Zhishang Chemical

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Zhishang Chemical

4-Aminobenzoic Acid CAS 150-13-0

Molecular Formula: C7H7NO2

Formula Weight: 137.14

ZSpharmac: 4-Aminobenzoic Acid Supplier

Product Name: 4-Aminobenzoic Acid
CAS No: 150-13-0
Purity: 99%

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Basic Info

Product Name:4-Aminobenzoic Acid
Other Names:P-Aminobenzoic Acid
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:White to Light Yellow Crystalline Powder
EINECS No.:205-753-0
Provide:4-Aminobenzoic Acid MSDS;
4-Aminobenzoic Acid COA

What is 4-Aminobenzoic Acid?

4-Aminobenzoic Acid is just among one of the most essential fragrant amino acids. It is an integral part of the substances necessary for the development as well as division of body cells. It has an irreplaceable function in the metabolic price of life. It is utilized in yeast, liver, bran as well as additionally malt. The material is really high. 4-Aminobenzoic Acid can eliminate anemia activated by absence of red cell, viral anemia, sprue and anemia while expecting. 4-Aminobenzoic Acid is a high-efficiency dietary item with the almost all – vitamin B-100, which can efficiently improve the 3 major metabolic rates of the body, adequately combat neurosis as well as ease anxiety and also stress and anxiety. The compatibility of 4-aminobenzoic acid with penicillin or streptomycin can successfully enhance the bacteriostatic result.

4-Aminobenzoic Acid Property

Melting point 187-189 °C(lit.)
Boiling point 251.96°C (rough estimate)
density 1.374 g/mL at 25 °C(lit.)
refractive index 1.5323 (estimate)
Fp 250 °C
storage temp. 2-8°C
solubility 95% ethanol: soluble5%, clear to slightly hazy, colorless to yellow
form Crystalline Powder
pka2.50, 4.87(at 25℃)
color White to light yellow
PH3.5 (5g/l, H2O, 20℃)
PH Range3.5
Water Solubility 4.7 g/L (20 ºC)


4-Aminobenzoic Acid Uses

4-Aminobenzoic acid is just one of among the most vital terrific scenting amino acids. It is a vital part of the compounds required for the development in addition to department of body cells. It has an irreplaceable attribute in the metabolic procedure of life. It is utilized in yeast, liver, bran along with malt. The product is exceptionally high. 4-Aminobenzoic acid can relieve anemia caused by lack of red cell, viral anemia, sprue as well as anemia while pregnant. 4-Aminobenzoic acid is a high-efficiency dietary item with the cornerstone – vitamin B-100, which can effectively enhance the three major metabolic rates of the body, entirely combat neurosis in addition to likewise get rid of nervousness. The compatibility of 4-aminobenzoic acid with penicillin or streptomycin can properly improve the bacteriostatic end result. 4-Aminobenzoic acid is furthermore a crucial fantastic chemical sources. In relation to medication, it is an essential intermediate in the synthesis of blood tonic-folic acid, and similarly a coagulant-p-carboxybenzylamine. It is in addition made use of in the manufacture of treatment for rickets, rheumatism, in addition to arthritis., Use medications. In the cosmetics market, it is a critical intermediate of human sunscreen together with hair advancement associates; in the natural chemical market, it is used to prepare countless ester products, which can be benefited from as product modifiers, in addition to can in addition be made use of to produce responsive dyes, azo Special intermediates for dyes. Examples of its application are as follows:

1) Synthesis of ethyl 4-aminobenzoate, including the following steps: dissolving 4-aminobenzoic acid with alcohol to prepare a 4-aminobenzoic acid solution with a mass fraction of 5-30%; Add thionyl chloride dropwise to the aminobenzoic acid solution to carry out the esterification reaction, after the dropwise addition, the temperature is raised to reflux, and the reaction is carried out for 4-10 hours; A weak base is added to neutralize to pH 7-8, and the solid matter is separated out and then filtered, washed with water, and dried to obtain 4-aminobenzoic acid ethyl ester product. The present invention uses 4-aminobenzoic acid as raw material, uses thionyl chloride as dehydrating agent to carry out esterification reaction to prepare ethyl 4-aminobenzoate, has fast reaction speed, high yield and high product purity, and has good industrial performance application prospects.

2) The preparation of an adefovir drug co-crystal using 4-aminobenzoic acid as a co-crystal precursor belongs to the technical field of drug co-crystals. The space group of the drug co-crystal is monoclinic system, and one adefovir molecule, two 4-aminobenzoic acid molecules and one water molecule are combined through hydrogen bonds to form the adefovir-aminobenzoic acid drug. The basic building block of a co-crystal. The solvent selected in the preparation process of the drug co-crystal of the present invention is water, and the adopted method is the solution co-crystallization method. Since Adefovir is slightly soluble in cold water and easily soluble in hot water, it is heated and stirred to dissolve and then placed in an oven to keep warm for a period of time. After cooling, crystals crystallize out. The drug co-crystal prepared by the invention has obvious improvement in solubility, stability and bioavailability besides inheriting the characteristics of traditional raw materials for treating hepatitis B disease.

3) To prepare a 4-aminobenzoic acid non-destructively modified carbon fiber reinforced paper-based wet friction material, first add carbon fiber, 4-aminobenzoic acid and excess hydrochloric acid into a three-necked flask, and then slowly add a certain amount of hypochlorite after the reaction reaches a certain temperature. Sodium nitrate, and short-time diazotization reaction in an oil bath with magnetic stirring to obtain carbon fibers grafted with benzoic acid on the surface. Then, the modified carbon fiber is mixed with aramid fiber, paper fiber, filler and resin to prepare friction material base paper, and then hot-pressed and cured to obtain a paper-based wet friction material modified with 4-aminobenzoic acid. The friction material samples were tested for friction and wear performance. The coefficient of kinetic friction reached 0.12-0.15, and the wear rate was 0.9×10-8cm3/J-1.2×10-8cm3/J, showing excellent friction and wear performance. The process is simple and the cost is low. , is an efficient and environmentally friendly graft modification treatment method, which has a wide range of application prospects.

4-Aminobenzoic Acid Production Method

Water, sodium chloride and hydrochloric acid were added in sequence to the reaction pot. Start stirring and heat up to 50-60°C, add 9/10 amount of iron powder, continue to heat up to 98-102°C, hold for 1 hour, stop heating, slowly add p-nitrobenzoic acid at 95°C, about 1-1.5h After adding, add iron powder, keep at 98-102℃ for 1h, let cool to 80℃, add 30% liquid caustic soda to adjust pH=8.5-9, filter under pressure, wash with a small amount of water, combine the filtrate with a small amount of washing liquid, press in Acid precipitation pot, cool to 30-34℃, add hydrosulfite to decolorize, filter. Add acid to the filtrate to adjust pH=3.5-4, continue to cool to below 10°C, shake off water, and dry to obtain the finished product. Yield 84-88%. (2) Obtained by catalytic hydrogenation of p-nitrobenzoic acid. Add industrial p-nitrobenzoic acid and water to a 1000ml beaker, adjust pH=6-7 with 22% sodium hydroxide under stirring, and then add Rani Nickel, the feed liquid was pumped into a swinging autoclave under stirring, replaced with hydrogen and nitrogen for two times respectively, recharged to 3.43MPa, and reacted at a pressure of 3.43-2.54MPa and a temperature of 134-140 ℃ for about 5 hours. The end point is that the hydrogen pressure does not drop. After the reaction is completed, the finished product is obtained by filtration and drying. The yield is above 80%.

About Products:
If you need 4-Aminobenzoic Acid, a cosmetic raw material, please contact our service staff directly, we will provide you with high-quality products at the best price.
Our company, as an experienced 4-Aminobenzoic Acid manufacturer and supplier, ZSpharmac will provide 4-Aminobenzoic Acid raw materials to customers all over the world for a long time.
Over the years, the company has been adhering to the spirit of “integrity management, strict quality control, and customer first”, and has won unanimous praise from domestic and foreign customers.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

Help China Chemicals to benefit the happiness of human life
Become the most trusted chemical supplier in the world
Striver – oriented, enrich employees, customer first, deep service, seek development
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Cosmetic raw materials
  • Products/Service:Cosmetic raw materials (flavors and fragrances,antioxidant products, moisturizing and hydrating, whitening agents, cosmetic additives)
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.


After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.


Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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