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2-Phenoxyethanol CAS 122-99-6

Molecular Formula: C8H10O2

Formula Weight: 138.16

ZSpharmac: 2-Phenoxyethanol Supplier

Product Name: 2-Phenoxyethanol
CAS No: 122-99-6
Purity: 99%

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Basic Info

Product Name:2-Phenoxyethanol
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:Clear Colorless Liquid
EINECS No.:204-589-7
Storage:Store Below +30°C.
Provide:2-Phenoxyethanol MSDS;
2-Phenoxyethanol COA

What is 2-Phenoxyethanol?

Phenoxyethanol is an anemic oily liquid that has anti-bacterial and also disinfectant residential properties as well as is generally used together with quaternary ammonium salts. Phenoxyethanol is an aromatic ether alcohol substance with a high boiling point and low volatility (to ensure that phenoxyethanol will not volatilize right into the air, be breathed in by the human body, and also have the danger of breathing poisoning), additionally called ethylene glycol phenyl ether. It is a phenolic ether natural substance often used in skin treatment items. It can be produced by etherification of ethylene glycol and phenanol, and is frequently discovered in skin treatment lotions as well as sunscreens.

2-Phenoxyethanol Property

Melting point 

11-13 °C (lit.)

Boiling point 

247 °C (lit.)


1.102 g/mL at 25 °C (lit.)

vapor density 

4.8 (vs air)

vapor pressure 

0.01 mm Hg ( 20 °C)

refractive index 

n20/D 1.539


>230 °F

storage temp. 

Store below +30°C.


soluble, clear, colorless to very faintly yellow






Clear colorless

Specific Gravity

1.109 (20/4℃)


Faint aromatic odor

PH Range

7 at 10 g/l at 23 °C


7 (10g/l, H2O, 23℃)

explosive limit


Odor Type


Water Solubility 

30 g/L (20 ºC)


Application of 2-Phenoxyethanol

Generally made use of as a substitute for the really harmful salt azide in organic buffer treatments due to the fact that 2-phenoxyethanol is less damaging and chemically inactive towards copper and also lead. It is usually made use of as a chemical in cosmetics, vaccinations as well as medications.

On top of that, 2-Phenoxyethanol is also a fixative in fragrances and also a component in insect repellants and anti-bacterials. It can also be used as a solvent for cellulose acetate, dyes, inks in addition to products. Used as a chemical in medicines, cosmetics in addition to lubricants. Phenoxyethanol is just somewhat soluble in water, as well as can be used as an anesthetic for fish in tank farming and also natural synthesis.

The compounds currently used as fundamental chemicals usually launch formaldehyde, which is normally thought about to be hazardous to the body. Compared with these substances that release formaldehyde, phenoxyethanol lacks a question a better alternative. In Japan as well as likewise the European Union, the concentration of phenoxyethanol in cosmetics is limited to 1%.

2-Phenoxyethanol Detection Method

1. Detection method of 2-Phenoxyethanol

“Specification” “physical and chemical test method 4.7 methyl chloroisothiazolinone and other 12 kinds of components” stipulates the method of high performance liquid chromatography to determine the content of 12 kinds of preservatives such as phenoxyethanol, in which the detection limit of phenoxyethanol is 0.1 μg, the detection concentration is 200μg/g.

Current standards, including the recommended national standard “GB/T 26517-2011 Determination of Twenty-four Preservatives in Cosmetics by High Performance Liquid Chromatography” implemented on October 1, 2011 and the recommended one that will be implemented on April 1, 2019 Industry standard “QB/T 5290-2018 Phenoxyethanol Raw Materials for Cosmetics”.

2. 2-Phenoxyethanol risk substance detection method

1. Dioxane, its chemical name is 1,4-dioxane, and another name is dioxane. It is colorless and has a slight fragrance. From the perspective of chemical toxicity, it is slightly toxic , is irritating to the skin, eyes and respiratory system, and may cause damage to the liver, kidneys and nervous system.

The “General Requirements for Cosmetics Safety” in the “Specifications” clearly stipulates that the limit value of dioxane is ≤30 mg/kg (ppm), and stipulates two detection methods (“Physical and Chemical Test Methods” 2.19 Dioxane test method), using gas phase Chromatography-mass spectrometry is used to determine the content of dioxane in cosmetics, and the detection limit is 2 µg. One is quantified by the standard addition single-point method; the other is calculated by the standard curve method.

The national recommended standard “GB/T 30932-2014 Determination of Prohibited Dioxane Residues in Cosmetics Headspace Gas Chromatography-Mass Spectrometry” detection limit is 0.8mg/kg, by using deuterated dioxane as internal standard , after calculating the correction factors of dioxane and deuterated dioxane, the content of dioxane is obtained.

At present, when detecting dioxane, most testing institutions use the detection methods in the “Specifications” as the standard, and adopt the first method or the second method according to the actual situation of the laboratory.

II. Diethylene glycol, also known as diethylene glycol and diethylene glycol ether, is a colorless, transparent, hygroscopic viscous liquid; it has a pungent smell and is a low-toxic chemical substance. After entering the human body, it is quickly excreted due to metabolism , no obvious accumulation, so far no evidence of carcinogenicity, teratogenicity and mutagenicity has been found, but high dose intake can damage the kidneys.

Diethylene glycol is a banned substance in both China and the EU. It is stipulated in the EU’s restricted substance list that as a trace ingredient brought in, it cannot exceed 0.1% in the end product. That is, the “Opinions on Diethylene Glycol” (SCCP/1181/08) issued by SCCP (EU Consumer Products Technology Committee) in 2008 concluded that “diethylene glycol is used as a raw material such as glycerin and polyethylene glycol in cosmetics. , it is safe if the maximum concentration in the finished product does not exceed 0.1%.

2-Phenoxyethanol Disinfectant Compounding Technology

In order to overcome the inability of traditional single long chain and double long chain compound quaternary ammonium salts to quickly sterilize at low concentrations, or compound alcohol, isopropanol, or add glutaraldehyde, o-phthalaldehyde, urotropine, chlorine acetate The technical indicators can only be realized after a certain period of time. The traditional disinfectants are flammable, volatile, ineffective, irritating, and sensitizing. The present invention provides a 2-Phenoxyethanol disinfectant compounding technology.

The technical scheme adopted in the present invention is: the present invention is by ① 1-2% ethylene glycol phenyl ether, ② 0.03-0.05% bisoctyl dimethyl ammonium chloride, ③ 0.03-0.05% didecyl dimethyl ammonium chloride Methyl ammonium chloride, ④ 0.1% glycerin, ⑤ 0.1% provitamin B5, chelating agent, stabilizer, the aqueous solution (1000mg/L) that pH adjuster forms, can be when PH value is 6.72 weak acidity, Effectively kill all indicator bacteria such as fungi, yeast, mold, E. coli, Staphylococcus aureus, Candida albicans, Pseudomonas aeruginosa and viruses in 0.5 minutes, the killing rate is greater than 99.999%, the bactericidal concentration is low, and the toxicity is Actual non-toxic grade, non-irritating to damaged skin, mucous membranes and eyes, non-corrosive to stainless steel, copper, aluminum and other materials, good biodegradability, friendly to the environment, especially overcoming the traditional single long chain and double chain The long-chain compound quaternary ammonium salt cannot quickly sterilize bacteria at low concentrations, or it needs to be compounded with alcohol, isopropanol, glutaraldehyde, o-phthalaldehyde, urotropine, chlorhexidine acetate, etc. to achieve technical indicators. The invention can produce military, medical and civilian sanitation disinfectant, which is easy to prepare and low in cost. It can be used for disinfection of damaged skin without volatilization and can be stored for more than 5 years. It can directly treat wounds during wars and natural disasters. Media spraying, eliminating the need for cotton swabs and other media, overcomes the disadvantages of flammability, volatile failure, irritation, and sensitization of traditional disinfectants. Easy to use and so on.

Compared with the prior art, the beneficial effect of the present invention is that the low concentration kills all indicator bacteria in 0.5 minutes when the pH value is weakly acidic at 6.72, and the killing rate is greater than 99.999%, the bactericidal concentration is low, and the toxicity is practically non-existent. Toxic level. It can be directly diluted with deionized water. In special cases, it can be blended with clean water. Its anti-hard water ability will not affect the sterilization effect. It is colorless, odorless, non-yellowing, and non-fading. Easy to use.

About Products:
If you need 2-Phenoxyethanol as a cosmetic raw material, please contact our service staff directly, we will provide you with high-quality products at the best price.
As an experienced 2-Phenoxyethanol manufacturer and supplier, ZSpharmac will provide 2-Phenoxyethanol raw materials to customers all over the world for a long time.
Over the years, the company has been adhering to the spirit of “integrity management, strict quality control, customer first”, and has won unanimous praise from domestic and foreign customers.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

Help China Chemicals to benefit the happiness of human life
Become the most trusted chemical supplier in the world
Striver – oriented, enrich employees, customer first, deep service, seek development
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Cosmetic raw materials
  • Products/Service:Cosmetic raw materials (flavors and fragrances,antioxidant products, moisturizing and hydrating, whitening agents, cosmetic additives)
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.


After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.


Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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