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4-Butylresorcinol CAS 18979-61-8

Molecular Formula: C10H14O2

Formula Weight: 166.22

ZSpharmac: 4-Butylresorcinol Supplier

Product Name: 4-Butylresorcinol
CAS No: 18979-61-8
Purity: 99%

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Basic Info

Product Name:4-Butylresorcinol
Other Names:4-Butylbenzene-1,3-Diol
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:White to Pale Yellow Powder
EINECS No.:606-191-2
Storage:Inert Atmosphere,Room Temperature
Provide:4-Butylresorcinol MSDS;
4-Butylresorcinol COA

What is 4-Butylresorcinol?

4-Butylresorcinol, likewise referred to as Rucinol, is an energetic component in a range of cosmetics, which can inhibit the manufacturing of melanin. Specifically, it can prevent both enzymes necessary for melanin production, namely tyrosinase as well as 5, 6-Dihydroxyindole-2-carboxylic acid-oxidase. Presently, there are 2 primary approaches for manufacturing 4-Butylresorcinol: Approach 1: using palladium carbon in methanol solvent to lower 4-butyrylresorcinol by catalytic hydrogenation. Catalytic hydrogenation is a typical gas-liquid-solid three-phase heterogeneous response. In order to guarantee the full call of the 3 stages, high temperature and high pressure (15atm) problems are called for, which not only takes in high power, but likewise has combustible as well as explosive properties of H2 in the system., In case of leak, there will certainly be a significant potential security threat, plus the use of palladium carbon, the cost is fairly high. Method 2: utilizing zinc amalgam to lower 4-Butylresorcinol under the condition of hydrochloric acid at 120 ° C. Because the response is accomplished on the surface of the turned on zinc, a brand-new zinc amalgam is required for each action of the reaction; the response temperature level is high, resulting in a big loss of the concentration of hydrochloric acid, and it is essential to add focused hydrochloric acid to maintain the acidity; a big amount of pollution is generated Zinc amalgam. Both methods discussed above are the traditional techniques reported until now, as well as there are evident problems in the scale-up of the procedure. Furthermore, in the standard activator response, the response is exothermic as well as produces a large quantity of gas when feeding materials, which positions an excellent safety and security hazard and raises the problem of procedure scale-up.

4-Butylresorcinol Property

Melting point 50.0 to 55.0 °C
Boiling point 166°C/7mmHg(lit.)
density 1.092±0.06 g/cm3(Predicted)
vapor pressure 0.041Pa at 25℃
storage temp. Inert atmosphere,Room Temperature
form Powder
color white to pale yellow powder


4-Butylresorcinol Mechanism of Action

The lightening pathway of 4-Butylresorcinol generally concentrates on the 2nd major pathway – the intracellular restraint of melanocytes, as well as because of its tiny dimension, it can conveniently permeate right into the skin, pierce right into the energetic center of tyrosinase, as well as exert a strong repressive task. Tyrosinase plays a key duty in melanin manufacturing, regulating the rate of melanin deposition. On the other hand 4-Butylresorcinol can inhibit the synthesis of tyrosinase in B16 cancer malignancy cells without causing any kind of cytotoxicity.


In the 3 procedures of melanin source synthesis, 4-Butylresorcinol not just has a vital inhibitory outcome on tyrosinase task, yet furthermore has a synergistic impact on its bleaching activity at the same time.

Prior to melanin synthesis, it interrupts the synthesis along with glycosylation of tyrosinase to stop the enzyme from being soaked up by melanosomes.

Throughout melanin synthesis, protects against chemical job, functions as a competitive inhibitor of tyrosinase as well as TRP1 enzymes, decreases growth of spin-offs that promote melanogenesis.

After melanin is manufactured, it enhances the deterioration of tyrosinase, inhibits the transfer of melanosomes to keratinocytes, as well as has a light removing impact because of the action of fatty acids. This feature is improved by the visibility of fats and manages tyrosinase destruction.

Application of 4-Butylresorcinol

4-Butylresorcinol prevents pigment formation by hindering the enzyme tyrosinase needed for pigment synthesis (pigment manufacturing) by 4-n-butylresorcinol. 4-n-Butylresorcinol firstly hinders coloring and then stops the development of melanin which creates extreme coloring of nevi. A disadvantage of 4-Butylresorcinol in terms of formula is its tendency to discolor itself as well as the cosmetic or skin-related prep work including it. Its application examples are as complies with:

1) Prepare whitening and freckle-removing cream, including the initial component, the second component, the third part, the fourth component and also the fifth element: the first part includes the following components (expressed in regards to mass portion): Cetearyl Ether-6 as well as Cetearyl Alcohol 1.5-2.5; Cetearyl Ether-25 1.5-2.5; 16-18 Alcohol 1.8-2.8; Isooctyl Palmitate 2.5-3.5; Squalane 1.5-2.5; today invention integrates the very first component, the second part, the third element, the 4th part and the 5th element right into a lightening and also freckle-removing cream according to a scientific and affordable proportion, which improves skin absorption of the bleaching and also freckle-removing lotion The stamina guarantees that the whitening and freckle lotion can be fully soaked up, and also because 4-Butylresorcinol is a strong anti-oxidant as well as a good tyrosine acid reducing representative, it can recover the oxidized and also blemished melanocytes to light and even colorless Consequently, including 4-n-butyl resorcinol to the lightening and blemish cream enhances the skin brightening impact of the lightening as well as freckle cream.

2) Prepare a substance resorcinol liposome with high utilization price and great photostability. The technological option taken on is: a substance resorcinol liposome, which is composed of the following resources in mass portion: 3% phenylethyl resorcinol; 3% n-butyl resorcinol, 4 hexyl resorcinol Hydroquinone 3%, Niacinamide 1%, Arbutin α 1%, Tranexamic acid 1%, Lipid material 5-10%; Emulsifier 3-4%; Thickener 0.5-2%; Light stabilizer 1 ~ 1.5%; the equilibrium is water; the lipid product is neodecanoin, the emulsifier is soybean lecithin, the thickener is aluminum magnesium silicate, and the light stabilizer is diphenylmethane Acyl methane. The invention has superb water solubility, high active component material, safe and also harmless, and also great biocompatibility.

3) Preparation job of a skin outside prep work having a considerable lightening cosmetic function, which minimizes extreme melanin development along with hence shows a skin lightening result while protecting natural bleaching, including materials such as the complying with and/or salts thereof as well as also 4-Butylresorcinol along with/ Or its salt: 5,7-dihydroxy-3,6-dimethoxy-2-(5-hydroxy-4-methoxyphenyl)-4 H-l-benzopyran-4-one, 5, 7-dihydroxy-3,6,8-trimethoxy-2-(3,4,5-trihydroxyphenyl)-4 H-1-benzopyran-4-one, 3,5-diethyl Oxy-6,7-dimethoxy-2-(5-ethoxy-4-methoxyphenyl)-4 H-l-benzopyran-4-one, as well as likewise 5,6-dihydroxy -3,7-Dimethoxy-2-(5-hydroxy-2,4-dimethoxyphenyl)-4 H-1-benzopyran-4-one.

4-Butylresorcinol Preparation

4-Butylresorcinol was prepared as adheres to:

Evaluate 100g of 4-n-butyryl resorcinol as well as liquify it in toluene, cool it in ice to 0 ° C, after that slowly add 32g (1.5 eq) salt borohydride in sets, and respond at room temperature for 12 hours after the addition; then pour it into the pre- Warm component 1, preheat to 80 ° C; mix 67g of Raney nickel and isopropanol into preheat block 2, as well as preheat to 80 ° C. Then include the above 2 preheated materials into the response component, as well as the home time is controlled at 200s. Gather the response remedy spurting, pour into ice water to appease, filter off the strong, evaporate most of the toluene, add 330mL of dichloromethane for removal, evaporate the dichloromethane to dryness, and also acquire 82g of white strong 4-n-butylresorcinol, Return 89%, HPLC purity 99.3%.

About Products:
If you need 4-Butylresorcinol as a cosmetic raw material, please contact our service staff directly, we will provide you with high-quality products at the best price.
As an experienced 4-Butylresorcinol manufacturer and supplier, ZSpharmac will provide 4-Butylresorcinol raw materials to customers all over the world for a long time.
Over the years, the company has been adhering to the spirit of “integrity management, strict quality control, customer first”, and has won unanimous praise from domestic and foreign customers.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

Help China Chemicals to benefit the happiness of human life
Become the most trusted chemical supplier in the world
Striver – oriented, enrich employees, customer first, deep service, seek development
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Cosmetic raw materials
  • Products/Service:Cosmetic raw materials (flavors and fragrances,antioxidant products, moisturizing and hydrating, whitening agents, cosmetic additives)
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.


After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.


Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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