Zhishang Chemical

Welcome to Zhishang Chemical      +86-176 5311 3209     Simon@sdzschem.com

Zhishang Chemical
Close this search box.

3-O-Ethyl-L-Ascorbic Acid CAS 86404-04-8

Molecular Formula: C8H12O6

Formula Weight: 204.18

ZSpharmac: 3-O-Ethyl-L-Ascorbic Acid Supplier

Product Name: 3-O-Ethyl-L-Ascorbic Acid
CAS No: 86404-04-8
Purity: 99%

Navigation Bar

Basic Info

Product Name:3-O-Ethyl-L-Ascorbic Acid
Other Names:Vitamin C Ethyl Ether
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:White to Off-White Solid
EINECS No.:617-849-3
Storage:Sealed in Dry,2-8°C
Provide:3-O-Ethyl-L-Ascorbic Acid MSDS;
3-O-Ethyl-L-Ascorbic Acid COA

What is 3-O-Ethyl-L-Ascorbic Acid?

3-O-Ethyl-L-Ascorbic Acid is a very beneficial vitamin C derivative. It is not simply exceptionally secure in chemical materials, it is a non-discoloring vitamin C derivative, as well as also it is lipophilic as well as hydrophilic. It has significantly expanded its series of application, especially in day-to-day chemistry. 3-O-Ethyl-L-Ascorbic Acid can swiftly get in the dermis with the stratum corneum. After going into the body, it is extremely straightforward to be decayed by the organic enzymes in the body to put in the organic results of vitamin C.

Because vitamin C has 4 hydroxyl groups in its framework, it can not be straight absorbed by the skin, in addition to it is conveniently oxidized to create staining. As a bleaching agent, its use in cosmetics is limited. The vitamin C ethyl ether gotten after the 3-hydroxyl is alkylated is a vitamin C by-product that does not change color and additionally does not impact its organic activity, hence filling out the gap on the market for similar products. Studies have actually disclosed that 3-O-Ethyl-L-Ascorbic Acid gets in the skin as well as is conveniently broken down by enzymes to play the function of vitamin C.

3-O-Ethyl-L-Ascorbic Acid Property

Melting point 112.0 to 116.0 °C
Boiling point 551.5±50.0 °C(Predicted)
density 1.46±0.1 g/cm3(Predicted)
vapor pressure 0-0Pa at 20-25℃
storage temp. Sealed in dry,2-8°C
solubility Methanol (Slightly), Water (Slightly)
form Solid
color White to Off-White


3-O-Ethyl-L-Ascorbic Acid Product Efficacy

1. 3-O-Ethyl-L-Ascorbic Acid prevents tyrosinase task, prevents the development of melanin, minimizes melanin to colorless, as well as properly lightens the skin.

2. After VC ethyl ether enters the dermis, it straight participates in the synthesis of collagen as well as fixings the activity of skin cells, enhancing collagen, making the skin plump as well as elastic, making the skin fragile and also smooth.

3.3-O-Ethyl-L-Ascorbic Acid has exceptional antioxidant impact in cosmetics and guarantees the application of VC. Compared to VC, VC ethyl ether is extremely stable and does not alter shade. Really accomplish the effect of lightening and also blemish removal.

4. Solid anti-bacterial and also anti-inflammatory effects, anti-inflammation caused by sunlight.

5. 3-O-Ethyl-L-Ascorbic Acid has a lipophilic as well as hydrophilic structure, which is conveniently taken in by the skin and can straight get to the dermis

6. Good stability, light resistance, warmth resistance, acid resistance, alkali resistance, salt resistance and air oxidation

Application of 3-O-Ethyl-L-Ascorbic Acid

3-O-Ethyl-L-Ascorbic Acid (vitamin C ethyl ether) is an oil-water soluble material, which permits the formulator to include it to the oil stage or water phase, and also can also be included at high or low temperature level, so that it is convenient Much more significantly, this twin solubility makes it easier to penetrate the stratum corneum as well as get in the dermis to exert its organic results, which is not readily available in various other vitamin C by-products. It can block the development of melanin by inhibiting the activity of tyrosinase; it has bleaching and freckle elimination impacts (when 2% is included); it can resist swelling triggered by sunshine and has solid antibacterial as well as anti-inflammatory effects; The skin is glossy as well as elastic, the activity of skin cells is fixed, and also the production of collagen is promoted.

CN201610866558.7 provides a whitening composition, which includes the extract of euphorbic acid, 3-O-Ethyl-L-Ascorbic Acid and auxiliary agents, further, the whitening composition includes 0.5~5.0wt% of euphorbic acid Huoxuedan extract, 0.2-3.0wt% 3-O-ethyl ascorbic acid and the balance of additives. In the present application, by adding the extract of euproxetan and 3-O-Ethyl-L-Ascorbic Acid to the whitening composition, the resulting composition has a better whitening effect; further, the above two components are compounded , so that the whitening composition achieves the best whitening effect, and the mildness is better. The present application also provides a skin care product.

CN201510804504.3 discloses a manufacturing method of peony whitening facial cleanser, comprising the following steps: adding glycerin, glyceryl glucoside, myristic acid, ascorbyl phosphatidic acid, palmitic acid, potassium hydroxide, 3-O-Ethyl-L-Ascorbic Acid, Macrogol-8, Hydroxyethyl Cellulose, Butylated Hydroxytoluene, Methylparaben, Sodium Methyl Lauroyl Taurate, Polyquaternium-39, Disodium EDTA, Glyceryl Oleate, Benzene Put oxyethanol, methylisothiazolinone, butanediol and deionized water in a container, heat to 90°C and stir to dissolve; keep warm for 10 minutes and cool to 30°C; add peony root extract, oat amino acids, bamboo leaf extract Stir for 3-10 minutes; add 1.8-2.2 parts of citric acid to adjust the pH value; let it stand for defoaming, cool to room temperature, and fill it into a finished product. The invention has comprehensive nutrition and remarkable effect, and the 3-O-Ethyl-L-Ascorbic Acid makes the facial cleanser have whitening effect while cleaning the face.

3-O-Ethyl-L-Ascorbic Acid Preparation

Step 1 Preparation of 5,6-O-isopropylidene-L-ascorbic acid
176 g (1 mol) of ascorbic acid and 870 g (15 mol) of acetone were sequentially added into a 5L reactor, stirred for 10 minutes, 6.5 g (0.05 mol) of oxalyl chloride was added dropwise under ice-cooling conditions, and reacted at 30°C for 9 hours. After the reaction was completed, the filter cake and filtrate A were obtained after filtration. The filtrate A was used for later use. The filter cake was washed with 80 g of acetone and dried to obtain 195.1 g of 5,6-O-isopropylidene-L-ascorbic acid with a yield of 90.2%.

Add calcium oxide 74 grams (1.32mol) in filtrate A, stir 3 hours, filter, and filtrate is dried 12 hours with 90 grams of molecular sieves, filters, and obtains the acetone filtrate B after treatment, and this acetone filtrate B can utilize again.

176 g of ascorbic acid was added to the treated acetone filtrate B, stirred for 10 minutes, 6.5 g of oxalyl chloride was added dropwise under ice-cooling conditions, and the reaction was carried out at 30° C. for 9 hours. After the reaction, filter again to obtain the filter cake and filtrate C, wash the filter cake with 80 g of acetone, and dry to obtain 200.5 g of 5,6-O-isopropylidene-L-ascorbic acid, with a yield of 92.7%.

Add 74 grams of calcium oxide to the filtrate C, stir for 3 hours, filter, and dry the filtrate with 90 grams of molecular sieves for 12 hours, filter to obtain the acetone filtrate D, which can be reused.

Add 176 g of ascorbic acid to the dried acetone filtrate D, stir for 10 minutes, add 6.5 g of oxalyl chloride dropwise under ice-bath conditions, and react at 30° C. for 9 hours. After the reaction was completed, filter, wash the filter cake with 80 g of acetone, and dry to obtain 206.1 g of 5,6-O-isopropylidene-L-ascorbic acid, with a yield of 95.3%.

Step 2 Preparation of 3-O-ethyl-5,6-O-isopropylidene-L-ascorbic acid
Add 216.2 grams of 5,6-O-isopropylidene-L-ascorbic acid prepared in step 1 into a 5L reactor, add 430 grams (9.3mol) of ethanol, stir for 30 minutes, add 131 grams of sodium bicarbonate (1.56 mol), slowly added dropwise 200 grams of diethyl sulfate (1.3mol), gradually heated to 55°C, reacted at this temperature for 6.5 hours, then concentrated the reaction solution, added 250 grams of dichloromethane (2.94mol) to dissolve the product, After filtration and recrystallization, 203.5 g of 3-O-ethyl-5,6-O-isopropylidene-L-ascorbic acid was obtained, with a yield of 83.4%.

Step 3 Preparation of Ascorbic Acid Ethyl Ether
Add 244 grams of 3-O-ethyl-5,6-O-isopropylidene-L-ascorbic acid prepared in step 2, 320 grams of ethanol, stir to dissolve, 55 grams of hydrogen chloride ethanol solution, water 30 grams, heated to 55°C, reacted for 4 hours, concentrated the reaction solution to one-third of the original volume, added an equal volume of dichloromethane for recrystallization, and obtained 190.4 grams of 3-O-ethyl ascorbic acid ether, with a yield of 93.3%; continue Recrystallized with dichloromethane and ethanol (volume ratio 2:1), to obtain 177.5 g of 3-O-Ethyl-L-Ascorbic Acid (molecular weight 204.18), yield 86.9%.

About That Product:
If you need 3-O-Ethyl-L-Ascorbic Acid as a cosmetic raw material, please contact our service staff directly, and we will provide you with high-quality products at the best price.
As an experienced 3-O-Ethyl-L-Ascorbic Acid manufacturer and supplier, ZSpharmac will provide 3-O-Ethyl-L-Ascorbic Acid raw materials to customers all over the world for a long time.
Over the years, the company has been adhering to the spirit of “integrity management, strict quality control, customer first”, and has won unanimous praise from domestic and foreign customers.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

Help China Chemicals to benefit the happiness of human life
Become the most trusted chemical supplier in the world
Striver – oriented, enrich employees, customer first, deep service, seek development
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Cosmetic raw materials
  • Products/Service:Cosmetic raw materials (flavors and fragrances,antioxidant products, moisturizing and hydrating, whitening agents, cosmetic additives)
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.


After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.


Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

Get 3-O-Ethyl-L-Ascorbic Acid Quotation