4-Aminobenzoic Acid CAS 150-13-0

Molecular Formula: C7H7NO2

Formula Weight: 137.14

ZSpharmac: 4-Aminobenzoic Acid Supplement Supplier

Product Name: 4-Aminobenzoic Acid

CAS No: 150-13-0

Purity: 99%

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Basic Info

Product Name:	4-Aminobenzoic Acid
Other Names:	P-Aminobenzoic Acid
CAS:	150-13-0
Place of Origin:	Shandong, China
Brand Name:	ZSpharmac
Type:	Cosmetic Raw Materials
Appearance:	White to Light Yellow Crystalline Powder
EINECS No.:	205-753-0
Storage:	2-8°C
Provide:	4-Aminobenzoic Acid MSDS； 4-Aminobenzoic Acid COA

What is 4-Aminobenzoic Acid?

4-Aminobenzoic acid is amongst among one of the most vital fragrant amino acids. It is a vital part of the substances critical for the development as well as additionally department of body cells. It plays an irreplaceable responsibility in the metabolic process of life. It is taken advantage of in yeast, liver, bran, malt The material is truly high. 4-aminobenzoic acid can reduce anemia triggered by lack of red cell, viral anemia, sprue looseness of the bowels as well as anemia while expectant. 4-Aminobenzoic acid as the foundation of high-efficiency sustenance– complex vitamin B-100 can effectively enhance the 3 significant metabolic prices of the body, comprehensively combat neurosis and eliminate stress. The mix of 4-aminobenzoic acid in addition to penicillin or streptomycin can correctly boost the anti-bacterial impact.

4-Aminobenzoic Acid Property

Melting point	187-189 °C(lit.)
Boiling point	251.96°C (rough estimate)
density	1.374 g/mL at 25 °C(lit.)
vapor pressure	0Pa at 25℃
refractive index	1.5323 (estimate)
Fp	250 °C
storage temp.	2-8°C
solubility	95% ethanol: soluble5%, clear to slightly hazy, colorless to yellow
form	Crystalline Powder
pka	2.50, 4.87(at 25℃)
color	White to light yellow

4-Aminobenzoic Acid Uses

According to study, 4-Aminobenzoic Acid was first used as a UV filter in sunscreen solutions in the 1970s, partially because it can be tightly bound to epidermal cells and is tough to clean off with water, despite a towel. It is extremely believed to be linked to cancer as well as raises totally free radicals that create DNA damage.

Due to its solid connection with B vitamins, PABA can be generated by E. coli in the colon and also is a necessary nutrient for microorganisms, not vital for human wellness. Nevertheless, according to Wikipedia, the absence of 4-Aminobenzoic Acid in the body can bring about some skin diseases, including scleroderma, eczema, skin infection, and also skin hypopigmentation places.

“Currently one of the most typically used derivatives of PABA are more secure and also much more efficient, such as Octyl Dimethyl PABA (padimate O).” It is the only PABA ester approved by the FDA; the substance The chemical properties are similar to 4-Aminobenzoic Acid, but not annoying. Nevertheless, it is still controversial and can still create allergic reactions. As A Result, Padimate O ought to only be used in conjunction with various other components to boost SPF.

4-Aminobenzoic Acid is now hardly ever made use of in sunscreen products due to the fact that it has many negative adverse effects. It has been revealed to trigger allergies in 4% of people. It has likewise been found to produce complimentary radicals that can create particular DNA defects in human cells, raising cancer cells risk.

One of the main features of PABA in sunscreens is to filter UV rays from the skin’s surface area, converting it right into warmth, yet this warm is also soaked up by the skin. If light is converted into heat at the base layer of the skin, it can additionally trigger damage to cell development, bring about DNA damages and problems. In a research study published in Setting + Health News, researchers at the Sloan Cancer Research Center located that PABA sunscreens can protect against sunburn and also malignant epithelial growths, but not cancer malignancy. Since 1935, the incidence of cancer malignancy in the USA and also Europe has actually increased 20-fold.

The Cosmetics Data source mentions that 4-Aminobenzoic Acid is a risky component that can create neurological and organ poisoning, cancer, allergies, reproductive toxicity, mobile adjustments, and also immunotoxicity. But the FDA still authorizes it for usage.

4-Aminobenzoic Acid Production Method

Add water, sodium chloride as well as also hydrochloric acid in turn in the action pot. Beginning mixing and also heat up to 50-60 ° C, add 9/10 quantity of iron powder, remain to heat up to 98-102 ° C, maintain cozy for 1h, stopped residence heating, slowly include p-nitrobenzoic acid at 95 ° C, relating to 1-1.5 h After including, include iron powder, keep warm at 98-102 ° C for 1 hour, enable awesome to 80 ° C, add 30% fluid caustic soda to adjust pH=8.5-9, press filter, tidy with a small amount of water, integrate the filtrate with a small amount of cream, and press into Acid analysis pot, cooled to 30-34 ℃, adding salt hydrosulfite for decolorization, and also filtering system. Consist of acid to the filtrate to change pH=3.5-4, proceed cooling to listed here 10 ° C, eliminate water, as well as additionally completely dry to obtain the ended up product. Return 84-88%. (2) It is managed catalytic hydrogenation of p-nitrobenzoic acid. Include commercial p-nitrobenzoic acid as well as likewise water right into a 1000ml beaker, transform the pH to 6-7 with 22% sodium hydroxide under mixing, and afterwards include Raney Nickel, the feed fluid is pumped into a swinging autoclave under mixing, changed twice with hydrogen as well as also nitrogen respectively, as well as afterwards pressurized to 3.43 MPa, as well as responded at a stress of 3.43-2.54 MPa as well as likewise a temperature level of 134-140 ° C for concerning 5h. till the hydrogen pressure does not decrease as completion point. After the response, filter and also completely dry to get p-aminobenzoic acid. The return is more than 80%.

Precautions for 4-Aminobenzoic Acid Operation:

The reaction starts to heat slowly, and attention should be paid to prevent bumping.

The precipitation must be boiled in a water bath until it turns black, and two layers of filter paper can be placed in the hot suction filter to prevent through-filtration.

When washing the filter residue with hot water, 40 mL of water is too much, which will cause too much filtrate to be concentrated, and the dosage can be reduced appropriately.

Tin eventually becomes tin tetrachloride in the reduction, which is also soluble in water, and now it is alkaline with concentrated ammonia water, and the hydrochloride of p-aminobenzoic acid becomes ammonium salt and is soluble in water, but tin tetrachloride It is converted into hydroxide and precipitated to remove.

Since tin hydroxide reacts with strong alkali to form water-soluble stannate, ammonia water is used instead of sodium hydroxide solution for alkalization.

About Products:
If you need 4-Aminobenzoic Acid this cosmetic raw material, please contact our service personnel directly, we will provide you with high-quality products at the best price.
As an experienced 4-Aminobenzoic Acid manufacturer and supplier, ZSpharmac will provide 4-Aminobenzoic Acid raw materials to customers all over the world for a long time.
Over the years, the company has been adhering to the spirit of “integrity management, strict quality control, customer first”, and has won unanimous praise from domestic and foreign customers.

Company Profile and Corporate Culture

Company Profile：

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture：

OUR MISSION
Help China Chemicals to benefit the happiness of human life
OUR VISSION
Become the most trusted chemical supplier in the world
OUR BUSINESS PHILOSOPHY
Striver – oriented, enrich employees, customer first, deep service, seek development
OUR VALUES
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info

Business Type: Manufacturer
Product Range: Cosmetic raw materials
Products/Service:Cosmetic raw materials (flavors and fragrances,antioxidant products, moisturizing and hydrating, whitening agents, cosmetic additives)
Total Employees: 51~100
Capital (Million US $): 10000000RMB
Year Established: 2016

Production Capacity

No. of Production Lines : 8
No. of QC Staff : 5 -10 People
OEM Services Provided : yes
Factory Size (Sq.meters) : 3,000-5,000 square meters
Certificate: ISO9001 , CE , GMP , API , MSDS
Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.

Service

Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.

After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.

FAQ

Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.

HOW TO CONFIRM THE PRODUCT QUALITY BEFORE PLACING ORDERS?

You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

Is there a discount?

Different quantity has different discount.

Shipping

1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.