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2,6-Diaminopyridine CAS 141-86-6

Molecular Formula: C5H7N3

Formula Weight: 109.13

ZSpharmac: 2,6-Diaminopyridine Raw Material Supplier

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Product Name: 2,6-Diaminopyridine
CAS No: 141-86-6
Purity: 99%

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Basic Info

Product Name:2,6-Diaminopyridine
Other Names:Diaminopyridine
CAS:141-86-6
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:Beige Flakes
EINECS No.:205-507-2
Storage:Store Below +30°C.
Provide:2,6-Diaminopyridine MSDS;
2,6-Diaminopyridine COA

What is 2,6-Diaminopyridine?

2,6-Diaminopyridine is one of the intermediates for medicines, pesticides and dyes. According to U.S. patent US1680108, phenazopyridine hydrochloride produced from this intermediate is an important drug for the treatment of urinary system diseases; according to British patent BP1,025,414, hair conditioners synthesized using this intermediate are effective in treating black hair dyes. The light fastness is significantly improved.

2,6-Diaminopyridine Property

Melting point 117-122 °C (lit.)
Boiling point 285 °C (lit.)
density 1.7110 (rough estimate)
refractive index 1.5340 (estimate)
Fp 155°C
storage temp. Store below +30°C.
solubility 180g/l
pka6.13±0.24(Predicted)
form Flakes or Crystalline Powder
color Beige to dark brown-gray
PH>7 (H2O)
Water Solubility 9.9 g/100 mL (20 ºC)

 

2,6-Diaminopyridine Uses

  1. 2,6-diaminopyridine can be used to synthesize pentamidine by-products with anti-tumor activity as well as DNA-binding activity. It can also be utilized to manufacture N-monocarbamyl by-products of symmetric diamines with antiviral activity. Its derivatives can be utilized as molecular sensing unit designs for nucleic acid detection.
  2. 2,6-diaminopyridine is presently generally used in the production of an analgesic medication abroad – Phenazopyridine [CAS No.94-78-0], which is claimed to alleviate pain, burning as well as pain caused by urinary tract infections and other conditions.

2,6-Diaminopyridine Preparation Method

A preparation approach of 2,6-diaminopyridine, characterized because the preparation approach is: home heating salt amide, organic solvent as well as stage transfer driver to 140-220 ° C for insulation, adding pyridine dropwise within 0.5-3 hrs, Accomplish the Chichibabin response for 3 to 10 hrs. When the response is complete, awesome the temperature level to 50 to 100 ° C, include water to execute a hydrolysis response at 30 to 100 ° C, cool, crystallize at 5 to 40 ° C, and also filter to get the 2,6-diaminopyridine., the stage transfer stimulant is a C6 to C9 aromatic amine or a C2 to C6 aliphatic alcohol amine or a blend of both, and the natural solvent is a C8 to C12 chain hydrocarbon or fragrant hydrocarbon or diphenyl ether, so The mass proportion of the salt amide to pyridine is 2.0-4.0:1.0, the mass proportion of the phase transfer catalyst to pyridine is 0.5-3.0:1.0, and the mass of the organic solvent is 1 of the mass of pyridine.|4 times, and the mass of water is 3-10 times that of pyridine.

The organic solvent as well as phase transfer stimulant can be recycled.

The stage transfer catalyst is a C6-C9 fragrant amine and/or a C2-C6 aliphatic alcohol amine, that is, it can be a C6-C9 fragrant amine, such as aniline, N, N-dimethylaniline, p-methylaniline, O-methylaniline, 2,4,6-trimethylaniline, etc can also be C2 to C6 fatty alcohol amines, such as ethanolamine, propanolamine, butanolamine, diethanolamine, triethanolamine, and so on, or C6 A blend of|C9 fragrant amines as well as C2|C6 fatty alcoholamines, C6|C9 aromatic amines and also C6|C9 aromatic amines, or C2|C6 fatty alcoholamines as well as C2|C6 fatty alcoholamines; the blend The natural solvent is a C8-C12 chain hydrocarbon or fragrant hydrocarbon or diphenyl ether, such as nonane, decane, dodecane, decalin, tetralin, diphenyl ether, and so on; the sodium amide and also pyridine The material quantity proportion of the phase transfer driver as well as pyridine is 2.0|4.0:1.0, ideally 2.5|3.0:1.0, and also the product quantity ratio of the phase transfer catalyst as well as pyridine is 0.5|3.0:1.0, ideally 0.5|1.0:1.0; The mass of the organic solvent is 1 to 4 times the mass of pyridine, preferably 1.5 to 2.5 times; the mass of the water is 3 to 10 times the mass of pyridine, ideally 5.0 to 7.0 times. The pyridine leaking time is ideally 1 to 2 hours; the Chichibabin reaction time is preferably 3 to 6 hours, as well as the response temperature is ideally 150 to 180 ° C; the hydrolysis reaction temperature level is ideally 50 to 80 ° C; the crystallization temperature is 5 to 40 ° C, preferably 18 to 28 ° C.

Contact Us

About Products:
If you need 2,6-Diaminopyridine as a cosmetic raw material, please contact our service staff directly and we will provide you with high-quality products at the best price.
As an experienced 2,6-Diaminopyridine manufacturer and supplier, our company, ZSpharmac will provide 2,6-Diaminopyridine raw materials to customers around the world for a long time.
Over the years, the company has adhered to the spirit of “integrity management, strict quality control, and customer first” and has won unanimous praise from customers at home and abroad.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

OUR MISSION
Help China Chemicals to benefit the happiness of human life
OUR VISSION
Become the most trusted chemical supplier in the world
OUR BUSINESS PHILOSOPHY
Striver – oriented, enrich employees, customer first, deep service, seek development
OUR VALUES
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Cosmetic raw materials
  • Products/Service:Cosmetic raw materials (flavors and fragrances,antioxidant products, moisturizing and hydrating, whitening agents, cosmetic additives)
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.

Service

Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.

 

After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.

FAQ

Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.

 

HOW TO CONFIRM THE PRODUCT QUALITY BEFORE PLACING ORDERS?

You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.

Shipping

1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

Get 2,6-Diaminopyridine Quotation