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2,2'-Bipyridine CAS 366-18-7

Molecular Formula: C10H8N2

Formula Weight: 156.18

ZSpharmac: 2,2′-Bipyridine Supplement

Product Name: 2,2′-Bipyridine
CAS No: 366-18-7
Purity: 99%

Basic Info

Product Name:2,2′-Bipyridine
Other Names:2,2′-Dipyridyl
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Pharmaceutical Intermediates
Appearance:White to Almost White Crystalline Powder
EINECS No.:206-674-4
Storage:Room Temp
Provide:2,2′-Bipyridine MSDS;
2,2′-Bipyridine COA

What is 2,2'-Bipyridine?

2,2′-bipyridine is among the isomers of bipyridine, an anemic solid. It is a bidentate chelating ligand that can form complicateds with several steel ions, so it can be used as a redox indicator. The complicateds with ruthenium and also platinum have solid bright residential or commercial properties and also may have possible applications.
Bipy and its derivatives can be obtained by dehydrogenation of pyridine and Raney nickel. Common 2,2′-bipyridine complexes include:
Mo(CO)4(bipy), similar to Mo(CO)6;
RuCl2(bipy)2, synthetic precursor;
[Ru(bipy)3]Cl2, a commonly used luminescent substance;
[Fe(bipy)3]2+ for colorimetric analysis of ferrous ions.
The general formula of the tri(bipy) type complex is [M(bipy)3]n+ (M = metal ion: Cr, Fe, Co, Ru, Rh, etc.), the central atom is an octahedral six-coordination, and there are two Enantiomers:

2,2'-Bipyridine Properties:

Melting point 70-73 °C(lit.)
Boiling point 273 °C(lit.)
density 1.1668 (rough estimate)
refractive index 1.4820 (estimate)
Fp 121 °C
storage temp. room temp
solubility 5.5g/l
form Crystalline Powder
pkapK1:-0.52(+2);pK2:4.352(+1) (20°C)
color White to almost white
OdorCharacteristic odour
PH7.5 (5g/l, H2O, 25℃)
Water Solubility 5.5 g/L 22 ºC


2,2'-Bipyridine Uses

  1. 2,2′-bipyridine is an intermediate in organic synthesis and medicine. Electroless copper plating additive, used in conjunction with potassium ferrocyanide, can effectively control the copper deposition rate and avoid the formation of cuprous oxide.
  2. 2,2′-bipyridine is used for the determination of ferrous, silver, cadmium and molybdenum as a redox indicator.
  3. 2,2′-bipyridine is used in transition metal-catalyzed and aluminum-initiated polymerizations; as a metalloproteinase inhibitor and a high-affinity iron chelator.

Production Method of 2,2'-Bipyridine

It is derived from the reaction of pyridine and ferric chloride. Take 70g of anhydrous pyridine and mix with 13g of anhydrous ferric chloride, heat and react at 300℃ in a sealed tube for about 35h. After cooling, the reactant solidified into red-black crystals, the sealing tube was opened, and the red-black solution of the solid was washed out with a small amount of hot water. The oily impurities were removed by extraction with ether. After neutralization with sodium bicarbonate, excess pyridine was removed by heating with steam. The mixture was then made strongly basic, and the 2,2′-bipyridine was distilled off with steam. The distillate was acidified, evaporated and concentrated, added with sodium hydroxide, extracted with ether, and the ether was removed to obtain the crude product. The crude product is recrystallized with B and decolorized with activated carbon to obtain pure product. In addition, the product can also be obtained by the reaction of α-picoline [109-06-8] and potassium permanganate after purification.

2,2'-Bipyridine Exposure Summary and Environmental Fate

The use of 2,2′-bipyridine in the production of the herbicide diquat may result in its direct release into the environment or through various waste streams. If released into air, the estimated vapor pressure at 25 °C is 1.3X10-5 mm Hg, indicating that 2,2′-bipyridine will be present in both the vapor and particulate phases in the ambient atmosphere. Gas-phase 2,2′-bipyridine will degrade in the atmosphere by reaction with photochemically generated hydroxyl radicals; the half-life of this reaction in air is estimated to be 12.5 days. The particulate phase 2,2′-bipyridine will be removed from the atmosphere by wet and dry deposition. If released into soil, 2,2′-bipyridine is expected to have moderate mobility based on an estimated Koc of 160. Based on estimated Henry’s, volatilization from moist soil surfaces is not expected to be a significant fate process. The s-law constant is 5.4X10-10 atm-cu m/mole. If released to the estimated Koc, 2,2′-bipyridine is expected to adsorb into suspended solids and sediments, but cations are expected to adsorb strongly. Based on estimated Henry’s Law constants for this compound, volatilization from the water surface is not expected to be a significant fate process. An estimated BCF of 3 indicates a low potential for bioconcentration in aquatic organisms. 2,2′-bipyridine is slowly oxidized by photochemically generated hydroxyl radicals in aqueous solution with a half-life of approximately 129 days. Skin contact with the compound in workplaces where 2,2′-bipyridine is produced or used may result in occupational exposure to 2,2′-bipyridine.

Use the structure estimation method (1). This corresponds to an atmospheric half-life of approximately 12 days and an atmospheric concentration of 5X10+5 hydroxyl radicals/cm3 (1). The rate constant for the reaction of 2,2′-bipyridine with photochemically generated hydroxyl radicals in water was measured to be 6.2X10+9 M-1 sec-1 at 21 °C and a pH of 9.3(2), which corresponds to 1X10 Water half-life of about 129 days at a hydroxyl radical concentration of -17 M (3). Due to the lack of hydrolyzable functional groups, 2,2′-bipyridine is not expected to undergo hydrolysis in the environment (4). No data are available to assess the potential for direct photolysis of this compound.

Pharmacological Classification of 2,2'-Bipyridine

chelating agent
A chemical that binds to and removes ions from a solution. Many chelating agents work by forming coordination complexes with metals.
Indicators and Reagents
Substances used for the detection, identification, analysis, etc. An indicator is a substance that changes in physical appearance (such as color) at or near the end point of a chemical titration (for example, at the transition between acidity and alkalinity). A reagent is a substance used to detect or determine another substance by chemical or microscopic means, especially analysis. The types of reagents are precipitants, solvents, oxidants, reducing agents, fluxes and colorimetric reagents. (See all compounds classified as indicators and reagents.)

2,2'-Bipyridine Antidote and First Aid

Basic treatment: Establish a clear airway. Aspirate if necessary. Watch for signs of respiratory insufficiency and assist with ventilation if necessary. Inhale oxygen at a rate of 10 to 15 L/min through a non-rebreather mask. Display for lung edema and treat if required … Screen for shock and also deal with if necessary … For eye contamination, flush eyes quickly with water.Continuously flush each eye with saline during transport…do not use emetics. If the patient can swallow, has a strong gag reflex and is not drooling, rinse mouth and dilute with 5 ml/kg to 200 ml of water. Managed Activated Carbon… /Aromatic Hydrocarbons and Related Compounds/
Advanced treatment: Consider orotracheal or nasotracheal intubation to control the airway in patients who are unconscious or have stopped breathing. Positive pressure ventilation techniques with a bag-valve mask device may be beneficial. If necessary, monitor heart rhythm and treat arrhythmia…Initiate IV with D5W/SRP: “keep open”, minimum flow/. If there are signs of hypovolemia, use lactated Ringer’s solution. Watch for signs of fluid overload. Consider medical treatment for pulmonary edema… Diazepam (Valium) for seizures… Use proparacaine hydrochloride to assist with eye irrigation… / Aromatic hydrocarbons and related compounds /

Company Profile and Company Culture

Company Profile

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Company Culture:

our mission
Help China Chemicals to benefit the happiness of human life
our vision
Become the most trusted chemical supplier in the world
our business philosophy
Striver – oriented, enrich employees, customer first, deep service, seek development
our values
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Additive , Chemical Auxiliary & Catalyst , Organic Chemicals
  • Products/Service: Organic Intermediate,Inorganic Chemistry, APIs, Dyestuffs And Pigments, Fragrance And Spices, Food Additives
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.


After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.


Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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