Zhishang Chemical

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Zhishang Chemical

4-Butylresorcinol CAS 18979-61-8

Molecular Formula: C10H14O2

Formula Weight: 166.22

ZSpharmac: 4-Butylresorcinol Supplement

Product Name: 4-Butylresorcinol
CAS No: 18979-61-8
Purity: 99%

Basic Info

Product Name:4-Butylresorcinol
Other Names:4-Butylbenzene-1,3-Diol
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:White to Pale Yellow Powder
Storage:Inert Atmosphere,Room Temperature
Provide:4-Butylresorcinol MSDS;
4-Butylresorcinol COA

What is 4-Butylresorcinol?

4-Butylresorcinol, likewise called Rucinol, is an active component in a variety of cosmetics as well as can prevent the production of melanin. Especially, it can hinder both enzymes necessary for the production of melanin, particularly phenol Aminidase as well as 5,6-dihydroxyindole-2-carboxylic acid-oxidase.

At present, there are two primary approaches for synthesizing 4-Butylresorcinol: Approach 1: take on palladium carbon in methanol solvent to lower 4-Butylresorcinol by catalytic hydrogenation approach. In order to make certain complete call of the 3 stages, high temperature as well as high pressure (15atm) problems are called for, which not just eats high energy, but likewise has flammable and also eruptive residential or commercial properties in the system., in case of leakage, there will be a massive security threat, combined with the use of palladium carbon, the price is high. Technique 2: 4-Butylresorcinol was reduced by zinc amalgam under the problem of hydrochloric acid at 120 ° C. Since the response is executed on the triggered zinc surface, a new zinc amalgam needs to be prepared every time this step is carried out; the reaction temperature is high, resulting in a large loss of the focus of hydrochloric acid, and also it is needed to add concentrated hydrochloric acid to preserve the acidity; causing a large amount of air pollution Zinc amalgam. The two approaches pointed out above are standard approaches reported thus far, and they have apparent problems when the procedure is scaled up. Furthermore, in the conventional response kettle response, the reaction is exothermic and a large amount of gas is produced throughout feeding, which postures a fantastic safety hazard and also increases the trouble of process boosting.

4-Butylresorcinol Properties:

Melting point 50.0 to 55.0 °C
Boiling point 166°C/7mmHg(lit.)
density 1.092±0.06 g/cm3(Predicted)
storage temp. Inert atmosphere,Room Temperature
color white to pale yellow powder


4-Butylresorcinol Application

4-Butylresorcinol inhibits pigment formation in the following way: 4-Butylresorcinol inhibits the enzyme tyrosinase required for pigment synthesis (pigment production). 4-Butylresorcinol first inhibits pigmentation and then prevents the formation of melanin, which causes the intense pigmentation of moles. A disadvantage of 4-Butylresorcinol in formulation is that it tends to discolour itself and the cosmetic or dermatological preparations containing it. Examples of its application are as follows:

1) Preparation of whitening and freckle-removing cream, including the first component, the second component, the third component, the fourth component and the fifth component: the first component includes the following components (expressed in mass percentage): Cetearyl Ether-6 and Cetearyl Alcohol 1.5-2.5; Cetearyl Ether-25 1.5-2.5; 16-18 Alcohol 1.8-2.8; Isooctyl Palmitate 2.5-3.5; Squalane 1.5-2.5; the present invention combines the first component, the second component, the third component, the fourth component and the fifth component into a whitening and freckle-removing cream according to a scientific and reasonable ratio, which improves the skin absorption of the whitening and freckle-removing cream. It ensures that the whitening and freckle-removing cream can be fully absorbed, and because 4-Butylresorcinol is a strong antioxidant and a good tyrosine acid reducing agent, it can reduce the oxidative discoloration of melanocytes. It is restored to light color or even colorless, so 4-Butylresorcinol is added to the whitening and freckle-removing cream to improve the skin-brightening effect of the whitening and freckle-removing cream.

2) To prepare a compound resorcinol liposome with high utilization rate and good photostability. The technical scheme adopted is: a compound resorcinol liposome, which is composed of the following raw materials in terms of mass percentage: 3% of phenylethyl resorcinol; 3% of 4-n-butylresorcinol, 4% of hexyl Hydroquinone 3%, niacinamide 1%, arbutin α1%, tranexamic acid 1%, lipid material 5-10%; emulsifier 3-4%; thickener 0.5-2%; light stabilizer 1 ~1.5%; the balance is water; the lipid material is glyceryl neocaprate, the emulsifier is soybean lecithin, the thickener is magnesium aluminum silicate, and the light stabilizer is diphenylmethane Acylmethane. The invention has excellent water solubility, high content of effective components, non-toxic and harmless, and good biocompatibility.

3) Preparation of an external preparation for skin having a substantial whitening cosmetic function, which inhibits excessive melanin formation and thus exhibits a skin whitening effect while maintaining natural whitening, including compounds such as the following and/or salts thereof and 4-n-butyl Resorcinol and/or its salts: 5,7-dihydroxy-3,6-dimethoxy-2-(5-hydroxy-4-methoxyphenyl)-4H-l-benzopyran -4-one, 5,7-dihydroxy-3,6,8-trimethoxy-2-(3,4,5-trihydroxyphenyl)-4H-1-benzopyran-4-one, 3,5-diethoxy-6,7-dimethoxy-2-(5-ethoxy-4-methoxyphenyl)-4H-1-benzopyran-4-one, and 5,6-Dihydroxy-3,7-dimethoxy-2-(5-hydroxy-2,4-dimethoxyphenyl)-4H-1-benzopyran-4-one.

4-Butylresorcinol Preparation

4-Butylresorcinol is prepared as follows:

Weigh 100g of 4-Butylresorcinol and dissolve it in toluene, ice bath to 0°C, then slowly add 32g (1.5eq) of sodium borohydride in batches, and react at room temperature for 12h after the addition; Heat module 1, preheat to 80°C; mix 67 g of Raney nickel and isopropanol into preheat module 2, and preheat to 80°C. Then, the above two preheated materials were added to the reaction module, and the residence time was controlled at 200s. The outflowing reaction solution was collected, poured into ice water to quench, the solid was filtered off, most of the toluene was distilled off, 330 mL of dichloromethane was added for extraction, and the dichloromethane was evaporated to dryness to obtain 82 g of 4-Butylresorcinol as a white solid, Yield 89%, HPLC purity 99.3%.

Efficacy and Safety of 4-Butylresorcinol in the Treatment of Melasma

Melasma is a persistent, traumatic condition that is commonly difficult to deal with. 4-Butylresorcinol is a newly developed hypopigmentation agent that inhibits both tyrosinase as well as TRP-1. Given that 3-10 was first reported in 1995, the hypopigmentation efficiency of 4-Butylresorcinol has actually been validated by several artificial insemination as well as in vivo researches. In an 18-week placebo-controlled clinical research, 0.3% serum 4-Butylresorcinol considerably boosted signs and symptoms in people with post-laser pigmented sores compared to sugar pill. In chloasma individuals, 4-Butylresorcinol 0.3% lotion was found to be effective in 84% of chloasma clients in a 24-week open-label therapy study9. In an additional recent randomized, double-blind, vehicle-controlled, faceted research of 28 patients with melasma, 0.3% lotion 4-Butylresorcinol was found to be much more efficient than car controls after 12 weeks of application Substantially greater efficacy, based upon clinical analysis and colorimetric measurements 10. Nonetheless, in previous studies, reasonably lasting use 4-Butylresorcinol was needed to achieve hypopigmentation impacts. Furthermore, in a recent double-blind study, 8/28 people (28.6%) knowledgeable adverse events, consisting of moderate erythema, dry skin, scaling, as well as scaling. Butyl Resorcinol was made for this medical research study.

To our knowledge, this is the very first research to examine the impacts of 0.1% 4-Butylresorcinol cream in clients with melasma. Contrasted to vehicle, 4-Butylresorcinol 0.1% cream revealed substantial effectiveness even after 4 weeks of treatment and continued with the end of the research study.

In general, the mean modification in MI at the end of the research was -4.87% and +2.21% for 4-Butylresorcinol-treated skin as well as vehicle-treated skin, specifically, a statistically substantial distinction (p < 0.0005). All patients endured the therapy well, as well as negative events were mild and transient.

The results reveal that decreased focus of 4-Butylresorcinol can be made use of safely in the therapy of melasma. On top of that, 0.1% 4-n-butylresorcinol had the ability to accomplish a just as reliable or even extra effective therapy in less time than previous researches.

Nonetheless, in this study, we did not scientifically evaluate improvement. Medical analysis might not be suitable for examining the degree of enhancement in those pigmented sores treated cosmetically, which may show only subtle differences.Bioengineering measurements are standard methods for assessing pigment status13. Our results are comparable to those of Khemis et al. 10 When we compare objective data obtained through bioengineering measurements. Further studies using various bioengineering measurements and clinical evaluation methods will help demonstrate the hypopigmentation efficacy of 0.1% 4-Butylresorcinol cream in the treatment of melasma.

In conclusion, 4-Butylresorcinol 0.1% cream showed significant efficacy compared to vehicle alone and was well tolerated for the treatment of melasma.


Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Cultur:

Help China Chemicals to benefit the happiness of human life
Become the most trusted chemical supplier in the world
Striver – oriented, enrich employees, customer first, deep service, seek development
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Additive , Chemical Auxiliary & Catalyst , Organic Chemicals
  • Products/Service: Organic Intermediate,Inorganic Chemistry, APIs, Dyestuffs And Pigments, Fragrance And Spices, Food Additives
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.


After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.


Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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