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2-Nitrotoluene CAS 88-72-2

Molecular Formula: C7H7NO2

Formula Weight: 137.14

ZSpharmac: 2-Nitrotoluene Supplement

Product Name: 2-Nitrotoluene
CAS No: 88-72-2
Purity: 99%

Basic Info

Product Name:2-Nitrotoluene
Other Names:2-Nitrotoluene, 99+%
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Organic Chemical Raw Materials
Appearance:Clear Yellow to Yellow-Green Liquid
EINECS No.:201-853-3
Storage:Store Below +30°C.
Provide:2-Nitrotoluene MSDS;
2-Nitrotoluene COA

What is 2-Nitrotoluene?

Ortho-nitrotoluene is also known as 2-nitrotoluene, 1-methyl-2-nitrobenzene. Yellow oily transparent liquid. There is the smell of nitrobenzene. The relative density is 1.1629. Melting point -2.9°C (α type, stable type), -9.5°C (β type, unstable type). Boiling point 221.7°C, 118°C (2.133×103Pa), 50.0°C (0.133×103Pa). Flash point 106.1 ℃ (closed). Refractive index 1.5450. Viscosity 0.0262mPa·s (15°C). Vapor pressure (×103Pa): 10.906 (5°C), 12.639 (10°C), 14.612 (20°C), 15.892 (30°C). Slightly soluble in water (0.061 at 30°C), soluble in benzene, chloroform and petroleum ether, miscible with ethanol and ether. Evaporates with water vapor. Due to the strong electron-withdrawing property of the nitro group, the methyl group is easily oxidized. According to the oxidation conditions, o-nitrobenzaldehyde or o-nitrobenzoic acid can be generated; when reduced under the action of a catalyst, o-toluidine can be generated, and nitration can be continued to generate 2,4 or 2,6 dinitrotoluene; can also be chlorinated to generate nitrobenzyl chloride; can also generate azo compounds. Oral LD50801mg/kg for rats. o-Nitrotoluene is mainly used as a dye raw material to prepare dyes such as 4-chloro-2-nitrotoluene, 6-chloro-2-nitrotoluene, o-toluidine, bi-o-toluidine and 2,6-dichlorobenzaldehyde Intermediate; 4-chloro-2-nitrotoluene is also a pharmaceutical raw material; o-toluidine is also a raw material for pesticides and fungicides and a fragrance raw material; preparation of 2,2′-dinitrobenzyl, o-nitrobenzyl bromide and bromohexyl alkane and other pharmaceutical raw materials; preparation of indole as a raw material for amino acids and plant growth regulators; prep work of indole as a resources for amino acids and also plant growth regulatory authorities; prep work of dinitrotoluene as a resources for gunpowder; o-toluidine can likewise be used as a vulcanization accelerator; preparation of o-nitrobenzoic acid as a pharmaceutical resources.

2-Nitrotoluene Properties:

Melting point -9 °C
Boiling point 225 °C(lit.)
density 1.163 g/mL at 25 °C(lit.)
vapor density 4.72
vapor pressure 0.1 hPa (20 °C)
refractive index n20/D 1.546(lit.)
Fp 223 °F
storage temp. Store below +30°C.
solubility 0.65g/l (experimental)
form Liquid
color Clear yellow to yellow-green
PH6-8 (H2O)
explosive limit1.47-8.8%(V)
Water Solubility 0.44 g/L (20 ºC)


2-Nitrotoluene Uses

  1. 2-Nitrotoluene is used as an intermediate for dyes and pesticides, as well as in the production of coatings, plastics and medicines, etc.
  2. 2-Nitrotoluene is mainly used in the production of o-toluidine and bitoluidine, and is a crucial resources for dyes, coverings, plastics as well as medicines. In the pharmaceutical sector, it is made use of for the production of nifedipine, tongining, imipramine hydrochloride, bromhexylamine hydrochloride, diclofenac sodium penicillin, and so on.

2-Nitrotoluene Production Method

Toluene is nitrated with mixed acid to generate mixed nitrotoluene, mainly o-nitrotoluene (about two-thirds) and p-nitrotoluene (about one-third), which are separated to obtain pure products. Add toluene into the reactor, cool it to below 25°C, add the prepared mixed acid (i.e. 25-30% nitric acid, 55-58% sulfuric acid and 20-21% water), and adjust the temperature not to exceed 50°C. Stir continuously for 1-2h, then stand for 6h, separate the generated nitrotoluene, wash with water and alkali to remove unreacted toluene and aliphatic compounds, the composition of the crude nitrotoluene product is o-nitrotoluene 55-60 %, meta 2-5%, para 35-40%. Yield 90-95%. Each isomer can be separated by crude distillation and crystallization using the difference in boiling point and melting point. That is, the crude nitrotoluene is first vacuum distilled to separate most of the o-nitrotoluene, and the residual fraction containing more p-nitrotoluene is then distilled under reduced pressure, cooled, crystallized, and separated to obtain finished product. A high-boiling tar-like substance remained in the still. The meta-nitrotoluene is contained in the mother liquor after the separation of the para-isomer, and is obtained by rectification after repeated accumulation. The purity of ortho- and para-nitrotoluene can reach 98% and 99%, respectively. The domestic process is two pots connected in series, and the reaction temperature is 40-45°C for the main pot and 50-55°C for the secondary pot. The preparation of mixed acid is roughly similar, nitric acid 26-28%, sulfuric acid 56-57%, water 16-18%. Raw material consumption quota: toluene (98%) 800kg/t, nitric acid (98%) 470kg/t, sulfuric acid (92.5%) 450kg/t, caustic soda (42%) 100kg/t.

2-Nitrotoluene application

o-Nitrotoluene can be used as a raw material to synthesize other compounds such as o-nitrobenzaldehyde, o-nitrobenzoic acid, and dinitrotoluene.
1. For the preparation of o-nitrobenzaldehyde. Take o-nitrotoluene as raw material, select the metal phthalocyanine of general formula (I) structure, the mononuclear metalloporphyrin of general formula (II), (III) structure or the μ-oxygen binuclear metalloporphyrin of general formula (IV) structure Any one of the phenoline is used as a catalyst, in the formula, M1, M2, M3, M4, M5 are transition metal atoms, M1=Fe, Co, Cu, Zn, M2=Fe, Mn, Co, Cu, Zn, M3= Fe, Mn, Co, M4 and M5 can be the same or different, when they are the same, M4=M5=Fe, Mn, Co, when not, M4=Fe, M5=Mn or M4=Fe, M5=Co, R can be It can be carboxyl or hydrogen, R1 and R2 can be hydrogen, halogen, nitro, hydroxyl, alkoxy, ligand X is chlorine, the amount of catalyst used is 0.2-1.0% of the weight of o-nitrotoluene, and methanol is used as Solvent, in 3.0~6.0mol/L strong alkaline methanol solution, pass oxygen of 0.8~3.0MPa, control the reaction temperature to be 25~60℃, and the reaction time to be 6~48h to obtain the crude product of o-nitrobenzaldehyde. After separation as well as purification by conventional methods, o-nitrobenzaldehyde penalty items are obtained.The structures of general formula (I), (II), (III) and (IV) are respectively as follows:

2. For the preparation of o-nitrobenzoic acid. Without adding any catalyst, using o-nitrotoluene as raw material, oxygen as oxidant, sodium hydroxide as alkali, the reaction temperature is 25-85 ℃, and the reaction is carried out in solvent alcohol or its aqueous solution for 5-72 hours. Treatment, separation and purification to obtain the o-nitrobenzoic acid.Therapy, splitting up and purification to acquire the o-nitrobenzoic acid. The method calls for no stimulant; the raw materials and solvents are cheap; the reaction temperature is moderate; the manufacturing control is easy, the return can be as high as 90%,. and it is suitable for mass preparation and industrialization, and has broad application prospects.

3. For the preparation of dinitrotoluene. Using o-nitrotoluene as raw material, using fuming acid sulfur-fuming nitric acid nitration system to carry out nitration reaction at room temperature, the dinitrotoluene mixture was obtained in high yield. The proportion of 2,4-DNT in the dinitrotoluene mixture can reach 75%. By taking on the nitration reaction at space temperature level, the generation of trinitrotoluene is avoided, and also the safety and security of the nitration process is enhanced.Specifically, it includes the following steps: in the first step, add fuming sulfuric acid to the reactor first, then dropwise add o-nitrotoluene, and then add fuming nitric acid after mixing evenly, and continue the reaction; in the second step, after the reaction is completed, add the mixed solution Pour into crushed ice to precipitate solids. After the ice cubes are completely melted, the solids obtained by suction filtration are washed with hot water, cooled, suction filtered, and dried to obtain dinitrotoluene. Wherein, the mass fraction of sulfur trioxide in the oleum in the first step is 5~25%; the consumption ratio of o-nitrotoluene, oleum, concentrated nitric acid is 1 mol: 0.40~0.65 L: 1~1.05 mol In the first step, the temperature of reaction is maintained at 5~30 ℃, and the reaction times is 2~3h; In the second step, the mass fraction of 2,4-dinitrotoluene in the obtained dinitrotoluene is 72~75% ; The nitrification process adopts discontinuous production or continuous production.

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Additive , Chemical Auxiliary & Catalyst , Organic Chemicals
  • Products/Service: Organic Intermediate,Inorganic Chemistry, APIs, Dyestuffs And Pigments, Fragrance And Spices, Food Additives
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


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We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

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Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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