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4-Nitrotoluene CAS 99-99-0

Molecular Formula: C7H7NO2

Formula Weight: 137.14

ZSpharmac: 4-Nitrotoluene Supplement

Product Name: 4-Nitrotoluene
CAS No: 99-99-0
Purity: 99%

Basic Info

Product Name:4-Nitrotoluene
Other Names:4-Nitrotoluene, 99%
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Organic Chemical Raw Materials
Appearance:Yellow Crystalline Solid
EINECS No.:202-808-0
Storage:Warehouse Ventilation Low Temperature Drying 2-8 ° C
Provide:4-Nitrotoluene MSDS;
4-Nitrotoluene COA

What is 4-Nitrotoluene?

4-Nitrotoluene is also known as 1-methyl-4-nitrobenzene, pale yellow crystal, melting point 54.5℃, boiling point 238.3℃. Soluble in benzene, ether, chloroform, carbon tetrachloride, soluble in ethanol, insoluble in water, and volatile with water vapor. Toxic! Mainly used in the manufacture of p-toluidine, bitoluidine, p-nitroformic acid, p-nitrotoluene-2-sulfonic acid, 3-chloro-4-nitrotoluene, etc. It is used as an intermediate for dyes, medicines, pesticides, synthetic materials, auxiliaries, and the like. This product is obtained by nitration of toluene with mixed acid and separation. At the same time co-production of o-nitrotoluene.

4-Nitrotoluene Properties:

Melting point 52-54 °C (lit.)
Boiling point 238 °C (lit.)
density 1.392 g/mL at 25 °C (lit.)
vapor density 4.7 (vs air)
vapor pressure 5 mm Hg ( 85 °C)
refractive index 1.5382
Fp 223 °F
storage temp. 2-8°C
solubility 0.26g/l
form Crystalline Solid
pka11.27 (Perrin, 1972)
color Yellow
Specific Gravity1.392
explosive limit1.6%(V)
Water Solubility 0.35 g/L (20 ºC)


4-Nitrotoluene Uses

  1. 4-Nitrotoluene is used in the manufacture of p-toluidine, toluene diisocyanate, etc. It is also used as an intermediate for pesticides, dyes, medicines, plastics and synthetic fiber auxiliaries.
  2. 4-Nitrotoluene p-Nitrotoluene is an intermediate of herbicides such as Chlormelon, and also an important chemical raw material. It can produce p-toluidine, p-nitrobenzoic acid, p-nitrotoluenesulfonic acid, 2-chloro-4 -Nitrotoluene, 2-nitro-4-methylaniline, dinitrotoluene, etc., and intermediates for medicines and dyes.
  3. 4-Nitrotoluene is mainly used in the manufacture of p-toluidine, toluene diisocyanate, toluidine, p-nitrobenzoic acid, p-nitrotoluene-2-sulfonic acid, 2-nitro-p-toluidine, 3-chloro-4 -Nitrotoluene, dinitrotoluene, etc., are also used as dye intermediates and intermediates of pesticides, pharmaceuticals, plastics and synthetic fiber auxiliaries.

4-Nitrotoluene Production Method

Toluene is nitrified with mixed acid, and p-nitrotoluene is obtained by separation, and o-nitrotoluene is co-produced at the same time.
The preparation method is as follows: adding toluene into a nitrification reaction kettle, cooling it to below 25°C, adding a prepared mixed acid (25%-30% nitric acid, 55%-58% sulfuric acid and 20%-21% water), the temperature rises, and the temperature is adjusted. Do not exceed 50°C, continue stirring for 1-2h, the reaction ends, stand for 6h, and separate, wash with water and alkali the generated nitrobenzene. The crude nitrotoluene contains o-nitrotoluene, p-nitrotoluene and m-nitrotoluene. toluene. The crude nitrotoluene is subjected to vacuum distillation to separate most of the o-nitrotoluene, and the residual fraction containing more p-nitrotoluene is then separated by vacuum distillation, and the p-nitrotoluene is obtained by cooling and crystallization separation, The meta-nitrobenzene is obtained by rectification after accumulation in the mother liquor during the separation of the para-isomer.

Other Applications of 4-Nitrotoluene

1. Synthesis of p-bromobenzaldehyde with p-nitrotoluene
p-Bromobenzaldehyde is an important pharmaceutical and dye intermediate. The existing method for synthesizing p-bromobenzaldehyde mainly uses p-bromotoluene as a raw material. One is to generate benzyl dibromobenzene through a photochemical bromination reaction, which is then obtained by hydrolysis. The method has been industrialized. Cerium methyl sulfate is obtained by oxidation of oxidant. Their common disadvantage is that the cost of raw materials is high, and the former uses highly volatile and hazardous liquid bromine, while the latter adopts an oxidation method that is difficult to control industrially.
CN97106992.1 proposes a method for synthesizing p-bromobenzaldehyde with p-nitrotoluene as raw material. In the present invention, p-nitrotoluene is used as a raw material, and under the catalysis of a phase transfer catalyst, a disproportionation reaction occurs with a sodium polysulfide solution to generate p-aminobenzaldehyde. Under the catalysis of copper or copper, p-bromobenzaldehyde is generated. The sodium polysulfide solution is formed by the action of sodium sulfide (Na2S.9H2O) and elemental sulfur. The molar ratio of sodium sulfide to sulfur is 1:2-1:4. Sodium polysulfide and p-nitrotoluene are in 95%-65% ethanol solution under the action of phase transfer catalyst to produce p-aminobenzaldehyde, and a small amount of p-toluidine is produced. The molar ratio of sodium polysulfide to p-nitrotoluene is 1:3-1:5, the addition amount of the phase transfer catalyst is 1%-5% of the amount of p-nitrotoluene participating in the reaction, and 1 mol of p-nitrotoluene is required to participate in the reaction. 95% ethanol 400-600ml, the reaction temperature is 80-90℃. Under the above conditions, the yield of p-aminobenzaldehyde is >90%.
The phase-transfer catalyst adopted is one of tetrabutylammonium bromide, cetyltrimethylammonium bromide, tetrabutylammonium iodide, N-dimethylformamide, Tween or a mixture of two thereof. Mixed phase transfer catalysts work better. The obtained p-aminobenzaldehyde is distilled by steam, and crystallized by cooling to obtain the wet product, which directly participates in the next step reaction without drying. The acidification of p-aminobenzaldehyde uses sulfuric acid as acidifying agent and sodium nitrite as diazotizing agent. After the diazotization is completed, drop the diazonium salt solution into the newly prepared cuprous bromide hydrobromic acid solution or the newly prepared reduced copper hydrobromic acid suspension. After 1 hour, steam distillation was carried out, and the distillate was filtered and washed to obtain colorless or pale yellow p-bromobenzaldehyde. Purity >98%. 1mol of p-aminobenzaldehyde needs 0.5-1mol of cuprous bromide or 0.05-0.1mol of reduced copper to participate in the reaction, and 2-3mol of hydrobromic acid is required. The preparation of cuprous bromide adopts the usual method. The yield of p-bromobenzaldehyde relative to p-nitrotoluene was 55-65%. The invention provides a method for synthesizing p-bromobenzaldehyde by using p-nitrotoluene as a raw material. By adopting the method to synthesize p-bromobenzaldehyde, the cost of raw materials is low, the industrialization is easy to be realized, and the product purity reaches 99%.
2. For the synthesis of DSD acid
4,4′-Diaminostilbene-2,2’disulfonic acid (DSD acid for short) is an amphoteric compound that contains not only an acidic group sulfonic acid group, but also a basic amino group, which can directly It has condensation reaction with cyanuric chloride, and can also be coupled with most aromatic compounds after diazotization. Therefore, using DSD as raw material, a series of direct dyes, acid dyes and reactive dyes can be synthesized.
At present, the process route for synthesizing DSD acid in most domestic manufacturers is that p-nitrotoluene is sulfonated to generate p-nitrotoluene-o-sulfonic acid (NTS acid for short), and then oxidized in an alkaline medium to generate 4,4′-dinitro stilbene-2,2′-disulfonic acid (referred to as dinitro acid or DNS acid), and finally obtained DSD acid by reduction. CN201510732494.7 provides a DSD acid synthesis process, which combines electrodialysis and bipolar membrane electrodialysis to replace the salting-out step in the traditional process. The usage of the raw material salt reduces the salt content in the subsequent reaction, and at the same time makes full use of the inorganic resources generated in the process, improves the quality and yield of the product, and reduces the process cost.
A DSD acid synthesis process is characterized by comprising the following steps: (1) p-nitrotoluene is subjected to a sulfonation reaction to generate p-nitrotoluene-o-sulfonic acid; (2) p-nitrotoluene-o-sulfonic acid is subjected to The oxidative condensation reaction obtains an oxidative condensation reaction solution; the oxidative condensation reaction solution is treated by electrodialysis to obtain an organic solution containing an intermediate product 4,4′-dinitrostilbene-2,2′-disulfonic acid (DNS acid) and containing brine; (3) subjecting the organic liquid in step (2) to reduction reaction and acid precipitation to obtain a DSD acid product; the brine containing brine is treated in a bipolar membrane electrodialysis system to prepare aqueous sulfuric acid, aqueous sodium hydroxide and dilute brine ; Sulfuric acid aqueous solution and sodium hydroxide aqueous solution can be reused in the DSD acid synthesis process respectively.
3. Synthesis of p-hydroxybenzaldehyde from p-nitrotoluene
With the increasing use of p-hydroxybenzaldehyde, the domestic and foreign market demand is also increasing. Domestic and foreign manufacturers and research departments have been conducting long-term and in-depth research on its production process, and there have been a large number of research reports. . At present, there are mainly 6 kinds of production processes reported at home and abroad, two of which are the most worthy of attention: one is a two-step classical synthesis process using p-nitrotoluene as raw material, redox first, and then diazotization reaction. , the synthesis reaction scheme is shown in Figure 1; the other is a new synthesis process that uses p-cresol as a raw material, under the action of a mixed catalyst of cobalt and copper compounds, and synthesizes the target product through pure oxygen oxidation.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

Our Mission
Help China Chemicals to benefit the happiness of human life
Our Vision
Become the most trusted chemical supplier in the world
Our Business Philosophy
Striver – oriented, enrich employees, customer first, deep service, seek development
Our Values
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Additive , Chemical Auxiliary & Catalyst , Organic Chemicals
  • Products/Service: Organic Intermediate,Inorganic Chemistry, APIs, Dyestuffs And Pigments, Fragrance And Spices, Food Additives
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.


After-Sales Service

*The fact of logistics information monitoring.

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Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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