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4-Methylanisole CAS 104-93-8

Molecular Formula: C8H10O

Formula Weight: 122.16

ZSpharmac: 4-Methylanisole Supplier

Product Name: 4-Methylanisole
CAS No: 104-93-8
Purity: 99%

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Basic Info

Product Name:4-Methylanisole
Other Names:P-Cresyl Ether
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:Clear Colorless to Slightly Yellow Liquid
EINECS No.:203-253-7
Storage:Room Temperature
Provide:4-Methylanisole MSDS;
4-Methylanisole COA

What is 4-Methylanisole?

P-methyl anisole, additionally called 4-methyl anisole, p-methoxytoluene, is an anisole by-product. Naturally present in ylang oil as well as cananga ylang oil, it has the fragrance of violet as well as ylang blossom. It is a very vital chemical basic material and also is extensively used in the fields of medication, seasonings as well as organic synthesis intermediates. This product is an edible spice that is permitted to be made use of according to GB2760-86 of our country. It is primarily made use of to prepare walnut, hazelnut and also various other nut tastes; it is likewise utilized to prepare artificial tastes such as ylang-ylang, cananga, violet, as well as daffodil. In addition, it is additionally used as an intermediate in organic synthesis to manufacture a series of chemical products such as anisaldehyde.

4-Methylanisole Property

Melting point 


Boiling point 

174 °C(lit.)


0.969 g/mL at 25 °C(lit.)

vapor pressure 

5.25 mm Hg ( 50 °C)

refractive index 

n20/D 1.511(lit.)


128 °F

storage temp. 

Sealed in dry,Room Temperature


Chloroform (Soluble), Ethyl Acetate (Slightly)




Clear colorless to slightly yellow


at 1.00 % in dipropylene glycol. naphthyl cresol ylang powdery nutty

Odor Type


Odor Threshold


explosive limit


Water Solubility 

slightly soluble


4-Methylanisole Uses

  1. 4-Methylanisole can be utilized in a suitable quantity in the scent sorts of jasmine, white orchid, ylang-ylang, narcissus, daffodil, rosin, hyacinth, and gorse. It can also be utilized in a percentage for lily of the valley, rose, and also lavender. It can be used in soap significance with bromostyrene, and also occasionally utilized in food significance, mainly used in nut taste, such as walnut as well as hazelnut essence.
  2. 4-Methylanisole is an edible spice that is permitted to be made use of based on GB 2760-96. Primarily used to prepare walnut, hazelnut as well as various other nut flavors.

Preparation of 4-Methylanisole

Method 1: Usage tetrabutylammonium bromide as a phase transfer driver to catalyze the response of p-cresol and dimethyl sulfate to synthesize p-methylanisole. The results reveal that when the molar proportion of dimethyl sulfate and also p-cresol is 1.4, the amount of stage transfer stimulant is 6%, pH= 8, the water bathroom temperature level is controlled at 50-60 ° C, and the reaction time is 6h, the greatest return of 4-Methylanisole can reach 92.36%.

Include 10.5 mL (0.1 mol) of p-cresol as well as 30mL of toluene into a three-necked flask furnished with a magnet, thermostat, dropping funnel, and also spherical reflux condenser, mix magnetically as well as warmth to 50 ° C in a water bath at the same time, include phase Transfer catalyst tetrabutylammonium bromide 1.93 g (0.006 mol), use a specific amount of 30% K2CO3 service to change the pH to be alkaline, regulate the temperature at 50-60 ° C, continue mixing for 40min, and also slowly drop (CH3) 2SO4 into the response container The solution was 13.23 mL (0.14 mol), and the going down time was 50min. At the same time, the pH of the remedy was regulated to be 8. After the dropping, the response was refluxed at the very same temperature for 6h. After the response was finished, the top organic layer was washed with 3 × 20mL10% ammonia water, as well as the liquid layer was gotten rid of by separation. Laundry with saturated NaCl service until neutral, and also completely dry with anhydrous CaCl2, filter, and also boil down under reduced pressure to gather the product. The item yield is 92.36%.

Technique 2: a prep work method of 4-Methylanisole, especially comprising the adhering to actions:
1) Neutralization response: p-cresol: 100.0 g (web content: 99.1%, 0.9176 mol), absolute ethanol: 600ml, open nitrogen defense, set nitrogen flow: 0.5 l/min. The external wall of the four-necked flask is cooled with cooling water, as well as the inner temperature is regulated not to go beyond 35 ° C. Gradually include sodium hydroxide: 37.5 g (0.9375 mol) right into the four-necked flask from the thermometer mouth (take out the thermostat). After feeding, the response was stirred for 1.0 hr. After the response is finished, the outer wall of the four-neck flask is heated with 85-90 ° C hot water, as well as the ethanol is constantly distilled out under the defense of nitrogen. In the later stage of purification, the outflow speed of ethanol will lessen and smaller. When the discharge of ethanol is really tiny, vacuum recuperation is executed, and the vacuum level is regulated to be above -0.08 MPa to recoup the ethanol to dry skin. The residue in the four-necked flask is sodium p-cresol, quantity: 121.1 g, content: regarding 98.2%.

2) Methylation response 1: In a 500ml four-necked flask geared up with a thermometer, a stirring paddle as well as a reflux condenser, placed the prepared salt p-cresol: 50.0 g (web content: concerning 98.2%, 0.3777 mol), cyclohexane Alkane: 300ml. The external wall surface of the four-neck flask was maintained warm with 40 ° C warm water, began stirring, as well as adjusted the stirring rate to be greater than 500r/min. Weigh dimethyl sulfate: 50.0 g (content: 98.7%, 0.3917 mol) and also participate in the consistent pressure dropping funnel, after that drop the dimethyl sulfate in the consistent stress dropping channel to four The methylation response was accomplished in a flask. After the enhancement of dimethyl sulfate is complete, keep the temperature for 5.0 to 8.0 hours.

3) Post-processing: After warmth preservation, filter after cooling. The filter cake was washed with 100ml cyclohexane, as well as dried out to acquire salt methyl sulfate: 50.8 g, content: 97.3%. After the filtrate was cleaned with alkaline water, the solvent was recouped (the cleaned alkaline water was made use of once again). After recuperation of the solvent, p-methylanisole was acquired: 45.6 g, material: 98.1%, yield: 97.0%.

4) Methylation response 2: take into a 500ml three-neck flask geared up with a thermostat, a stirring paddle as well as a reflux condenser: 42.5 g of sodium p-cresol (web content: concerning 98.2%, 0.3210 mol), methyl tetrahydrofuran: 300ml, Dry sodium methyl sulfate: 50.8 g (content: 97.3%, 0.3689 mol). Stirring was begun, and also the outer wall of the three-neck flask was heated up with an electric heating mantle, and also the response was refluxed for 5.0 to 8.0 hours. After the reaction was completed, it was cooled down to room temperature.

5) Post-processing: After cooling down, filter, and the filter cake is made of salt sulfate for detailed application. The filtrate was moved to a 500ml three-necked flask to recover methyl tetrahydrofuran. After healing, 4-Methylanisole was acquired: 38.5 g, detected content: 97.2%, return: 95.5%.

Optimization of the Preparation Method of 4-Methylanisole

The purpose of this study is to address the problems of low synthesis yield of p-methylanisole in the prior art, or the use of toxic and harmful methylation raw materials, or the difficulty of post-processing caused by the use of quaternary ammonium salts that are easily decomposed by heat for phase transfer catalysis. , aiming to provide a green, efficient and economically feasible method for synthesizing p-methylanisole.

When DMC is used as the raw material for methylation, there are generally two reactions, methylation and carbonylation, and the present invention only tends to one method of methylation.

In order to solve the above problems, the present invention adopts the following technical scheme: a kind of synthetic method of 4-Methylanisole, p-cresol and dimethyl carbonate undergo methylation reaction in the liquid-liquid two-phase reaction system, wherein with water as solvent , using Turkey red oil as an emulsifier to prepare p-methyl anisole.

Among them, the molar ratio of p-cresol to dimethyl carbonate is 1:1.5-1:20; the reaction temperature is controlled in the range of 130-180°C, and the reaction time is generally 5-8 hours.

About Products:
If you need 4-Methylanisole as a cosmetic raw material, please contact our service staff directly, we will provide you with high-quality products at the best price.
As an experienced 4-Methylanisole manufacturer and supplier, ZSpharmac will provide 4-Methylanisole raw materials for customers all over the world for a long time.
Over the years, the company has been adhering to the spirit of “integrity management, strict quality control, customer first”, and has won unanimous praise from domestic and foreign customers.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

Help China Chemicals to benefit the happiness of human life
Become the most trusted chemical supplier in the world
Striver – oriented, enrich employees, customer first, deep service, seek development
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Cosmetic raw materials
  • Products/Service:Cosmetic raw materials (flavors and fragrances,antioxidant products, moisturizing and hydrating, whitening agents, cosmetic additives)
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


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We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

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Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

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1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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