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4-Methylacetophenone CAS 122-00-9

Molecular Formula: C9H10O

Formula Weight: 134.18

ZSpharmac: 4-Methylacetophenone Supplier Manufacturers

Product Name: 4-Methylacetophenone
CAS No: 122-00-9
Purity: 99%

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Basic Info

Product Name:4-Methylacetophenone
Other Names:Acetophenone
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:Clear Colorless to Pale Yellow Liquid
EINECS No.:204-514-8
Storage:Store Below +30°C.
Provide:4-Methylacetophenone MSDS;
4-Methylacetophenone COA

What is 4-Methylacetophenone?

4-Methylacetophenone is an aromatic substance with a wonderful, fruity, nutty and also vanilla-like fragrance. Additionally, p-methoxyacetophenone sometimes smells like butter or sugar. At room temperature level, p-methoxyacetophenone is strong, with white to light yellow crystals. When melted, the white crystals develop into a clear liquid.
The substance is utilized as a cigarette additive, seasoning and also contributed to food flavoring. P-methoxyacetophenone can be located normally in castoreum (glandular secretion of beavers). p-Methoxyacetophenone can be manufactured from anisole and acetyl chloride with Friedel-Crafts response.

4-Methylacetophenone Property

Melting point 

22-24 °C (lit.)

Boiling point 

226 °C (lit.)


1.004 g/mL at 20 °C 1.005 g/mL at 25 °C (lit.)

vapor pressure 

0.52 hPa (25 °C)

refractive index 

n20/D 1.533(lit.)


198 °F

storage temp. 

Store below +30°C.






Clear colorless to pale yellow


at 10.00 % in dipropylene glycol. hawthorn sweet mimosa coumarin cherry acetophenone

Odor Type


explosive limit


Water Solubility 

0.37 g/L (15 ºC)


4-Methylacetophenone Uses

  1. 4-Methylacetophenone is a food flavor that is enabled to be made use of according to GB 2760 1996. It is primarily made use of to prepare almond, nut, cherry, xiangzhuo and strawberry tastes.
  2. 4-Methylacetophenone is used as seasoning, herbicide intermediate and also natural synthesis.
  3. 4-Methylacetophenone can be used in mimosa, hawthorn, acacia, acacia, primrose, sunflower, hyacinth, lavender, lily, woody, mossy as well as other kinds. It can be made use of along with coumarin, anisaldehyde, as well as jasminal in lavender, fenwei, Suxinlan, and also brand-new trim grass for soap. It can be used in almond, vanilla as well as bean-flavored food tastes in a small amount, and also can additionally be utilized in cigarette flavors in a small amount.
  4. 4-Methylacetophenone has an aroma comparable to hawthorn, and has alfalfa, honey, strawberry and aroma, and also the flower and fruity fragrance is sharp and also pleasant. It can be used in the preparation of lavender significance for Acacia kind soap, etc.

Application of 4-Methylacetophenone

1. For the preparation of celecoxib
Celecoxib, trade name: Celebrex, chemical name: 4 [5( 4‑methylphenyl) 3( trifluoromethyl) 1H‑pyrazole‑1‑yl] benzene Sulfonamide, with a chemical formula of C17H14F3N3O2S, is the very first particular type 2 cyclooxygenase (COX-2) prevention launched by Searle, U.S.A.. Its selectivity for COX-2 is 375 times that of COX-1. It is primarily made use of in For the treatment of osteo arthritis as well as rheumatoid arthritis, the anti-inflammatory task amounts indomethacin, yet practically no intestinal negative effects. The artificial technique of celecoxib is mostly that 4-Methylacetophenone is condensed by Claisen to acquire a β-diketone intermediate, and then cyclized with p-hydrazinobenzenesulfonamide to obtain celecoxib.

2. For the synthesis of 4-chloro-2-cyano-N, N-dimethyl-5-( 4-methylphenyl) -1 H-imidazole-1-sulfonamide.
4-Chloro-2-cyano-N, N-dimethyl-5-( 4-methylphenyl) -1 H-imidazole-1-sulfonamide (cyanazifazol) was developed by Japan Ishihara Sangyo Co., Ltd., The brand-new generation of imidazole fungicides jointly developed with BASF is primarily made use of to stop and also regulate conditions triggered by oomycete virus, such as: potato late curse, tomato late affliction, grape downy mold, cucumber downy mold, etc. It has excellent protective activity, long recurring impact, and also is immune to rainfall disintegration. It can be utilized for both soil therapy as well as foliar spray, as well as has really low toxicity as well as excellent environmental compatibility.

CN201410165615.X offers a brief response cycle, easy post-treatment, ideal for batch industrial production of 4-chloro-2-cyano-N, N-dimethyl-5-( 4-methylphenyl) -1 H-imidazole- 1-sulfonamide method. The synthetic course supplied by the present development is as adheres to:.

In the initial step, 2-carbonyl-2-p-phenylmethylacetaldehyde is synthesized from 4-Methylacetophenone, and also the procedure is as complies with: add selenium dioxide, water as well as dioxane to a three-necked response flask, as well as warm to 50 Dissolve selenium dioxide at ~ 70 ° C, include p-methylacetophenone, warm up to 90-120 ° C, respond for 4-6 hrs, cool to area temperature, filter out the created elemental selenium, concentrate under lowered stress to remove the solvent, add Oil ether defeating to acquire crude 2-carbonyl-2-p-benzyl acetaldehyde, recrystallization with a blended solvent of oil ether and ethyl acetate to acquire 2-carbonyl-2-p-benzyl with a pureness of more than 98% Acetaldehyde. Wherein, the molar ratio of p-methylacetophenone, selenium dioxide, water and dioxane is 1:1 ~ 2:0.1 ~ 0.5:3 ~ 10, and the volume proportion of oil ether as well as ethyl acetate is 10 ~ 15:1.

3. Made use of in the synthesis of 4-acetylbenzoic acid.
4-Acetobenzoic acid primarily synthesizes the synthesis of brand-new medication intermediate N-methyl-2-( 4-acetyl-5-nitrobenzimidazole, as well as benzimidazole and also its derivatives are energetic ingredients of several new medicines. Such as Cramizol antihistamines, etitrazine, strong anesthetics, benzyl imidazole, antispasmodics and also antifungal medicines belong to this type of derivatives, as well as its synthesis has certain academic value and strong sensible value. Formerly The production cost of synthesizing 4-acetylbenzoic acid is high, and also the discharge of 3 wastes is huge, which significantly influences the use and promotion. In the prior art, the reaction temperature level is high, the quantity of potassium permanganate is big, and also the response time is long. CN201210161777.7 provides a low production price, production procedure environmental protection, the preparation technique of the high 4-acetylbenzoic acid of yield.Comprise the following steps:

( 1) Oxidation, include 4-Methylacetophenone, water and also anhydrous zinc chloride into the response pot, mix evenly, slowly heat up to 35 ~ 40 ℃, divide potassium permanganate into 5 equal parts, include one part every 15 ~ 20 minutes After feeding, control the reaction temperature level at 48-55 ° C. After the addition, control the response temperature level at 40-45 ° C, maintain it cozy for 1.5 hours, after that lower the temperature to 17-22 ° C, centrifuge, as well as dry to acquire the crude product of 4-acetylbenzoic acid.

( 2) Mix the ready crude 4-acetylbenzoic acid with anhydrous acetic acid, warm to reflux for 0.5-1.5 hrs, filter while warm, centrifuge, and also dry to obtain 4-acetylbenzoic acid.

Preparation of 4-Methylacetophenone

CN201610777734.X gives an approach for preparing p-methylacetophenone with better performance, more environmental protection and also basic production process. In order to achieve the above object, the technological scheme embraced by the existing invention is: a kind of prep work approach of 4-Methylacetophenone supplied consists of the complying with processing steps:

( 1) raw material prep work: the manufacturing raw material of this methyl acetophenone consists of complying with elements (components by weight): 3-5 parts of toluene, 50-60 parts of acylating reagent, 100-120 parts of natural solvent, 5-10 parts of catalyst 10-15 parts of light weight aluminum trichloride;

( 2) Filling up the catalyst: the driver is equally filled up right into the repaired bed activator, as well as the dealt with bed is preheated, and the pre-heating temperature level is 120-150 ° C;

( 3) Single acylation response: send the toluene and also acylating reagent in the action (1) right into the fixed-bed activator symmetrical, as well as execute pressurized home heating, the heating temperature is 150-200 ° C, and the response time is 20- 30min;

( 4) Include vibration response: aluminum trichloride is taken part the solution that action (3) obtains and responds, and also the length of reaction is 10-20min;
( 5) additional acylation reaction: including a natural solvent to the reaction solution acquired symphonious (4 ), as well as boosting the heating temperature level as well as stress, the heating temperature level is 250-300 ° C;

( 6) Purification treatment: the mixed solution acquired in step (5) is gone through a correction tower for constant rectification, and also the rectification temperature level is 160-180 ° C.

The present innovation utilizes toluene and an acylating representative as the main raw materials to execute an acylation response to acquire p-methylacetophenone, and includes an added acylation response procedure on the basis of the standard process, including a very first acylation response and also a second acylation reaction, 4-Methylacetophenone with greater purity can be acquired through step-by-step acylation response, and the reactor in this preparation approach has basic structure, secure procedure, simple control, and very easy realization of massive and also constant production, which deserves promoting.

About Products:
If you need 4-Methylacetophenone as a cosmetic raw material, please contact our service staff directly, we will provide you with high-quality products at the best price.
As an experienced manufacturer and supplier of 4-Methylacetophenone, ZSpharmac will provide 4-Methylacetophenone raw materials for customers all over the world for a long time.
Over the years, the company has been adhering to the spirit of “integrity management, strict quality control, customer first”, and has won unanimous praise from domestic and foreign customers.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

Help China Chemicals to benefit the happiness of human life
Become the most trusted chemical supplier in the world
Striver – oriented, enrich employees, customer first, deep service, seek development
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Cosmetic raw materials
  • Products/Service:Cosmetic raw materials (flavors and fragrances,antioxidant products, moisturizing and hydrating, whitening agents, cosmetic additives)
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.


After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.


Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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