Zhishang Chemical

Welcome to Zhishang Chemical      +86-176 5311 3209     Simon@sdzschem.com

Zhishang Chemical

3-Dimethylaminopropylamine CAS 109-55-7

Molecular Formula: C5H14N2

Formula Weight: 102.18

ZSpharmac: 3-Dimethylaminopropylamine Supplement

Product Name: 3-Dimethylaminopropylamine
CAS No: 109-55-7
Purity: 99%

Basic Info

Product Name:3-Dimethylaminopropylamine
Other Names:DMAPA
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:Clear Liquid
EINECS No.:203-680-9
Storage:Store Below +30°C.
Provide:3-Dimethylaminopropylamine MSDS;
3-Dimethylaminopropylamine COA

What is 3-Dimethylaminopropylamine?

3-Dimethylaminopropylamine are an important class of chemical substances and are widely used as raw materials, intermediates or products. For example, diamines are important structural units in the process of synthesizing polyamides and in other polycondensation reactions. N,N-Dimethyl-1,3-diaminopropane (DMAPA) is an important intermediate, used for example in the industrial preparation of lubricants, in addition, DMAPA is used as a raw material for the preparation of coagulants, which itself should have Corrosion resistance.

3-Dimethylaminopropylamine Properties:

Melting point -60 °C
Boiling point 133 °C(lit.)
density 0.812 g/mL at 25 °C(lit.)
vapor density 3.6 (vs air)
vapor pressure 5 mm Hg ( 20 °C)
refractive index n20/D 1.435(lit.)
Fp 90 °F
storage temp. Store below +30°C.
form Liquid
color Clear
PH12.7 (100g/l, H2O, 20℃)
explosive limit2.3-12.35%(V)
Water Solubility SOLUBLE


3-Dimethylaminopropylamine Uses

  1. 3-Dimethylaminopropylamine is widely used in the manufacture of cosmetic raw materials, such as palmamide dimethylpropylamine, cocamidopropyl betaine, mink oil amidopropylamine, etc.
  2. 3-Dimethylaminopropylamine is an intermediate of the fungicide propamocarb.
  3. 3-Dimethylaminopropylamine is used as an intermediate in organic synthesis to prepare dyes, ion exchange resins, epoxy resin curing agents, oils and additives for cyanide-free electro-galvanizing, fiber and leather treatment agents and fungicides. This product contains both primary and tertiary amino groups in the molecule. It is used as epoxy resin curing agent and has two functions of curing agent and accelerator. Mainly used for laminates, castings and adhesives, etc., the general dosage is 2-6 parts.
  4. 3-Dimethylaminopropylamine is used in organic synthesis. Epoxy hardener.

3-Dimethylaminopropylamine Preparation

report one,
Step 1. Obtain a mixture of acrylonitrile and dimethylamine in a molar ratio of 1:1 to 3, and vaporize the mixture at a temperature of 100 to 120°C to obtain a primary vaporized mixture;

Step 2. The amination reaction is carried out with the primary vaporization mixture under the action of a portion of the activated carrier. The reaction temperature is 100-120° C., the reaction pressure is 0.3-0.5MPa, and the volumetric space velocity of acrylonitrile is 0.1-0.25h-1. Obtain a catalytic mixture;

Step 3. The primary catalytic mixture is vaporized at a high temperature under the condition of 150-180 °C to obtain a secondary vaporized mixture;

Step 4. The secondary vaporization mixture is subjected to hydrogenation reaction under the action of another activated carrier, the reaction temperature is 150-180°C, the reaction pressure is 0.3-0.5MPa; the volume space velocity is 0.1-0.25h-1, and the secondary catalyst;

Step 5, the secondary catalyst is cooled to 40° C., and the liquid phase is collected, and the liquid phase is specifically N,N-dimethyl-1,3-diaminopropane.

report two,
A method for preparing 3-Dimethylaminopropylamine, the method comprises the following steps:

a) Add acrylonitrile into the synthesis kettle, control the temperature to 120℃, add dimethylamine under the condition of stirring and cooling water circulation cooling, remove dimethylamine through vacuum distillation, pressure 0.03MPa, and prepare N,N-dimethylamine Methylaminoacrylonitrile; the molar ratio of acrylonitrile to dimethylamine is 1:1;

b) Add the 3-Dimethylaminopropylamine obtained in step a) into the autoclave, add a hydrogenation catalyst, feed liquid ammonia into the autoclave, heat up to 80°C, keep the pressure at 2.5MPa, and feed hydrogen , stirring while maintaining the temperature at 80 ° C, the reaction, the initial distillation after sedimentation, rectification to obtain N,N-dimethyl-1,3-propanediamine, and then storage tank packaging; hydrogenation catalyst and N,N-dimethyl The molar ratio of propionitrile is 10:1; in the initial distillation, the fraction with a temperature greater than 134 ° C is sent to rectification. Take the reaction liquid in the autoclave to detect, the content of 3-Dimethylaminopropylamine is 99.4 %, the residual content of propionitrile is 0.01%, the impurity content of light components is 0.15%, the content of impurities in heavy components is 0.61%, and the secondary amine is 0.37%.

3-Dimethylaminopropylamine Other Applications

Application 1.
CN201511019713.3 discloses an artemisinin derivative and a synthesis method and application thereof. The artemisinin derivative is 3-Dimethylaminopropylamine -10-azadeoxyartemisinin, which uses artemisinin as a raw material and is successively mixed with N. , 3-Dimethylaminopropylamine and p-toluenesulfonic acid reaction. By investigating the proliferation inhibitory activity of the derivative on various human tumor cell lines and human normal cell lines, the applicant found that it can inhibit human bladder cancer cells T-24, human ovarian cancer cells SK-OV-3, and human gastric cancer cells MGC80- 3 All three cell lines showed significant proliferation inhibitory activity and had good potential medicinal value, and were expected to be used in the preparation of various anti-tumor drugs.

Application 2.
CN201510025397.4 discloses a 1,8-naphthalimide derivative and a synthesis method and application thereof. The derivative is N-(3,4-methylenedioxyphenethyl)-4-(3-N,N-dimethylamino)propylamino-1,8-naphthalimide, which is The compound is obtained by reacting 4-bromo-1,8 naphthalene dicarboxylic anhydride with 3,4-methylenedioxyphenethylamine and N,N-dimethyl-1,3-diaminopropane successively. The synthesis method is simple and easy to control. The applicant has investigated its proliferation inhibitory activity on 9 human tumor cell lines and two normal cell lines, and the results show that its in vitro anti-tumor activity is significant, has good potential medicinal value, and is expected to be used in various anti-tumor drugs. preparation.

Application three,
CN201911150842.4 discloses a preparation method of an amphiphilic polymer-modified ultrafiltration membrane, which belongs to the technical field of membrane separation. Alkyl-4,4′-diaminodiphenylmethane and 3-Dimethylaminopropylamine were dissolved together in a mixed solution of dimethylformamide and triethylamine, and copolymerized at low temperature to prepare polymer amide polymer, 2. The polyamide polymer is reacted with 1,3-propane sultone to obtain amphiphilic zwitterionic polyamide, 3. The amphiphilic zwitterionic polyamide is obtained by blending with polysulfone The membrane casting solution is used to prepare the ultrafiltration membrane by the non-solvent induced phase inversion method. In the casting solution of organic solvent, the hydrophobic polyamide segment in the amphiphilic polymer is similar in polarity to polysulfone, which increases its compatibility. In the aqueous phase, the hydrophilic segments in the amphiphilic polymer are enriched on the membrane surface, which plays an antifouling effect.

3-Dimethylaminopropylamine TSCA Test Submission

Subchronic oral administration of 3-Dimethylaminopropylamine (CAS # 109-55-7) by oral gavage in groups of Wistar rats (5/sex/group) at doses of 0, 10, 50 and 250 mg/kg-day Toxicity was assessed for 28 days. Due to the high mortality rate (3/5) in 250 mg/kg females during the initial study, a second trial was conducted in 5 female rats receiving 250 mg/kg and combined data from 10 high-dose females . All animals were necropsied on day 29 of the study. Only women in the high-dose group (4/10) died during the 28-day treatment period. Clinical symptoms were intermittently observed in this group between days 11 and 24 of the study, mainly in concurrent deceased patients, including hypoactivity, unsteady gait, abdominal swelling, and dyspnea. A solitary high-dose male exhibited impaired breathing. Body weight, organ weight, food and water intake, urinalysis, hematology, and clinical chemistry assessments were not significantly different from the control group at any dose. After autopsy, the lungs were discolored with red spots on the surface and foamy contents, and a small isolated spleen, a gross pathological feature found only in deceased females. Microscopic examination revealed marked lesions in these animals, including organ congestion, pulmonary hemorrhage and/or edema, and severe loss and atrophy of splenic lymphoid follicles and lymphatic sheaths. One symptomatic man in the 250 mg/kg dose group exhibited focal epithelial degeneration of the anterior stomach, which the authors claim may be due to the compound’s stimulatory effects.

2. 3-Dimethylaminopropylamine (CAS # 109-55-7) was reviewed for skin sensitization in 15 women Hartley test subject by a maximization test. Induction contained 3 sets of 0.1 mL intradermal shots, flanking the dorsal midline in the shoulder area, with each dual shot consisting of a 1-5% v/v service in pure water (undefined pre-test focus, no topical or systemic action), 1-5% v/v solution in Freund’s total adjuvant (FCA) and FCA alone. After 7 days of induction, difficulty with 0.3 mL of topically applied 1% pure water for 48 h under a closed spot covering the entire examination area. A second 48-hour challenge was executed 21 days later on with topical application of 0.3 mL of 5% solution and also an additional private car, each on either side of the dorsal midline to cover the triplet test site. Although pre-test excitement results were not supplied, the writers concluded that 93% (14/15) of the pets checked had a positive response, compared to 0% (0/6) as well as 100% responses to dinitrogen in the vehicle/FCA control team. The chlorobenzene (positive control) team developed an optimum category of “extreme” sensitization after a 2nd difficulty with 5% N,N-dimethyl-1,3-propanediamine.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

Help China Chemicals to benefit the happiness of human life
Become the most trusted chemical supplier in the world
Striver – oriented, enrich employees, customer first, deep service, seek development
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Additive , Chemical Auxiliary & Catalyst , Organic Chemicals
  • Products/Service: Organic Intermediate,Inorganic Chemistry, APIs, Dyestuffs And Pigments, Fragrance And Spices, Food Additives
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.


After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.


Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

Get 3-Dimethylaminopropylamine Quotation