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3-Methylindole CAS 83-34-1

Molecular Formula: C9H9N

Formula Weight: 131.17

ZSpharmac: 3-Methylindole Supplier

Product Name: 3-Methylindole
CAS No: 83-34-1
Purity: 99%

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Basic Info

Product Name:3-Methylindole
Other Names:3-Methyl-1H-indole
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:White Flakes
EINECS No.:201-471-7
Storage:Store Below +30°C.
Provide:3-Methylindole MSDS;
3-Methylindole COA

What is 3-Methylindole?

3-Methylindole white scales or powdery crystals (from petroleum ether), gradually darken when exposed to air; with (fecal) and strong indole-like animal smell. The momentum is very powerful, the diffusion is strong, and it is very long-lasting. When the concentration is high, the breath is disgusting, and only in extremely low concentrations, there is a big civet-like animal smell. On the palate it is warm and overripe fruity. Melting point 96°C (93-96°C); boiling point 265-266°C; soluble in boiling water, soluble in ethanol and other common organic solvents.

3-Methylindole Property

Melting point 

92-97 °C (lit.)

Boiling point 

265-266 °C (lit.)


1.0111 (estimate)

refractive index 

1.6070 (estimate)


132 °C

storage temp. 

Store below +30°C.


Crystalline Powder or Flakes




Almost white to pale brown


indole-like odor

Odor Threshold


Water Solubility 

Soluble in water, Ether, Alcohols, Benzene, Acetone, Chloroform.


Light Sensitive


3-Methylindole Uses

3-Methylindole has a very good fragrance-fixing value, and is often used as a fragrance-fixing agent, but only a trace amount can be used to impart a civet fragrance in floral fragrances, giving people an overripe floral fragrance. It is often used to prepare civet incense. In the fragrance formula, it is often used together with phenylacetic acid, civetone or macrocyclic ketones to obtain a good natural animal fragrance effect, and the effect is better when used together with sandalwood fragrance. In the essence, it will gradually change with other aldehyde fragrances and produce unpleasant smell. Discoloration is also severe. Only a very trace amount is used in grapes, cheese, fruity, nutty and other types in food. Such as preparing a formula for replacing corpse smell in police dog corpse search training, which relates to the technical field of chemical formula. The formula for replacing corpse odor in police dog search training includes the following components by mass fraction: cadaverine 20-30%, putrescine 28-33%, carbonamide 17.5-20%, ethanethiol 6-10% , Sodium sulfide 13? 18% and 3-Methylindole 3? 8%. This formula is similar to the formula for human corpses, and can effectively train cadaver dogs, and several chemicals in the formula are solid and liquid at room temperature, which is easy to carry and use.

Ecological Information on 3-Methylindole

3-Methylindole is a normally occurring compound located in beetroot, dung, and also netrandra timber. It is likewise generated industrially, made use of as a fixative in the perfume market and as a preservative, as well as may be launched right into the environment from different waste streams. It has an extrapolated vapor stress of 0.005 mm Hg at 25 ° C and exists only in the gas stage in the ambient environment. The approximated Koc value of 600 indicates that 3-methylindole is less mobile in soil. Based upon an estimated Henry’s Law constant of 2.1X10-6 atm-cu m/mol, volatilization from damp soil surface areas is likely. Methanogens improved from marsh dirts completely mineralized this substance. In water, 3-methylindole might adsorb onto debris or particle matter relying on its Koc worth. Volatilization from the water surface area is anticipated from its estimated Henry’s Legislation constant. The approximated half-lives for the design river and version lake are 20 days and also 148 days, specifically. 3-Methylindole might undergo hydrophotooxidation when revealed to all-natural sunshine. The major item of photooxidative deterioration of 3-methylindole is thought about to be o-(N-formyl)aminoacetophenone. Bioconcentrations in aquatic organisms are considered modest, not high, based upon an approximated BCF value of 56. There are presently no information on office direct exposure to 3-methylindole. Although groundwater tracking data are limited, the general population might be revealed to 3-methylindole through usage of polluted groundwater.

Duration of Inhibition of 3-Methylindole Production By Monensin

A series of artificial insemination and also in vivo experiments were executed to identify whether continual feeding of monensin for approximately 56 days would decrease the conversion of ruminal L-tryptophan (TRP) to 3-methylindole (3MI). Fourteen adult beef cattle were adjusted to a 3-week upkeep diet. In Experiment I, the tasting time for enhancing 3MI production was identified. Tests II to IV were designed to establish the duration of effectiveness of monensin in decreasing 3MI focus in vitro as well as in vivo. In tests II, III and also IV, fifty percent of the cows were fed 200 mg monensin X head-1 X d-1 for 21, 36 and also 55 days, specifically, as well as the continuing to be cows acted as controls. All cows were fed the control diet plan for 21 days between each test. Volatile fat (VFA) focus and artificial insemination conversion of TRP to 3MI were figured out in rumen fluid examples gathered throughout trials I to IV. On day 28 of Experiment IV, acute bovine lung edema and also emphysema (ABPE) was induced in all cows with a dental dosage of 0.35 g TRP/kg body weight. Rumen focus of 3MI as well as indole were determined every 96 hrs. The results of Trial I showed that rumen fluid gathered 15 hrs after feeding yielded the greatest in vitro conversion of TRP to 3MI. Consequently, samples of rumen fluid were collected in Trial run II, III and IV during that time. Artificial insemination conversion of TRP to 3MI was lower in monensin-treated cows (12.1%) contrasted to controls (25.6%) (P <.01). Monensin minimized 3MI manufacturing by 55 days, the longest time tested in these experiments.

Occurrence, Effects, and Microbial Transformation of 3-Methylindole: a critical review

Odor pollution is among the seven significant public hazards that prevail in the world as well as has caused more and more public issues in the past few decades. 3-Methylindole (skatole) is generated from tryptophan by anaerobic microorganisms in pet guts as well as the setting as well as is just one of one of the most infamous fecal-smelling substances in pet waste, wastewater treatment plants, and public toilets. Ecological concentrations of skatole can even reach mg/L or mg/kg levels, especially in pet manure. Along with the undesirable odor, evidence recommends that skatole can cause lung toxicity, boar taint, and bacteriostatic results in rumen pets as well as human beings, as well as our understanding of its eco-friendly as well as physical significance is still in its infancy. The skatole production pathway and also key enzymes have actually been revealed, nonetheless, the hidden systems impacting skatole manufacturing stay evasive. Biodegradation is taken into consideration as a viable technique to remove skatole, however an extensive understanding of metabolic pathways under cardio as well as anaerobic problems is still lacking, and also the functional genes responsible for skatole biodegradation continue to be a black box. This testimonial offers extensive details on the event, ecological and biological effects, and also microbial change of skatole. Some vital concerns deserving of further study are additionally detailed.

About That Product:
If you need 3-Methylindole as a cosmetic raw material, please contact our service staff directly, we will provide you with high-quality products at the best price.
As an experienced 3-Methylindole manufacturer and supplier, ZSpharmac will provide 3-Methylindole raw materials to customers all over the world for a long time.
Over the years, the company has been adhering to the spirit of “integrity management, strict quality control, customer first”, and has won unanimous praise from domestic and foreign customers.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

Help China Chemicals to benefit the happiness of human life
Become the most trusted chemical supplier in the world
Striver – oriented, enrich employees, customer first, deep service, seek development
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Cosmetic raw materials
  • Products/Service:Cosmetic raw materials (flavors and fragrances,antioxidant products, moisturizing and hydrating, whitening agents, cosmetic additives)
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.


After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.


Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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