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4-Hexylresorcinol CAS 136-77-6

Molecular Formula: C12H18O2

Formula Weight: 194.27

ZSpharmac: 4-Hexylresorcinol Supplier

Product Name: 4-Hexylresorcinol
CAS No: 136-77-6
Purity: 99%

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Basic Info

Product Name:4-Hexylresorcinol
Other Names:4-Hexyl-1,3-Benzenediol
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:White Powder and/or Chunks
EINECS No.:205-257-4
Provide:4-Hexylresorcinol MSDS;
4-Hexylresorcinol COA

What is 4-Hexylresorcinol?

4-Hexylresorcinol is a replaced dihydroxybenzene. It has disinfectant, anthelmintic and also local anesthetic properties. It can be used in topical application for small skin infections, and also as a dental solution or throat lozenges for discomfort relief as well as emergency treatment antiseptic. The compound might additionally be generally utilized in numerous commercial cosmetic anti-aging lotions, while recurring research study is exploring the possibility of using hexylresorcinol as an anti-cancer therapy – all signs that currently require more study and screening.

4-Hexylresorcinol Property

Melting point 65-67 °C (lit.)
Boiling point 333-335 °C (lit.)
density 1.0010 (rough estimate)
vapor pressure 0.001Pa at 25℃
refractive index 1.5050 (estimate)
Fp >100°C
storage temp. 2-8°C
solubility chloroform: 50 mg/mL, clear
form Powder and/or Chunks
pkapKa 9.1 (Uncertain)
color White to pale orange or pale pink
PH7.7 (0.5g/l, H2O, 20℃)
Water Solubility 0.05 g/100 mL (18 ºC)


4-Hexylresorcinol Uses

  1. 4-Hexylresorcinol is a brand-new type of antioxidant as well as color-protecting agent that can hinder browning. It can be utilized to stop browning of shrimp. It ought to be used in a proper amount according to production needs, and the residual quantity needs to not surpass 1mg/kg.
  2. 4-Hexylresorcinol is an anti-oxidant; a pigment stabilizer; an enzyme browning inhibitor; a handling help.

Production Method of 4-Hexylresorcinol

Place 1/2 amount of hexanoic acid into the dissolution pot, add anhydrous zinc chloride, warmth and stir to liquify the mixture at around 120 ° C; put the other half of caproic acid right into the condensation pot, include resorcinol, mix to dissolve; Include the above zinc chloride/caproic acid service dropwise at about 120 ° C, lower the pressure to 93kPa, keep the temperature level for 3 hours, and distill the water generated by the response at the same time; pot, dehydration under continuous stress, dehydration under minimized pressure, as well as recovery of unreacted hexanoic acid to acquire the condensation product hexanoyl resorcinol.
Include zinc amalgam to hexanoyl resorcinol, then include industrial hydrochloric acid, stir as well as raise the temperature to 75-80 ° C, after that normally raise the temperature to 104-110 ° C, and also keep the temperature for 1.5-2.0 h. Reduced the temperature level to 80 ° C as well as examine completion factor of the response; after the conclusion of the reaction, reduced the temperature to below 40 ° C, different the lowered item, clean with water and boil down off the water under minimized pressure, accumulate the portion at 145-152 ° C (133-266Pa) to obtain 4-hexylresorcinol Unrefined phenol, the yield is 90%; the crude product is recrystallized from oil ether to obtain the ended up item.

4-Hexylresorcinol Residue Detection Standard

4-Hexylresorcinol is a white, yellow-white needle-like crystal, which turns brown and also pink when subjected to light and air. It has a weak odor as well as a solid astringent preference, and also can cause numbness to the tongue. In medicine, 4-hexylresorcinol has a lengthy background of application as a coughing sedative. In the field of food, 4-hexylresorcinol, as a new kind of antioxidant, was first utilized in the conservation of shrimp, and also later on in the conservation of veggies and fruits.

The speculative outcomes show that 4-hexylresorcinol has a great fresh-keeping effect, which can prevent shrimps from turning black, hinder the browning of mushrooms, fresh-cut pears, as well as potatoes, prolong the storage space duration of fresh-cut apples, and prevent microbial development. development, play an antibacterial duty. Yet whatever sort of additive it is, it can not be included at will, otherwise it will cause harm to the body. Therefore, quantitative discovery of 4-hexylresorcinol deposits in food is essential to ensure food security.

In order to meet the current food testing needs, the National Health And Wellness Commission as well as the State Administration for Market Policy issued GB 5009.280-2020 “National Food Safety And Security Criterion – Decision of 4-hexylresorcinol Deposits in Food”.

This conventional specifies the technique for the determination of 4-hexylresorcinol residues in shrimp as well as crabs, as well as is applicable to the decision of 4-hexylresorcinol deposits in shrimps and also crabs. The conventional states that when shrimp and crab evaluate 2.00 g, the detection restriction is 0.0200 mg/kg, as well as the metrology limitation is 0.0500 mg/kg.

Program according to the requirement, when utilizing this criterion to determine the recurring quantity of 4-hexylresorcinol in shrimp and crab, require to utilize fluid chromatograph, equilibrium, rotating evaporator, vortex mixer, ultrasonic generator, centrifuge, consistent tools, and so on.

GB 5009.280-2020 “National Food Security Standard Resolution of 4-hexylresorcinol deposits in food” will certainly be executed on March 11, 2021, and will change SN/T3641 -2013 “4-hexylresorcinol in exported aquatic items Resorcinol deposit detection technique”. Compared with SN/T3641 -2013 “Discovery approach for 4-hexylresorcinol deposits in exported aquatic products”, the changes in the new standard are mainly shown in two elements: 1. The name of the requirement is changed to “National Food Safety Standard 4-Hexyl Resorcinol in Food – Determination of recurring amount of hexylresorcinol”; 2. Modified the operation of the pretreatment part.

Every revision of the requirement is the enhancement of the basic system. It is thought that the application of the new standard will certainly further improve the food screening criteria and offer more assurances for my country’s food safety and security.

About Products:
If you need 4-Hexylresorcinol as a cosmetic raw material, please contact our service staff directly, we will provide you with high-quality products at the best price.
As an experienced 4-Hexylresorcinol manufacturer and supplier, ZSpharmac will provide 4-Hexylresorcinol raw materials to customers all over the world for a long time.
Over the years, the company has been adhering to the spirit of “integrity management, strict quality control, customer first”, and has won unanimous praise from domestic and foreign customers.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

Help China Chemicals to benefit the happiness of human life
Become the most trusted chemical supplier in the world
Striver – oriented, enrich employees, customer first, deep service, seek development
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Cosmetic raw materials
  • Products/Service:Cosmetic raw materials (flavors and fragrances,antioxidant products, moisturizing and hydrating, whitening agents, cosmetic additives)
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.


After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.


Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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