4-Butylresorcinol inhibits pigment formation in the following way: 4-Butylresorcinol inhibits the enzyme tyrosinase required for pigment synthesis (pigment production). 4-Butylresorcinol first inhibits pigmentation and then prevents the formation of melanin, which causes the intense pigmentation of moles. A disadvantage of 4-Butylresorcinol in formulation is that it tends to discolour itself and the cosmetic or dermatological preparations containing it. Examples of its application are as follows:
1) Preparation of whitening and freckle-removing cream, including the first component, the second component, the third component, the fourth component and the fifth component: the first component includes the following components (expressed in mass percentage): Cetearyl Ether-6 and Cetearyl Alcohol 1.5-2.5; Cetearyl Ether-25 1.5-2.5; 16-18 Alcohol 1.8-2.8; Isooctyl Palmitate 2.5-3.5; Squalane 1.5-2.5; the present invention combines the first component, the second component, the third component, the fourth component and the fifth component into a whitening and freckle-removing cream according to a scientific and reasonable ratio, which improves the skin absorption of the whitening and freckle-removing cream. It ensures that the whitening and freckle-removing cream can be fully absorbed, and because 4-Butylresorcinol is a strong antioxidant and a good tyrosine acid reducing agent, it can reduce the oxidative discoloration of melanocytes. It is restored to light color or even colorless, so 4-Butylresorcinol is added to the whitening and freckle-removing cream to improve the skin-brightening effect of the whitening and freckle-removing cream.
2) To prepare a compound resorcinol liposome with high utilization rate and good photostability. The technical scheme adopted is: a compound resorcinol liposome, which is composed of the following raw materials in terms of mass percentage: 3% of phenylethyl resorcinol; 3% of 4-n-butylresorcinol, 4% of hexyl Hydroquinone 3%, niacinamide 1%, arbutin α1%, tranexamic acid 1%, lipid material 5-10%; emulsifier 3-4%; thickener 0.5-2%; light stabilizer 1 ～1.5%; the balance is water; the lipid material is glyceryl neocaprate, the emulsifier is soybean lecithin, the thickener is magnesium aluminum silicate, and the light stabilizer is diphenylmethane Acylmethane. The invention has excellent water solubility, high content of effective components, non-toxic and harmless, and good biocompatibility.
3) Preparation of an external preparation for skin having a substantial whitening cosmetic function, which inhibits excessive melanin formation and thus exhibits a skin whitening effect while maintaining natural whitening, including compounds such as the following and/or salts thereof and 4-n-butyl Resorcinol and/or its salts: 5,7-dihydroxy-3,6-dimethoxy-2-(5-hydroxy-4-methoxyphenyl)-4H-l-benzopyran -4-one, 5,7-dihydroxy-3,6,8-trimethoxy-2-(3,4,5-trihydroxyphenyl)-4H-1-benzopyran-4-one, 3,5-diethoxy-6,7-dimethoxy-2-(5-ethoxy-4-methoxyphenyl)-4H-1-benzopyran-4-one, and 5,6-Dihydroxy-3,7-dimethoxy-2-(5-hydroxy-2,4-dimethoxyphenyl)-4H-1-benzopyran-4-one.