4-Aminobenzoic acid is just one of among the most vital terrific scenting amino acids. It is a vital part of the compounds required for the development in addition to department of body cells. It has an irreplaceable attribute in the metabolic procedure of life. It is utilized in yeast, liver, bran along with malt. The product is exceptionally high. 4-Aminobenzoic acid can relieve anemia caused by lack of red cell, viral anemia, sprue as well as anemia while pregnant. 4-Aminobenzoic acid is a high-efficiency dietary item with the cornerstone – vitamin B-100, which can effectively enhance the three major metabolic rates of the body, entirely combat neurosis in addition to likewise get rid of nervousness. The compatibility of 4-aminobenzoic acid with penicillin or streptomycin can properly improve the bacteriostatic end result. 4-Aminobenzoic acid is furthermore a crucial fantastic chemical sources. In relation to medication, it is an essential intermediate in the synthesis of blood tonic-folic acid, and similarly a coagulant-p-carboxybenzylamine. It is in addition made use of in the manufacture of treatment for rickets, rheumatism, in addition to arthritis., Use medications. In the cosmetics market, it is a critical intermediate of human sunscreen together with hair advancement associates; in the natural chemical market, it is used to prepare countless ester products, which can be benefited from as product modifiers, in addition to can in addition be made use of to produce responsive dyes, azo Special intermediates for dyes. Examples of its application are as follows:
1) Synthesis of ethyl 4-aminobenzoate, including the following steps: dissolving 4-aminobenzoic acid with alcohol to prepare a 4-aminobenzoic acid solution with a mass fraction of 5-30%; Add thionyl chloride dropwise to the aminobenzoic acid solution to carry out the esterification reaction, after the dropwise addition, the temperature is raised to reflux, and the reaction is carried out for 4-10 hours; A weak base is added to neutralize to pH 7-8, and the solid matter is separated out and then filtered, washed with water, and dried to obtain 4-aminobenzoic acid ethyl ester product. The present invention uses 4-aminobenzoic acid as raw material, uses thionyl chloride as dehydrating agent to carry out esterification reaction to prepare ethyl 4-aminobenzoate, has fast reaction speed, high yield and high product purity, and has good industrial performance application prospects.
2) The preparation of an adefovir drug co-crystal using 4-aminobenzoic acid as a co-crystal precursor belongs to the technical field of drug co-crystals. The space group of the drug co-crystal is monoclinic system, and one adefovir molecule, two 4-aminobenzoic acid molecules and one water molecule are combined through hydrogen bonds to form the adefovir-aminobenzoic acid drug. The basic building block of a co-crystal. The solvent selected in the preparation process of the drug co-crystal of the present invention is water, and the adopted method is the solution co-crystallization method. Since Adefovir is slightly soluble in cold water and easily soluble in hot water, it is heated and stirred to dissolve and then placed in an oven to keep warm for a period of time. After cooling, crystals crystallize out. The drug co-crystal prepared by the invention has obvious improvement in solubility, stability and bioavailability besides inheriting the characteristics of traditional raw materials for treating hepatitis B disease.
3) To prepare a 4-aminobenzoic acid non-destructively modified carbon fiber reinforced paper-based wet friction material, first add carbon fiber, 4-aminobenzoic acid and excess hydrochloric acid into a three-necked flask, and then slowly add a certain amount of hypochlorite after the reaction reaches a certain temperature. Sodium nitrate, and short-time diazotization reaction in an oil bath with magnetic stirring to obtain carbon fibers grafted with benzoic acid on the surface. Then, the modified carbon fiber is mixed with aramid fiber, paper fiber, filler and resin to prepare friction material base paper, and then hot-pressed and cured to obtain a paper-based wet friction material modified with 4-aminobenzoic acid. The friction material samples were tested for friction and wear performance. The coefficient of kinetic friction reached 0.12-0.15, and the wear rate was 0.9×10-8cm3/J-1.2×10-8cm3/J, showing excellent friction and wear performance. The process is simple and the cost is low. , is an efficient and environmentally friendly graft modification treatment method, which has a wide range of application prospects.
