, octahydro-7-methyl-1,4-methylenenaphthalene-6(2H)-one, 3-methyl-5-propyl-2 -cyclohexene-1-one, octahydro-5-methoxy-4,7-methylene-1H-indene-2-carboxaldehyde, 6-methylquinoline, phenoxyacetaldehyde, γ- Caprylactone, 9-ethylidene-3-oxatricyclo(,7)undecane-4-one, 2,3,3-trimethyl-2H-inden-1-one, 4 -Methyl-5-thiazole ethanol, 7-methoxy-3,7-dimethyloctanal, 3-methyl-1-phenyl-3-pentanol, 2-phenylpropanal dimethyl acetal One or more compounds selected from aldehyde, octahydro-2H-1-chromen-2-one as well as 2,6,6-trimethylcyclohexa-1,3-diene-1-carbonaldehyde as Energetic ingredients.

Those bug spray or thermosensing inhibitor can be applied to the skin of mammals including human beings, attached to or kept in straight or indirect contact with the skin, such as garments, accessories, etc, or sprayed inside your home, It can be utilized to ward off bugs in a fixed space such as an automobile (including dissipation or volatilization), and also can be prepared in the form of a make-up by properly mixing other ingredients such as solvents or different formula additives according to the usage technique. Those bug spray or thermosensitivity inhibitor can additionally be made use of as a material for imparting insect repellent activity to skin exterior preparations, cleansers, skin cosmetics, hair cosmetics, fabric softeners, fabric therapy agents, and so forth.

6-Methylquinoline Preparation

A technique for extracting high-purity 6-methylpyridine, consisting of the complying with steps:
Step 1, adding the unrefined item of 6-methylquinoline with a pureness of 30-50% to ethanol with 1-3 times the weight of 6-methylquinoline, as well as including focused sulfuric acid dropwise under the problem of 30-50 ° C to react;

Action 2: After warming the response remedy to reflux for 30-50 mins under stirring problems, stop heating, let the system decrease to area temperature level, quit mixing, take shape and also filter, and obtain 6-methylquinolinesulfonic acid with a pureness of 97% -98% Salt;

Action 3, using a combined solvent of ethanol and also water to recrystallize 6-methylquinolinesulfonate.

Step 4, dissolve the recrystallized crystals in water, add salt hydroxide to the solution while mixing, and control the temperature level at 40-60 ° C; when the pH worth of the material is between 8 and also 9, proceed mixing for thirty minutes, and after that statically The layers were separated, and the target 6-methylquinoline was obtained by fluid separation.

About Products:
If you need 6-Methylquinoline as a cosmetic raw material, please contact our service staff directly, we will provide you with high-quality products at the best price.
As an experienced 6-Methylquinoline manufacturer and supplier, ZSpharmac will provide 6-Methylquinoline raw materials for customers all over the world for a long time.
Over the years, the company has been adhering to the spirit of “integrity management, strict quality control, customer first”, and has won unanimous praise from domestic and foreign customers.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

Help China Chemicals to benefit the happiness of human life
Become the most trusted chemical supplier in the world
Striver – oriented, enrich employees, customer first, deep service, seek development
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Cosmetic raw materials
  • Products/Service:Cosmetic raw materials (flavors and fragrances,antioxidant products, moisturizing and hydrating, whitening agents, cosmetic additives)
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.


After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.


Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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