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2,6-Diaminopyridine CAS 141-86-6

Molecular Formula: C5H7N3

Formula Weight: 109.13

ZSpharmac: 2,6-Diaminopyridine Supplier

Product Name: 2,6-Diaminopyridine
CAS No: 141-86-6
Purity: 99%

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Basic Info

Product Name:2,6-Diaminopyridine
Other Names:2,6-Diamino-Pyridin
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:Beige to Dark Brown-Gray Crystalline Powder
EINECS No.:205-507-2
Storage:Store Below +30°C.
Provide:2,6-Diaminopyridine MSDS;
2,6-Diaminopyridine COA

What is 2,6-Diaminopyridine?

2,6-Diaminopyridine is one of the intermediates of medicine, pesticide and dyestuff. According to the U.S. Patent US1680108 report, the phenazopyridine hydrochloride produced as a raw material with this intermediate is an important drug for the treatment of urinary system diseases; The light fastness has been significantly improved.

2,6-Diaminopyridine Property

Melting point 117-122 °C (lit.)
Boiling point 285 °C (lit.)
density 1.7110 (rough estimate)
refractive index 1.5340 (estimate)
Fp 155°C
storage temp. Store below +30°C.
solubility 180g/l
form Flakes or Crystalline Powder
color Beige to dark brown-gray
PH>7 (H2O)
Water Solubility 9.9 g/100 mL (20 ºC)


2,6-Diaminopyridine Uses

  1. 2,6-diaminopyridine can be utilized to manufacture pentamidine derivatives with antitumor task and DNA binding activity. It can likewise be made use of to synthesize N-monocarbamoyl derivatives of in proportion diamines with antiviral activity. Its by-products can be utilized as molecular sensing unit versions for nucleic acid discovery.
  2. 2,6-Diaminopyridine can be made use of for coupling diazo compounds.
  3. 2,6-Diaminopyridine is presently mostly used in the production of a painkiller– Phenazopyridine [CASNo.94-78-0] abroad, which is said to relieve pain, burning as well as pain brought on by urinary system tract infections as well as other diseases. The drug is a prescription medicine in the United States, an over the counter medicine in Canada, as well as has actually not yet been generated in China. The brand name of the medicine in the USA are: Azo-Standard, Baridium, Eridium, Geridium, Phenazodine, Pyridiate, Pyridium, Urodine, Urogesic, Viridium; the brand name of the medicine in Canada are: Phenazo, Pyridium.

2,6-Diaminopyridine Preparation Method

A method for preparing 2,6-diaminopyridine, which is characterized in that the preparation method comprises: heating sodium amide, an organic solvent and a phase transfer catalyst to 140-220°C to keep warm, adding pyridine dropwise within 0.5-3 hours, Carry out Chichibabin reaction for 3-10 hours, the reaction is complete, cool down to 50-100°C, add water to carry out hydrolysis reaction at 30-100°C, cool, crystallize at 5-40°C, and filter to obtain the 2,6-diaminopyridine , the phase transfer catalyst is C6~C9 aromatic amine or C2~C6 fatty alcohol amine or a mixture of both, and the described organic solvent is C8~C12 chain hydrocarbon or aromatic hydrocarbon or diphenyl ether, so The substance ratio of the sodium amide and pyridine is 2.0~4.0:1.0, the substance ratio of the phase transfer catalyst and pyridine is 0.5~3.0:1.0, and the quality of the organic solvent is 1% of the pyridine mass. ~4 times, the quality of the water is 3~10 times of the quality of pyridine.

The organic solvent and phase transfer catalyst can be recycled.

The phase transfer catalyst is C6-C9 aromatic amine and/or C2-C6 fatty alcohol amine, that is, C6-C9 aromatic amine, such as aniline, N,N-dimethylaniline, p-methylaniline, O-methylaniline, 2,4,6-trimethylaniline, etc., can also be C2~C6 fatty alcohol amines, such as ethanolamine, propanolamine, butanolamine, diethanolamine, triethanolamine, etc., or C6 A mixture of ~C9 aromatic amine and C2~C6 fatty alcohol amine, C6~C9 aromatic amine and C6~C9 aromatic amine or C2~C6 fatty alcohol amine and C2~C6 fatty alcohol amine; the said The organic solvent is C8~C12 chain hydrocarbon or aromatic hydrocarbon or diphenyl ether, such as nonane, decane, dodecane, decahydronaphthalene, tetrahydronaphthalene, diphenyl ether, etc.; the sodium amide and pyridine The molar ratio of the substance is 2.0~4.0:1.0, preferably 2.5~3.0:1.0, the molar ratio of the phase transfer catalyst and pyridine is 0.5~3.0:1.0, preferably 0.5~1.0:1.0; The quality of the organic solvent is 1 to 4 times of the quality of pyridine, preferably 1.5 to 2.5 times; the quality of the water is 3 to 10 times of the quality of pyridine, preferably 5.0 to 7.0 times. The time for adding pyridine is preferably 1 to 2 hours; the Chichibabin reaction time is preferably 3 to 6 hours, and the reaction temperature is preferably 150 to 180°C; the hydrolysis reaction temperature is preferably 50 to 80°C; the crystallization temperature is 5 to 40°C , preferably 18-28°C.

Intramolecular Proton Transfer Effect of 2,6-Diaminopyridine

The photophysical habits of 2,6-diaminopyridine (DAP) in different polarity, pH, β-cyclodextrin (β-CD) solvents was examined and also compared to 2-aminopyridine (2AP). The inclusion complexes of both molecules with β-CD were examined by UV-Vis, fluorescence, FT-IR, 1H NMR, SEM and also AM1 approaches. Solvent researches reveal that i) DAP has even more red-shifted absorption and emission maxima than 2AP particles, and ii) the enhancement of amino teams to 2AP properly enhances the resonant communications in the pyridine ring. The normal red shift observed in acidic pH services suggests intramolecular proton transfer (IPT) in both particles. β-CD studies show that i) the routine red-shifted absorption as well as emission maxima observed in the AP molecule at pH ~ 7 show that the pyridine ring is encapsulated in the β-CD cavity (forming a 1:1 clathrate) as well as ii) At pH ~ 1, a blue-shifted absorption maximum was noted in 2AP, due to the protonated amino group being deeply loaded right into the hydrophobic part of the β-CD cavity. solution

About Products:
If you need 2,6-Diaminopyridine as a cosmetic raw material, please contact our service staff directly, and we will provide you with high-quality products at the best price.
As an experienced manufacturer and supplier of 2,6-Diaminopyridine, ZSpharmac will provide 2,6-Diaminopyridine raw materials for customers all over the world for a long time.
Over the years, the company has been adhering to the spirit of “integrity management, strict quality control, customer first”, and has won unanimous praise from domestic and foreign customers.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

Help China Chemicals to benefit the happiness of human life
Become the most trusted chemical supplier in the world
Striver – oriented, enrich employees, customer first, deep service, seek development
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Cosmetic raw materials
  • Products/Service:Cosmetic raw materials (flavors and fragrances,antioxidant products, moisturizing and hydrating, whitening agents, cosmetic additives)
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.


After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.


Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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