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6-Methylcoumarin CAS 92-48-8

Molecular Formula: C10H8O2

Formula Weight: 160.17

ZSpharmac: 6-Methylcoumarin Supplier

Product Name: 6-Methylcoumarin
CAS No: 92-48-8
Purity: 99%

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Basic Info

Product Name:6-Methylcoumarin
Other Names:6-Methyl-Coumari
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:White to Almost White Powder to Crystal
EINECS No.:202-158-8
Storage:Room Temperature
Provide:6-Methylcoumarin MSDS;
6-Methylcoumarin COA

What is 6-Methylcoumarin?

6-Methylcoumarin is an organic compound and a coumarin derivative. Coumarin is a class of compounds with the basic structure of benzopyrone, while 6-methylcoumarin is a derivative with a methyl substituent on the coumarin core. Its chemical formula is C₁₀H₈O₂, its molecular weight is 160.16 g/mol, and its CAS registration number is 92-48-8.

This compound has certain fluorescent properties, so it is widely used in the fields of fluorescent labeling, fluorescent probes, and fluorescence analysis. Due to its good stability and fluorescence efficiency, 6-methylcoumarin and its derivatives are often used as biomarkers, which can be attached to proteins, nucleic acids or other biological macromolecules to track and detect these molecules. Behavior within a cell or organism.

In addition, 6-methylcoumarin may also have certain biological activities, such as antioxidant, anti-inflammatory or even anti-cancer effects, which makes it also have certain potential value in drug development and biomedical research.

6-Methylcoumarin Property

Melting point 

73-76 °C (lit.)

Boiling point 

303 °C/725 mmHg (lit.)


1.0924 (rough estimate)

refractive index 

1.5300 (estimate)



storage temp. 

Sealed in dry,Room Temperature


DMSO : ≥ 125 mg/mL (780.42 mM)


powder to crystal


White to Almost white


6-Methylcoumarin Uses

Fluorescent labeling and detection: 6-Methylcoumarin is often used as a fluorescent probe or marker due to its fluorescent properties. In biochemistry, molecular biology, and medical diagnostics, it can be combined with proteins, nucleic acids, or other biological molecules to track the distribution, migration, and interactions of these molecules within cells. Its stable fluorescence properties facilitate sensitive and specific detection, such as in fluorescent immunoassays, cell imaging, and high-throughput screening.

Medicine and drug development: 6-methylcoumarin and its derivatives have certain biological activities, including anti-inflammatory, antibacterial, anti-tumor and antioxidant effects. These properties make them important candidate molecules in drug discovery, either to develop new drugs or to improve the performance of existing drugs. For example, they can serve as drug precursors or intermediates and participate in the synthesis of compounds with specific therapeutic effects.

Fragrances and flavors: Although it is named “coumarin”, 6-methylcoumarin itself is not directly used as a fragrance. However, coumarin compounds usually have certain odor properties, so in some cases they may be used as building blocks for synthetic fragrances and indirectly used to modulate the aroma of perfumes, cosmetics and detergents.

Organic synthesis intermediates: In organic synthesis chemistry, 6-methylcoumarin, as a multifunctional intermediate, can participate in a variety of chemical reactions, such as oxidation, reduction, alkylation, acylation, etc., and is used for synthesis Other complex organic compounds, including dyes, pesticides, plastic additives and photosensitive materials.

Materials Science: In the field of materials science, 6-methylcoumarin and its derivatives may be used to prepare polymer materials, photosensitive resins or optoelectronic materials with special properties, such as applications in optoelectronic devices, sensors and luminescent materials.

Agricultural fields: Although direct applications are rare, coumarins are sometimes used as plant growth regulators or as ingredients in pesticides, by affecting plant physiological processes or controlling pests.

6-Prominent Applications of Methylcumarin in Makeup

Photoprotectants: Coumarin compounds, including 6-methylcoumarin, have the ability to absorb ultraviolet rays. In theory, they may be developed as light stabilizers or ultraviolet absorbers and added to sunscreen products to help protect the skin from UV rays. Damage from UV rays.

Fluorescent enhancer: In some innovative cosmetic designs, the fluorescent properties of 6-methylcoumarin may be used to enhance the visual effect of the product, such as cosmetics that are visible at night or nail polish and nail polish with special luminous effects. In makeup products.

As a synthetic intermediate: Although not directly used in cosmetic formulations, 6-methylcoumarin, as an intermediate in organic synthesis, may participate in the synthesis process of certain cosmetic raw materials, such as certain spices, preservatives or special functions. Preparation of active ingredients.

Potential bioactive applications: In view of the antioxidant, anti-inflammatory and other properties that coumarin compounds may exhibit in vivo, future research may explore the anti-aging, skin repair or improvement of skin conditions of 6-methylcoumarin. application potential.

6-Methylcumarin Advantages

  1. Fluorescence properties: One of the biggest features of 6-methylcoumarin is its fluorescence properties, which makes it of great value in the field of fluorescent labeling and detection. It emits bright fluorescence, has good stability and controllability, and is suitable for use as a biomarker for easy application in biomedical research such as fluorescence microscopy, flow cytometry, and high-throughput screening.
  2. Chemical stability: As an organic compound, 6-methylcoumarin is relatively stable at room temperature and easy to store and handle. This is an important advantage for laboratory research and industrial applications, reducing the need for transportation and storage. loss and danger.
  3. Versatility: As a synthetic intermediate, 6-methylcoumarin can participate in a variety of chemical reactions, such as acylation, alkylation, oxidation reactions, etc., making it an effective starting point for the synthesis of various organic compounds. Substances, suitable for fields such as pharmaceuticals, dye synthesis and new material development.
  4. Potential biological activity: Although the direct biological activity of 6-methylcoumarin may be limited, its structural analogs often show anti-inflammatory, antioxidant, antibacterial and other biological activities in nature. This characteristic suggests that it may be used as a starting point for drug development. Through structural modification, it is expected to obtain compounds with specific biological activities.
  5. Availability and cost: As a commercially produced chemical, 6-methylcoumarin is relatively easy to obtain and affordable in the market, which is conducive to its widespread adoption in applied research and production at different scales.


Kim T, Kang JK, Hyun CG. 6-Methylcoumarin Promotes Melanogenesis through the PKA/CREB, MAPK, AKT/PI3K, and GSK3β/β-Catenin Signaling Pathways. Molecules. 2023 Jun 5;28(11):4551. doi: 10.3390/molecules28114551. PMID: 37299026; PMCID: PMC10254710.

As a company specializing in the production and supply of 6-Methylcumarin raw materials, we are committed to providing customers with high-quality products and preferential prices. We have rich experience and technology to ensure product quality and stable supply. No matter where you are, we can provide you with the 6-Methylcumarin raw materials you need to support your production and research and development.

We always adhere to the principle of honest operation, strictly control product quality, and serve every customer with a customer-first attitude. Over the years, we have established good cooperative relationships with customers at home and abroad and won their trust and praise.

If you have needs or are interested in our products, please contact our service staff directly, we will wholeheartedly provide you with the best quality services and products. Looking forward to cooperating with you and developing together

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

Help China Chemicals to benefit the happiness of human life
Become the most trusted chemical supplier in the world
Striver – oriented, enrich employees, customer first, deep service, seek development
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Cosmetic raw materials
  • Products/Service:Cosmetic raw materials (flavors and fragrances,antioxidant products, moisturizing and hydrating, whitening agents, cosmetic additives)
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.


After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.


Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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