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4-Methyl-2-Pentanone CAS 108-10-1

Molecular Formula: C6H12O

Formula Weight: 100.16

ZSpharmac: 4-Methyl-2-Pentanone Supplement

Product Name: 4-Methyl-2-Pentanone
CAS No: 108-10-1
Purity: 99%

Basic Info

Product Name:4-Methyl-2-Pentanone
Other Names:2 Hydroxy 4 Pentanone
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Organic Chemical Raw Materials
Appearance:Colorless Liquid
EINECS No.:203-550-1
Storage:Store at +5°C to +30°C.
Provide:4-Methyl-2-Pentanone MSDS;
4-Methyl-2-Pentanone COA

What is 4-Methyl-2-Pentanone?

4-Methyl-2-pentanone (methyl isobutyl ketone) reagent is widely used in chemical as well as pharmaceutical solvents, splitting up and also recuperation of nuclear fission items and also clinical study. The content of 4-methyl-2-pentanone sold on the market is less than or equal to 99%, which consists of a small amount of contaminations such as alcohol, acidic compounds and also water. 4-Methyl-2-pentanone is made use of as a solvent for nitrocellulose, lacquers and also some polymers and also resins, as well as is also used in the synthesis of 2-(1-hydroxy-3-methylbutyne)-1 h-indene-1, 3(2H)-dione reactant.

4-Methyl-2-Pentanone Properties:

Melting point -80 °C (lit.)
Boiling point 117-118 °C
density 0.801 g/mL at 25 °C (lit.)
vapor density 3.5 (vs air)
vapor pressure 15 mm Hg ( 20 °C)
refractive index n20/D 1.395(lit.)
Fp 56 °F
storage temp. Store at +5°C to +30°C.
solubility water: soluble20g/L
form Liquid
color APHA: ≤15
OdorPleasant; mild, characteristic; sharp; non-residual; ketonic.
Odor Threshold0.17ppm
explosive limit1.2-8%, 93°F
Water Solubility 17 g/L (20 ºC)


4-Methyl-2-Pentanone Uses

  1. 4-Methyl-2-pentanone is used as a pharmaceutical and also color intermediate. The chemical Mite-Danjing produced by o-chlorobenzaldehyde can manage the termites on dry crops as well as fruit trees.
  2. 4-Methyl-2-pentanone is utilized as a solvent for nitrocellulose, resins, gums, and so on. Extractant for sure not natural salts. Organic Synthesis.
  3. 4-Methyl-2-pentanone is utilized as a solvent as well as likewise as a dewaxing representative for lubing oils.
  4. 4-Methyl-2-pentanone is used as a fragrance. Mainly utilized to prepare rum, cheese and fruit tastes.
  5. 4-Methyl-2-pentanone is an outstanding tool boiling point solvent. It is made use of as mineral dressing representative, solvent for oil dewaxing, coupler for shade film, solvent for tetracycline, pyrethrins and DDT, adhesive, rubber glue, covering up paint for airplanes and also versions. It can also be made use of as an anticoagulant as well as diluent for vinyl resins.


The object of the present innovation is to, for the acetone in the prior art 2-methylpentane/acetone azeotrope is not recycled, cause the trouble that raw material acetone usage is high, give a sort of boosted item separation technique, to lower acetone usage, thereby lowering the manufacturing expense of the product. The technical plan of the present invention is as complies with: the reaction raw material acetone is responded in the existence of a hydrogen-containing gas and a stimulant, the catalyst is separated into a hydrogen-containing gas via a gas-liquid separator, and also the staying liquid is cooled down and cooled down, and after that firstly goes into the 2-methylmethane Base pentane tower, 2-methylpentane as well as acetone are distilled from the top of the tower in the form of azeotrope (the theoretical azeotrope make-up is 56wt% 2-methylpentane and also 44wt% acetone under typical pressure), the kettle fluid enters the acetone recuperation tower. In the acetone healing tower, the excess acetone is vaporized from the top of the acetone recuperation tower as well as circulated to the reaction system; the pot fluid gets in the very first phase separator to separate the water phase and also the oil stage, the water phase departures the tool, and also the oil stage gets in the MIBK in the dehydration tower. In the MIBK dehydration tower, water as well as methyl isobutyl ketone are eliminated from the top of the tower in the form of an azeotrope (its azeotrope structure is 75 wt% methyl isobutyl ketone, 25 wt % water at normal stress) After steaming, it enters the 2nd phase separator. After phase separation, the oil phase is utilized as the reflux of the MIBK dehydration tower, and the water phase spurts from all-time low of the 2nd phase separator and is sent of the device. The MIBK dehydration tower still liquid enters the methyl isobutyl ketone tower, the methyl isobutyl ketone is steamed from the top of the tower, and also the heavy components continue to be in the still liquid. The reconstituted is a mix of diisobutyl ketone (DIBK) and also mesitylene (TMB).

The present invention is characterized in that, on the basis of the existing method, an extraction and recovery step for acetone is added, and the azeotrope (2-methylpentane/acetone) that comes out from the top of the 2-MPA tower is separated to recover acetone, so The process of described acetone extraction and recovery is: the azeotrope that the 2-MPA tower top comes out first enters the extraction device to extract with water, then in the phase separator, the extraction mixed solution is phase-separated, and the separated oil phase (2-methyl) pentane) directly out of the apparatus, and the separated aqueous phase (mixture of water and acetone) is reserved for further processing.

The above-mentioned separated water phase can be further processed by the following methods: it can be directly recycled to the acetone recovery tower feed port, and after mixing with the material from the bottom of the 2-methylpentane tower, it enters the acetone recovery tower; or the separated water The phase first enters the crude dehydration tower for dehydration, and the dehydrated acetone (containing 95wt% of acetone and 5wt% of water) is recycled to the feed port of the acetone recovery tower, mixed with the material from the bottom of the 2-methylpentane tower, and then enters the acetone Recovery tower; the separated water phase can also be firstly entered into a fine dehydration tower for dehydration, and the dehydrated acetone (with water content of less than 0.5wt%) is directly recycled to the feed port of the reaction system.

The above-mentioned extraction is carried out by utilizing the properties that acetone and water can be mutually dissolved in any proportion, and the extraction device used can be a conventional extraction tower or a stirred tank, and the weight ratio of the extraction feed to water is 1 : 1 to 1: 0.2. The acetone extractant used in the present invention can be water, and can also be other solvents that are mutually soluble with acetone and insoluble with 2-MPA.

The Purification Method of 4-Methyl-2-Pentanone

A method for purifying high-purity organic solvent 4-methyl-2-pentanone, the steps are as follows:

(1) The raw material 4-methyl-2-pentanone (content is about 99%) is lifted to the top of the adsorption column, wherein the adsorption column is 1.2M in height, 3.0cm in diameter, and the amount of the acid alumina adsorbent inside is the column height 4/5, the raw material is adsorbed at a speed of 30mL/min; in the column, 4-methyl-2-pentanone is fully contacted with the adsorbent acidic alumina, so that a small amount of alcohols and acidic impurities are adsorbed, and the adsorption effluent is detected. The quality of the effluent to be adsorbed is qualified, that is, each index of the effluent is close to the technical index requirements of the chromatographic grade (see Table 1 for specific technical index requirements), enter the next step operation, and remove the pre-adsorption fraction with high impurities.

(2) the 4-methyl-2-pentanone flowing out of the above-mentioned adsorption column is entered into the drying column, the column height is 1.2M, the diameter is 3.0cm, and the anhydrous calcium sulfate dried by baking is loaded, and the 4-methyl sulfate after drying is measured. – The water content of 2-pentanone, the water content should be controlled at ≤ 0.05%, and the next step will be performed after the water content is qualified; if the water content is greater than 0.1%, it means that the desiccant has been saturated with water and must be replaced before drying.

(3) above-mentioned 4-methyl-2-pentanone after drying is pushed into the glass rectifying still of 20L and carries out rectification, utilizes electric heating, controls about 200 ℃ of temperature at the bottom of the still, 4-methyl-2 – The liquid temperature of pentanone is about 120°C, the liquid temperature is about 117°C, and the reflux ratio is controlled to be 1:0.5 to 1:2. Bottled and sealed under nitrogen protection, a qualified chromatographic grade 4-methyl-2-pentanone product (purity ≥99.5%) is obtained, and the front fraction is further processed.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

Help China Chemicals to benefit the happiness of human life
Become the most trusted chemical supplier in the world
Striver – oriented, enrich employees, customer first, deep service, seek development
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Additive , Chemical Auxiliary & Catalyst , Organic Chemicals
  • Products/Service: Organic Intermediate,Inorganic Chemistry, APIs, Dyestuffs And Pigments, Fragrance And Spices, Food Additives
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.


After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.


Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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