Zhishang Chemical

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Zhishang Chemical

4-Chloro-3,5-Dimethylphenol CAS 88-04-0

Molecular Formula: C8H9ClO

Formula Weight: 156.61

ZSpharmac: 4-Chloro-3,5-Dimethylphenol Supplement

Product Name: 4-Chloro-3,5-Dimethylphenol
CAS No: 88-04-0
Purity: 99%

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Basic Info

Product Name:4-Chloro-3,5-Dimethylphenol
Other Names:P-Chlorometa-Xylenol
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:White to Light Beige Crystalline Powder or Crystals
EINECS No.:201-793-8
Provide:4-Chloro-3,5-Dimethylphenol MSDS;
4-Chloro-3,5-Dimethylphenol COA

What is 4-Chloro-3,5-Dimethylphenol?

4 chloro 3 5 dimethylphenol is called Chloroxylenol, which is slightly soluble in water at 25°C and belongs to halogenated phenolic disinfectants.

4-Chloro-3,5-Dimethylphenol Property

Melting point 114-116 °C(lit.)
Boiling point 246 °C
density 0.67 g/cm3
refractive index 1.5523 (estimate)
Fp 132 °C
storage temp. 2-8°C
solubility methanol: soluble1g/10 mL, clear to faintly turbid, colorless to very faintly yellow
form Crystalline Powder or Crystals
color White to light beige
PH7 (0.2g/l, H2O)
Water Solubility 0.3 g/L (20 ºC)


4-Chloro-3,5-Dimethylphenol Uses

  1. 4-Chloro-3,5-Dimethylphenol is a chemical as well as bactericide. It is made use of to avoid mold and is also an anti-bacterial representative. Preservatives (topical and also urinary system).
  2. 4-Chloro-3,5-Dimethylphenol is a chemical as well as bactericide. It is made use of in solutions, cosmetics, inks, plywood, and also plastics.Excellent warmth resistance and also weather resistance, less water removal, as well as strong durability in material, the basic dose is 2%. The product is low toxicity. The dental LD50 of computer mice was 3450 mg/kg.
  3. 4-Chloro-3,5-Dimethylphenol can be utilized in numerous antibacterial treatment processes, such as antibacterial therapy of natural leather, antibacterial therapy of paper, antibacterial as well as antifungal therapy of textiles, and also anti-bacterial and antifungal treatment of photos, etc.

Can 4-Chloro-3,5-Dimethylphenol Disinfectant Eliminate the New Coronavirus?

At present, the latest official diagnosis and treatment plan points out that “the understanding of the physicochemical properties of coronavirus mostly comes from the research on SARS-CoV and MERS-CoV”.

The International Committee on Taxonomy of Viruses officially named the new coronavirus “SARS-CoV-2”, and its genetic characteristics are significantly different from SARSr-CoV and MERSr-CoV. Current research shows that SARS-CoV-2 is more than 85% homologous to bat SARS-like coronavirus (bat-SL-CoVZC45). Previous genomic studies have shown that SARS-CoV is unique in that it contains both mammalian and avian ancestors, and the impact of this recombination in humans has been disastrous.

Although 4-Chloro-3,5-Dimethylphenol has been widely used over the years, its mode of action has not been well studied.

The author wants to start from the mechanism of action of disinfectants to see if it is possible that 4-Chloro-3,5-Dimethylphenol can kill the virus. It seems that there is no way!

Look around and find articles with two alternative experimental studies.

If you don’t want to understand the experimental process, you can directly see the conclusion

In 2005, Wolff et al. used coronavirus 229E to test the antiviral activity of 4.8% 4-Chloro-3,5-Dimethylphenol.

Note: Human coronavirus 229E (HCoV-229E) is a single-stranded positive-stranded RNA virus belonging to the family Coronaviridae, genus Alphacoronavirus, which is one of the viruses that cause the common cold.

experimental method

The 4.8% p-chloro-meta-xylenol stock solution is diluted at 1:40 (v/v) to be tested. At room temperature (23±2°C), prepare several (not mentioned in the text) stainless steel discs (0.7 mm thick, 1 cm in diameter) as carriers in a glass dish as shown in the figure below, and drop each of them on it first. 10 microliters of virus suspension, let it dry for 1 hour, and then dropwise add 50 microliters of the disinfectant to be tested, p-chlorometaxylenol. After 10 minutes of action, the 229E coronavirus was significantly reduced.

The same test method, 75% ethanol for 5 minutes can significantly reduce the virus. It can be seen that the antiviral activity of p-chlorometaxylenol is not superior to that of alcohol.

In 2009, Christine Dellanno et al. used mouse hepatitis virus (MHV-1) to test the antiviral activity of 4.8% 4-Chloro-3,5-Dimethylphenol. The stock solution was diluted 1:40 (v/v) to be tested.

Note: Mouse hepatitis virus (MHV) is a single-stranded positive-stranded RNA virus belonging to the family Coronaviridae and genus Betacoronavirus. Can cause epidemic mouse disease, clinical manifestations of hepatitis, encephalitis and enteritis, high mortality. Before the discovery of SARS-CoV, mouse hepatitis virus was the most well-studied coronavirus, whether in vivo, in vitro or at the molecular level, and an alternative to SARS-CoV.

Adsorption of Triclosan and 4-Chloro-3,5-Dimethylphenol by Co-NPC

With the enhancement of living demands, automation of chemicals, big intake of daily chemical items and also population growth, it is not suggested to contaminate water sources with organics such as phenolic fungicides. In this research, the cobalt-based zeolite imidazole framework 67 (ZIF-67(Co)) was made by a “one-pot” method to prepare the most effective cobalt-based N-doped magnetic porous carbon (Co-NPC). Carbonization by ZIF-67(Carbon Monoxide) in N environment. The materials were tested for adsorption-desorption and likewise magnetization assessment utilizing X-ray diffractometer (XRD), scanning electron microscopic lense (SEM), infrared spectroscopy (IR), Raman spectroscopy, X-ray photoelectron spectroscopy (XPS), N2. These characterizations suggested that Co-NPCs were effectively prepared. Because of the initial morphology of ZIF-67(Carbon monoxide) crystals, Co-NPC in addition has good porosity, magnetic structures in addition to big specific surface. In water, Co-NPC-800 has wonderful adsorption ability for aromatic fungicides such as triclosan (TCS) as well as 4-Chloro-3,5-Dimethylphenol. The adsorption of both on Co-NPC-800 reached equilibrium within 3 minutes, which complied with the pseudo-second-order kinetic version. At 298 K, the optimum adsorption abilities of Co-NPC-800 for TCS as well as also PCMX were 163 along with 39 mg · g, specifically. The adsorption of TCS as well as PCMX by Co-NPC-800 is a spontaneous endothermic process with minimized decline. The binding of Co-NPC-800 along with phenols originates from the various communications of electrostatic, π-π in addition to hydrogen bonding results. In addition to that, Co-NPC-800 can be regrowed by basic cleaning and can be recycled at the very least 3 times by magnet. Co-NPC-800 has great porosity, big specific surface, comparable adsorption ability along with fast adsorption time, as well as can be generally used in ecological fields such as sewage system treatment.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

Help China Chemicals to benefit the happiness of human life
Become the most trusted chemical supplier in the world
Striver – oriented, enrich employees, customer first, deep service, seek development
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Additive , Chemical Auxiliary & Catalyst , Organic Chemicals
  • Products/Service: Organic Intermediate,Inorganic Chemistry, APIs, Dyestuffs And Pigments, Fragrance And Spices, Food Additives
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.


After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.


Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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