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4-Methoxybenzyl Alcohol CAS 78-98-8

Molecular Formula: C3H4O2

Formula Weight: 72.06

ZSpharmac: 4-Methoxybenzyl Alcohol Supplement

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Product Name: 4-Methoxybenzyl Alcohol
CAS No: 78-98-8
Purity: 99%

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Basic Info

Product Name:4-Methoxybenzyl Alcohol
Other Names:Methylglyoxal
CAS:78-98-8
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Flavors and Fragrances
Appearance:Clear Yellow to Yellow-Brown Solution
EINECS No.:201-164-8
Storage:2-8°C
Provide:4-Methoxybenzyl Alcohol MSDS;
4-Methoxybenzyl Alcohol COA

What is 4-Methoxybenzyl Alcohol?

4-Methoxybenzyl Alcohol, likewise referred to as celebrity anise oil, is colorless, transparent or light yellow liquid when the temperature level is above 20 degrees Celsius. When the temperature level drops, half-cracked crystals will certainly speed up, with the scent and sweet taste of anethole. A little soluble in water, easily soluble in ethanol, ether as well as chloroform. Octagon belongs to the Magnoliaceae family, aniseed genus. Its fruit is an aggregated fruit with an octagonal shape, so it is commonly called celebrity anise, also known as aniseed and so forth. 4-Methoxybenzyl Alcohol is an intricate aromatic oil that is unstable and also somewhat thick. The color is preferably gray-white, as well as the yellow is somewhat inferior. The preference is pleasant as well as piercing, with a solid celebrity anise scent. At the temperature level of 10-15 ℃, it will coagulate when stirred. Its main ingredient is trans-anethole, the web content of which is as high as 80%. It additionally has α-pinene, limonene, linalool, safrole, Methylglyoxal Miel, anisone, 4-terpineol, wormwood, anisaldehyde and also other active ingredients. Star anise oil is a sort of aromatic oil that is very technical and also difficult to recognize without chemical instruments. Today, the high quality of star anise oil is still evaluated by the buyer’s eyes as well as nose in the production location. Celebrity anise oil is primarily utilized to draw out anethole in the perfume market, and then manufacture anisaldehyde, 4-Methoxybenzyl Alcohol (p-methoxybenzyl alcohol, 4-methoxybenzyl alcohol). These monomeric flavors are extensively made use of in tooth paste, food, soap and cosmetic flavors. Its fruit is a food seasoning as well as spice generally used by the Chinese people. At the same time, celebrity anise oil is the main resources for the synthesis of the unfavorable hormone diethylstilbestrol in the pharmaceutical market. Given that star anise oil is lighter than water and also is suspended on the water surface, the water after oil-water splitting up consists of celebrity anise oil and also is gone back to the purification pot for re-distillation to enhance the oil return.

4-Methoxybenzyl Alcohol Properties:

Melting point 22-25 °C (lit.)
Boiling point 259 °C (lit.)
density 1.113 g/mL at 25 °C (lit.)
refractive index n20/D 1.544(lit.)
  
Fp 230 °F
storage temp. -20°C
solubility alcohol: freely soluble
form Liquid After Melting
pka14.43±0.10(Predicted)
Specific Gravity1.108
color Clear colorless to yellow
PH6.3 (10g/l, H2O, 20℃)
explosive limit0.9-7.3%(V)
Water Solubility insoluble

 

4-Methoxybenzyl Alcohol Uses

  1. 4-Methoxybenzyl Alcohol is It can also be used for saffron-type flavor that needs the fragrance of sheathing orchid to harmonize the fragrance as well as enhance the fragrance of bean.
  2. 4-Methoxybenzyl Alcohol is a permitted edible flavor specified in GB 2760-1996. Mostly for the preparation of vanilla, chocolate, cacao, almond, peach and other flavors.
  3. 4-Methoxybenzyl Alcohol is used in the preparation of medications and also scents.
  4. 4-Methoxybenzyl Alcohol is an alcoholic synthetic scent. Generally used as a mixing flavor of jasmine, clove, pleasant pea, gardenia and other flavors, and made use of in cosmetics such as fragrance.
  5. 4-Methoxybenzyl Alcohol offers short-term defense to the anti-isomeric OH-group of carbs.

Applications of 4-Methoxybenzyl Alcohol

4-Methoxybenzyl Alcohol, also known as anisol, is a colorless to slightly yellow liquid at room temperature and pressure, with a melting point of 24°C and a boiling point of 259°C. 4-Methoxybenzyl Alcohol has a sweet fruity aroma like peach, soft and lasting fragrance, and can be used for the preparation of high-grade tobacco and food flavors.

CN201410185362.2 provides a method for preparing high-quality 4-Methoxybenzyl Alcohol, wherein without using an initiator, especially a halogen-based initiator, cheap oxygen is used as an oxidant for oxidation reaction, avoiding the use of chemical oxidants and other organic peroxides. Oxide oxidant, the hydrogenation reaction conditions are mild, the selectivity is high, almost no excessive hydrogenation reaction occurs, the reaction material and catalyst can be recycled and applied, which reduces the cost and the generation of three wastes, so it is economical, environmentally friendly, green and efficient, and has The characteristics of simplicity, easy control and industrial production, the reaction chemical formula is:

4-Methoxybenzyl Alcohol is catalyzed by oxygen in liquid phase to generate p-methoxybenzaldehyde, anisyl acetate and a small amount of p-methoxybenzoic acid. Optionally, after the recovery of solvent acetic acid and catalyst, direct alkaline hydrolysis is carried out to obtain a mixture containing p-methoxybenzaldehyde and p-methoxybenzyl alcohol through oil-water separation, and a small amount of p-methoxybenzoic acid generated by oxidation is removed simultaneously. Then through catalytic hydrogenation, p-methoxybenzaldehyde is converted into 4-Methoxybenzyl Alcohol, and finally high-quality 4-Methoxybenzyl Alcohol is obtained through rectification.

Examples are as follows:

Put 488.8Kg of acetic acid (KF<1%), 30.2Kg of cobalt acetate, 13.2Kg of manganese acetate and 122.2Kg of p-methoxytoluene into the dry stainless steel oxidation kettle. For 6.5h under the normal pressure (that is, the gauge pressure is 0MPa), the reaction is kept warm and oxygen is stopped, and sampling is performed for GC and HPLC detection. The GC results are: p-methoxytoluene 51.5365%, p-methoxybenzaldehyde 16.8333%, p-methoxybenzaldehyde Methoxybenzyl alcohol 1.5437% and anisyl acetate 28.9929%, the ratio of aldehyde to acid detected by HPLC was 52.8:1.

After the oxidation reaction was completed, the recovered acetic acid KF=4.87%, and the acetic acid content was 90.92%, which was directly used in the next batch of oxidation reactions. Acetic acid recovery finishes, under nitrogen protection, wash with 200Kg, 100Kg and 50Kg of clean tap water respectively, after stirring 30min, stand for stratification to obtain water phase I405.4Kg and oil phase I152Kg. Take the oil phase for GC and HPLC detection, the GC results are, p-methoxytoluene 51.8266%, p-methoxybenzaldehyde 16.6041%, p-methoxybenzyl alcohol 1.2122% and anisyl acetate 29.6071%, HPLC detects the ratio of aldehyde to acid 67:1.

Put 200Kg of water and 60Kg of sodium hydroxide into the hydrolysis reaction kettle, dissolve and heat up to 80-85 ° C, drop the oil phase I152Kg in 30min, keep the temperature for 1.5-2h after the dripping, after the reaction is completed, stand for stratification to obtain Water phase II 265.5 Kg and oil phase II 143 Kg. The oil phase was taken for GC and HPLC detection. The GC results were: p-methoxytoluene 51.8215%, p-methoxybenzaldehyde 16.7277%, 4-Methoxybenzyl Alcohol 30.8563%, and the aldehyde-acid ratio detected by HPLC was 2502:1.

The water phase I405.4Kg was transferred into the still, and the stirring was turned on, and the normal pressure was heated to 100-121 ℃, and 352Kg of reclaimed water was used for mechanical application, and distillation bottom catalyst I was used for oxidation reaction.

In the autoclave, 143Kg of oil phase II, 20Kg of skeleton nickel catalyst (15% water content), and 300Kg of anhydrous methanol were added. It was evacuated 3 times with nitrogen and 3 times with hydrogen. The hydrogenation pressure is set at 0.3-0.4 MPa, and the reaction temperature is set at 80-90°C. Continue to feed hydrogen into the hydrogenation kettle until the hydrogen is no longer absorbed. The temperature of the autoclave was lowered to 30-40°C, the hydrogen in the autoclave was evacuated, and then evacuated three times with nitrogen. The material in the kettle is filtered by a press, and then the catalyst is recovered for the next batch, and the filtrate is recovered for the next batch. 58.2Kg, GC purity 99.87%, Methylglyoxal Miel 61.2Kg, GC purity 99.54%, yield 86.0%.

CN201410185353.3 provides a co-production method capable of simultaneously preparing high-quality 4-Methoxybenzyl Alcohol, anisyl acetate, p-methoxybenzaldehyde and 4-Methoxybenzyl Alcohol, avoiding the use of initiators in the oxidation reaction stage , especially halogen initiators, use cheap oxygen as oxidant, avoid the use of chemical oxidants and other organic peroxide oxidants, use mild alkaline hydrolysis conditions, and use self-closing circulation to realize material circulation, thus reducing manufacturing costs. The generation of three wastes and three wastes reduces the pressure on environmental protection, and also has the characteristics of simplicity, easy control and industrial production. Through a synthesis process comprising the following steps, p-methoxytoluene is used as a raw material, and in the presence of a halogen-free catalyst, Methylglyoxal Miel, anisyl acetate, 4-Methoxybenzyl Alcohol, and p-methoxybenzene are generated by oxygen oxidation. Formic acid, can obtain high-quality Methylglyoxal Miel, anisyl acetate, p-methoxybenzaldehyde and p-methoxybenzoic acid, the reaction formula is:

Examples are as follows:

Put 488.8Kg of acetic acid (KF<1%), 25.2Kg of cobalt acetate, 12.5Kg of manganese acetate and 122.2Kg of p-methoxytoluene into the dry stainless steel oxidation kettle. (gauge pressure) is 0.10MPa and the reaction is incubated for 6.5h and then oxygen is stopped. The samples are taken for GC and HPLC detection. The GC results are: Benzyl alcohol 1.1660% and anisyl acetate 20.5117%, the ratio of aldehyde to acid detected by HPLC was 13.2:1. After the oxidation reaction is completed, the recovered acetic acid KF=5.42%, and the acetic acid content is 89.29%, which is directly used in the next batch of oxidation reactions. Acetic acid recovery was completed, under nitrogen protection, washed with 200Kg, 100Kg and 50Kg of clean tap water respectively, stirred for 30min and left to stand for stratification to obtain water phase I399.3Kg and oil phase I150.5Kg.

Take the oil phase for GC and HPLC detection, the GC results are, p-methoxytoluene 51.5072%, p-methoxybenzaldehyde 25.8914%, 4-Methoxybenzyl Alcohol 0.9629% and anisyl acetate 20.9071%, HPLC detects the ratio of aldehyde to acid 13.5:1. Under nitrogen protection, add the oil phase I150.5Kg obtained by water washing into the still, add 5Kg of anhydrous sodium carbonate, and distill under reduced pressure to obtain the organic phase II137Kg. 100Kg of water was added to the bottom of the distillation, neutralized with 72% sulfuric acid to pH=2-3, and filtered to obtain 4.5Kg of 4-Methoxybenzyl Alcohol. The organic phase II 137Kg was rectified at a still temperature of 110-124° C. and a pressure of 6-8mmHg to obtain p-methoxytoluene 57.9Kg, with a GC purity of 99.87%, and was rectified at a still temperature of 124-130° C. and a pressure of 3-5mmHg to obtain p-methoxytoluene. Oxybenzaldehyde 33.7Kg, GC purity 99.27%, and rectification at a kettle temperature of 136-138°C and 3-5mmHg pressure to obtain 35.1Kg anisyl acetate, GC purity 99.93%. The water phase I405.4Kg was transferred into the still, and the stirring was turned on, and the normal pressure was heated to 100-121 ℃, and 352Kg of reclaimed water was used for mechanical application, and distillation bottom catalyst I was used for oxidation reaction. Put 192Kg of water and 48Kg of sodium hydroxide into the hydrolysis reactor, dissolve and heat up to 65-75 ° C, dropwise add 35.1Kg of anisyl acetate within 30min, and keep the temperature for 1.5-2h after the completion of the reaction. The layers were separated to obtain 248.1Kg of water phase II and 28.1Kg of crude 4-Methoxybenzyl Alcohol, with a GC purity of 99.19%. Then, rectification is carried out at a kettle temperature of 130-136° C. and a pressure of 3-5 mmHg to obtain a finished product of 4-Methoxybenzyl Alcohol of 25.6Kg with a GC purity of 99.85%.

Preparation method of 4-Methoxybenzyl Alcohol

report one,
4-Methoxybenzaldehyde (136 mg, 1.0 mmol), pet cat. [Ir] (1.1 mg, 0.002 mmol, 0.2 mol%) and also isopropanol (5 mL) were together contributed to a 25 mL Kelvin tube, N2 protected, 82 ℃ response 6h. Cooled down to room temperature level, the solvent was eliminated by rotary evaporation, and afterwards the pure target compound was acquired by column chromatography (developing solvent: petroleum ether/ethyl acetate), return: 94%.

report two,
p-Methoxybenzaldehyde (4.08g, 30mmol) was dissolved in methanol (70mL), at 0°C, sodium borohydride (1.7g, 45mmol) was added in portions, reacted for 1h, concentrated, water (20mL) and ethyl acetate were added Ester (40 mL), separated the organic phase, the aqueous phase was extracted three times with ethyl acetate (20 mL), the organic phases were combined, dried over anhydrous sodium sulfate, filtered, and concentrated to give a transparent oil Methylglyoxal Miel (4.1 g, yield: 99 %). Structural characterization: 1HNMR (400MHz, DMSO-d): δ=7.23 (d, J=8.2Hz, 2H), 6.88 (d, J=7.8Hz, 2H), 5.03 (d, J=1.3Hz, OH, 1H) ), 4.42(d, J=5.7Hz, 2H), 3.74(s, 3H).

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

OUR MISSION
Help China Chemicals to benefit the happiness of human life
OUR VISSION
Become the most trusted chemical supplier in the world
OUR BUSINESS PHILOSOPHY
Striver – oriented, enrich employees, customer first, deep service, seek development
OUR VALUES
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Additive , Chemical Auxiliary & Catalyst , Organic Chemicals
  • Products/Service: Organic Intermediate,Inorganic Chemistry, APIs, Dyestuffs And Pigments, Fragrance And Spices, Food Additives
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.

Service

Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.

 

After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.

FAQ

Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.

 

HOW TO CONFIRM THE PRODUCT QUALITY BEFORE PLACING ORDERS?

You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.

Shipping

1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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